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O13318

- PHR2_CANAL

UniProt

O13318 - PHR2_CANAL

Protein

pH-responsive protein 2

Gene

PHR2

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 2 (19 Oct 2011)
      Previous versions | rss
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    Functioni

    Required for apical cell growth and plays an essential role in morphogenesis. May be integral to the pathogenic ability of the organism By similarity.By similarity

    GO - Molecular functioni

    1. 1,3-beta-glucanosyltransferase activity Source: CGD
    2. glucanosyltransferase activity Source: CGD
    3. hydrolase activity, hydrolyzing O-glycosyl compounds Source: CGD

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. fungal-type cell wall organization Source: CGD
    3. pathogenesis Source: CGD

    Protein family/group databases

    CAZyiCBM43. Carbohydrate-Binding Module Family 43.
    GH72. Glycoside Hydrolase Family 72.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    pH-responsive protein 2
    Alternative name(s):
    pH-regulated protein 2
    Gene namesi
    Name:PHR2
    ORF Names:CaO19.13500, CaO19.6081
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0005209. PHR2.

    Subcellular locationi

    GO - Cellular componenti

    1. anchored component of plasma membrane Source: CGD
    2. cell surface Source: CGD
    3. fungal-type cell wall Source: CGD
    4. hyphal cell wall Source: CGD
    5. plasma membrane Source: CGD
    6. yeast-form cell wall Source: CGD

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 515493pH-responsive protein 2PRO_0000010485Add
    BLAST
    Propeptidei516 – 54429Removed in mature formSequence AnalysisPRO_0000010486Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi40 – 401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi59 – 591N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi147 – 1471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi408 – 4081N-linked (GlcNAc...)Sequence Analysis
    Lipidationi515 – 5151GPI-anchor amidated serineSequence Analysis

    Keywords - PTMi

    Glycoprotein, GPI-anchor, Lipoprotein

    Miscellaneous databases

    PMAP-CutDBQ5AB91.

    Expressioni

    Inductioni

    Repressed at pH values above 6 and progressively induced at more acidic pH values.

    Interactioni

    Protein-protein interaction databases

    STRINGi5476.CAL0005209.

    Structurei

    3D structure databases

    ProteinModelPortaliO13318.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi440 – 52182Ser-richAdd
    BLAST
    Compositional biasi491 – 51323Poly-SerAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 72 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG73259.
    OrthoDBiEOG7K3TW7.

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    InterProiIPR004886. Glucanosyltransferase.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR012946. X8.
    [Graphical view]
    PfamiPF03198. Glyco_hydro_72. 1 hit.
    PF07983. X8. 1 hit.
    [Graphical view]
    SMARTiSM00768. X8. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O13318-1 [UniParc]FASTAAdd to Basket

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    MLLKSLFPSI LAATSFVSSV AAEDLPAIEI VGNKFFYSNN GSQFYIKGIA    50
    YQQNNLDSNE SFVDPLANPE HCKRDIPYLE AVDTNVIRVY ALDTSQDHTE 100
    CMQMLQDAGI YVIADLSQPD ESINRDDPSW DLDLFERYTS VVDLFHNYTN 150
    ILGFFAGNEV TNKKSNTDAS AFVKAAIRDT KAYIKSKGYR SIPVGYSAND 200
    DSAIRVSLAD YFACGDEDEA ADFFGINMYE WCGDSSYKAS GYESATNDYK 250
    NLGIPIFFSE YGCNEVRPRK FTEVATLFGD QMTPVWSGGI VYMYFEEENN 300
    YGLVSIKDNT VSTLKDYSYY SSEIKDIHPS SAKASAESAS SISRTTCPTN 350
    TNNWEASTNL PPTPDKEVCE CMSASLKCVV DDKVDSDDYS DLFSYICAKI 400
    DCDGINANGT TGEYGAYSPC HSKDKLSFVM NLYYEQNKES KSACDFGGSA 450
    SLQSAKTASS CSAYLSSAGS SGLGTVSGTV RTDTSQSTSD SGSGSSSSSS 500
    SSSSSSSSGS SGSKSAASIV SVNLLTKIAT IGISIVVGFG LITM 544
    Length:544
    Mass (Da):58,716
    Last modified:October 19, 2011 - v2
    Checksum:i0F474FAD270A1EDD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti84 – 841T → YDS in AAB80716. (PubMed:9315654)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF011386 Genomic DNA. Translation: AAB80716.1.
    AACQ01000036 Genomic DNA. Translation: EAL00035.1.
    AACQ01000035 Genomic DNA. Translation: EAL00142.1.
    RefSeqiXP_718939.1. XM_713846.1.
    XP_719043.1. XM_713950.1.

    Genome annotation databases

    GeneIDi3639334.
    3639457.
    KEGGical:CaO19.13500.
    cal:CaO19.6081.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF011386 Genomic DNA. Translation: AAB80716.1 .
    AACQ01000036 Genomic DNA. Translation: EAL00035.1 .
    AACQ01000035 Genomic DNA. Translation: EAL00142.1 .
    RefSeqi XP_718939.1. XM_713846.1.
    XP_719043.1. XM_713950.1.

    3D structure databases

    ProteinModelPortali O13318.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0005209.

    Protein family/group databases

    CAZyi CBM43. Carbohydrate-Binding Module Family 43.
    GH72. Glycoside Hydrolase Family 72.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3639334.
    3639457.
    KEGGi cal:CaO19.13500.
    cal:CaO19.6081.

    Organism-specific databases

    CGDi CAL0005209. PHR2.

    Phylogenomic databases

    eggNOGi NOG73259.
    OrthoDBi EOG7K3TW7.

    Miscellaneous databases

    PMAP-CutDB Q5AB91.

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    InterProi IPR004886. Glucanosyltransferase.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR012946. X8.
    [Graphical view ]
    Pfami PF03198. Glyco_hydro_72. 1 hit.
    PF07983. X8. 1 hit.
    [Graphical view ]
    SMARTi SM00768. X8. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "PHR2 of Candida albicans encodes a functional homolog of the pH-regulated gene PHR1 with an inverted pattern of pH-dependent expression."
      Muehlschlegel F.A., Fonzi W.A.
      Mol. Cell. Biol. 17:5960-5967(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiPHR2_CANAL
    AccessioniPrimary (citable) accession number: O13318
    Secondary accession number(s): Q5AB91
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: October 19, 2011
    Last modified: October 1, 2014
    This is version 80 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3