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Protein

Podosporapepsin

Gene

PAPA

Organism
Podospora anserina (Pleurage anserina)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei126PROSITE-ProRule annotation1
Active sitei310PROSITE-ProRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Hydrolase, Protease

Protein family/group databases

MEROPSiA01.044.

Names & Taxonomyi

Protein namesi
Recommended name:
Podosporapepsin (EC:3.4.23.-)
Gene namesi
Name:PAPA
OrganismiPodospora anserina (Pleurage anserina)
Taxonomic identifieri5145 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesLasiosphaeriaceaePodospora

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
PropeptideiPRO_000002587729 – 91Activation peptideBy similarityAdd BLAST63
ChainiPRO_000002587892 – 425PodosporapepsinAdd BLAST334

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi184N-linked (GlcNAc...)Sequence analysis1
Glycosylationi273N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi346 ↔ 381By similarity
Glycosylationi370N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

Expressioni

Inductioni

Expressed under carbon starvation conditions.

Interactioni

Protein-protein interaction databases

STRINGi515849.XP_001906820.1.

Structurei

3D structure databases

ProteinModelPortaliO13340.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini108 – 419Peptidase A1PROSITE-ProRule annotationAdd BLAST312

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated
Contains 1 peptidase A1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1339. Eukaryota.
ENOG410XNV7. LUCA.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PfamiPF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 2 hits.
PS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O13340-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSLTDLFLA SLLVPTSPWL CLPPRIDTID QRGGRVTLKQ VRNPRGHKAF
60 70 80 90 100
NPARATYRTF LKYGVPAPDY IKKAVAHIDE EQEEAFARIK RDTGSAAAIP
110 120 130 140 150
INEVDIAYVT PVTIGTPPQT LMLDLDTGSS DLWVFSSLTP SNQVRGQEIY
160 170 180 190 200
SPTKSSTSKL LSGHTWSIRY GDGSGSRGTV YTDNFTIGGL EVKSQAVQAA
210 220 230 240 250
LEVSSMLTQE QSLDGLVGLG FSALNTVRPS SQLTFFDNAR PNLDEEVFTA
260 270 280 290 300
DLKYHATGSY DFGFIDSKKY AGNITYTAVQ QSPGYWTHSL SGYSVGSGAF
310 320 330 340 350
QASQISGISD TGTTLLYLPT AIVTAYYRQV QGAQNSQYYG GYVFPCSSTL
360 370 380 390 400
PTFTFGIEGA RFTIPASYIN YTRISPTSTT CYGGLQSSSG LGINIFGDVA
410 420
LKRAFVVFSG TNPPRIGFAI KPLAS
Length:425
Mass (Da):45,921
Last modified:January 1, 1998 - v1
Checksum:iDA66CAA215183214
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016054 Genomic DNA. Translation: AAC49997.1.
PIRiJC6557.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016054 Genomic DNA. Translation: AAC49997.1.
PIRiJC6557.

3D structure databases

ProteinModelPortaliO13340.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi515849.XP_001906820.1.

Protein family/group databases

MEROPSiA01.044.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG1339. Eukaryota.
ENOG410XNV7. LUCA.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PfamiPF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 2 hits.
PS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCARP_PODAS
AccessioniPrimary (citable) accession number: O13340
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 1, 1998
Last modified: October 5, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.