pH-responsive protein 2 precursor - Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

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O13318 (PHR2_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 74. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
pH-responsive protein 2

Alternative name(s):
pH-regulated protein 2

Gene names

Name:	PHR2
ORF Names:	CaO19.13500, CaO19.6081

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida ›

Protein attributes

Sequence length	544 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Required for apical cell growth and plays an essential role in morphogenesis. May be integral to the pathogenic ability of the organism By similarity.
Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor Potential.
Induction	Repressed at pH values above 6 and progressively induced at more acidic pH values.
Sequence similarities	Belongs to the glycosyl hydrolase 72 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Signal
PTM	GPI-anchor Glycoprotein Lipoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro fungal-type cell wall organization Inferred from mutant phenotype PubMed 10559174 PubMed 16652171. Source: CGD pathogenesis Inferred from mutant phenotype PubMed 9632601. Source: CGD
Cellular_component	anchored to plasma membrane Inferred from direct assay PubMed 19824013. Source: CGD cell surface Inferred from direct assay PubMed 18712765. Source: CGD hyphal cell wall Inferred from direct assay PubMed 18712765 PubMed 19555771. Source: CGD yeast-form cell wall Inferred from direct assay PubMed 18712765 PubMed 19555771. Source: CGD
Molecular_function	glucanosyltransferase activity Inferred from direct assay PubMed 10809732. Source: CGD hydrolase activity, hydrolyzing O-glycosyl compounds Inferred from sequence or structural similarity PubMed 10559174. Source: CGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 22

Potential

Chain

23 – 515

493

pH-responsive protein 2

PRO_0000010485

Propeptide

516 – 544

Removed in mature form Potential

PRO_0000010486

Regions

Compositional bias

440 – 521

Ser-rich

Compositional bias

491 – 513

Poly-Ser

Amino acid modifications

Lipidation

515

GPI-anchor amidated serine Potential

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

147

N-linked (GlcNAc...) Potential

Glycosylation

408

N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict

T → YDS in AAB80716. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

O13318 [UniParc].

Last modified October 19, 2011. Version 2.
Checksum: 0F474FAD270A1EDD
Show »

FASTA

544

58,716

        10         20         30         40         50         60 
MLLKSLFPSI LAATSFVSSV AAEDLPAIEI VGNKFFYSNN GSQFYIKGIA YQQNNLDSNE 

        70         80         90        100        110        120 
SFVDPLANPE HCKRDIPYLE AVDTNVIRVY ALDTSQDHTE CMQMLQDAGI YVIADLSQPD 

       130        140        150        160        170        180 
ESINRDDPSW DLDLFERYTS VVDLFHNYTN ILGFFAGNEV TNKKSNTDAS AFVKAAIRDT 

       190        200        210        220        230        240 
KAYIKSKGYR SIPVGYSAND DSAIRVSLAD YFACGDEDEA ADFFGINMYE WCGDSSYKAS 

       250        260        270        280        290        300 
GYESATNDYK NLGIPIFFSE YGCNEVRPRK FTEVATLFGD QMTPVWSGGI VYMYFEEENN 

       310        320        330        340        350        360 
YGLVSIKDNT VSTLKDYSYY SSEIKDIHPS SAKASAESAS SISRTTCPTN TNNWEASTNL 

       370        380        390        400        410        420 
PPTPDKEVCE CMSASLKCVV DDKVDSDDYS DLFSYICAKI DCDGINANGT TGEYGAYSPC 

       430        440        450        460        470        480 
HSKDKLSFVM NLYYEQNKES KSACDFGGSA SLQSAKTASS CSAYLSSAGS SGLGTVSGTV 

       490        500        510        520        530        540 
RTDTSQSTSD SGSGSSSSSS SSSSSSSSGS SGSKSAASIV SVNLLTKIAT IGISIVVGFG 


LITM

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"PHR2 of Candida albicans encodes a functional homolog of the pH-regulated gene PHR1 with an inverted pattern of pH-dependent expression." Muehlschlegel F.A., Fonzi W.A. Mol. Cell. Biol. 17:5960-5967(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.
[2]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF011386 Genomic DNA. Translation: AAB80716.1. AACQ01000036 Genomic DNA. Translation: EAL00035.1. AACQ01000035 Genomic DNA. Translation: EAL00142.1.
RefSeq	XP_718939.1. XM_713846.1. XP_719043.1. XM_713950.1.
3D structure databases
ProteinModelPortal	O13318.
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0005209.
Protein family/group databases
CAZy	CBM43. Carbohydrate-Binding Module Family 43. GH72. Glycoside Hydrolase Family 72.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3639334. 3639457.
KEGG	cal:CaO19.13500. cal:CaO19.6081.
Organism-specific databases
CGD	CAL0005209. PHR2.
Phylogenomic databases
eggNOG	NOG73259.
Family and domain databases
Gene3D	3.20.20.80. 1 hit.
InterPro	IPR004886. Glucanosyltransferase. IPR013781. Glyco_hydro_catalytic_dom. IPR017853. Glycoside_hydrolase_SF. IPR012946. X8. [Graphical view]
Pfam	PF03198. Glyco_hydro_72. 1 hit. PF07983. X8. 1 hit. [Graphical view]
SMART	SM00768. X8. 1 hit. [Graphical view]
SUPFAM	SSF51445. Glyco_hydro_cat. 1 hit.
ProtoNet	Search...
Other
PMAP-CutDB	Q5AB91.

Entry information

Entry name

PHR2_CANAL

Accession

Primary (citable) accession number: O13318
Secondary accession number(s): Q5AB91

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	October 19, 2011
Last modified:	May 1, 2013
This is version 74 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Candida albicans

Candida albicans: entries and gene names

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Other

Entry information

Relevant documents