Reviewed, UniProtKB/Swiss-Prot O13427 (GLY1_CANAL)

Names and origin

Protein names

Recommended name:
    Threonine aldolase
    EC=4.1.2.5

Gene names

Name:

GLY1

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	374 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-threonine = glycine + acetaldehyde.
Cofactor	Pyridoxal phosphate.
Pathway	Amino-acid degradation; L-threonine degradation via aldolase pathway; acetaldehyde and glycine from L-threonine: step 1/1.
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the threonine aldolase family.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Molecular function	Lyase
Gene Ontology (GO)
Biological process	cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro threonine aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 374	374	Threonine aldolase		PRO_0000121570
Amino acid modifications
	Modified residue	213	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	O13427-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: AE44C349FA83F7C0	FASTA	374	41,811
	10 20 30 40 50 60 MTADEEETFT TFNEFRSDTF TVPTRAMVED GFMNATFGDS VYQEDETTLR LESKMCEITG 70 80 90 100 110 120 KPAALFCVSG TMSNQIGLRA NLVQPPYSIL CDYRAHVFLH EAGGLATLSQ AMVHPVRPSN 130 140 150 160 170 180 GNYLTFEDVL GNVTYDDDGD IHAAPTKVIS LENTLHGIII PIEEIRKISE FCRENDIRLH 190 200 210 220 230 240 LDGARLWNAS VATGISIKEY CSYFDSVSLC LSKSLGAPIG SVLVGDEKFI RKANHFKKQS 250 260 270 280 290 300 GGGIRQAGIM SAMAIHAIDY NLSKLELSHN YAKQIGDFCQ EHGIKLESPV DTSLVFLDLK 310 320 330 340 350 360 ANKMDPNRLV ELGRTKYNVK LMGQRIACHF QLSQESVDNV KKCILECLEY HQKHPHKDDG 370 RNNKKMYSLD AIKK

References

[1]

"Glycine metabolism in Candida albicans: characterization of the serine hydroxymethyltransferase (SHM1, SHM2) and threonine aldolase (GLY1) genes." McNeil J.B., Flynn J., Tsao N., Monschau N., Stahmann K., Haynes R.H., McIntosh E.M., Pearlman R.E. Yeast 16:167-175(2000) [PubMed: 10641038] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF009967 Genomic DNA. Translation: AAB64198.1.
3D structure databases
HSSP	HSSP built from PDB template 1M6S based on UniProtKB Q9X266.
ModBase	Search...
Enzyme and pathway databases
BRENDA	4.1.2.5. 1124.
Family and domain databases
InterPro	IPR001597. ArAA_b-elim_lyase/Thr_aldolase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
Pfam	PF01212. Beta_elim_lyase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLY1_CANAL

Accession

Primary (citable) accession number: O13427

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	January 1, 1998
Last modified:	September 22, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)