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O13294

- IDH2_CANTR

UniProt

O13294 - IDH2_CANTR

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Protein

Isocitrate dehydrogenase [NADP] peroxisomal

Gene
IDP2
Organism
Candida tropicalis (Yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in N-alkane metabolism, glutamate synthesis, and/or NADPH generation in the peroxisomes.

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei80 – 801Substrate By similarity
Binding sitei85 – 851NADP By similarity
Binding sitei112 – 1121Substrate By similarity
Binding sitei135 – 1351Substrate By similarity
Sitei142 – 1421Critical for catalysis By similarity
Sitei214 – 2141Critical for catalysis By similarity
Metal bindingi254 – 2541Magnesium or manganese By similarity
Binding sitei262 – 2621NADP By similarity
Metal bindingi277 – 2771Magnesium or manganese By similarity
Binding sitei330 – 3301NADP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi78 – 803NADP By similarity
Nucleotide bindingi312 – 3176NADP By similarity

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. isocitrate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP] peroxisomal (EC:1.1.1.42)
Short name:
IDH
Alternative name(s):
CtIDP2
Oxalosuccinate decarboxylase
PS-NADP-IDH
Gene namesi
Name:IDP2
OrganismiCandida tropicalis (Yeast)
Taxonomic identifieri5482 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Subcellular locationi

GO - Cellular componenti

  1. peroxisome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 411410Isocitrate dehydrogenase [NADP] peroxisomalPRO_0000083583Add
BLAST

Proteomic databases

PRIDEiO13294.

Expressioni

Inductioni

By N-alkanes.

Structurei

3D structure databases

ProteinModelPortaliO13294.
SMRiO13294. Positions 6-409.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni97 – 1037Substrate binding By similarity

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O13294-1 [UniParc]FASTAAdd to Basket

« Hide

MGEIQKITVK NPIVEMDGDE MTRIIWQFIK DKLILPYLNV DLKYYDLGIE    50
YRDKTDDKVT TDAAEAILQY GVGVKCATIT PDEARVKEFN LKKMWLSPNG 100
TLRNVIGGTV FREPIVIDNI PRIVPSWEKP IIIGRHAFGD QYKATDVVIP 150
AAGDLKLVFK PKDGGEVQEF PVYQFDGPGV ALSMYNTDAS ITDFAESSFQ 200
LAIERKLNLF SSTKNTILKK YDGKFKDIFE GLYASKYKTK MDELGIWYEH 250
RLIDDMVAQM LKSKGGYIIA MKNYDGDVQS DIVAQGFGSL GLMTSVLVTP 300
DGKAFESEAA HGTVTRHYRQ HQQGKETSTN SIASIYAWTR GLIQRGKLDD 350
TPEVVKFAEE LEKAVIETVS KDNIMTKDLA LTQGKTDRSS YVTTEEFIDG 400
VANRLNKNLG Y 411
Length:411
Mass (Da):46,171
Last modified:January 23, 2007 - v3
Checksum:i3E47A093C45F5915
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB007994 Genomic DNA. Translation: BAA22846.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB007994 Genomic DNA. Translation: BAA22846.1 .

3D structure databases

ProteinModelPortali O13294.
SMRi O13294. Positions 6-409.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi O13294.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Gene analysis of an NADP-linked isocitrate dehydrogenase localized in peroxisomes of the n-alkane-assimilating yeast Candida tropicalis."
    Kawachi H., Shimizu K., Atomi H., Sanuki S., Ueda M., Tanaka A.
    Eur. J. Biochem. 250:205-211(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-16.
    Strain: ATCC 20336 / pK233 / NCYC 997.

Entry informationi

Entry nameiIDH2_CANTR
AccessioniPrimary (citable) accession number: O13294
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: January 23, 2007
Last modified: October 16, 2013
This is version 71 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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