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O13439 (ACEA_COPCI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Isocitrate lyase

Short name=ICL
Short name=Isocitrase
Short name=Isocitratase
EC=4.1.3.1
Gene names
Name:ACU-7
OrganismCoprinopsis cinerea (Inky cap fungus) (Hormographiella aspergillata)
Taxonomic identifier5346 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesPsathyrellaceaeCoprinopsis

Protein attributes

Sequence length537 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate = succinate + glyoxylate.

Pathway

Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.

Subunit structure

Homotetramer By similarity.

Subcellular location

Peroxisome By similarity.

Sequence similarities

Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.

Ontologies

Keywords
   Biological processGlyoxylate bypass
Tricarboxylic acid cycle
   Cellular componentPeroxisome
   Molecular functionLyase
Gene Ontology (GO)
   Biological_processglyoxylate cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentperoxisome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionisocitrate lyase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 537537Isocitrate lyase
PRO_0000068787

Regions

Motif535 – 5373Microbody targeting signal Potential

Sites

Active site2031 By similarity

Sequences

Sequence LengthMass (Da)Tools
O13439 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: EEAB953191CDFA82

FASTA53759,358
        10         20         30         40         50         60 
MSSERAQFAS EVAEVERWWK SPRFARVNRP YTAADVVSKR GTIKINYPSD VQGKKLWKLL 

        70         80         90        100        110        120 
SEHAKNGTPS HTYGALDPVQ VTKMAKYLET VYVSGWQSSS TASSSNEPGP DLADYPSNTV 

       130        140        150        160        170        180 
PNKVEHLFMA QLFHDRKQRE ARSRMSDAEL ANTPVIDYLR PIVADADTGH GGLTAVMKLT 

       190        200        210        220        230        240 
KMFVEKGAAG IHIEDQAPGT KKCGHMAGKV LVPIQEHINR LVAIRLQYDI MGVENLVVAR 

       250        260        270        280        290        300 
TDSEAATLIT SNIDDRDHPF IQGSTNPSLP PLNNVMVEAE AQGKTGDQLQ AIEDGWIKAA 

       310        320        330        340        350        360 
NLQLFPQALA QALANEGASR STVEKLVARV SRLSWSQAVA VAQKEFGLKQ VPYWNWDAPR 

       370        380        390        400        410        420 
TREGYYRYQG GTECAIHRAN AFAPYADLLW METKKPILAQ AKEFAAGVHA VHPGQWLAYN 

       430        440        450        460        470        480 
LSPSFNWKLL PQRQDMQAYV WELGKLGFVW QFITLAGLHS NAYISDLFAQ NFAKTGMKAY 

       490        500        510        520        530 
VELVQSRERE IGCDVLTHQK WSGADYADSL IKTVTGGVSS TAAMGAGVTE SQFTSKL 

« Hide

References

[1]"Molecular analysis of the isocitrate lyase gene (acu-7) of the mushroom Coprinus cinereus."
Chaure P.T., Casselton L.A., Connerton I.F.
Gene 184:185-187(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: JV6.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X98860 Genomic DNA. Translation: CAA67367.1.
PIRJC6182.

3D structure databases

ProteinModelPortalO13439.
SMRO13439. Positions 1-517.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00703; UER00719.

Family and domain databases

Gene3D3.20.20.60. 2 hits.
InterProIPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PANTHERPTHR21631:SF3. PTHR21631:SF3. 1 hit.
PfamPF00463. ICL. 1 hit.
[Graphical view]
PIRSFPIRSF001362. Isocit_lyase. 1 hit.
SUPFAMSSF51621. SSF51621. 1 hit.
TIGRFAMsTIGR01346. isocit_lyase. 1 hit.
PROSITEPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACEA_COPCI
AccessionPrimary (citable) accession number: O13439
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: May 14, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways