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O13433

- PLC1_CANAX

UniProt

O13433 - PLC1_CANAX

Protein

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1

Gene

PLC1

Organism
Candida albicans (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

    Catalytic activityi

    1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei579 – 5791PROSITE-ProRule annotation
    Active sitei642 – 6421PROSITE-ProRule annotation
    Binding sitei724 – 7241SubstrateBy similarity
    Binding sitei726 – 7261SubstrateBy similarity
    Binding sitei823 – 8231SubstrateBy similarity
    Binding sitei852 – 8521SubstrateBy similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. phosphatidylinositol phospholipase C activity Source: UniProtKB-EC
    3. signal transducer activity Source: UniProtKB-KW

    GO - Biological processi

    1. intracellular signal transduction Source: InterPro
    2. lipid catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Transducer

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1 (EC:3.1.4.11)
    Alternative name(s):
    Phosphoinositide phospholipase C
    Phospholipase C-1
    Short name:
    PLC-1
    Gene namesi
    Name:PLC1
    OrganismiCandida albicans (Yeast)
    Taxonomic identifieri5476 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 109910991-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1PRO_0000088512Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliO13433.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini566 – 726161PI-PLC X-boxPROSITE-ProRule annotationAdd
    BLAST
    Domaini794 – 912119PI-PLC Y-boxPROSITE-ProRule annotationAdd
    BLAST
    Domaini938 – 1066129C2Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi90 – 10213Poly-SerAdd
    BLAST
    Compositional biasi239 – 2435Poly-Thr
    Compositional biasi517 – 5204Poly-Asp
    Compositional biasi619 – 6235Poly-Thr
    Compositional biasi629 – 6324Poly-Asp
    Compositional biasi743 – 76018Poly-ThrAdd
    BLAST
    Compositional biasi918 – 9214Poly-Ser

    Sequence similaritiesi

    Contains 1 C2 domain.Curated
    Contains 1 PI-PLC X-box domain.PROSITE-ProRule annotation
    Contains 1 PI-PLC Y-box domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG149692.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    2.60.40.150. 1 hit.
    3.20.20.190. 2 hits.
    InterProiIPR000008. C2_dom.
    IPR011992. EF-hand-dom_pair.
    IPR001192. PI-PLC_fam.
    IPR017946. PLC-like_Pdiesterase_TIM-brl.
    IPR000909. PLipase_C_PInositol-sp_X_dom.
    IPR001711. PLipase_C_Pinositol-sp_Y.
    [Graphical view]
    PANTHERiPTHR10336. PTHR10336. 1 hit.
    PfamiPF00388. PI-PLC-X. 1 hit.
    PF00387. PI-PLC-Y. 1 hit.
    [Graphical view]
    PRINTSiPR00390. PHPHLIPASEC.
    SMARTiSM00239. C2. 1 hit.
    SM00148. PLCXc. 1 hit.
    SM00149. PLCYc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 1 hit.
    SSF51695. SSF51695. 1 hit.
    PROSITEiPS50007. PIPLC_X_DOMAIN. 1 hit.
    PS50008. PIPLC_Y_DOMAIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O13433-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLESLNRRNS IDSNQADNDN DNDNHSNDEL SPSELYYSPS GSPPKSQLLL     50
    RKSSSPSSYS PIKSDLPNIY SHLRSNDSES PPQPSPKQQS SLSSSSSSSS 100
    SSNTKSSTTK NIFKKLLRIN KSSDNIDESR SIVSNNGGSP MSDSTTVTST 150
    LSTDTAPKRG KSIQRSQILH HTDSDSLYLE NQIELRPEIS KSIGNIKIPS 200
    IFTNDGMPLL KISHKSKKRI LFWIDPSCFK FSWRMANSTT TTTSATTSAT 250
    TSGLPQGITN TTALSNSAII STPAIATSAI HRLSITNRTT HEFVLDDIKS 300
    IYIQNEGSGY REELNISQKL EKNWITIIYF NHKKNSLKSL HLITDNDHDF 350
    KKLISAIYNL KQLRSQLAKE FLIDLNELDE NYVKMLLNKE LLAGDNGNVD 400
    GNEVDIRKSH KHVREFLSFN DILKYSKRLN INVNTNHLQQ IFDQVLLLSS 450
    ATTEKPVSTP LFEKGLNFEQ FKQFVSILKD RKDLQEIWDS LAQGKEVLQF 500
    DEIKNFIINI QKENFSDDDD NSTINLIFQK YCSNDNGWNK ESLNEYLLSS 550
    YSTPYREITQ TQTNYYDYPL NEYFISSSHN TYLTGRQVAG DSSVEGYIRT 600
    LQRGCRCVEI DIWNGDSNTT TTTVIGTKDD DDKNEYEPIV NHGRTFTKPI 650
    SFANVIRAIK KFAFIVSPWP LILSLEIHCS PECQIKVVNI LKDILGENMI 700
    IAPIDIDSVI LPSPAELKHK FIIKVKKTTS FQNLIETENG SFTTSTTTTT 750
    TTTTTTTTAT SLSEDNENNK SNSSSTSSFI IRRRKNKSPK IINELSNLGI 800
    YTQGIKFRNF SLPESKTFNH CFSLGEKSIN RMIKDDDKKI SLDKHNRRYL 850
    MRVYPSGTRL KSSNFNPLPY WSHGVQMVAT NWQTYDLGQQ LNEALFENKI 900
    FQGYVLKPSV LRKPTLKSSS SNVDTRTSLT TTNSKTIRFN FEIISGHQLP 950
    KFPKDDYKDQ AINPYISFEI IGAQDVQWDN NDSSPIAPTT SSSPFIRTTK 1000
    IIRENGFNPN FNTKFSGSII TTTNDLIFIK FVVYASTSLN YPDYGENFPI 1050
    AILVTKLNYL KQGYRYIYLN DLLGEQLVYS SIFIKIEYDE DLLNEFINK 1099
    Length:1,099
    Mass (Da):124,592
    Last modified:January 1, 1998 - v1
    Checksum:iD54D687D53A2829B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y13975 Genomic DNA. Translation: CAA74308.1.
    PIRiT18257.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y13975 Genomic DNA. Translation: CAA74308.1 .
    PIRi T18257.

    3D structure databases

    ProteinModelPortali O13433.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi NOG149692.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    2.60.40.150. 1 hit.
    3.20.20.190. 2 hits.
    InterProi IPR000008. C2_dom.
    IPR011992. EF-hand-dom_pair.
    IPR001192. PI-PLC_fam.
    IPR017946. PLC-like_Pdiesterase_TIM-brl.
    IPR000909. PLipase_C_PInositol-sp_X_dom.
    IPR001711. PLipase_C_Pinositol-sp_Y.
    [Graphical view ]
    PANTHERi PTHR10336. PTHR10336. 1 hit.
    Pfami PF00388. PI-PLC-X. 1 hit.
    PF00387. PI-PLC-Y. 1 hit.
    [Graphical view ]
    PRINTSi PR00390. PHPHLIPASEC.
    SMARTi SM00239. C2. 1 hit.
    SM00148. PLCXc. 1 hit.
    SM00149. PLCYc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 1 hit.
    SSF51695. SSF51695. 1 hit.
    PROSITEi PS50007. PIPLC_X_DOMAIN. 1 hit.
    PS50008. PIPLC_Y_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genetic characterization of a phospholipase C gene from Candida albicans: presence of homologous sequences in Candida species other than Candida albicans."
      Bennett D.E., McCreary C.E., Coleman D.C.
      Microbiology 144:55-72(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 132A.

    Entry informationi

    Entry nameiPLC1_CANAX
    AccessioniPrimary (citable) accession number: O13433
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3