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Protein

TATA-box-binding protein

Gene

TBP

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
TATA-box-binding protein
Alternative name(s):
TATA sequence-binding protein
TATA-binding factor
TATA-box factor
Transcription initiation factor TFIID TBP subunit
Gene namesi
Name:TBP
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 302302TATA-box-binding proteinPRO_0000153959Add
BLAST

Proteomic databases

PaxDbiO13270.

Interactioni

Subunit structurei

Belongs to the TFIID complex together with the TBP-associated factors (TAFs). Binds DNA as monomer.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000036926.

Structurei

3D structure databases

ProteinModelPortaliO13270.
SMRiO13270. Positions 122-301.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati128 – 204771Add
BLAST
Repeati218 – 295782Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi55 – 639Poly-Gln

Sequence similaritiesi

Belongs to the TBP family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3302. Eukaryota.
COG2101. LUCA.
HOGENOMiHOG000105164.
HOVERGENiHBG044997.
InParanoidiO13270.
KOiK03120.
PhylomeDBiO13270.

Family and domain databases

CDDicd04516. TBP_eukaryotes. 1 hit.
Gene3Di3.30.310.10. 2 hits.
HAMAPiMF_00408. TATA_bind_prot_arch. 1 hit.
InterProiIPR012295. Beta2_adaptin/TBP_C_dom.
IPR000814. TBP.
IPR030491. TBP_CS.
IPR033710. TBP_eukaryotic.
[Graphical view]
PANTHERiPTHR10126. PTHR10126. 1 hit.
PfamiPF00352. TBP. 2 hits.
[Graphical view]
PRINTSiPR00686. TIFACTORIID.
PROSITEiPS00351. TFIID. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O13270-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQNNSLPPY AQGLASPQGA MTPGIPIFSP MMPYGTGLTP QPVQSTNSLS
60 70 80 90 100
ILEEQQRQQQ QQQAAQSSTS QQATQGTSGQ TPQLFHSQTL TTAPLPGTTP
110 120 130 140 150
LYPSPMTPMT PITPATPASE SSGIVPQLQN IVSTVNLGCK LDLKTIALRA
160 170 180 190 200
RNAEYNPKRF AAVIMRIREP RTTALIFSSG KMVCTGAKSE EQSRLAARKY
210 220 230 240 250
ARVVQKLGFP AKFLDFKIQN MVGSCDVKFP IRLEGLVLTH QQFSSYEPEL
260 270 280 290 300
FPGLIYRMIK PRIVLLIFVS GKVVLTGAKV RAEIYEAFEN IYPILKGFRK

TT
Length:302
Mass (Da):33,134
Last modified:July 1, 1997 - v1
Checksum:i1BEB9EB846F13ACA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83127 mRNA. Translation: BAA20297.1.
D83126 mRNA. Translation: BAA20296.1.
D83135 Genomic DNA. Translation: BAA20298.1.
PIRiJC5513.
RefSeqiNP_990434.1. NM_205103.1.
UniGeneiGga.1006.

Genome annotation databases

GeneIDi395995.
KEGGigga:395995.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83127 mRNA. Translation: BAA20297.1.
D83126 mRNA. Translation: BAA20296.1.
D83135 Genomic DNA. Translation: BAA20298.1.
PIRiJC5513.
RefSeqiNP_990434.1. NM_205103.1.
UniGeneiGga.1006.

3D structure databases

ProteinModelPortaliO13270.
SMRiO13270. Positions 122-301.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000036926.

Proteomic databases

PaxDbiO13270.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395995.
KEGGigga:395995.

Organism-specific databases

CTDi6908.

Phylogenomic databases

eggNOGiKOG3302. Eukaryota.
COG2101. LUCA.
HOGENOMiHOG000105164.
HOVERGENiHBG044997.
InParanoidiO13270.
KOiK03120.
PhylomeDBiO13270.

Miscellaneous databases

PROiO13270.

Family and domain databases

CDDicd04516. TBP_eukaryotes. 1 hit.
Gene3Di3.30.310.10. 2 hits.
HAMAPiMF_00408. TATA_bind_prot_arch. 1 hit.
InterProiIPR012295. Beta2_adaptin/TBP_C_dom.
IPR000814. TBP.
IPR030491. TBP_CS.
IPR033710. TBP_eukaryotic.
[Graphical view]
PANTHERiPTHR10126. PTHR10126. 1 hit.
PfamiPF00352. TBP. 2 hits.
[Graphical view]
PRINTSiPR00686. TIFACTORIID.
PROSITEiPS00351. TFIID. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTBP_CHICK
AccessioniPrimary (citable) accession number: O13270
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: September 7, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.