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Protein

Isocitrate dehydrogenase [NADP] peroxisomal

Gene

IDP2

Organism
Candida tropicalis (Yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in N-alkane metabolism, glutamate synthesis, and/or NADPH generation in the peroxisomes.

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 1 Mg2+ or Mn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei80SubstrateBy similarity1
Binding sitei85NADPBy similarity1
Binding sitei112SubstrateBy similarity1
Binding sitei135SubstrateBy similarity1
Sitei142Critical for catalysisBy similarity1
Sitei214Critical for catalysisBy similarity1
Metal bindingi254Magnesium or manganeseBy similarity1
Binding sitei262NADPBy similarity1
Metal bindingi277Magnesium or manganeseBy similarity1
Binding sitei330NADP; via amide nitrogen and carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi78 – 80NADPBy similarity3
Nucleotide bindingi312 – 317NADPBy similarity6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP] peroxisomal (EC:1.1.1.42)
Short name:
IDH
Alternative name(s):
CtIDP2
Oxalosuccinate decarboxylase
PS-NADP-IDH
Gene namesi
Name:IDP2
OrganismiCandida tropicalis (Yeast)
Taxonomic identifieri5482 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000835832 – 411Isocitrate dehydrogenase [NADP] peroxisomalAdd BLAST410

Proteomic databases

PRIDEiO13294.

Expressioni

Inductioni

By N-alkanes.

Interactioni

Protein-protein interaction databases

STRINGi294747.XP_002546127.1.

Structurei

3D structure databases

ProteinModelPortaliO13294.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni97 – 103Substrate bindingBy similarity7

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1526. Eukaryota.
COG0538. LUCA.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
SMARTiSM01329. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O13294-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEIQKITVK NPIVEMDGDE MTRIIWQFIK DKLILPYLNV DLKYYDLGIE
60 70 80 90 100
YRDKTDDKVT TDAAEAILQY GVGVKCATIT PDEARVKEFN LKKMWLSPNG
110 120 130 140 150
TLRNVIGGTV FREPIVIDNI PRIVPSWEKP IIIGRHAFGD QYKATDVVIP
160 170 180 190 200
AAGDLKLVFK PKDGGEVQEF PVYQFDGPGV ALSMYNTDAS ITDFAESSFQ
210 220 230 240 250
LAIERKLNLF SSTKNTILKK YDGKFKDIFE GLYASKYKTK MDELGIWYEH
260 270 280 290 300
RLIDDMVAQM LKSKGGYIIA MKNYDGDVQS DIVAQGFGSL GLMTSVLVTP
310 320 330 340 350
DGKAFESEAA HGTVTRHYRQ HQQGKETSTN SIASIYAWTR GLIQRGKLDD
360 370 380 390 400
TPEVVKFAEE LEKAVIETVS KDNIMTKDLA LTQGKTDRSS YVTTEEFIDG
410
VANRLNKNLG Y
Length:411
Mass (Da):46,171
Last modified:January 23, 2007 - v3
Checksum:i3E47A093C45F5915
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007994 Genomic DNA. Translation: BAA22846.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007994 Genomic DNA. Translation: BAA22846.1.

3D structure databases

ProteinModelPortaliO13294.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi294747.XP_002546127.1.

Proteomic databases

PRIDEiO13294.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG1526. Eukaryota.
COG0538. LUCA.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
SMARTiSM01329. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIDH2_CANTR
AccessioniPrimary (citable) accession number: O13294
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: January 23, 2007
Last modified: October 5, 2016
This is version 81 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.