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Protein

Telomerase reverse transcriptase

Gene

trt1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.2 Publications

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).PROSITE-ProRule annotation1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi590 – 5901Magnesium; catalyticPROSITE-ProRule annotation
Metal bindingi742 – 7421Magnesium; catalyticPROSITE-ProRule annotation
Metal bindingi743 – 7431Magnesium; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • RNA binding Source: PomBase
  • telomerase RNA binding Source: GO_Central
  • telomerase RNA reverse transcriptase activity Source: UniProtKB
  • telomeric DNA binding Source: GO_Central

GO - Biological processi

  • DNA strand elongation Source: UniProtKB
  • telomere maintenance Source: PomBase
  • telomere maintenance via telomerase Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed DNA polymerase, Transferase

Keywords - Ligandi

DNA-binding, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-SPO-171319. Telomere Extension By Telomerase.

Names & Taxonomyi

Protein namesi
Recommended name:
Telomerase reverse transcriptaseImported (EC:2.7.7.491 Publication)
Alternative name(s):
Telomerase catalytic subunit1 Publication
Gene namesi
Name:trt1Imported
ORF Names:SPBC29A3.14cImported
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC29A3.14c.
PomBaseiSPBC29A3.14c. trt1.

Subcellular locationi

GO - Cellular componenti

  • nuclear chromosome, telomeric region Source: PomBase
  • nucleus Source: PomBase
  • telomerase catalytic core complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 988988Telomerase reverse transcriptasePRO_0000054931Add
BLAST

Interactioni

Subunit structurei

Catalytic subunit of the telomerase holoenzyme complex composed minimally of trt1 and the telomerase RNA template component (PubMed:24793650). Interacts with est1 (PubMed:12676088).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
est1O748042EBI-1556874,EBI-1556899

Protein-protein interaction databases

BioGridi277127. 67 interactions.
DIPiDIP-38463N.
IntActiO13339. 1 interaction.
MINTiMINT-4666576.

Structurei

3D structure databases

ProteinModelPortaliO13339.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini486 – 807322Reverse transcriptasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 reverse transcriptase domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiO13339.
KOiK11126.
OMAiYSNICER.
OrthoDBiEOG092C2JUX.
PhylomeDBiO13339.

Family and domain databases

InterProiIPR000477. RT_dom.
IPR021891. Telomerase_RBD.
IPR003545. Telomerase_RT.
[Graphical view]
PANTHERiPTHR12066:SF0. PTHR12066:SF0. 1 hit.
PfamiPF00078. RVT_1. 1 hit.
PF12009. Telomerase_RBD. 1 hit.
[Graphical view]
PRINTSiPR01365. TELOMERASERT.
SMARTiSM00975. Telomerase_RBD. 1 hit.
[Graphical view]
PROSITEiPS50878. RT_POL. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O13339-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTEHHTPKSR ILRFLENQYV YLCTLNDYVQ LVLRGSPASS YSNICERLRS
60 70 80 90 100
DVQTSFSIFL HSTVVGFDSK PDEGVQFSSP KCSQSELIAN VVKQMFDESF
110 120 130 140 150
ERRRNLLMKG FSMNHEDFRA MHVNGVQNDL VSTFPNYLIS ILESKNWQLL
160 170 180 190 200
LEIIGSDAMH YLLSKGSIFE ALPNDNYLQI SGIPLFKNNV FEETVSKKRK
210 220 230 240 250
RTIETSITQN KSARKEVSWN SISISRFSIF YRSSYKKFKQ DLYFNLHSIC
260 270 280 290 300
DRNTVHMWLQ WIFPRQFGLI NAFQVKQLHK VIPLVSQSTV VPKRLLKVYP
310 320 330 340 350
LIEQTAKRLH RISLSKVYNH YCPYIDTHDD EKILSYSLKP NQVFAFLRSI
360 370 380 390 400
LVRVFPKLIW GNQRIFEIIL KDLETFLKLS RYESFSLHYL MSNIKISEIE
410 420 430 440 450
WLVLGKRSNA KMCLSDFEKR KQIFAEFIYW LYNSFIIPIL QSFFYITESS
460 470 480 490 500
DLRNRTVYFR KDIWKLLCRP FITSMKMEAF EKINENNVRM DTQKTTLPPA
510 520 530 540 550
VIRLLPKKNT FRLITNLRKR FLIKMGSNKK MLVSTNQTLR PVASILKHLI
560 570 580 590 600
NEESSGIPFN LEVYMKLLTF KKDLLKHRMF GRKKYFVRID IKSCYDRIKQ
610 620 630 640 650
DLMFRIVKKK LKDPEFVIRK YATIHATSDR ATKNFVSEAF SYFDMVPFEK
660 670 680 690 700
VVQLLSMKTS DTLFVDFVDY WTKSSSEIFK MLKEHLSGHI VKIGNSQYLQ
710 720 730 740 750
KVGIPQGSIL SSFLCHFYME DLIDEYLSFT KKKGSVLLRV VDDFLFITVN
760 770 780 790 800
KKDAKKFLNL SLRGFEKHNF STSLEKTVIN FENSNGIINN TFFNESKKRM
810 820 830 840 850
PFFGFSVNMR SLDTLLACPK IDEALFNSTS VELTKHMGKS FFYKILRSSL
860 870 880 890 900
ASFAQVFIDI THNSKFNSCC NIYRLGYSMC MRAQAYLKRM KDIFIPQRMF
910 920 930 940 950
ITDLLNVIGR KIWKKLAEIL GYTSRRFLSS AEVKWLFCLG MRDGLKPSFK
960 970 980
YHPCFEQLIY QFQSLTDLIK PLRPVLRQVL FLHRRIAD
Length:988
Mass (Da):116,329
Last modified:January 1, 1998 - v1
Checksum:iAB2DC7030228F443
GO
Isoform 2 (identifier: O13339-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     524-524: K → KQ

Show »
Length:989
Mass (Da):116,457
Checksum:i6B5BFA43499BEAD1
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei524 – 5241K → KQ in isoform 2. CuratedVSP_006395

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF015783 Genomic DNA. Translation: AAC49802.1.
AF015783 Genomic DNA. Translation: AAC49803.1.
CU329671 Genomic DNA. Translation: CAA18391.1.
PIRiT03838.
RefSeqiNP_595842.1. NM_001021746.2. [O13339-1]

Genome annotation databases

EnsemblFungiiSPBC29A3.14c.1; SPBC29A3.14c.1:pep; SPBC29A3.14c. [O13339-1]
GeneIDi2540601.
KEGGispo:SPBC29A3.14c.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF015783 Genomic DNA. Translation: AAC49802.1.
AF015783 Genomic DNA. Translation: AAC49803.1.
CU329671 Genomic DNA. Translation: CAA18391.1.
PIRiT03838.
RefSeqiNP_595842.1. NM_001021746.2. [O13339-1]

3D structure databases

ProteinModelPortaliO13339.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277127. 67 interactions.
DIPiDIP-38463N.
IntActiO13339. 1 interaction.
MINTiMINT-4666576.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC29A3.14c.1; SPBC29A3.14c.1:pep; SPBC29A3.14c. [O13339-1]
GeneIDi2540601.
KEGGispo:SPBC29A3.14c.

Organism-specific databases

EuPathDBiFungiDB:SPBC29A3.14c.
PomBaseiSPBC29A3.14c. trt1.

Phylogenomic databases

InParanoidiO13339.
KOiK11126.
OMAiYSNICER.
OrthoDBiEOG092C2JUX.
PhylomeDBiO13339.

Enzyme and pathway databases

ReactomeiR-SPO-171319. Telomere Extension By Telomerase.

Miscellaneous databases

PROiO13339.

Family and domain databases

InterProiIPR000477. RT_dom.
IPR021891. Telomerase_RBD.
IPR003545. Telomerase_RT.
[Graphical view]
PANTHERiPTHR12066:SF0. PTHR12066:SF0. 1 hit.
PfamiPF00078. RVT_1. 1 hit.
PF12009. Telomerase_RBD. 1 hit.
[Graphical view]
PRINTSiPR01365. TELOMERASERT.
SMARTiSM00975. Telomerase_RBD. 1 hit.
[Graphical view]
PROSITEiPS50878. RT_POL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTERT_SCHPO
AccessioniPrimary (citable) accession number: O13339
Secondary accession number(s): O13338
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Deletion causes telomere shortening and senescence.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.