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Reviewed, UniProtKB/Swiss-Prot O13298 (PHD1_SCHPO)

Last modified November 3, 2009. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Histone deacetylase phd1
    EC=3.5.1.98
Gene names
Name: phd1
Synonyms: hda1
ORF Names: SPAC3G9.07c
OrganismSchizosaccharomyces pombe (Fission yeast) [Complete proteome]
Taxonomic identifier4896 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length434 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity. Is not essential.

Catalytic activity

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Subcellular location

Nucleus Potential.

Sequence similarities

Belongs to the histone deacetylase family. Type 1 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 434434Histone deacetylase phd1
PRO_0000114725

Regions

Region26 – 339314Histone deacetylase

Sites

Active site1581 By similarity

Sequences

Sequence LengthMass (Da)Tools
O13298-1 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: CA2FF0D34CA536EA

FASTA43449,381
        10         20         30         40         50         60 
MDTPETSTPY EQVEKGSFFS FRPQKKRVTY HLDEQVGNYH YGDKHPMKPH RITITNHLVM 

        70         80         90        100        110        120 
GYGLHNKMSV FSPRMATFGE MSEFHREDYL DFLKRVTPDN AEQFADKFQQ FNIGDDCPVF 

       130        140        150        160        170        180 
DGTYEFSQRS AGASLDASRK LVQGQTDIAI NWSGGLHHAK RGEASGFCYV NDIVLAILNM 

       190        200        210        220        230        240 
LRFFPRVLYI DIDIHHGDGV QQAFYESDRV LTVSFHKYNG DFFPATGNFD ENGVKGGKYF 

       250        260        270        280        290        300 
ALNVPLEDGI GDEQYTSLFK SIIEPTINTF QPSAIVLQCG ADSLGYDRLG VFNLSIHAHG 

       310        320        330        340        350        360 
ECVRFTRSFN IPMLVVGGGG YTLRNVARAW CYETSICVNE QIPSELPRET LYYEFFAPDY 

       370        380        390        400        410        420 
TLHPRLTTKI ENKNTPKALE DLRIRALEQL RYLGGAPSVQ MQQIPPDLTG HLEEEDERLN 

       430 
DEYLDKAVDV RVRG 

« Hide

References

« Hide 'large scale' references
[1]"phd1+, a histone deacetylase gene of Schizosaccharomyces pombe, is required for the meiotic cell cycle and resistance to trichostatin A."
Kim Y.B., Honda A., Yoshida M., Horinouchi S.
FEBS Lett. 436:193-196(1998) [PubMed: 9781677] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 38366 / 972.
[3]"Genetic characterisation of hda1+, a putative fission yeast histone deacetylase gene."
Olsson T.G.S., Ekwall K., Allshire R.C., Sunnerhagen P., Partridge J.F., Richardson W.A.
Nucleic Acids Res. 26:3247-3254(1998) [PubMed: 9628926] [Abstract]
Cited for: CHARACTERIZATION.

Cross-references

Sequence databases

AB008888 Genomic DNA. Translation: BAA23598.1.
CU329670 Genomic DNA. Translation: CAA15916.1.
PIRT11643.
RefSeqNP_594079.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGO13298.

Genome annotation databases

GeneID2543643.
GenomeReviewsGene locus phd1 in contig CU329670_GR.
KEGGspo:SPAC3G9.07c.
NMPDRfig|4896.1.peg.4049.

Organism-specific databases

GeneDB_SpombeSPAC3G9.07c.

Phylogenomic databases

OMAIHTATAL.

Enzyme and pathway databases

BioCycSPOM-XXX-01:SPOM-XXX-01-001706-MON.

Gene expression databases

ArrayExpressO13298.

Family and domain databases

InterProIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
[Graphical view]
Gene3DG3DSA:3.40.800.20. His_deacetylse. 1 hit.
PANTHERPTHR10625. His_deacetylse. 1 hit.
PTHR10625:SF28. His_deacetylse_1. 1 hit.
PfamPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSPR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNetSearch...

Entry information

Entry namePHD1_SCHPO
AccessionPrimary (citable) accession number: O13298
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 3, 2009
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents