Reviewed,
UniProtKB/Swiss-Prot O13356 (CHS1_CRYNV)
Last modified
October 13, 2009.
Version 52.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Chitin synthase 1 EC=2.4.1.16 Alternative name(s): Chitin-UDP acetyl-glucosaminyl transferase 1 Class-IV chitin synthase 1 | ||
| Gene names |
| ||
| Organism | Cryptococcus neoformans var. grubii (Filobasidiella neoformans var. grubii) | ||
| Taxonomic identifier | 178876 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Tremellomycetes › Tremellales › Tremellaceae › Filobasidiella › Filobasidiella/Cryptococcus neoformans species complex |
Protein attributes
| Sequence length | 1041 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Plays a major role in cell wall biogenesis. |
| Catalytic activity | UDP-N-acetyl-D-glucosamine + (1,4-(N-acetyl-beta-D-glucosaminyl))(n) = UDP + (1,4-(N-acetyl-beta-D-glucosaminyl))(n+1). |
| Subcellular location | |
| Sequence similarities | Belongs to the chitin synthase family. Class IV subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Cell wall biogenesis/degradation |
| Cellular component | Cell membrane Membrane |
| Domain | Transmembrane |
| Molecular function | Glycosyltransferase Transferase |
| Gene Ontology (GO) | |
| Biological process | cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | chitin synthase activity Inferred from electronic annotation. Source: EC heme bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1041 | 1041 | Chitin synthase 1 | PRO_0000193689 | |||||
Regions | |||||||||
| Transmembrane | 77 – 97 | 21 | Potential | ||||||
| Transmembrane | 109 – 129 | 21 | Potential | ||||||
| Transmembrane | 335 – 355 | 21 | Potential | ||||||
| Transmembrane | 824 – 844 | 21 | Potential | ||||||
| Transmembrane | 861 – 881 | 21 | Potential | ||||||
| Transmembrane | 885 – 905 | 21 | Potential | ||||||
Sequences
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References
| [1] | "chs1, a class IV chitin synthase of Cryptococcus neoformans." Specht C.A. Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: H99. |
Cross-references
Sequence databases | |
|---|---|
| AF021318 Genomic DNA. Translation: AAB71697.1. | |
| PIR | T31097. |
3D structure databases | |
| ModBase | Search... |
Protein family/group databases | |
| CAZy | GT2. Glycosyltransferase Family 2. |
Enzyme and pathway databases | |
| BRENDA | 2.4.1.16. 303268. |
Family and domain databases | |
| InterPro | IPR004835. Chitin_synth_fng. IPR001199. Cyt_B5. [Graphical view] |
| Pfam | PF03142. Chitin_synth_2. 1 hit. PF00173. Cyt-b5. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | CHS1_CRYNV | ||||||||
| Accession | Primary (citable) accession number: O13356 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||

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