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O13433

- PLC1_CANAX

UniProt

O13433 - PLC1_CANAX

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Protein

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1

Gene

PLC1

Organism
Candida albicans (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei579 – 5791PROSITE-ProRule annotation
Active sitei642 – 6421PROSITE-ProRule annotation
Binding sitei724 – 7241SubstrateBy similarity
Binding sitei726 – 7261SubstrateBy similarity
Binding sitei823 – 8231SubstrateBy similarity
Binding sitei852 – 8521SubstrateBy similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. phosphatidylinositol phospholipase C activity Source: UniProtKB-EC
  3. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. lipid catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transducer

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1 (EC:3.1.4.11)
Alternative name(s):
Phosphoinositide phospholipase C
Phospholipase C-1
Short name:
PLC-1
Gene namesi
Name:PLC1
OrganismiCandida albicans (Yeast)
Taxonomic identifieri5476 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 109910991-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1PRO_0000088512Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO13433.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini566 – 726161PI-PLC X-boxPROSITE-ProRule annotationAdd
BLAST
Domaini794 – 912119PI-PLC Y-boxPROSITE-ProRule annotationAdd
BLAST
Domaini938 – 1066129C2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi90 – 10213Poly-SerAdd
BLAST
Compositional biasi239 – 2435Poly-Thr
Compositional biasi517 – 5204Poly-Asp
Compositional biasi619 – 6235Poly-Thr
Compositional biasi629 – 6324Poly-Asp
Compositional biasi743 – 76018Poly-ThrAdd
BLAST
Compositional biasi918 – 9214Poly-Ser

Sequence similaritiesi

Contains 1 C2 domain.Curated
Contains 1 PI-PLC X-box domain.PROSITE-ProRule annotation
Contains 1 PI-PLC Y-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG149692.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR001192. PI-PLC_fam.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PfamiPF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view]
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEiPS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O13433-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLESLNRRNS IDSNQADNDN DNDNHSNDEL SPSELYYSPS GSPPKSQLLL
60 70 80 90 100
RKSSSPSSYS PIKSDLPNIY SHLRSNDSES PPQPSPKQQS SLSSSSSSSS
110 120 130 140 150
SSNTKSSTTK NIFKKLLRIN KSSDNIDESR SIVSNNGGSP MSDSTTVTST
160 170 180 190 200
LSTDTAPKRG KSIQRSQILH HTDSDSLYLE NQIELRPEIS KSIGNIKIPS
210 220 230 240 250
IFTNDGMPLL KISHKSKKRI LFWIDPSCFK FSWRMANSTT TTTSATTSAT
260 270 280 290 300
TSGLPQGITN TTALSNSAII STPAIATSAI HRLSITNRTT HEFVLDDIKS
310 320 330 340 350
IYIQNEGSGY REELNISQKL EKNWITIIYF NHKKNSLKSL HLITDNDHDF
360 370 380 390 400
KKLISAIYNL KQLRSQLAKE FLIDLNELDE NYVKMLLNKE LLAGDNGNVD
410 420 430 440 450
GNEVDIRKSH KHVREFLSFN DILKYSKRLN INVNTNHLQQ IFDQVLLLSS
460 470 480 490 500
ATTEKPVSTP LFEKGLNFEQ FKQFVSILKD RKDLQEIWDS LAQGKEVLQF
510 520 530 540 550
DEIKNFIINI QKENFSDDDD NSTINLIFQK YCSNDNGWNK ESLNEYLLSS
560 570 580 590 600
YSTPYREITQ TQTNYYDYPL NEYFISSSHN TYLTGRQVAG DSSVEGYIRT
610 620 630 640 650
LQRGCRCVEI DIWNGDSNTT TTTVIGTKDD DDKNEYEPIV NHGRTFTKPI
660 670 680 690 700
SFANVIRAIK KFAFIVSPWP LILSLEIHCS PECQIKVVNI LKDILGENMI
710 720 730 740 750
IAPIDIDSVI LPSPAELKHK FIIKVKKTTS FQNLIETENG SFTTSTTTTT
760 770 780 790 800
TTTTTTTTAT SLSEDNENNK SNSSSTSSFI IRRRKNKSPK IINELSNLGI
810 820 830 840 850
YTQGIKFRNF SLPESKTFNH CFSLGEKSIN RMIKDDDKKI SLDKHNRRYL
860 870 880 890 900
MRVYPSGTRL KSSNFNPLPY WSHGVQMVAT NWQTYDLGQQ LNEALFENKI
910 920 930 940 950
FQGYVLKPSV LRKPTLKSSS SNVDTRTSLT TTNSKTIRFN FEIISGHQLP
960 970 980 990 1000
KFPKDDYKDQ AINPYISFEI IGAQDVQWDN NDSSPIAPTT SSSPFIRTTK
1010 1020 1030 1040 1050
IIRENGFNPN FNTKFSGSII TTTNDLIFIK FVVYASTSLN YPDYGENFPI
1060 1070 1080 1090
AILVTKLNYL KQGYRYIYLN DLLGEQLVYS SIFIKIEYDE DLLNEFINK
Length:1,099
Mass (Da):124,592
Last modified:January 1, 1998 - v1
Checksum:iD54D687D53A2829B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13975 Genomic DNA. Translation: CAA74308.1.
PIRiT18257.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13975 Genomic DNA. Translation: CAA74308.1 .
PIRi T18257.

3D structure databases

ProteinModelPortali O13433.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG149692.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProi IPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR001192. PI-PLC_fam.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view ]
PANTHERi PTHR10336. PTHR10336. 1 hit.
Pfami PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view ]
PRINTSi PR00390. PHPHLIPASEC.
SMARTi SM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEi PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genetic characterization of a phospholipase C gene from Candida albicans: presence of homologous sequences in Candida species other than Candida albicans."
    Bennett D.E., McCreary C.E., Coleman D.C.
    Microbiology 144:55-72(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 132A.

Entry informationi

Entry nameiPLC1_CANAX
AccessioniPrimary (citable) accession number: O13433
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3