Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O13318

- PHR2_CANAL

UniProt

O13318 - PHR2_CANAL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

pH-responsive protein 2

Gene

PHR2

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Required for apical cell growth and plays an essential role in morphogenesis. May be integral to the pathogenic ability of the organism (By similarity).By similarity

GO - Molecular functioni

  1. 1,3-beta-glucanosyltransferase activity Source: CGD
  2. glucanosyltransferase activity Source: CGD

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. fungal-type cell wall organization Source: CGD
  3. pathogenesis Source: CGD
Complete GO annotation...

Protein family/group databases

CAZyiCBM43. Carbohydrate-Binding Module Family 43.
GH72. Glycoside Hydrolase Family 72.

Names & Taxonomyi

Protein namesi
Recommended name:
pH-responsive protein 2
Alternative name(s):
pH-regulated protein 2
Gene namesi
Name:PHR2
ORF Names:CaO19.13500, CaO19.6081
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0005209. PHR2.

Subcellular locationi

GO - Cellular componenti

  1. anchored component of plasma membrane Source: CGD
  2. cell surface Source: CGD
  3. fungal-type cell wall Source: CGD
  4. hyphal cell wall Source: CGD
  5. plasma membrane Source: CGD
  6. yeast-form cell wall Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 515493pH-responsive protein 2PRO_0000010485Add
BLAST
Propeptidei516 – 54429Removed in mature formSequence AnalysisPRO_0000010486Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi40 – 401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi59 – 591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi147 – 1471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi408 – 4081N-linked (GlcNAc...)Sequence Analysis
Lipidationi515 – 5151GPI-anchor amidated serineSequence Analysis

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Miscellaneous databases

PMAP-CutDBQ5AB91.

Expressioni

Inductioni

Repressed at pH values above 6 and progressively induced at more acidic pH values.

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0005209.

Structurei

3D structure databases

ProteinModelPortaliO13318.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi440 – 52182Ser-richAdd
BLAST
Compositional biasi491 – 51323Poly-SerAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyl hydrolase 72 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG73259.
InParanoidiO13318.
OrthoDBiEOG7K3TW7.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR004886. Glucanosyltransferase.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR012946. X8.
[Graphical view]
PfamiPF03198. Glyco_hydro_72. 1 hit.
PF07983. X8. 1 hit.
[Graphical view]
SMARTiSM00768. X8. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O13318-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLLKSLFPSI LAATSFVSSV AAEDLPAIEI VGNKFFYSNN GSQFYIKGIA
60 70 80 90 100
YQQNNLDSNE SFVDPLANPE HCKRDIPYLE AVDTNVIRVY ALDTSQDHTE
110 120 130 140 150
CMQMLQDAGI YVIADLSQPD ESINRDDPSW DLDLFERYTS VVDLFHNYTN
160 170 180 190 200
ILGFFAGNEV TNKKSNTDAS AFVKAAIRDT KAYIKSKGYR SIPVGYSAND
210 220 230 240 250
DSAIRVSLAD YFACGDEDEA ADFFGINMYE WCGDSSYKAS GYESATNDYK
260 270 280 290 300
NLGIPIFFSE YGCNEVRPRK FTEVATLFGD QMTPVWSGGI VYMYFEEENN
310 320 330 340 350
YGLVSIKDNT VSTLKDYSYY SSEIKDIHPS SAKASAESAS SISRTTCPTN
360 370 380 390 400
TNNWEASTNL PPTPDKEVCE CMSASLKCVV DDKVDSDDYS DLFSYICAKI
410 420 430 440 450
DCDGINANGT TGEYGAYSPC HSKDKLSFVM NLYYEQNKES KSACDFGGSA
460 470 480 490 500
SLQSAKTASS CSAYLSSAGS SGLGTVSGTV RTDTSQSTSD SGSGSSSSSS
510 520 530 540
SSSSSSSSGS SGSKSAASIV SVNLLTKIAT IGISIVVGFG LITM
Length:544
Mass (Da):58,716
Last modified:October 19, 2011 - v2
Checksum:i0F474FAD270A1EDD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti84 – 841T → YDS in AAB80716. (PubMed:9315654)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF011386 Genomic DNA. Translation: AAB80716.1.
AACQ01000036 Genomic DNA. Translation: EAL00035.1.
AACQ01000035 Genomic DNA. Translation: EAL00142.1.
RefSeqiXP_718939.1. XM_713846.1.
XP_719043.1. XM_713950.1.

Genome annotation databases

GeneIDi3639334.
3639457.
KEGGical:CaO19.13500.
cal:CaO19.6081.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF011386 Genomic DNA. Translation: AAB80716.1 .
AACQ01000036 Genomic DNA. Translation: EAL00035.1 .
AACQ01000035 Genomic DNA. Translation: EAL00142.1 .
RefSeqi XP_718939.1. XM_713846.1.
XP_719043.1. XM_713950.1.

3D structure databases

ProteinModelPortali O13318.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0005209.

Protein family/group databases

CAZyi CBM43. Carbohydrate-Binding Module Family 43.
GH72. Glycoside Hydrolase Family 72.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3639334.
3639457.
KEGGi cal:CaO19.13500.
cal:CaO19.6081.

Organism-specific databases

CGDi CAL0005209. PHR2.

Phylogenomic databases

eggNOGi NOG73259.
InParanoidi O13318.
OrthoDBi EOG7K3TW7.

Miscellaneous databases

PMAP-CutDB Q5AB91.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR004886. Glucanosyltransferase.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR012946. X8.
[Graphical view ]
Pfami PF03198. Glyco_hydro_72. 1 hit.
PF07983. X8. 1 hit.
[Graphical view ]
SMARTi SM00768. X8. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "PHR2 of Candida albicans encodes a functional homolog of the pH-regulated gene PHR1 with an inverted pattern of pH-dependent expression."
    Muehlschlegel F.A., Fonzi W.A.
    Mol. Cell. Biol. 17:5960-5967(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiPHR2_CANAL
AccessioniPrimary (citable) accession number: O13318
Secondary accession number(s): Q5AB91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 19, 2011
Last modified: October 29, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3