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Protein

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1

Gene

PLC1

Organism
Candida albicans (Yeast)
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei579PROSITE-ProRule annotation1
Active sitei642PROSITE-ProRule annotation1
Binding sitei724SubstrateBy similarity1
Binding sitei726SubstrateBy similarity1
Binding sitei823SubstrateBy similarity1
Binding sitei852SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Transducer
Biological processLipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1 (EC:3.1.4.11)
Alternative name(s):
Phosphoinositide phospholipase C
Phospholipase C-1
Short name:
PLC-1
Gene namesi
Name:PLC1
OrganismiCandida albicans (Yeast)
Taxonomic identifieri5476 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000885121 – 10991-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1Add BLAST1099

Structurei

3D structure databases

ProteinModelPortaliO13433
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini566 – 726PI-PLC X-boxPROSITE-ProRule annotationAdd BLAST161
Domaini794 – 912PI-PLC Y-boxPROSITE-ProRule annotationAdd BLAST119
Domaini938 – 1066C2Add BLAST129

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi90 – 102Poly-SerAdd BLAST13
Compositional biasi239 – 243Poly-Thr5
Compositional biasi517 – 520Poly-Asp4
Compositional biasi619 – 623Poly-Thr5
Compositional biasi629 – 632Poly-Asp4
Compositional biasi743 – 760Poly-ThrAdd BLAST18
Compositional biasi918 – 921Poly-Ser4

Family and domain databases

CDDicd13360 PH_PLC_fungal, 1 hit
Gene3Di2.60.40.150, 1 hit
3.20.20.190, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR011992 EF-hand-dom_pair
IPR001192 PI-PLC_fam
IPR017946 PLC-like_Pdiesterase_TIM-brl
IPR037755 Plc1_PH
IPR000909 PLipase_C_PInositol-sp_X_dom
IPR001711 PLipase_C_Pinositol-sp_Y
PANTHERiPTHR10336 PTHR10336, 2 hits
PfamiView protein in Pfam
PF00388 PI-PLC-X, 1 hit
PF00387 PI-PLC-Y, 1 hit
PRINTSiPR00390 PHPHLIPASEC
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00148 PLCXc, 1 hit
SM00149 PLCYc, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF51695 SSF51695, 1 hit
PROSITEiView protein in PROSITE
PS50007 PIPLC_X_DOMAIN, 1 hit
PS50008 PIPLC_Y_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

O13433-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLESLNRRNS IDSNQADNDN DNDNHSNDEL SPSELYYSPS GSPPKSQLLL
60 70 80 90 100
RKSSSPSSYS PIKSDLPNIY SHLRSNDSES PPQPSPKQQS SLSSSSSSSS
110 120 130 140 150
SSNTKSSTTK NIFKKLLRIN KSSDNIDESR SIVSNNGGSP MSDSTTVTST
160 170 180 190 200
LSTDTAPKRG KSIQRSQILH HTDSDSLYLE NQIELRPEIS KSIGNIKIPS
210 220 230 240 250
IFTNDGMPLL KISHKSKKRI LFWIDPSCFK FSWRMANSTT TTTSATTSAT
260 270 280 290 300
TSGLPQGITN TTALSNSAII STPAIATSAI HRLSITNRTT HEFVLDDIKS
310 320 330 340 350
IYIQNEGSGY REELNISQKL EKNWITIIYF NHKKNSLKSL HLITDNDHDF
360 370 380 390 400
KKLISAIYNL KQLRSQLAKE FLIDLNELDE NYVKMLLNKE LLAGDNGNVD
410 420 430 440 450
GNEVDIRKSH KHVREFLSFN DILKYSKRLN INVNTNHLQQ IFDQVLLLSS
460 470 480 490 500
ATTEKPVSTP LFEKGLNFEQ FKQFVSILKD RKDLQEIWDS LAQGKEVLQF
510 520 530 540 550
DEIKNFIINI QKENFSDDDD NSTINLIFQK YCSNDNGWNK ESLNEYLLSS
560 570 580 590 600
YSTPYREITQ TQTNYYDYPL NEYFISSSHN TYLTGRQVAG DSSVEGYIRT
610 620 630 640 650
LQRGCRCVEI DIWNGDSNTT TTTVIGTKDD DDKNEYEPIV NHGRTFTKPI
660 670 680 690 700
SFANVIRAIK KFAFIVSPWP LILSLEIHCS PECQIKVVNI LKDILGENMI
710 720 730 740 750
IAPIDIDSVI LPSPAELKHK FIIKVKKTTS FQNLIETENG SFTTSTTTTT
760 770 780 790 800
TTTTTTTTAT SLSEDNENNK SNSSSTSSFI IRRRKNKSPK IINELSNLGI
810 820 830 840 850
YTQGIKFRNF SLPESKTFNH CFSLGEKSIN RMIKDDDKKI SLDKHNRRYL
860 870 880 890 900
MRVYPSGTRL KSSNFNPLPY WSHGVQMVAT NWQTYDLGQQ LNEALFENKI
910 920 930 940 950
FQGYVLKPSV LRKPTLKSSS SNVDTRTSLT TTNSKTIRFN FEIISGHQLP
960 970 980 990 1000
KFPKDDYKDQ AINPYISFEI IGAQDVQWDN NDSSPIAPTT SSSPFIRTTK
1010 1020 1030 1040 1050
IIRENGFNPN FNTKFSGSII TTTNDLIFIK FVVYASTSLN YPDYGENFPI
1060 1070 1080 1090
AILVTKLNYL KQGYRYIYLN DLLGEQLVYS SIFIKIEYDE DLLNEFINK
Length:1,099
Mass (Da):124,592
Last modified:January 1, 1998 - v1
Checksum:iD54D687D53A2829B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13975 Genomic DNA Translation: CAA74308.1
PIRiT18257

Similar proteinsi

Entry informationi

Entry nameiPLC1_CANAX
AccessioniPrimary (citable) accession number: O13433
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health