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O13433

- PLC1_CANAX

UniProt

O13433 - PLC1_CANAX

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Protein

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1

Gene
PLC1
Organism
Candida albicans (Yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein predictedi

Functioni

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei579 – 5791 By similarity
Active sitei642 – 6421 By similarity
Binding sitei724 – 7241Substrate By similarity
Binding sitei726 – 7261Substrate By similarity
Binding sitei823 – 8231Substrate By similarity
Binding sitei852 – 8521Substrate By similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. phosphatidylinositol phospholipase C activity Source: UniProtKB-EC
  3. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. lipid catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transducer

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1 (EC:3.1.4.11)
Alternative name(s):
Phosphoinositide phospholipase C
Phospholipase C-1
Short name:
PLC-1
Gene namesi
Name:PLC1
OrganismiCandida albicans (Yeast)
Taxonomic identifieri5476 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 109910991-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1PRO_0000088512Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO13433.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini566 – 726161PI-PLC X-boxAdd
BLAST
Domaini794 – 912119PI-PLC Y-boxAdd
BLAST
Domaini938 – 1066129C2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi90 – 10213Poly-SerAdd
BLAST
Compositional biasi239 – 2435Poly-Thr
Compositional biasi517 – 5204Poly-Asp
Compositional biasi619 – 6235Poly-Thr
Compositional biasi629 – 6324Poly-Asp
Compositional biasi743 – 76018Poly-ThrAdd
BLAST
Compositional biasi918 – 9214Poly-Ser

Sequence similaritiesi

Contains 1 C2 domain.

Phylogenomic databases

eggNOGiNOG149692.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR001192. PI-PLC_fam.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PfamiPF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view]
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEiPS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O13433-1 [UniParc]FASTAAdd to Basket

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MLESLNRRNS IDSNQADNDN DNDNHSNDEL SPSELYYSPS GSPPKSQLLL     50
RKSSSPSSYS PIKSDLPNIY SHLRSNDSES PPQPSPKQQS SLSSSSSSSS 100
SSNTKSSTTK NIFKKLLRIN KSSDNIDESR SIVSNNGGSP MSDSTTVTST 150
LSTDTAPKRG KSIQRSQILH HTDSDSLYLE NQIELRPEIS KSIGNIKIPS 200
IFTNDGMPLL KISHKSKKRI LFWIDPSCFK FSWRMANSTT TTTSATTSAT 250
TSGLPQGITN TTALSNSAII STPAIATSAI HRLSITNRTT HEFVLDDIKS 300
IYIQNEGSGY REELNISQKL EKNWITIIYF NHKKNSLKSL HLITDNDHDF 350
KKLISAIYNL KQLRSQLAKE FLIDLNELDE NYVKMLLNKE LLAGDNGNVD 400
GNEVDIRKSH KHVREFLSFN DILKYSKRLN INVNTNHLQQ IFDQVLLLSS 450
ATTEKPVSTP LFEKGLNFEQ FKQFVSILKD RKDLQEIWDS LAQGKEVLQF 500
DEIKNFIINI QKENFSDDDD NSTINLIFQK YCSNDNGWNK ESLNEYLLSS 550
YSTPYREITQ TQTNYYDYPL NEYFISSSHN TYLTGRQVAG DSSVEGYIRT 600
LQRGCRCVEI DIWNGDSNTT TTTVIGTKDD DDKNEYEPIV NHGRTFTKPI 650
SFANVIRAIK KFAFIVSPWP LILSLEIHCS PECQIKVVNI LKDILGENMI 700
IAPIDIDSVI LPSPAELKHK FIIKVKKTTS FQNLIETENG SFTTSTTTTT 750
TTTTTTTTAT SLSEDNENNK SNSSSTSSFI IRRRKNKSPK IINELSNLGI 800
YTQGIKFRNF SLPESKTFNH CFSLGEKSIN RMIKDDDKKI SLDKHNRRYL 850
MRVYPSGTRL KSSNFNPLPY WSHGVQMVAT NWQTYDLGQQ LNEALFENKI 900
FQGYVLKPSV LRKPTLKSSS SNVDTRTSLT TTNSKTIRFN FEIISGHQLP 950
KFPKDDYKDQ AINPYISFEI IGAQDVQWDN NDSSPIAPTT SSSPFIRTTK 1000
IIRENGFNPN FNTKFSGSII TTTNDLIFIK FVVYASTSLN YPDYGENFPI 1050
AILVTKLNYL KQGYRYIYLN DLLGEQLVYS SIFIKIEYDE DLLNEFINK 1099
Length:1,099
Mass (Da):124,592
Last modified:January 1, 1998 - v1
Checksum:iD54D687D53A2829B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y13975 Genomic DNA. Translation: CAA74308.1.
PIRiT18257.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y13975 Genomic DNA. Translation: CAA74308.1 .
PIRi T18257.

3D structure databases

ProteinModelPortali O13433.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG149692.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProi IPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR001192. PI-PLC_fam.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view ]
PANTHERi PTHR10336. PTHR10336. 1 hit.
Pfami PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view ]
PRINTSi PR00390. PHPHLIPASEC.
SMARTi SM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEi PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genetic characterization of a phospholipase C gene from Candida albicans: presence of homologous sequences in Candida species other than Candida albicans."
    Bennett D.E., McCreary C.E., Coleman D.C.
    Microbiology 144:55-72(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 132A.

Entry informationi

Entry nameiPLC1_CANAX
AccessioniPrimary (citable) accession number: O13433
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: June 11, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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