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Protein

Transcription initiation factor TFIID subunit 5

Gene

taf5

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

TAFs are components of the transcription factor IID (TFIID) complex that are essential for mediating regulation of RNA polymerase transcription. Regulates the genes involved in ubiquitin-dependent proteolysis during the progression of M-phase of mitosis.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-SPO-674695. RNA Polymerase II Pre-transcription Events.
R-SPO-73776. RNA Polymerase II Promoter Escape.
R-SPO-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-SPO-75953. RNA Polymerase II Transcription Initiation.
R-SPO-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 5
Alternative name(s):
Transcription initiation factor TFIID 72 kDa subunit
Short name:
TAFII-72
Gene namesi
Name:taf5
Synonyms:taf72
ORF Names:SPCC5E4.03c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC5E4.03c.
PomBaseiSPCC5E4.03c. taf5.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
  • SAGA complex Source: PomBase
  • transcription factor TFIID complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000512591 – 643Transcription initiation factor TFIID subunit 5Add BLAST643

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei256Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO13282.
PRIDEiO13282.

PTM databases

iPTMnetiO13282.

Interactioni

Subunit structurei

Component of the TFIID and SAGA complexes. TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs) whose MWs range from 25-150 kDa (By similarity). Interacts with gcn5. Interacts (via C-terminal WD repeat-containing region) with taf6.By similarity2 Publications

Protein-protein interaction databases

BioGridi275919. 18 interactors.
IntActiO13282. 7 interactors.
MINTiMINT-4666456.

Structurei

3D structure databases

ProteinModelPortaliO13282.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 40LisHPROSITE-ProRule annotationAdd BLAST33
Repeati322 – 361WD 1Add BLAST40
Repeati377 – 416WD 2Add BLAST40
Repeati419 – 458WD 3Add BLAST40
Repeati461 – 500WD 4Add BLAST40
Repeati503 – 542WD 5Add BLAST40
Repeati545 – 584WD 6Add BLAST40

Sequence similaritiesi

Belongs to the WD repeat TAF5 family.Curated
Contains 1 LisH domain.PROSITE-ProRule annotation
Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOGENOMiHOG000212424.
InParanoidiO13282.
KOiK03130.
OMAiEDARPKY.
OrthoDBiEOG092C10HM.
PhylomeDBiO13282.

Family and domain databases

CDDicd08044. TAF5_NTD2. 1 hit.
Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR006594. LisH.
IPR007582. TFIID_NTD2.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08513. LisH. 1 hit.
PF04494. TFIID_NTD2. 1 hit.
PF00400. WD40. 6 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00667. LisH. 1 hit.
SM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50896. LISH. 1 hit.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O13282-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSATNGPQPQ DLNRIVLDYL AKKGYSRTEA MLRLEASGSG VSVEEKLKSI
60 70 80 90 100
EETPDAYTHT YTILRDWVDS SLELYKAELH RILFPIFVHS YLNLLSQDHY
110 120 130 140 150
EAAKQFYELF KDDHTDLHDF DVKNLKSLSL PSHVAEDRTA QQYRQNKYQL
160 170 180 190 200
HFSRITFDLL LHFLFENVSN GGSIIIKLIN QHIDIHIVPG RPTVLENAKV
210 220 230 240 250
INEQEGITGQ SFERGDAQLQ PVKLQQMPMD KEMEKIVEMD LEEEDMMHQN
260 270 280 290 300
DPNNQSPKLL KEFRKLHEPN AEDAPSRDYI PLPPHKGVDI LSEVEAVKDW
310 320 330 340 350
SKRLHLGPRA SLPSVCMYTF HHTNNNMNCA EFSPDSTMIA CGFQESYIRL
360 370 380 390 400
WSIKADKKSL PKSTSVEDSD GSVRLLSHSG PVYGTTFSPD NKYLLSCSED
410 420 430 440 450
ASARLWSVDT KTALVAYKGH TGPVWDVAFG PFGHYFATAS HDQTAQLWSC
460 470 480 490 500
DHIYPLRVFA GHLSDVDCVT FHPNSAYVLT GSSDKTCRLW DVHRGHSVRV
510 520 530 540 550
FNGHTQPVTA VAIAPDGHTM ASADSEGLIH LWDIGTGRRI KTMRGHRGNI
560 570 580 590 600
YSLSFSREST VLVSGGSDCT VRAWDVFKTN YNNPVSSSLT GSVVTPFSAK
610 620 630 640
TSTFNEVNWS TSPDQMVALY TKQTPIFNVS FTRRNLCLAI SVS
Length:643
Mass (Da):72,380
Last modified:January 1, 1998 - v1
Checksum:i859434527430F3B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001372 Genomic DNA. Translation: BAA22162.1.
CU329672 Genomic DNA. Translation: CAA21958.1.
PIRiT41454.
RefSeqiNP_587902.1. NM_001022894.2.

Genome annotation databases

EnsemblFungiiSPCC5E4.03c.1; SPCC5E4.03c.1:pep; SPCC5E4.03c.
GeneIDi2539353.
KEGGispo:SPCC5E4.03c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001372 Genomic DNA. Translation: BAA22162.1.
CU329672 Genomic DNA. Translation: CAA21958.1.
PIRiT41454.
RefSeqiNP_587902.1. NM_001022894.2.

3D structure databases

ProteinModelPortaliO13282.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275919. 18 interactors.
IntActiO13282. 7 interactors.
MINTiMINT-4666456.

PTM databases

iPTMnetiO13282.

Proteomic databases

MaxQBiO13282.
PRIDEiO13282.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC5E4.03c.1; SPCC5E4.03c.1:pep; SPCC5E4.03c.
GeneIDi2539353.
KEGGispo:SPCC5E4.03c.

Organism-specific databases

EuPathDBiFungiDB:SPCC5E4.03c.
PomBaseiSPCC5E4.03c. taf5.

Phylogenomic databases

HOGENOMiHOG000212424.
InParanoidiO13282.
KOiK03130.
OMAiEDARPKY.
OrthoDBiEOG092C10HM.
PhylomeDBiO13282.

Enzyme and pathway databases

ReactomeiR-SPO-674695. RNA Polymerase II Pre-transcription Events.
R-SPO-73776. RNA Polymerase II Promoter Escape.
R-SPO-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-SPO-75953. RNA Polymerase II Transcription Initiation.
R-SPO-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Miscellaneous databases

PROiO13282.

Family and domain databases

CDDicd08044. TAF5_NTD2. 1 hit.
Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR006594. LisH.
IPR007582. TFIID_NTD2.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08513. LisH. 1 hit.
PF04494. TFIID_NTD2. 1 hit.
PF00400. WD40. 6 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00667. LisH. 1 hit.
SM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50896. LISH. 1 hit.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAF5_SCHPO
AccessioniPrimary (citable) accession number: O13282
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: January 1, 1998
Last modified: October 5, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.