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O13287

- 6PGD_CANAX

UniProt

O13287 - 6PGD_CANAX

Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene

DOR14

Organism
Candida albicans (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.By similarity

    Catalytic activityi

    6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei128 – 1281NADPBy similarity
    Binding sitei128 – 1281SubstrateBy similarity
    Active sitei208 – 2081Proton acceptorBy similarity
    Active sitei215 – 2151Proton donorBy similarity
    Binding sitei216 – 2161SubstrateBy similarity
    Binding sitei286 – 2861Substrate; via amide nitrogenBy similarity
    Binding sitei313 – 3131SubstrateBy similarity
    Binding sitei474 – 4741Substrate; shared with dimeric partnerBy similarity
    Binding sitei480 – 4801Substrate; shared with dimeric partnerBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi35 – 406NADPBy similarity
    Nucleotide bindingi58 – 603NADPBy similarity
    Nucleotide bindingi100 – 1023NADPBy similarity

    GO - Molecular functioni

    1. NADP binding Source: InterPro
    2. phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB-EC

    GO - Biological processi

    1. D-gluconate metabolic process Source: UniProtKB-KW
    2. pentose-phosphate shunt Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Gluconate utilization, Pentose shunt

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00115; UER00410.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
    Gene namesi
    Name:DOR14
    OrganismiCandida albicans (Yeast)
    Taxonomic identifieri5476 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 5175176-phosphogluconate dehydrogenase, decarboxylatingPRO_0000090072Add
    BLAST

    Proteomic databases

    PRIDEiO13287.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliO13287.
    SMRiO13287. Positions 29-504.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni154 – 1563Substrate bindingBy similarity
    Regioni211 – 2122Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0362.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    1.20.5.320. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR006114. 6PGDH_C.
    IPR006113. 6PGDH_decarbox.
    IPR006115. 6PGDH_NADP-bd.
    IPR006184. 6PGdom_BS.
    IPR013328. DH_multihelical.
    IPR012284. Fibritin/6PGD_C-extension.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00393. 6PGD. 1 hit.
    PF03446. NAD_binding_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000109. 6PGD. 1 hit.
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR00873. gnd. 1 hit.
    PROSITEiPS00461. 6PGD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O13287-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKNFNALSRL SILSKQLSFN NTNSSIARGD IGLIGLAVMG QNLILNMADH    50
    GYTVVAYNRT TAKVDRFLEN EAKGKSILGA HSIKELVDQL KRPRRIMLLV 100
    KAGAPVDEFI NQLLPYLEEG DIIIDGGNSH FPDSNRRYEE LAKKGILFVG 150
    SGVSGGEEGA RTGPSLMPGG NEKAWPHIKE IFQDVAAKSD GEPCCDWVGD 200
    AGAGHYVKMV HNGIEYGDMQ LICEAYDLMK RVGKFEDKEI GDVFATWNKG 250
    VLDSFLIEIT RDILYYNDPT DGKPLVEKIL DTAGQKGTGK WTAVNALDLG 300
    IPVTLIGEAV FSRCLSAMKA ERVEASKALK GPQVTGESPI TDKKQFIDDL 350
    EQALYASKII SYTQGFMLMN QAAKDYGWKL NNAGIALMWR GGCIIRSVFL 400
    AEITAAYRKK PDLENLLLYP FFNDAITKAQ SGWRASVGKA IQYGIPTPAF 450
    STALAFYDGL RSERLPANLL QAQRDYFGAH TFKVLPGQEN ELLKKDEWIH 500
    INWTGRGGDV SSTTYDA 517
    Length:517
    Mass (Da):56,924
    Last modified:January 1, 1998 - v1
    Checksum:i91E3F520FFCABF7A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB006102 Genomic DNA. Translation: BAA21690.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB006102 Genomic DNA. Translation: BAA21690.1 .

    3D structure databases

    ProteinModelPortali O13287.
    SMRi O13287. Positions 29-504.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi O13287.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG0362.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00410 .

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    1.20.5.320. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR006114. 6PGDH_C.
    IPR006113. 6PGDH_decarbox.
    IPR006115. 6PGDH_NADP-bd.
    IPR006184. 6PGdom_BS.
    IPR013328. DH_multihelical.
    IPR012284. Fibritin/6PGD_C-extension.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00393. 6PGD. 1 hit.
    PF03446. NAD_binding_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000109. 6PGD. 1 hit.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR00873. gnd. 1 hit.
    PROSITEi PS00461. 6PGD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of DOR14 gene for 6-phosphogluconate dehydrogenase (6PGD) from Candida albicans."
      Watanabe M., Ishii N., Arisawa M., Aoki Y.
      Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 10259 / CBS 5796 / DSM 5817 / JCM 2078 / NBRC 1060.

    Entry informationi

    Entry namei6PGD_CANAX
    AccessioniPrimary (citable) accession number: O13287
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3