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Protein

Transcription initiation factor TFIID subunit 5

Gene

taf5

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

TAFs are components of the transcription factor IID (TFIID) complex that are essential for mediating regulation of RNA polymerase transcription. Regulates the genes involved in ubiquitin-dependent proteolysis during the progression of M-phase of mitosis.1 Publication

GO - Biological processi

  • chromatin remodeling Source: PomBase
  • histone acetylation Source: PomBase
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription initiation from RNA polymerase II promoter Source: PomBase

Keywordsi

Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 5
Alternative name(s):
Transcription initiation factor TFIID 72 kDa subunit
Short name:
TAFII-72
Gene namesi
Name:taf5
Synonyms:taf72
ORF Names:SPCC5E4.03c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC5E4.03c
PomBaseiSPCC5E4.03c taf5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000512591 – 643Transcription initiation factor TFIID subunit 5Add BLAST643

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei256Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO13282
PaxDbiO13282
PRIDEiO13282

PTM databases

iPTMnetiO13282

Interactioni

Subunit structurei

Component of the TFIID and SAGA complexes. TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs) whose MWs range from 25-150 kDa (By similarity). Interacts with gcn5. Interacts (via C-terminal WD repeat-containing region) with taf6.By similarity2 Publications

Protein-protein interaction databases

BioGridi27591918 interactors.
IntActiO13282 7 interactors.
MINTiO13282
STRINGi4896.SPCC5E4.03c.1

Structurei

3D structure databases

ProteinModelPortaliO13282
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 40LisHPROSITE-ProRule annotationAdd BLAST33
Repeati322 – 361WD 1Add BLAST40
Repeati377 – 416WD 2Add BLAST40
Repeati419 – 458WD 3Add BLAST40
Repeati461 – 500WD 4Add BLAST40
Repeati503 – 542WD 5Add BLAST40
Repeati545 – 584WD 6Add BLAST40

Sequence similaritiesi

Belongs to the WD repeat TAF5 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOGENOMiHOG000212424
InParanoidiO13282
KOiK03130
OMAiDCVQFHP
OrthoDBiEOG092C10HM
PhylomeDBiO13282

Family and domain databases

CDDicd08044 TAF5_NTD2, 1 hit
Gene3Di1.25.40.5001 hit
2.130.10.103 hits
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR006594 LisH
IPR007582 TFIID_NTD2
IPR037264 TFIID_NTD2_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF08513 LisH, 1 hit
PF04494 TFIID_NTD2, 1 hit
PF00400 WD40, 6 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00667 LisH, 1 hit
SM00320 WD40, 6 hits
SUPFAMiSSF160897 SSF160897, 1 hit
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50896 LISH, 1 hit
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

O13282-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSATNGPQPQ DLNRIVLDYL AKKGYSRTEA MLRLEASGSG VSVEEKLKSI
60 70 80 90 100
EETPDAYTHT YTILRDWVDS SLELYKAELH RILFPIFVHS YLNLLSQDHY
110 120 130 140 150
EAAKQFYELF KDDHTDLHDF DVKNLKSLSL PSHVAEDRTA QQYRQNKYQL
160 170 180 190 200
HFSRITFDLL LHFLFENVSN GGSIIIKLIN QHIDIHIVPG RPTVLENAKV
210 220 230 240 250
INEQEGITGQ SFERGDAQLQ PVKLQQMPMD KEMEKIVEMD LEEEDMMHQN
260 270 280 290 300
DPNNQSPKLL KEFRKLHEPN AEDAPSRDYI PLPPHKGVDI LSEVEAVKDW
310 320 330 340 350
SKRLHLGPRA SLPSVCMYTF HHTNNNMNCA EFSPDSTMIA CGFQESYIRL
360 370 380 390 400
WSIKADKKSL PKSTSVEDSD GSVRLLSHSG PVYGTTFSPD NKYLLSCSED
410 420 430 440 450
ASARLWSVDT KTALVAYKGH TGPVWDVAFG PFGHYFATAS HDQTAQLWSC
460 470 480 490 500
DHIYPLRVFA GHLSDVDCVT FHPNSAYVLT GSSDKTCRLW DVHRGHSVRV
510 520 530 540 550
FNGHTQPVTA VAIAPDGHTM ASADSEGLIH LWDIGTGRRI KTMRGHRGNI
560 570 580 590 600
YSLSFSREST VLVSGGSDCT VRAWDVFKTN YNNPVSSSLT GSVVTPFSAK
610 620 630 640
TSTFNEVNWS TSPDQMVALY TKQTPIFNVS FTRRNLCLAI SVS
Length:643
Mass (Da):72,380
Last modified:January 1, 1998 - v1
Checksum:i859434527430F3B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001372 Genomic DNA Translation: BAA22162.1
CU329672 Genomic DNA Translation: CAA21958.1
PIRiT41454
RefSeqiNP_587902.1, NM_001022894.2

Genome annotation databases

EnsemblFungiiSPCC5E4.03c.1; SPCC5E4.03c.1:pep; SPCC5E4.03c
GeneIDi2539353
KEGGispo:SPCC5E4.03c

Entry informationi

Entry nameiTAF5_SCHPO
AccessioniPrimary (citable) accession number: O13282
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome