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Protein

DNA mismatch repair protein msh-2

Gene

msh-2

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Involved in post-replicative DNA-mismatch repair. Binds to mismatch-containing DNA (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi659 – 6668ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair protein msh-2
Gene namesi
Name:msh-2
Synonyms:msh2
ORF Names:NCU02230
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 7, Linkage Group VII

Organism-specific databases

EuPathDBiFungiDB:NCU02230.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 937937DNA mismatch repair protein msh-2PRO_0000115189Add
BLAST

Interactioni

Subunit structurei

Heterodimer of msh2 and msh6.By similarity

Structurei

3D structure databases

ProteinModelPortaliO13396.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA mismatch repair MutS family.Curated

Phylogenomic databases

HOGENOMiHOG000196498.
InParanoidiO13396.
KOiK08735.
OMAiNDWYLAY.
OrthoDBiEOG773XQH.

Family and domain databases

Gene3Di3.30.420.110. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR011184. DNA_mismatch_repair_MutS.
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR032642. Msh2.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11361:SF35. PTHR11361:SF35. 1 hit.
PfamiPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
PIRSFiPIRSF005813. MSH2. 1 hit.
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O13396-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSRPELKVD DEHGFIRFYK SLPQLGEEAI RIFDRGDWYT AHGDDATFIA
60 70 80 90 100
RTVYKTTSVI RQLGRSDHTG LPSVTMTVTV FRQFLREALF KLGKRIEIWA
110 120 130 140 150
SPSGRMNWKV VKQASPGNLQ DVEDELGGQF EGAPVILAVK ISAKASEART
160 170 180 190 200
VGVCFADASV RELGVSEFLD NDLYSNFEAL LIQLGVKECI VTQDKGEKEK
210 220 230 240 250
DPELAKLRQI IDNCGVAIAE RSAGEFGTKD IEQDLSRLLK DERAASLLPQ
260 270 280 290 300
TDLKLAMGSA SALIKYLGIL HDPSNFGQYQ LYQHDLAQFM KLDAAALKAL
310 320 330 340 350
NLMPGARDGA KNMSLYGLLN HCKTPVGSRL LSQWLKQPLM NAEEIEKRQQ
360 370 380 390 400
LVEAFANDTE LRQSMQEEHL RSIPDLYRLS KRFQRGKATL EDVVRAYQVV
410 420 430 440 450
IRLPGFIGTL EGVMDEAYRD PLDEVYTNKL RELSDSLVKL QEMVETTVDL
460 470 480 490 500
DALDNHEFII KPEFDDSLRI IRKKLDRLRT DMDNEFAEAA EDLGQEREKK
510 520 530 540 550
IFLENHKVHG WCMRLTRTEA GCIRNNSRYL ECSTQKNGVY FTTKTLQALR
560 570 580 590 600
REFDQLSQNY NRTQSSLVNE VVGVAASYCP VLERLAAVLA HLDVIVSFAH
610 620 630 640 650
CSVHAPISYV RPKIHPRGTG RTVLTEARHP CMEVQDDVTF ITNDVTLTRE
660 670 680 690 700
DSSFLIITGP NMGGKSTYIR QIGVIALMAQ IGCFVPCSSA ELTIFDSILA
710 720 730 740 750
RVGASDSQLK GVSTFMAEML ETANILKSAT AESLIIIDEL GRGTSTYDGF
760 770 780 790 800
GLAWAISEHI VKEIGCFALF ATHFHELTAL ADQYPNVKNL HVTAHISGTD
810 820 830 840 850
TDTDVITDED EKAKKKREVT LLYKVEPGIC DQSFGIHVAE LVRFPDKVVR
860 870 880 890 900
MAKRKADELE DFTSKHEEEN GGGLGVQYSK QDVEEGSALL KDVLVKWKDE
910 920 930
VKSGRMSKEE MVARLKELVQ KDERLLGNPF FKSVQAL
Length:937
Mass (Da):105,069
Last modified:January 1, 1998 - v1
Checksum:iBC7AABE137423EB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030634 Genomic DNA. Translation: AAB84225.1.
CM002242 Genomic DNA. Translation: EAA30407.1.
RefSeqiXP_959643.1. XM_954550.2.

Genome annotation databases

EnsemblFungiiEFNCRT00000003090; EFNCRP00000003090; EFNCRG00000003087.
GeneIDi3875790.
KEGGincr:NCU02230.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030634 Genomic DNA. Translation: AAB84225.1.
CM002242 Genomic DNA. Translation: EAA30407.1.
RefSeqiXP_959643.1. XM_954550.2.

3D structure databases

ProteinModelPortaliO13396.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEFNCRT00000003090; EFNCRP00000003090; EFNCRG00000003087.
GeneIDi3875790.
KEGGincr:NCU02230.

Organism-specific databases

EuPathDBiFungiDB:NCU02230.

Phylogenomic databases

HOGENOMiHOG000196498.
InParanoidiO13396.
KOiK08735.
OMAiNDWYLAY.
OrthoDBiEOG773XQH.

Family and domain databases

Gene3Di3.30.420.110. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR011184. DNA_mismatch_repair_MutS.
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR032642. Msh2.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11361:SF35. PTHR11361:SF35. 1 hit.
PfamiPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
PIRSFiPIRSF005813. MSH2. 1 hit.
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Neurospora crassa MSH2, a MutS homolog."
    Huber D.H., Hausner G., Yamamoto K., Ishii C., Seidel-Rogol B.L., Bertrand H.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 74-OR23-1VA / FGSC 2489.
  2. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiMSH2_NEUCR
AccessioniPrimary (citable) accession number: O13396
Secondary accession number(s): Q7RVA5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: June 8, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.