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Protein

pH-responsive protein 2

Gene

PHR2

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Required for apical cell growth and plays an essential role in morphogenesis. May be integral to the pathogenic ability of the organism (By similarity).By similarity

GO - Molecular functioni

  • 1,3-beta-glucanosyltransferase activity Source: CGD
  • glucanosyltransferase activity Source: CGD

GO - Biological processi

  • carbohydrate metabolic process Source: InterPro
  • fungal-type cell wall organization Source: CGD
  • pathogenesis Source: CGD
Complete GO annotation...

Protein family/group databases

CAZyiCBM43. Carbohydrate-Binding Module Family 43.
GH72. Glycoside Hydrolase Family 72.

Names & Taxonomyi

Protein namesi
Recommended name:
pH-responsive protein 2
Alternative name(s):
pH-regulated protein 2
Gene namesi
Name:PHR2
ORF Names:CaO19.13500, CaO19.6081
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0000181783. PHR2.

Subcellular locationi

GO - Cellular componenti

  • anchored component of plasma membrane Source: CGD
  • cell surface Source: CGD
  • fungal-type cell wall Source: CGD
  • hyphal cell wall Source: CGD
  • plasma membrane Source: CGD
  • yeast-form cell wall Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001048523 – 515pH-responsive protein 2Add BLAST493
PropeptideiPRO_0000010486516 – 544Removed in mature formSequence analysisAdd BLAST29

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi40N-linked (GlcNAc...)Sequence analysis1
Glycosylationi59N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi72 ↔ 101By similarity
Glycosylationi147N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi214 ↔ 347By similarity
Disulfide bondi232 ↔ 263By similarity
Disulfide bondi369 ↔ 420By similarity
Disulfide bondi378 ↔ 444By similarity
Disulfide bondi397 ↔ 402By similarity
Glycosylationi408N-linked (GlcNAc...)Sequence analysis1
Lipidationi515GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PRIDEiO13318.

Miscellaneous databases

PMAP-CutDBQ5AB91.

Expressioni

Inductioni

Repressed at pH values above 6 and progressively induced at more acidic pH values.

Structurei

3D structure databases

ProteinModelPortaliO13318.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi440 – 521Ser-richAdd BLAST82
Compositional biasi491 – 513Poly-SerAdd BLAST23

Sequence similaritiesi

Belongs to the glycosyl hydrolase 72 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

InParanoidiO13318.
OrthoDBiEOG092C1TYR.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR004886. Glucanosyltransferase.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR012946. X8.
[Graphical view]
PfamiPF03198. Glyco_hydro_72. 1 hit.
PF07983. X8. 1 hit.
[Graphical view]
SMARTiSM00768. X8. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O13318-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLKSLFPSI LAATSFVSSV AAEDLPAIEI VGNKFFYSNN GSQFYIKGIA
60 70 80 90 100
YQQNNLDSNE SFVDPLANPE HCKRDIPYLE AVDTNVIRVY ALDTSQDHTE
110 120 130 140 150
CMQMLQDAGI YVIADLSQPD ESINRDDPSW DLDLFERYTS VVDLFHNYTN
160 170 180 190 200
ILGFFAGNEV TNKKSNTDAS AFVKAAIRDT KAYIKSKGYR SIPVGYSAND
210 220 230 240 250
DSAIRVSLAD YFACGDEDEA ADFFGINMYE WCGDSSYKAS GYESATNDYK
260 270 280 290 300
NLGIPIFFSE YGCNEVRPRK FTEVATLFGD QMTPVWSGGI VYMYFEEENN
310 320 330 340 350
YGLVSIKDNT VSTLKDYSYY SSEIKDIHPS SAKASAESAS SISRTTCPTN
360 370 380 390 400
TNNWEASTNL PPTPDKEVCE CMSASLKCVV DDKVDSDDYS DLFSYICAKI
410 420 430 440 450
DCDGINANGT TGEYGAYSPC HSKDKLSFVM NLYYEQNKES KSACDFGGSA
460 470 480 490 500
SLQSAKTASS CSAYLSSAGS SGLGTVSGTV RTDTSQSTSD SGSGSSSSSS
510 520 530 540
SSSSSSSSGS SGSKSAASIV SVNLLTKIAT IGISIVVGFG LITM
Length:544
Mass (Da):58,716
Last modified:October 19, 2011 - v2
Checksum:i0F474FAD270A1EDD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti84T → YDS in AAB80716 (PubMed:9315654).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF011386 Genomic DNA. Translation: AAB80716.1.
AACQ01000036 Genomic DNA. Translation: EAL00035.1.
AACQ01000035 Genomic DNA. Translation: EAL00142.1.
RefSeqiXP_718939.1. XM_713846.1.
XP_719043.1. XM_713950.1.

Genome annotation databases

EnsemblFungiiEAL00035; EAL00035; CaO19.13500.
EAL00142; EAL00142; CaO19.6081.
GeneIDi3639334.
3639457.
KEGGical:CaO19.13500.
cal:CaO19.6081.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF011386 Genomic DNA. Translation: AAB80716.1.
AACQ01000036 Genomic DNA. Translation: EAL00035.1.
AACQ01000035 Genomic DNA. Translation: EAL00142.1.
RefSeqiXP_718939.1. XM_713846.1.
XP_719043.1. XM_713950.1.

3D structure databases

ProteinModelPortaliO13318.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiCBM43. Carbohydrate-Binding Module Family 43.
GH72. Glycoside Hydrolase Family 72.

Proteomic databases

PRIDEiO13318.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAL00035; EAL00035; CaO19.13500.
EAL00142; EAL00142; CaO19.6081.
GeneIDi3639334.
3639457.
KEGGical:CaO19.13500.
cal:CaO19.6081.

Organism-specific databases

CGDiCAL0000181783. PHR2.

Phylogenomic databases

InParanoidiO13318.
OrthoDBiEOG092C1TYR.

Miscellaneous databases

PMAP-CutDBQ5AB91.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR004886. Glucanosyltransferase.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR012946. X8.
[Graphical view]
PfamiPF03198. Glyco_hydro_72. 1 hit.
PF07983. X8. 1 hit.
[Graphical view]
SMARTiSM00768. X8. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPHR2_CANAL
AccessioniPrimary (citable) accession number: O13318
Secondary accession number(s): Q5AB91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 19, 2011
Last modified: November 2, 2016
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.