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O13433 (PLC1_CANAX) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1

EC=3.1.4.11
Alternative name(s):
Phosphoinositide phospholipase C
Phospholipase C-1
Short name=PLC-1
Gene names
Name:PLC1
OrganismCandida albicans (Yeast)
Taxonomic identifier5476 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length1099 AA.
Sequence statusComplete.
Protein existencePredicted

General annotation (Comments)

Function

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

Catalytic activity

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

Sequence similarities

Contains 1 C2 domain.

Contains 1 PI-PLC X-box domain.

Contains 1 PI-PLC Y-box domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 109910991-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1
PRO_0000088512

Regions

Domain566 – 726161PI-PLC X-box
Domain794 – 912119PI-PLC Y-box
Domain938 – 1066129C2
Compositional bias90 – 10213Poly-Ser
Compositional bias239 – 2435Poly-Thr
Compositional bias517 – 5204Poly-Asp
Compositional bias619 – 6235Poly-Thr
Compositional bias629 – 6324Poly-Asp
Compositional bias743 – 76018Poly-Thr
Compositional bias918 – 9214Poly-Ser

Sites

Active site5791 By similarity
Active site6421 By similarity
Binding site7241Substrate By similarity
Binding site7261Substrate By similarity
Binding site8231Substrate By similarity
Binding site8521Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
O13433 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: D54D687D53A2829B

FASTA1,099124,592
        10         20         30         40         50         60 
MLESLNRRNS IDSNQADNDN DNDNHSNDEL SPSELYYSPS GSPPKSQLLL RKSSSPSSYS 

        70         80         90        100        110        120 
PIKSDLPNIY SHLRSNDSES PPQPSPKQQS SLSSSSSSSS SSNTKSSTTK NIFKKLLRIN 

       130        140        150        160        170        180 
KSSDNIDESR SIVSNNGGSP MSDSTTVTST LSTDTAPKRG KSIQRSQILH HTDSDSLYLE 

       190        200        210        220        230        240 
NQIELRPEIS KSIGNIKIPS IFTNDGMPLL KISHKSKKRI LFWIDPSCFK FSWRMANSTT 

       250        260        270        280        290        300 
TTTSATTSAT TSGLPQGITN TTALSNSAII STPAIATSAI HRLSITNRTT HEFVLDDIKS 

       310        320        330        340        350        360 
IYIQNEGSGY REELNISQKL EKNWITIIYF NHKKNSLKSL HLITDNDHDF KKLISAIYNL 

       370        380        390        400        410        420 
KQLRSQLAKE FLIDLNELDE NYVKMLLNKE LLAGDNGNVD GNEVDIRKSH KHVREFLSFN 

       430        440        450        460        470        480 
DILKYSKRLN INVNTNHLQQ IFDQVLLLSS ATTEKPVSTP LFEKGLNFEQ FKQFVSILKD 

       490        500        510        520        530        540 
RKDLQEIWDS LAQGKEVLQF DEIKNFIINI QKENFSDDDD NSTINLIFQK YCSNDNGWNK 

       550        560        570        580        590        600 
ESLNEYLLSS YSTPYREITQ TQTNYYDYPL NEYFISSSHN TYLTGRQVAG DSSVEGYIRT 

       610        620        630        640        650        660 
LQRGCRCVEI DIWNGDSNTT TTTVIGTKDD DDKNEYEPIV NHGRTFTKPI SFANVIRAIK 

       670        680        690        700        710        720 
KFAFIVSPWP LILSLEIHCS PECQIKVVNI LKDILGENMI IAPIDIDSVI LPSPAELKHK 

       730        740        750        760        770        780 
FIIKVKKTTS FQNLIETENG SFTTSTTTTT TTTTTTTTAT SLSEDNENNK SNSSSTSSFI 

       790        800        810        820        830        840 
IRRRKNKSPK IINELSNLGI YTQGIKFRNF SLPESKTFNH CFSLGEKSIN RMIKDDDKKI 

       850        860        870        880        890        900 
SLDKHNRRYL MRVYPSGTRL KSSNFNPLPY WSHGVQMVAT NWQTYDLGQQ LNEALFENKI 

       910        920        930        940        950        960 
FQGYVLKPSV LRKPTLKSSS SNVDTRTSLT TTNSKTIRFN FEIISGHQLP KFPKDDYKDQ 

       970        980        990       1000       1010       1020 
AINPYISFEI IGAQDVQWDN NDSSPIAPTT SSSPFIRTTK IIRENGFNPN FNTKFSGSII 

      1030       1040       1050       1060       1070       1080 
TTTNDLIFIK FVVYASTSLN YPDYGENFPI AILVTKLNYL KQGYRYIYLN DLLGEQLVYS 

      1090 
SIFIKIEYDE DLLNEFINK 

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References

[1]"Genetic characterization of a phospholipase C gene from Candida albicans: presence of homologous sequences in Candida species other than Candida albicans."
Bennett D.E., McCreary C.E., Coleman D.C.
Microbiology 144:55-72(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 132A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y13975 Genomic DNA. Translation: CAA74308.1.
PIRT18257.

3D structure databases

ProteinModelPortalO13433.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG149692.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR001192. PI-PLC_fam.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR028409. Plc1.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERPTHR10336. PTHR10336. 1 hit.
PTHR10336:SF20. PTHR10336:SF20. 1 hit.
PfamPF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view]
PRINTSPR00390. PHPHLIPASEC.
SMARTSM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMSSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEPS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePLC1_CANAX
AccessionPrimary (citable) accession number: O13433
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: April 16, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families