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O13318 (PHR2_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
pH-responsive protein 2
Alternative name(s):
pH-regulated protein 2
Gene names
Name:PHR2
ORF Names:CaO19.13500, CaO19.6081
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length544 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Required for apical cell growth and plays an essential role in morphogenesis. May be integral to the pathogenic ability of the organism By similarity.

Subcellular location

Cell membrane; Lipid-anchorGPI-anchor Potential.

Induction

Repressed at pH values above 6 and progressively induced at more acidic pH values.

Sequence similarities

Belongs to the glycosyl hydrolase 72 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 515493pH-responsive protein 2
PRO_0000010485
Propeptide516 – 54429Removed in mature form Potential
PRO_0000010486

Regions

Compositional bias440 – 52182Ser-rich
Compositional bias491 – 51323Poly-Ser

Amino acid modifications

Lipidation5151GPI-anchor amidated serine Potential
Glycosylation401N-linked (GlcNAc...) Potential
Glycosylation591N-linked (GlcNAc...) Potential
Glycosylation1471N-linked (GlcNAc...) Potential
Glycosylation4081N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict841T → YDS in AAB80716. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O13318 [UniParc].

Last modified October 19, 2011. Version 2.
Checksum: 0F474FAD270A1EDD

FASTA54458,716
        10         20         30         40         50         60 
MLLKSLFPSI LAATSFVSSV AAEDLPAIEI VGNKFFYSNN GSQFYIKGIA YQQNNLDSNE 

        70         80         90        100        110        120 
SFVDPLANPE HCKRDIPYLE AVDTNVIRVY ALDTSQDHTE CMQMLQDAGI YVIADLSQPD 

       130        140        150        160        170        180 
ESINRDDPSW DLDLFERYTS VVDLFHNYTN ILGFFAGNEV TNKKSNTDAS AFVKAAIRDT 

       190        200        210        220        230        240 
KAYIKSKGYR SIPVGYSAND DSAIRVSLAD YFACGDEDEA ADFFGINMYE WCGDSSYKAS 

       250        260        270        280        290        300 
GYESATNDYK NLGIPIFFSE YGCNEVRPRK FTEVATLFGD QMTPVWSGGI VYMYFEEENN 

       310        320        330        340        350        360 
YGLVSIKDNT VSTLKDYSYY SSEIKDIHPS SAKASAESAS SISRTTCPTN TNNWEASTNL 

       370        380        390        400        410        420 
PPTPDKEVCE CMSASLKCVV DDKVDSDDYS DLFSYICAKI DCDGINANGT TGEYGAYSPC 

       430        440        450        460        470        480 
HSKDKLSFVM NLYYEQNKES KSACDFGGSA SLQSAKTASS CSAYLSSAGS SGLGTVSGTV 

       490        500        510        520        530        540 
RTDTSQSTSD SGSGSSSSSS SSSSSSSSGS SGSKSAASIV SVNLLTKIAT IGISIVVGFG 


LITM 

« Hide

References

« Hide 'large scale' references
[1]"PHR2 of Candida albicans encodes a functional homolog of the pH-regulated gene PHR1 with an inverted pattern of pH-dependent expression."
Muehlschlegel F.A., Fonzi W.A.
Mol. Cell. Biol. 17:5960-5967(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.
[2]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF011386 Genomic DNA. Translation: AAB80716.1.
AACQ01000036 Genomic DNA. Translation: EAL00035.1.
AACQ01000035 Genomic DNA. Translation: EAL00142.1.
RefSeqXP_718939.1. XM_713846.1.
XP_719043.1. XM_713950.1.

3D structure databases

ProteinModelPortalO13318.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0005209.

Protein family/group databases

CAZyCBM43. Carbohydrate-Binding Module Family 43.
GH72. Glycoside Hydrolase Family 72.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3639334.
3639457.
KEGGcal:CaO19.13500.
cal:CaO19.6081.

Organism-specific databases

CGDCAL0005209. PHR2.

Phylogenomic databases

eggNOGNOG73259.
OrthoDBEOG7K3TW7.

Family and domain databases

Gene3D3.20.20.80. 1 hit.
InterProIPR004886. Glucanosyltransferase.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR012946. X8.
[Graphical view]
PfamPF03198. Glyco_hydro_72. 1 hit.
PF07983. X8. 1 hit.
[Graphical view]
SMARTSM00768. X8. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
ProtoNetSearch...

Other

PMAP-CutDBQ5AB91.

Entry information

Entry namePHR2_CANAL
AccessionPrimary (citable) accession number: O13318
Secondary accession number(s): Q5AB91
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 19, 2011
Last modified: April 16, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

Candida albicans

Candida albicans: entries and gene names