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Protein

Telomerase reverse transcriptase

Gene

trt1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.2 Publications

Miscellaneous

Deletion causes telomere shortening and senescence.

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).PROSITE-ProRule annotation1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi590Magnesium; catalyticPROSITE-ProRule annotation1
Metal bindingi742Magnesium; catalyticPROSITE-ProRule annotation1
Metal bindingi743Magnesium; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • RNA binding Source: PomBase
  • telomerase RNA binding Source: GO_Central
  • telomerase RNA reverse transcriptase activity Source: UniProtKB
  • telomeric DNA binding Source: PomBase

GO - Biological processi

  • DNA strand elongation Source: UniProtKB
  • telomere maintenance Source: PomBase
  • telomere maintenance via telomerase Source: PomBase

Keywordsi

Molecular functionDNA-binding, Nucleotidyltransferase, RNA-directed DNA polymerase, Transferase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-SPO-171319 Telomere Extension By Telomerase

Names & Taxonomyi

Protein namesi
Recommended name:
Telomerase reverse transcriptaseImported (EC:2.7.7.491 Publication)
Alternative name(s):
Telomerase catalytic subunit1 Publication
Gene namesi
Name:trt1Imported
ORF Names:SPBC29A3.14cImported
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC29A3.14c
PomBaseiSPBC29A3.14c trt1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000549311 – 988Telomerase reverse transcriptaseAdd BLAST988

Proteomic databases

PaxDbiO13339
PRIDEiO13339

Interactioni

Subunit structurei

Catalytic subunit of the telomerase holoenzyme complex composed minimally of trt1 and the telomerase RNA template component (PubMed:24793650). Interacts with est1 (PubMed:12676088).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
est1O748043EBI-1556874,EBI-1556899

Protein-protein interaction databases

BioGridi277127, 68 interactors
DIPiDIP-38463N
IntActiO13339, 1 interactor
STRINGi4896.SPBC29A3.14c.1

Structurei

3D structure databases

ProteinModelPortaliO13339
SMRiO13339
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini486 – 807Reverse transcriptasePROSITE-ProRule annotationAdd BLAST322

Sequence similaritiesi

Phylogenomic databases

InParanoidiO13339
KOiK11126
OMAiHNVFTSV
OrthoDBiEOG092C2JUX
PhylomeDBiO13339

Family and domain databases

InterProiView protein in InterPro
IPR000477 RT_dom
IPR021891 Telomerase_RBD
IPR003545 Telomerase_RT
PANTHERiPTHR12066 PTHR12066, 1 hit
PfamiView protein in Pfam
PF00078 RVT_1, 1 hit
PF12009 Telomerase_RBD, 1 hit
PRINTSiPR01365 TELOMERASERT
SMARTiView protein in SMART
SM00975 Telomerase_RBD, 1 hit
PROSITEiView protein in PROSITE
PS50878 RT_POL, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O13339-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTEHHTPKSR ILRFLENQYV YLCTLNDYVQ LVLRGSPASS YSNICERLRS
60 70 80 90 100
DVQTSFSIFL HSTVVGFDSK PDEGVQFSSP KCSQSELIAN VVKQMFDESF
110 120 130 140 150
ERRRNLLMKG FSMNHEDFRA MHVNGVQNDL VSTFPNYLIS ILESKNWQLL
160 170 180 190 200
LEIIGSDAMH YLLSKGSIFE ALPNDNYLQI SGIPLFKNNV FEETVSKKRK
210 220 230 240 250
RTIETSITQN KSARKEVSWN SISISRFSIF YRSSYKKFKQ DLYFNLHSIC
260 270 280 290 300
DRNTVHMWLQ WIFPRQFGLI NAFQVKQLHK VIPLVSQSTV VPKRLLKVYP
310 320 330 340 350
LIEQTAKRLH RISLSKVYNH YCPYIDTHDD EKILSYSLKP NQVFAFLRSI
360 370 380 390 400
LVRVFPKLIW GNQRIFEIIL KDLETFLKLS RYESFSLHYL MSNIKISEIE
410 420 430 440 450
WLVLGKRSNA KMCLSDFEKR KQIFAEFIYW LYNSFIIPIL QSFFYITESS
460 470 480 490 500
DLRNRTVYFR KDIWKLLCRP FITSMKMEAF EKINENNVRM DTQKTTLPPA
510 520 530 540 550
VIRLLPKKNT FRLITNLRKR FLIKMGSNKK MLVSTNQTLR PVASILKHLI
560 570 580 590 600
NEESSGIPFN LEVYMKLLTF KKDLLKHRMF GRKKYFVRID IKSCYDRIKQ
610 620 630 640 650
DLMFRIVKKK LKDPEFVIRK YATIHATSDR ATKNFVSEAF SYFDMVPFEK
660 670 680 690 700
VVQLLSMKTS DTLFVDFVDY WTKSSSEIFK MLKEHLSGHI VKIGNSQYLQ
710 720 730 740 750
KVGIPQGSIL SSFLCHFYME DLIDEYLSFT KKKGSVLLRV VDDFLFITVN
760 770 780 790 800
KKDAKKFLNL SLRGFEKHNF STSLEKTVIN FENSNGIINN TFFNESKKRM
810 820 830 840 850
PFFGFSVNMR SLDTLLACPK IDEALFNSTS VELTKHMGKS FFYKILRSSL
860 870 880 890 900
ASFAQVFIDI THNSKFNSCC NIYRLGYSMC MRAQAYLKRM KDIFIPQRMF
910 920 930 940 950
ITDLLNVIGR KIWKKLAEIL GYTSRRFLSS AEVKWLFCLG MRDGLKPSFK
960 970 980
YHPCFEQLIY QFQSLTDLIK PLRPVLRQVL FLHRRIAD
Length:988
Mass (Da):116,329
Last modified:January 1, 1998 - v1
Checksum:iAB2DC7030228F443
GO
Isoform 2 (identifier: O13339-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     524-524: K → KQ

Show »
Length:989
Mass (Da):116,457
Checksum:i6B5BFA43499BEAD1
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006395524K → KQ in isoform 2. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF015783 Genomic DNA Translation: AAC49802.1
AF015783 Genomic DNA Translation: AAC49803.1
CU329671 Genomic DNA Translation: CAA18391.1
PIRiT03838
RefSeqiNP_595842.1, NM_001021746.2

Genome annotation databases

EnsemblFungiiSPBC29A3.14c.1; SPBC29A3.14c.1:pep; SPBC29A3.14c [O13339-1]
GeneIDi2540601
KEGGispo:SPBC29A3.14c

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTERT_SCHPO
AccessioniPrimary (citable) accession number: O13339
Secondary accession number(s): O13338
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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