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Protein

Histone deacetylase phd1

Gene

phd1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Is not essential.By similarity

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei158By similarity1

GO - Molecular functioni

  • histone deacetylase activity Source: PomBase
  • histone deacetylase activity (H4-K16 specific) Source: PomBase
  • NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC

GO - Biological processi

  • heterochromatin assembly involved in chromatin silencing Source: PomBase
  • histone deacetylation Source: PomBase
  • regulation of nucleosome density Source: PomBase
  • regulation of transcription by RNA polymerase II Source: PomBase
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionChromatin regulator, Hydrolase, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase phd1 (EC:3.5.1.98)
Gene namesi
Name:phd1
Synonyms:hda1
ORF Names:SPAC3G9.07c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC3G9.07c
PomBaseiSPAC3G9.07c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001147251 – 434Histone deacetylase phd1Add BLAST434

Proteomic databases

MaxQBiO13298
PaxDbiO13298
PRIDEiO13298

Interactioni

Protein-protein interaction databases

BioGridi280057158 interactors.
STRINGi4896.SPAC3G9.07c.1

Structurei

3D structure databases

ProteinModelPortaliO13298
SMRiO13298
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni26 – 339Histone deacetylaseAdd BLAST314

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000225180
InParanoidiO13298
KOiK11483
OMAiPRAWTHL
OrthoDBiEOG092C1END
PhylomeDBiO13298

Family and domain databases

Gene3Di3.40.800.201 hit
InterProiView protein in InterPro
IPR000286 His_deacetylse
IPR003084 His_deacetylse_1
IPR023801 His_deacetylse_dom
IPR037138 His_deacetylse_dom_sf
IPR023696 Ureohydrolase_dom_sf
PANTHERiPTHR10625 PTHR10625, 1 hit
PfamiView protein in Pfam
PF00850 Hist_deacetyl, 1 hit
PIRSFiPIRSF037913 His_deacetylse_1, 1 hit
PRINTSiPR01270 HDASUPER
PR01271 HISDACETLASE
SUPFAMiSSF52768 SSF52768, 1 hit

Sequencei

Sequence statusi: Complete.

O13298-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTPETSTPY EQVEKGSFFS FRPQKKRVTY HLDEQVGNYH YGDKHPMKPH
60 70 80 90 100
RITITNHLVM GYGLHNKMSV FSPRMATFGE MSEFHREDYL DFLKRVTPDN
110 120 130 140 150
AEQFADKFQQ FNIGDDCPVF DGTYEFSQRS AGASLDASRK LVQGQTDIAI
160 170 180 190 200
NWSGGLHHAK RGEASGFCYV NDIVLAILNM LRFFPRVLYI DIDIHHGDGV
210 220 230 240 250
QQAFYESDRV LTVSFHKYNG DFFPATGNFD ENGVKGGKYF ALNVPLEDGI
260 270 280 290 300
GDEQYTSLFK SIIEPTINTF QPSAIVLQCG ADSLGYDRLG VFNLSIHAHG
310 320 330 340 350
ECVRFTRSFN IPMLVVGGGG YTLRNVARAW CYETSICVNE QIPSELPRET
360 370 380 390 400
LYYEFFAPDY TLHPRLTTKI ENKNTPKALE DLRIRALEQL RYLGGAPSVQ
410 420 430
MQQIPPDLTG HLEEEDERLN DEYLDKAVDV RVRG
Length:434
Mass (Da):49,381
Last modified:January 1, 1998 - v1
Checksum:iCA2FF0D34CA536EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008888 Genomic DNA Translation: BAA23598.1
CU329670 Genomic DNA Translation: CAA15916.1
PIRiT11643
RefSeqiNP_594079.1, NM_001019506.2

Genome annotation databases

EnsemblFungiiSPAC3G9.07c.1; SPAC3G9.07c.1:pep; SPAC3G9.07c
GeneIDi2543643
KEGGispo:SPAC3G9.07c

Entry informationi

Entry nameiPHD1_SCHPO
AccessioniPrimary (citable) accession number: O13298
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome