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O13285 (IDH1_CANTR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP], mitochondrial
Short name=IDH
EC=1.1.1.42
Alternative name(s):
CtIDP1
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase
Gene names
Name:IDP1
OrganismCandida tropicalis (Yeast)
Taxonomic identifier5482 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length430 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Mitochondrial IDP1 may regulate flux through the tricarboxylic acid cycle and respiration. Its probably critical function is the production of NADPH.

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Subunit structure

Homodimer By similarity.

Subcellular location

Mitochondrion.

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2727Mitochondrion By similarity
Chain28 – 430403Isocitrate dehydrogenase [NADP], mitochondrial
PRO_0000014424

Regions

Nucleotide binding101 – 1033NADP By similarity
Nucleotide binding335 – 3406NADP By similarity
Region120 – 1267Substrate binding By similarity

Sites

Metal binding2771Magnesium or manganese By similarity
Metal binding3001Magnesium or manganese By similarity
Binding site1031Substrate By similarity
Binding site1081NADP By similarity
Binding site1351Substrate By similarity
Binding site1581Substrate By similarity
Binding site2851NADP By similarity
Binding site3531NADP; via amide nitrogen and carbonyl oxygen By similarity
Site1651Critical for catalysis By similarity
Site2371Critical for catalysis By similarity

Sequences

Sequence LengthMass (Da)Tools
O13285 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 205A319496F0CCEB

FASTA43048,009
        10         20         30         40         50         60 
MIRASAIQRT AMLLRQLRGF STSATLADKI KVKNPIVELD GDEMTRIIWQ KIKDQLILPY 

        70         80         90        100        110        120 
LDVDLKYYDL GIESRDATDD QITIDAANAI KEYGVGVKCA TITPDEARVK EFHLKKMWLS 

       130        140        150        160        170        180 
PNGTIRNILG GTVFRESIII PCIPRLIPGW EKPIVIGRHA FGDQYKATDL VINEPGRLEL 

       190        200        210        220        230        240 
RFTPASGGEA QTQKVYDYTG PGVGLAMYNT DESITGFAHA SFKMALAKGL PLYMSTKNTI 

       250        260        270        280        290        300 
LKKYDGRFKD IFQQIYEQDY AAEFEKQGLW YEHRLIDDMV AQMIKSKGGF VMALKNYDGD 

       310        320        330        340        350        360 
VQSDIVAQGF GSLGLMTSAL MTPDGKAYEA EAAHGTVTRH YRQHQQGKET STNSIASIFA 

       370        380        390        400        410        420 
WTRGLAQRGK LDETPDVVDF ASKLEQATID TVEVDRIMTK DLALAMGKTD RSAYVTTTEF 

       430 
LDAVADRLKK

« Hide

References

[1]"Immunochemically distinct NADP-linked isocitrate dehydrogenase isozymes in mitochondria and peroxisomes of Candida tropicalis."
Imajo T., Kawachi H., Atomi H., Sanuki S., Yamamoto S., Ueda M., Tanaka A.
Arch. Microbiol. 168:389-395(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 20336 / pK233 / NCYC 997.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB004556 Genomic DNA. Translation: BAA22945.1.

3D structure databases

ProteinModelPortalO13285.
SMRO13285. Positions 29-430.
ModBaseSearch...

Proteomic databases

PRIDEO13285.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIDH1_CANTR
AccessionPrimary (citable) accession number: O13285
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: April 3, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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