Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ubiquitin-like protein pmt3/smt3

Gene

pmt3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for chromosome segregation where it may be involved in microtubule assembly. Loss of smt3 leads to an increase in telomere length.1 Publication

GO - Molecular functioni

  • protein tag Source: PomBase

GO - Biological processi

  • chromatin silencing at centromere Source: PomBase
  • chromatin silencing at silent mating-type cassette Source: PomBase
  • mitotic sister chromatid segregation Source: PomBase
  • negative regulation of histone H3-K14 acetylation Source: PomBase
  • negative regulation of histone H3-K4 methylation Source: PomBase
  • negative regulation of histone H3-K9 methylation Source: PomBase
  • protein sumoylation Source: PomBase
  • telomere maintenance Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-SPO-3065676. SUMO is conjugated to E1 (UBA2:SAE1).
R-SPO-3065678. SUMO is transferred from E1 to E2 (UBE2I, UBC9).
R-SPO-3065679. SUMO is proteolytically processed.
R-SPO-3108214. SUMOylation of DNA damage response and repair proteins.
R-SPO-3232118. SUMOylation of transcription factors.
R-SPO-4570464. SUMOylation of RNA binding proteins.
R-SPO-4615885. SUMOylation of DNA replication proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-like protein pmt3/smt3
Gene namesi
Name:pmt3
Synonyms:smt3, ubl2
ORF Names:SPBC365.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC365.06.
PomBaseiSPBC365.06. pmt3.

Subcellular locationi

GO - Cellular componenti

  • chromosome, centromeric region Source: GOC
  • linear element Source: PomBase
  • mitotic spindle pole body Source: PomBase
  • nucleus Source: PomBase
  • septin ring Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000359611 – 111Ubiquitin-like protein pmt3/smt3Add BLAST111
PropeptideiPRO_0000035962112 – 117Sequence analysis6

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki111Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)

Keywords - PTMi

Isopeptide bond

Proteomic databases

MaxQBiO13351.
PRIDEiO13351.

Interactioni

Subunit structurei

Interacts with rfp1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
rad22P365924EBI-966336,EBI-966242
rfp1O138265EBI-966336,EBI-3647269

Protein-protein interaction databases

BioGridi277443. 54 interactors.
IntActiO13351. 10 interactors.
MINTiMINT-4666598.

Structurei

3D structure databases

ProteinModelPortaliO13351.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 115Ubiquitin-likePROSITE-ProRule annotationAdd BLAST81

Sequence similaritiesi

Belongs to the ubiquitin family. SUMO subfamily.Curated
Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000207495.
InParanoidiO13351.
KOiK12160.
OMAiITENDSP.
OrthoDBiEOG092C5C59.
PhylomeDBiO13351.

Family and domain databases

CDDicd01763. Sumo. 1 hit.
InterProiIPR022617. Rad60/SUMO-like_dom.
IPR033950. Sumo.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF11976. Rad60-SLD. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O13351-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSESPSANIS DADKSAITPT TGDTSQQDVK PSTEHINLKV VGQDNNEVFF
60 70 80 90 100
KIKKTTEFSK LMKIYCARQG KSMNSLRFLV DGERIRPDQT PAELDMEDGD
110
QIEAVLEQLG GCTHLCL
Length:117
Mass (Da):12,935
Last modified:January 11, 2001 - v2
Checksum:i11C860EBEA172FD2
GO

Sequence cautioni

The sequence AAB71541 differs from that shown. Reason: Frameshift at position 29.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017187 Genomic DNA. Translation: BAA32595.1.
CU329671 Genomic DNA. Translation: CAB44758.1.
AF019235 mRNA. Translation: AAB71541.1. Frameshift.
PIRiT40313.
T43537.
RefSeqiNP_596035.1. NM_001021945.2.

Genome annotation databases

EnsemblFungiiSPBC365.06.1; SPBC365.06.1:pep; SPBC365.06.
GeneIDi2540927.
KEGGispo:SPBC365.06.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017187 Genomic DNA. Translation: BAA32595.1.
CU329671 Genomic DNA. Translation: CAB44758.1.
AF019235 mRNA. Translation: AAB71541.1. Frameshift.
PIRiT40313.
T43537.
RefSeqiNP_596035.1. NM_001021945.2.

3D structure databases

ProteinModelPortaliO13351.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277443. 54 interactors.
IntActiO13351. 10 interactors.
MINTiMINT-4666598.

Proteomic databases

MaxQBiO13351.
PRIDEiO13351.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC365.06.1; SPBC365.06.1:pep; SPBC365.06.
GeneIDi2540927.
KEGGispo:SPBC365.06.

Organism-specific databases

EuPathDBiFungiDB:SPBC365.06.
PomBaseiSPBC365.06. pmt3.

Phylogenomic databases

HOGENOMiHOG000207495.
InParanoidiO13351.
KOiK12160.
OMAiITENDSP.
OrthoDBiEOG092C5C59.
PhylomeDBiO13351.

Enzyme and pathway databases

ReactomeiR-SPO-3065676. SUMO is conjugated to E1 (UBA2:SAE1).
R-SPO-3065678. SUMO is transferred from E1 to E2 (UBE2I, UBC9).
R-SPO-3065679. SUMO is proteolytically processed.
R-SPO-3108214. SUMOylation of DNA damage response and repair proteins.
R-SPO-3232118. SUMOylation of transcription factors.
R-SPO-4570464. SUMOylation of RNA binding proteins.
R-SPO-4615885. SUMOylation of DNA replication proteins.

Miscellaneous databases

PROiO13351.

Family and domain databases

CDDicd01763. Sumo. 1 hit.
InterProiIPR022617. Rad60/SUMO-like_dom.
IPR033950. Sumo.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF11976. Rad60-SLD. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPMT3_SCHPO
AccessioniPrimary (citable) accession number: O13351
Secondary accession number(s): O74186
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 11, 2001
Last modified: November 30, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.