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Protein

Alcohol dehydrogenase 2

Gene

ADH2

Organism
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Converts ethanol to acetaldehyde.

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi44Zinc 1; catalyticBy similarity1
Metal bindingi67Zinc 1; catalyticBy similarity1
Metal bindingi98Zinc 2By similarity1
Metal bindingi101Zinc 2By similarity1
Metal bindingi104Zinc 2By similarity1
Metal bindingi112Zinc 2By similarity1
Metal bindingi154Zinc 1; catalyticBy similarity1
Binding sitei202NADBy similarity1
Binding sitei207NADBy similarity1
Binding sitei341NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi178 – 184NADBy similarity7
Nucleotide bindingi269 – 271NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 2 (EC:1.1.1.1)
Alternative name(s):
ADH 1
Alcohol dehydrogenase II
Gene namesi
Name:ADH2
Synonyms:ADH1
ORF Names:PICST_27980
OrganismiScheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
Taxonomic identifieri322104 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeScheffersomyces
Proteomesi
  • UP000002258 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607281 – 348Alcohol dehydrogenase 2Add BLAST348

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi322104.XP_001383210.1.

Structurei

3D structure databases

ProteinModelPortaliO13309.
SMRiO13309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0023. Eukaryota.
COG1064. LUCA.
InParanoidiO13309.
KOiK13953.
OMAiRKGAFPH.
OrthoDBiEOG092C2Q8E.

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

O13309-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIPTTQKAV IFETNGGPLL YKDIPVPKPK PNELLINVKY SGVCHTDLHA
60 70 80 90 100
WKGDWPLDTK LPLVGGHEGA GVVVALGENV TGWEIGDYAG IKWINGSCLQ
110 120 130 140 150
CEYCVTAHES NCPDADLSGY THDGSFQQYA TADAIQAARI PKGTDLALIA
160 170 180 190 200
PILCAGITVY KALKTAQLQA GQWVAVSGAA GGLGSLAIQY AKAMGYRVVG
210 220 230 240 250
IDGGADKGEF AKSLGAEVFV DFLSSKDVVA DVLKATNGGA HGVINVSVSE
260 270 280 290 300
RAMQQSVDYV RPTGTVVLVG LPAGAKVSAS VFSSVVRTIQ IKGSYVGNRA
310 320 330 340
DSAEAIDFFT RGLIKCPIKI VGLSELASVY ELMEQGKILG RYVVDTSK
Length:348
Mass (Da):36,565
Last modified:January 1, 1998 - v1
Checksum:iF6C813C98F56A148
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41Missing in CAA73690 (PubMed:9802210).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008244 Genomic DNA. Translation: AAC49990.1.
Y13238 Genomic DNA. Translation: CAA73690.1.
CP000496 Genomic DNA. Translation: ABN65181.1.
RefSeqiXP_001383210.1. XM_001383173.1.

Genome annotation databases

EnsemblFungiiABN65181; ABN65181; PICST_27980.
GeneIDi4837414.
KEGGipic:PICST_27980.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiADH2_PICST
AccessioniPrimary (citable) accession number: O13309
Secondary accession number(s): A3LQC2, O00090
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: June 7, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families