taf5

Functionⁱ

TAFs are components of the transcription factor IID (TFIID) complex that are essential for mediating regulation of RNA polymerase transcription. Regulates the genes involved in ubiquitin-dependent proteolysis during the progression of M-phase of mitosis.1 Publication

GO - Biological processⁱ

chromatin remodeling
Source: PomBase
Inferred by curatorⁱ
- 11972332
histone acetylation
Source: PomBase
Inferred by curatorⁱ
- 11972332
regulation of transcription, DNA-templated Source: UniProtKB-KW
transcription initiation from RNA polymerase II promoter
Source: PomBase
Inferred by curatorⁱ
- 11972332

Complete GO annotation...

Keywordsⁱ

Biological process	Transcription, Transcription regulation

Biological process

Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-SPO-674695. RNA Polymerase II Pre-transcription Events. R-SPO-73776. RNA Polymerase II Promoter Escape. R-SPO-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening. R-SPO-75953. RNA Polymerase II Transcription Initiation. R-SPO-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Reactomeⁱ

R-SPO-674695. RNA Polymerase II Pre-transcription Events.
R-SPO-73776. RNA Polymerase II Promoter Escape.
R-SPO-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-SPO-75953. RNA Polymerase II Transcription Initiation.
R-SPO-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription initiation factor TFIID subunit 5 Alternative name(s): Transcription initiation factor TFIID 72 kDa subunit Short name: TAFII-72
Gene namesⁱ	Name:taf5 Synonyms:taf72 ORF Names:SPCC5E4.03c
Organismⁱ	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifierⁱ	284812 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › Schizosaccharomyces pombe
Proteomesⁱ	UP000002485 Componentⁱ: Chromosome III

Organism-specific databases

EuPathDBⁱ	FungiDB:SPCC5E4.03c.
PomBaseⁱ	SPCC5E4.03c. taf5.

Subcellular locationⁱ

Nucleus By similarity

GO - Cellular componentⁱ

Complete GO annotation...

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000051259	1 – 643	Transcription initiation factor TFIID subunit 5Add BLAST		643

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	256	Phosphoserine1 Publication		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O13282.
PRIDEⁱ	O13282.

PTM databases

iPTMnetⁱ	O13282.

iPTMnetⁱ

O13282.

Interactionⁱ

Subunit structureⁱ

Component of the TFIID and SAGA complexes. TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs) whose MWs range from 25-150 kDa (By similarity). Interacts with gcn5. Interacts (via C-terminal WD repeat-containing region) with taf6.By similarity2 Publications

Protein-protein interaction databases

BioGridⁱ	275919. 18 interactors.
IntActⁱ	O13282. 7 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-4666456.
STRINGⁱ	4896.SPCC5E4.03c.1.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O13282.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	8 – 40	LisHPROSITE-ProRule annotationAdd BLAST	33
Repeatⁱ	322 – 361	WD 1Add BLAST	40
Repeatⁱ	377 – 416	WD 2Add BLAST	40
Repeatⁱ	419 – 458	WD 3Add BLAST	40
Repeatⁱ	461 – 500	WD 4Add BLAST	40
Repeatⁱ	503 – 542	WD 5Add BLAST	40
Repeatⁱ	545 – 584	WD 6Add BLAST	40

Sequence similaritiesⁱ

Belongs to the WD repeat TAF5 family.Curated

Keywords - Domainⁱ

Repeat, WD repeat

Phylogenomic databases

HOGENOMⁱ	HOG000212424.
InParanoidⁱ	O13282.
KEGG Orthology (KO) More...KOⁱ	K03130.
OMAⁱ	DCVQFHP.
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C10HM.
PhylomeDBⁱ	O13282.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd08044. TAF5_NTD2. 1 hit.
Gene3Dⁱ	2.130.10.10. 3 hits.
InterProⁱ	View protein in InterPro IPR020472. G-protein_beta_WD-40_rep. IPR006594. LisH. IPR007582. TFIID_NTD2. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08513. LisH. 1 hit. PF04494. TFIID_NTD2. 1 hit. PF00400. WD40. 6 hits.
PRINTSⁱ	PR00320. GPROTEINBRPT.
SMARTⁱ	View protein in SMART SM00667. LisH. 1 hit. SM00320. WD40. 6 hits.
SUPFAMⁱ	SSF50978. SSF50978. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50896. LISH. 1 hit. PS00678. WD_REPEATS_1. 2 hits. PS50082. WD_REPEATS_2. 6 hits. PS50294. WD_REPEATS_REGION. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

O13282-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSATNGPQPQ DLNRIVLDYL AKKGYSRTEA MLRLEASGSG VSVEEKLKSI 
        60         70         80         90        100
EETPDAYTHT YTILRDWVDS SLELYKAELH RILFPIFVHS YLNLLSQDHY 
       110        120        130        140        150
EAAKQFYELF KDDHTDLHDF DVKNLKSLSL PSHVAEDRTA QQYRQNKYQL 
       160        170        180        190        200
HFSRITFDLL LHFLFENVSN GGSIIIKLIN QHIDIHIVPG RPTVLENAKV 
       210        220        230        240        250
INEQEGITGQ SFERGDAQLQ PVKLQQMPMD KEMEKIVEMD LEEEDMMHQN 
       260        270        280        290        300
DPNNQSPKLL KEFRKLHEPN AEDAPSRDYI PLPPHKGVDI LSEVEAVKDW 
       310        320        330        340        350
SKRLHLGPRA SLPSVCMYTF HHTNNNMNCA EFSPDSTMIA CGFQESYIRL 
       360        370        380        390        400
WSIKADKKSL PKSTSVEDSD GSVRLLSHSG PVYGTTFSPD NKYLLSCSED 
       410        420        430        440        450
ASARLWSVDT KTALVAYKGH TGPVWDVAFG PFGHYFATAS HDQTAQLWSC 
       460        470        480        490        500
DHIYPLRVFA GHLSDVDCVT FHPNSAYVLT GSSDKTCRLW DVHRGHSVRV 
       510        520        530        540        550
FNGHTQPVTA VAIAPDGHTM ASADSEGLIH LWDIGTGRRI KTMRGHRGNI 
       560        570        580        590        600
YSLSFSREST VLVSGGSDCT VRAWDVFKTN YNNPVSSSLT GSVVTPFSAK 
       610        620        630        640 
TSTFNEVNWS TSPDQMVALY TKQTPIFNVS FTRRNLCLAI SVS

Length:643

Mass (Da):72,380

Last modified:January 1, 1998 - v1

Checksum:ⁱ859434527430F3B1

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB001372 Genomic DNA. Translation: BAA22162.1. CU329672 Genomic DNA. Translation: CAA21958.1.
PIRⁱ	T41454.
NCBI Reference Sequences More...RefSeqⁱ	NP_587902.1. NM_001022894.2.

Genome annotation databases

EnsemblFungiⁱ	SPCC5E4.03c.1; SPCC5E4.03c.1:pep; SPCC5E4.03c.
GeneIDⁱ	2539353.
KEGGⁱ	spo:SPCC5E4.03c.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB001372 Genomic DNA. Translation: BAA22162.1. CU329672 Genomic DNA. Translation: CAA21958.1.
PIRⁱ	T41454.
NCBI Reference Sequences More...RefSeqⁱ	NP_587902.1. NM_001022894.2.

3D structure databases

ProteinModelPortalⁱ	O13282.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	275919. 18 interactors.
IntActⁱ	O13282. 7 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-4666456.
STRINGⁱ	4896.SPCC5E4.03c.1.

PTM databases

iPTMnetⁱ	O13282.

iPTMnetⁱ

O13282.

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O13282.
PRIDEⁱ	O13282.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	SPCC5E4.03c.1; SPCC5E4.03c.1:pep; SPCC5E4.03c.
GeneIDⁱ	2539353.
KEGGⁱ	spo:SPCC5E4.03c.

Organism-specific databases

EuPathDBⁱ	FungiDB:SPCC5E4.03c.
PomBaseⁱ	SPCC5E4.03c. taf5.

Phylogenomic databases

HOGENOMⁱ	HOG000212424.
InParanoidⁱ	O13282.
KEGG Orthology (KO) More...KOⁱ	K03130.
OMAⁱ	DCVQFHP.
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C10HM.
PhylomeDBⁱ	O13282.

Enzyme and pathway databases

Reactomeⁱ	R-SPO-674695. RNA Polymerase II Pre-transcription Events. R-SPO-73776. RNA Polymerase II Promoter Escape. R-SPO-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening. R-SPO-75953. RNA Polymerase II Transcription Initiation. R-SPO-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Reactomeⁱ

R-SPO-674695. RNA Polymerase II Pre-transcription Events.
R-SPO-73776. RNA Polymerase II Promoter Escape.
R-SPO-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-SPO-75953. RNA Polymerase II Transcription Initiation.
R-SPO-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:O13282.

PROⁱ

PR:O13282.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd08044. TAF5_NTD2. 1 hit.
Gene3Dⁱ	2.130.10.10. 3 hits.
InterProⁱ	View protein in InterPro IPR020472. G-protein_beta_WD-40_rep. IPR006594. LisH. IPR007582. TFIID_NTD2. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08513. LisH. 1 hit. PF04494. TFIID_NTD2. 1 hit. PF00400. WD40. 6 hits.
PRINTSⁱ	PR00320. GPROTEINBRPT.
SMARTⁱ	View protein in SMART SM00667. LisH. 1 hit. SM00320. WD40. 6 hits.
SUPFAMⁱ	SSF50978. SSF50978. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50896. LISH. 1 hit. PS00678. WD_REPEATS_1. 2 hits. PS50082. WD_REPEATS_2. 6 hits. PS50294. WD_REPEATS_REGION. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TAF5_SCHPO
Accessionⁱ	O13282Primary (citable) accession number: O13282
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 6, 2002
	Last sequence update:	January 1, 1998
	Last modified:	July 5, 2017
	This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O13282 (TAF5_SCHPO)

Your basket is currently empty.

Transcription initiation factor TFIID subunit 5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ