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O13302

- IDH1_AJECA

UniProt

O13302 - IDH1_AJECA

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Protein

Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial

Gene

IDH1

Organism
Ajellomyces capsulatus (Darling's disease fungus) (Histoplasma capsulatum)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Performs an essential role in the oxidative function of the citric acid cycle.By similarity

Catalytic activityi

Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH.

Cofactori

Mg2+, Mn2+Note: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei137 – 1371SubstrateBy similarity
Binding sitei168 – 1681SubstrateBy similarity
Sitei175 – 1751Critical for catalysisBy similarity
Sitei222 – 2221Critical for catalysisBy similarity
Metal bindingi255 – 2551Magnesium or manganeseBy similarity
Binding sitei255 – 2551SubstrateBy similarity

GO - Molecular functioni

  1. isocitrate dehydrogenase (NAD+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial (EC:1.1.1.41)
Alternative name(s):
Isocitric dehydrogenase
NAD(+)-specific ICDH
Gene namesi
Name:IDH1
OrganismiAjellomyces capsulatus (Darling's disease fungus) (Histoplasma capsulatum)
Taxonomic identifieri5037 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeAjellomyces

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3535MitochondrionSequence AnalysisAdd
BLAST
Chaini36 – 388353Isocitrate dehydrogenase [NAD] subunit 1, mitochondrialPRO_0000014428Add
BLAST

Interactioni

Subunit structurei

Octamer of two non-identical subunits IDH1 and IDH2.By similarity

Structurei

3D structure databases

ProteinModelPortaliO13302.
SMRiO13302. Positions 48-386.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004434. Isocitrate_DH_NAD.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00175. mito_nad_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O13302-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFSLRTAQPA QSLFRAATNT YSTSLPRSAI AARSFATVQS DIFKPTKYGG
60 70 80 90 100
KYTVTLIPGD GIGTEVAESV KTIFKADNVP IEWEQVDVSG LDAGNKHSED
110 120 130 140 150
LFKESIASLK RNKLGLKGIL HTPVERSGHQ SFNVALRQEL DIYASIVLIK
160 170 180 190 200
NIPGYKTRHD NVDLCIIREN TEGEYSGLEH QSVSGVVESL KIITRAKSER
210 220 230 240 250
IAKFAFSFAL ANNRKKVTCI HKANIMKLAD GLFRSTFHKV AESYPTLETN
260 270 280 290 300
DMIVDNASMQ AVARPQQFDV MVMPNLYGGI LSNVGAALVG GPGIVPGCNM
310 320 330 340 350
GRDVAVFEPG CRHVGLDIKG KDQANPTALI LSGSMLLRHL GLDEHANRIS
360 370 380
KAVYDVIGEG VTRTRDMGGQ ASTHEFTRAV LDKMESAL
Length:388
Mass (Da):42,222
Last modified:January 1, 1998 - v1
Checksum:i7E80888D17CEBEF7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009036 mRNA. Translation: AAB63461.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009036 mRNA. Translation: AAB63461.1 .

3D structure databases

ProteinModelPortali O13302.
SMRi O13302. Positions 48-386.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004434. Isocitrate_DH_NAD.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00175. mito_nad_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation of a Histoplasma capsulatum cDNA that complements a mitochondrial NAD(+)-isocitrate dehydrogenase subunit I-deficient mutant of Saccharomyces cerevisiae."
    Johnson C.H., McEwen J.E.
    Yeast 15:799-804(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ATCC 26032 / G217B.

Entry informationi

Entry nameiIDH1_AJECA
AccessioniPrimary (citable) accession number: O13302
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: January 1, 1998
Last modified: November 26, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3