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Protein

Inositol phosphorylceramide synthase

Gene

AUR1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the addition of a phosphorylinositol group onto ceramide to form inositol phosphorylceramide, an essential step in sphingolipid biosynthesis.1 Publication

Enzyme regulationi

Inhibited by aureobasidin A (AbA), khafrefungin and rustmicin.1 Publication

Kineticsi

  1. KM=130 µM for phosphatidylinositol1 Publication
  2. KM=3.3 µM for C6-NBD-ceramide1 Publication
  1. Vmax=1864 pmol/min/mg enzyme for phosphatidylinositol1 Publication
  2. Vmax=884 pmol/min/mg enzyme for C6-NBD-ceramide1 Publication

GO - Molecular functioni

  • inositol phosphoceramide synthase activity Source: CGD

GO - Biological processi

  • cellular response to drug Source: CGD
  • sphingolipid metabolic process Source: CGD

Keywordsi

Molecular functionTransferase
Biological processLipid metabolism, Sphingolipid metabolism

Enzyme and pathway databases

SABIO-RKiO13332

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol phosphorylceramide synthase (EC:2.-.-.-)
Short name:
IPC synthase
Alternative name(s):
Aureobasidin A resistance protein homolog
Phosphatidylinositol:ceramide phosphoinositol transferase
Gene namesi
Name:AUR1
Ordered Locus Names:CAALFM_C501240WA
ORF Names:CaO19.1945, CaO19.9500
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 5

Organism-specific databases

CGDiCAL0000178882 AUR1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 54CytoplasmicBy similarityAdd BLAST54
Transmembranei55 – 75HelicalSequence analysisAdd BLAST21
Topological domaini76 – 77LumenalBy similarity2
Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Topological domaini99 – 100CytoplasmicBy similarity2
Transmembranei101 – 121HelicalSequence analysisAdd BLAST21
Topological domaini122 – 168LumenalBy similarityAdd BLAST47
Transmembranei169 – 189HelicalSequence analysisAdd BLAST21
Topological domaini190 – 191CytoplasmicBy similarity2
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Topological domaini213 – 258LumenalBy similarityAdd BLAST46
Transmembranei259 – 279HelicalSequence analysisAdd BLAST21
Topological domaini280 – 281CytoplasmicBy similarity2
Transmembranei282 – 302HelicalSequence analysisAdd BLAST21
Topological domaini303 – 304LumenalBy similarity2
Transmembranei305 – 325HelicalSequence analysisAdd BLAST21
Topological domaini326 – 471CytoplasmicBy similarityAdd BLAST146

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1641343

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000647641 – 471Inositol phosphorylceramide synthaseAdd BLAST471

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi145N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi228N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi256N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Chemistry databases

BindingDBiO13332

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi428 – 434Poly-Glu7

Sequence similaritiesi

Belongs to the AUR1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiO13332
OMAiCTPPWYE
OrthoDBiEOG092C20GL

Family and domain databases

InterProiView protein in InterPro
IPR026841 Aur1/Ipt1
IPR000326 P_Acid_Pase_2/haloperoxidase
PfamiView protein in Pfam
PF14378 PAP2_3, 1 hit
SMARTiView protein in SMART
SM00014 acidPPc, 1 hit

Sequencei

Sequence statusi: Complete.

O13332-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSILRSKI IQKPYQLFHY YFLSEKAPGS TVSDLNFDTN IQTSLRKLKH
60 70 80 90 100
HHWTVGEIFH YGFLVSILFF VFVVFPASFF IKLPIILAFA TCFLIPLTSQ
110 120 130 140 150
FFLPALPVFT WLALYFTCAK IPQEWKPAIT VKVLPAMETI LYGDNLSNVL
160 170 180 190 200
ATITTGVLDI LAWLPYGIIH FSFPFVLAAI IFLFGPPTAL RSFGFAFGYM
210 220 230 240 250
NLLGVLIQMA FPAAPPWYKN LHGLEPANYS MHGSPGGLGR IDKLLGVDMY
260 270 280 290 300
TTGFSNSSII FGAFPSLHSG CCIMEVLFLC WLFPRFKFVW VTYASWLWWS
310 320 330 340 350
TMYLTHHYFV DLIGGAMLSL TVFEFTKYKY LPKNKEGLFC RWSYTEIEKI
360 370 380 390 400
DIQEIDPLSY NYIPINSNDN ESRLYTRVYQ ESQVSPPSRA ETPEAFEMSN
410 420 430 440 450
FSRSRQSSKT QVPLSNLTNN DQVPGINEED EEEEGDEISS STPSVFEDEP
460 470
QGSTYAASSA TSVDDLDSKR N
Length:471
Mass (Da):53,458
Last modified:July 28, 2009 - v2
Checksum:i0CFE68ABF7125A7A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti365I → V in AAB67233 (Ref. 1) Curated1
Sequence conflicti388S → Q in AAB67233 (Ref. 1) Curated1
Sequence conflicti424P → S in AAB67233 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013799 Genomic DNA Translation: AAB67233.1
CP017627 Genomic DNA Translation: AOW29559.1
RefSeqiXP_715708.1, XM_710615.2

Genome annotation databases

EnsemblFungiiAOW29559; AOW29559; CAALFM_C501240WA
GeneIDi3642617
KEGGical:CAALFM_C501240WA

Similar proteinsi

Entry informationi

Entry nameiAUR1_CANAL
AccessioniPrimary (citable) accession number: O13332
Secondary accession number(s): A0A1D8PN38, Q5A1Q1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 28, 2009
Last modified: May 23, 2018
This is version 82 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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