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O13416 (PYRF_ASPOR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Uridine 5'-monophosphate synthase
Short name=UMP synthase
Gene names
Name:pyrG
ORF Names:AO090011000868
OrganismAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold) [Complete proteome]
Taxonomic identifier510516 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length277 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Sequence similarities

Belongs to the OMP decarboxylase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 277277Orotidine 5'-phosphate decarboxylase
PRO_0000134644

Regions

Region62 – 643Substrate binding By similarity
Region93 – 10210Substrate binding By similarity

Sites

Active site951Proton donor By similarity
Binding site401Substrate By similarity
Binding site2291Substrate By similarity
Binding site2471Substrate By similarity

Natural variations

Natural variant2601K → N in strain: KBN616.

Sequences

Sequence LengthMass (Da)Tools
O13416 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: C6F2EE037B112977

FASTA27730,282
        10         20         30         40         50         60 
MSSKSQLTYS ARASKHPNAL VKKLFEVAEA KKTNVTVSAD VTTTKELLDL ADRLGPYIAV 

        70         80         90        100        110        120 
IKTHIDILSD FSEETITGLK ALAEKHNFLI FEDRKFIDIG NTVQKQYHGG TLRISEWAHI 

       130        140        150        160        170        180 
INCSILPGEG IVEALAQTAS AEDFPYGSER GLLILAEMTS KGSLATGQYT TSSVDYARKY 

       190        200        210        220        230        240 
KKFVMGFVST RHLGEVQSEV SSPSEEEDFV VFTTGVNLSS KGDKLGQQYQ TPESAVGRGA 

       250        260        270 
DFIIAGRGIY AAPDPVEAAK QYQKEGWDAY LKRVGAQ 

« Hide

References

« Hide 'large scale' references
[1]Doumas A., Vandenbroek P.J.M., Affolter M., Monod M.
Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: TK3.
[2]"Nucleotide sequence of the pyrG gene from a shoyu koji mold, Aspergillus oryzae KBN616."
Kitamoto N., Yoshino S.
Nihon Shoyu Kenkyujo Zasshi 25:21-26(1999)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: KBN616.
[3]"Genome sequencing and analysis of Aspergillus oryzae."
Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K., Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H., Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E. expand/collapse author list , Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D., Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A., Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y., Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H., Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T., Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O., Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y., Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N., Kikuchi H.
Nature 438:1157-1161(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 42149 / RIB 40.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y13811 Genomic DNA. Translation: CAA74139.1.
AB017705 Genomic DNA. Translation: BAA33760.1.
AP007171 Genomic DNA. Translation: BAE65307.1.
RefSeqXP_001826440.1. XM_001826388.2.

3D structure databases

ProteinModelPortalO13416.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADAORAT00005566; CADAORAP00005465; CADAORAG00005566.
GeneID5998543.
KEGGaor:AOR_1_1464054.

Phylogenomic databases

HOGENOMHOG000213905.
KOK01591.
OMAMGQQYRT.
OrthoDBEOG7CVQ76.

Enzyme and pathway databases

UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_ASPOR
AccessionPrimary (citable) accession number: O13416
Secondary accession number(s): O74652, Q2TZF8
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: February 19, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways