Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O13287

- 6PGD_CANAX

UniProt

O13287 - 6PGD_CANAX

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene

DOR14

Organism
Candida albicans (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.By similarity

Catalytic activityi

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei128 – 1281NADPBy similarity
Binding sitei128 – 1281SubstrateBy similarity
Active sitei208 – 2081Proton acceptorBy similarity
Active sitei215 – 2151Proton donorBy similarity
Binding sitei216 – 2161SubstrateBy similarity
Binding sitei286 – 2861Substrate; via amide nitrogenBy similarity
Binding sitei313 – 3131SubstrateBy similarity
Binding sitei474 – 4741Substrate; shared with dimeric partnerBy similarity
Binding sitei480 – 4801Substrate; shared with dimeric partnerBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi35 – 406NADPBy similarity
Nucleotide bindingi58 – 603NADPBy similarity
Nucleotide bindingi100 – 1023NADPBy similarity

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB-EC

GO - Biological processi

  1. D-gluconate metabolic process Source: UniProtKB-KW
  2. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Gluconate utilization, Pentose shunt

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00410.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
Gene namesi
Name:DOR14
OrganismiCandida albicans (Yeast)
Taxonomic identifieri5476 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5175176-phosphogluconate dehydrogenase, decarboxylatingPRO_0000090072Add
BLAST

Proteomic databases

PRIDEiO13287.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliO13287.
SMRiO13287. Positions 29-504.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni154 – 1563Substrate bindingBy similarity
Regioni211 – 2122Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0362.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000109. 6PGD. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00873. gnd. 1 hit.
PROSITEiPS00461. 6PGD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O13287-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKNFNALSRL SILSKQLSFN NTNSSIARGD IGLIGLAVMG QNLILNMADH
60 70 80 90 100
GYTVVAYNRT TAKVDRFLEN EAKGKSILGA HSIKELVDQL KRPRRIMLLV
110 120 130 140 150
KAGAPVDEFI NQLLPYLEEG DIIIDGGNSH FPDSNRRYEE LAKKGILFVG
160 170 180 190 200
SGVSGGEEGA RTGPSLMPGG NEKAWPHIKE IFQDVAAKSD GEPCCDWVGD
210 220 230 240 250
AGAGHYVKMV HNGIEYGDMQ LICEAYDLMK RVGKFEDKEI GDVFATWNKG
260 270 280 290 300
VLDSFLIEIT RDILYYNDPT DGKPLVEKIL DTAGQKGTGK WTAVNALDLG
310 320 330 340 350
IPVTLIGEAV FSRCLSAMKA ERVEASKALK GPQVTGESPI TDKKQFIDDL
360 370 380 390 400
EQALYASKII SYTQGFMLMN QAAKDYGWKL NNAGIALMWR GGCIIRSVFL
410 420 430 440 450
AEITAAYRKK PDLENLLLYP FFNDAITKAQ SGWRASVGKA IQYGIPTPAF
460 470 480 490 500
STALAFYDGL RSERLPANLL QAQRDYFGAH TFKVLPGQEN ELLKKDEWIH
510
INWTGRGGDV SSTTYDA
Length:517
Mass (Da):56,924
Last modified:January 1, 1998 - v1
Checksum:i91E3F520FFCABF7A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006102 Genomic DNA. Translation: BAA21690.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006102 Genomic DNA. Translation: BAA21690.1 .

3D structure databases

ProteinModelPortali O13287.
SMRi O13287. Positions 29-504.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi O13287.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG0362.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00410 .

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000109. 6PGD. 1 hit.
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00873. gnd. 1 hit.
PROSITEi PS00461. 6PGD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of DOR14 gene for 6-phosphogluconate dehydrogenase (6PGD) from Candida albicans."
    Watanabe M., Ishii N., Arisawa M., Aoki Y.
    Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 10259 / CBS 5796 / DSM 5817 / JCM 2078 / NBRC 1060.

Entry informationi

Entry namei6PGD_CANAX
AccessioniPrimary (citable) accession number: O13287
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3