O13287 (6PGD_CANAX) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
6-phosphogluconate dehydrogenase, decarboxylating
EC=1.1.1.44

Gene names

Name:

DOR14

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	517 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity.
Catalytic activity	6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the 6-phosphogluconate dehydrogenase family.

Ontologies

Keywords
Biological process	Pentose shunt
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	pentose-phosphate shunt Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro phosphogluconate dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 517	517	6-phosphogluconate dehydrogenase, decarboxylating		PRO_0000090072
Regions
	Nucleotide binding	35 – 40	6	NADP By similarity
	Nucleotide binding	58 – 60	3	NADP By similarity
	Nucleotide binding	100 – 102	3	NADP By similarity
	Region	154 – 156	3	Substrate binding By similarity
	Region	211 – 212	2	Substrate binding By similarity
Sites
	Active site	208	1	Proton acceptor By similarity
	Active site	215	1	Proton donor By similarity
	Binding site	128	1	NADP By similarity
	Binding site	128	1	Substrate By similarity
	Binding site	216	1	Substrate By similarity
	Binding site	286	1	Substrate; via amide nitrogen By similarity
	Binding site	313	1	Substrate By similarity
	Binding site	474	1	Substrate; shared with dimeric partner By similarity
	Binding site	480	1	Substrate; shared with dimeric partner By similarity

Sequences

	Sequence		Length	Mass (Da)
	O13287 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 91E3F520FFCABF7A	FASTA	517	56,924
	10 20 30 40 50 60 MKNFNALSRL SILSKQLSFN NTNSSIARGD IGLIGLAVMG QNLILNMADH GYTVVAYNRT 70 80 90 100 110 120 TAKVDRFLEN EAKGKSILGA HSIKELVDQL KRPRRIMLLV KAGAPVDEFI NQLLPYLEEG 130 140 150 160 170 180 DIIIDGGNSH FPDSNRRYEE LAKKGILFVG SGVSGGEEGA RTGPSLMPGG NEKAWPHIKE 190 200 210 220 230 240 IFQDVAAKSD GEPCCDWVGD AGAGHYVKMV HNGIEYGDMQ LICEAYDLMK RVGKFEDKEI 250 260 270 280 290 300 GDVFATWNKG VLDSFLIEIT RDILYYNDPT DGKPLVEKIL DTAGQKGTGK WTAVNALDLG 310 320 330 340 350 360 IPVTLIGEAV FSRCLSAMKA ERVEASKALK GPQVTGESPI TDKKQFIDDL EQALYASKII 370 380 390 400 410 420 SYTQGFMLMN QAAKDYGWKL NNAGIALMWR GGCIIRSVFL AEITAAYRKK PDLENLLLYP 430 440 450 460 470 480 FFNDAITKAQ SGWRASVGKA IQYGIPTPAF STALAFYDGL RSERLPANLL QAQRDYFGAH 490 500 510 TFKVLPGQEN ELLKKDEWIH INWTGRGGDV SSTTYDA

References

[1]	"Molecular cloning of DOR14 gene for 6-phosphogluconate dehydrogenase (6PGD) from Candida albicans." Watanabe M., Ishii N., Arisawa M., Aoki Y. Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 10259 / CBS 5796 / DSM 5817 / JCM 2078 / NBRC 1060.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB006102 Genomic DNA. Translation: BAA21690.1.
3D structure databases
ProteinModelPortal	O13287.
SMR	O13287. Positions 29-504.
ModBase	Search...
Protein-protein interaction databases
STRING	O13287.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR006114. 6PGDH_C. IPR006113. 6PGDH_decarbox. IPR006115. 6PGDH_NADP-bd. IPR006184. 6PGdom_BS. IPR013328. DH_multihelical. IPR012284. Fibritin/6PGD_C-extension. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF00393. 6PGD. 1 hit. PF03446. NAD_binding_2. 1 hit. [Graphical view]
PIRSF	PIRSF000109. 6PGD. 1 hit.
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMs	TIGR00873. Gnd. 1 hit.
PROSITE	PS00461. 6PGD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

6PGD_CANAX

Accession

Primary (citable) accession number: O13287

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	January 1, 1998
Last modified:	October 19, 2011
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program