O13286A7VJ97SRW1_SCHPOWD repeat-containing protein srw1Suppressor of rad/wee1srw1ste9SPAC144.13cSchizosaccharomyces pombe (strain 972 / ATCC 24843)Fission yeastEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomycesA WD repeat protein controls the cell cycle and differentiation by negatively regulating Cdc2/B-type cyclin complexes.NUCLEOTIDE SEQUENCE [MRNA]FUNCTIONFission yeast ste9, a homolog of hct1/cdh1 and Fizzy-related, is a novel negative regulator of cell cycle progression during G1-phase.NUCLEOTIDE SEQUENCE [GENOMIC DNA]FUNCTIONThe genome sequence of Schizosaccharomyces pombe.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]Apc10 and Ste9/Srw1, two regulators of the APC-cyclosome, as well as the CDK inhibitor Rum1 are required for G1 cell-cycle arrest in fission yeast.FUNCTIONFission yeast Fizzy-related protein srw1p is a G(1)-specific promoter of mitotic cyclin B degradation.FUNCTIONPHOSPHORYLATION AT SER-62; THR-98; THR-177 AND SER-214MUTAGENESIS OF SER-62; THR-98; THR-177 AND SER-214ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]Phosphoproteome analysis of fission yeast.PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-187IDENTIFICATION BY MASS SPECTROMETRYHas a role in cell differentiation and cell cycling by negatively regulating cig2 and cdc12-associated cdc2. Down-regulates the level of cdc13, particularly in a nitrogen deprived environment. Regulator of cell cycle G1 phase progression. Prevents onset of mitosis during the pre-Start G1 period. Required for degradation of cdc13 mitotic cyclin B during G1 arrest but not during mitotic exit.NucleusPhosphorylated by cdc2-cdc13-CDK complex. This targets srw1 for proteolysis which in turn promotes cdc13 turnover. Dephosphorylated during G1 arrest.Belongs to the WD repeat CDC20/Fizzy family.Cell cycleNucleusPhosphoproteinReference proteomeRepeatWD repeatSATATASAMDEFDGFTRPTSSNSSANRNSNNSMNRVENNNSNSDSANTVDSRGDAHTRMRQGFEKSFPSSPNKKRPRTNEGDRFIPSRDASTELWTGFTKVEGPLTPVKKKQSVADRNFTTLLRSELFGSNDETFNNSPIATPNTTIGVSTPRTDSGIDDIELTQRTPPSSSHTSSSILQNTPVTPSRKIFHYLSPRDRNKSSYGKKAQYQDNPNRTIYSLSPVRSITKDLISASRLEGRELPSIPYRVLDAPGLAGDFYLNLLDWGQCNMLAVALASRVYLWSGISSEVTVMHNFYPTDTVTSLRWVQRGTHLAVGTHNGSVEIWDAATCKKTRTMSGHTERVGALSWNDHVLSSGGRDNHILHRDVRAPEHYFRVLTAHRQEVCGLEWNSNENLLASGGNDNALMVWDKFEEKPLYSFHNHIAAVKAITWSPHQRGILASGGGTADRTIKLWNTQRGSMLHNIDTGSQVCNLLWSKQTNEFISTHGFMENEVALWNYPSVSRVGTLKGHTDRVLYLAMSPNGENIVTGAADETLRFWKLFDSKSKHSASTMSSPFDPTMKIR
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