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O13439

- ACEA_COPCI

UniProt

O13439 - ACEA_COPCI

Protein

Isocitrate lyase

Gene

ACU-7

Organism
Coprinopsis cinerea (Inky cap fungus) (Hormographiella aspergillata)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate = succinate + glyoxylate.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei203 – 2031PROSITE-ProRule annotation

    GO - Molecular functioni

    1. isocitrate lyase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-UniPathway
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glyoxylate bypass, Tricarboxylic acid cycle

    Enzyme and pathway databases

    UniPathwayiUPA00703; UER00719.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate lyase (EC:4.1.3.1)
    Short name:
    ICL
    Short name:
    Isocitrase
    Short name:
    Isocitratase
    Gene namesi
    Name:ACU-7
    OrganismiCoprinopsis cinerea (Inky cap fungus) (Hormographiella aspergillata)
    Taxonomic identifieri5346 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesPsathyrellaceaeCoprinopsis

    Subcellular locationi

    Peroxisome By similarity

    GO - Cellular componenti

    1. peroxisome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 537537Isocitrate lyasePRO_0000068787Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliO13439.
    SMRiO13439. Positions 1-517.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi535 – 5373Microbody targeting signalSequence Analysis

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.20.20.60. 2 hits.
    InterProiIPR006254. Isocitrate_lyase.
    IPR018523. Isocitrate_lyase_ph_CS.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view]
    PANTHERiPTHR21631:SF3. PTHR21631:SF3. 1 hit.
    PfamiPF00463. ICL. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001362. Isocit_lyase. 1 hit.
    SUPFAMiSSF51621. SSF51621. 1 hit.
    TIGRFAMsiTIGR01346. isocit_lyase. 1 hit.
    PROSITEiPS00161. ISOCITRATE_LYASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O13439-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSERAQFAS EVAEVERWWK SPRFARVNRP YTAADVVSKR GTIKINYPSD    50
    VQGKKLWKLL SEHAKNGTPS HTYGALDPVQ VTKMAKYLET VYVSGWQSSS 100
    TASSSNEPGP DLADYPSNTV PNKVEHLFMA QLFHDRKQRE ARSRMSDAEL 150
    ANTPVIDYLR PIVADADTGH GGLTAVMKLT KMFVEKGAAG IHIEDQAPGT 200
    KKCGHMAGKV LVPIQEHINR LVAIRLQYDI MGVENLVVAR TDSEAATLIT 250
    SNIDDRDHPF IQGSTNPSLP PLNNVMVEAE AQGKTGDQLQ AIEDGWIKAA 300
    NLQLFPQALA QALANEGASR STVEKLVARV SRLSWSQAVA VAQKEFGLKQ 350
    VPYWNWDAPR TREGYYRYQG GTECAIHRAN AFAPYADLLW METKKPILAQ 400
    AKEFAAGVHA VHPGQWLAYN LSPSFNWKLL PQRQDMQAYV WELGKLGFVW 450
    QFITLAGLHS NAYISDLFAQ NFAKTGMKAY VELVQSRERE IGCDVLTHQK 500
    WSGADYADSL IKTVTGGVSS TAAMGAGVTE SQFTSKL 537
    Length:537
    Mass (Da):59,358
    Last modified:January 1, 1998 - v1
    Checksum:iEEAB953191CDFA82
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X98860 Genomic DNA. Translation: CAA67367.1.
    PIRiJC6182.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X98860 Genomic DNA. Translation: CAA67367.1 .
    PIRi JC6182.

    3D structure databases

    ProteinModelPortali O13439.
    SMRi O13439. Positions 1-517.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00703 ; UER00719 .

    Family and domain databases

    Gene3Di 3.20.20.60. 2 hits.
    InterProi IPR006254. Isocitrate_lyase.
    IPR018523. Isocitrate_lyase_ph_CS.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view ]
    PANTHERi PTHR21631:SF3. PTHR21631:SF3. 1 hit.
    Pfami PF00463. ICL. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001362. Isocit_lyase. 1 hit.
    SUPFAMi SSF51621. SSF51621. 1 hit.
    TIGRFAMsi TIGR01346. isocit_lyase. 1 hit.
    PROSITEi PS00161. ISOCITRATE_LYASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular analysis of the isocitrate lyase gene (acu-7) of the mushroom Coprinus cinereus."
      Chaure P.T., Casselton L.A., Connerton I.F.
      Gene 184:185-187(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: JV6.

    Entry informationi

    Entry nameiACEA_COPCI
    AccessioniPrimary (citable) accession number: O13439
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3