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Protein

TATA-box-binding protein

Gene

TBP

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription

Names & Taxonomyi

Protein namesi
Recommended name:
TATA-box-binding protein
Alternative name(s):
TATA sequence-binding protein
TATA-binding factor
TATA-box factor
Transcription initiation factor TFIID TBP subunit
Gene namesi
Name:TBP
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001539591 – 302TATA-box-binding proteinAdd BLAST302

Proteomic databases

PaxDbiO13270

Interactioni

Subunit structurei

Belongs to the TFIID complex together with the TBP-associated factors (TAFs). Binds DNA as monomer.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000036926

Structurei

3D structure databases

ProteinModelPortaliO13270
SMRiO13270
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati128 – 2041Add BLAST77
Repeati218 – 2952Add BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi55 – 63Poly-Gln9

Sequence similaritiesi

Belongs to the TBP family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3302 Eukaryota
COG2101 LUCA
HOGENOMiHOG000105164
HOVERGENiHBG044997
InParanoidiO13270
KOiK03120
PhylomeDBiO13270

Family and domain databases

CDDicd04516 TBP_eukaryotes, 1 hit
Gene3Di3.30.310.10, 2 hits
HAMAPiMF_00408 TATA_bind_prot_arch, 1 hit
InterProiView protein in InterPro
IPR000814 TBP
IPR030491 TBP_CS
IPR012295 TBP_dom_sf
IPR033710 TBP_eukaryotic
PANTHERiPTHR10126 PTHR10126, 1 hit
PfamiView protein in Pfam
PF00352 TBP, 2 hits
PRINTSiPR00686 TIFACTORIID
PROSITEiView protein in PROSITE
PS00351 TFIID, 2 hits

Sequencei

Sequence statusi: Complete.

O13270-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQNNSLPPY AQGLASPQGA MTPGIPIFSP MMPYGTGLTP QPVQSTNSLS
60 70 80 90 100
ILEEQQRQQQ QQQAAQSSTS QQATQGTSGQ TPQLFHSQTL TTAPLPGTTP
110 120 130 140 150
LYPSPMTPMT PITPATPASE SSGIVPQLQN IVSTVNLGCK LDLKTIALRA
160 170 180 190 200
RNAEYNPKRF AAVIMRIREP RTTALIFSSG KMVCTGAKSE EQSRLAARKY
210 220 230 240 250
ARVVQKLGFP AKFLDFKIQN MVGSCDVKFP IRLEGLVLTH QQFSSYEPEL
260 270 280 290 300
FPGLIYRMIK PRIVLLIFVS GKVVLTGAKV RAEIYEAFEN IYPILKGFRK

TT
Length:302
Mass (Da):33,134
Last modified:July 1, 1997 - v1
Checksum:i1BEB9EB846F13ACA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83127 mRNA Translation: BAA20297.1
D83126 mRNA Translation: BAA20296.1
D83135 Genomic DNA Translation: BAA20298.1
PIRiJC5513
RefSeqiNP_990434.1, NM_205103.1
UniGeneiGga.1006

Genome annotation databases

GeneIDi395995
KEGGigga:395995

Similar proteinsi

Entry informationi

Entry nameiTBP_CHICK
AccessioniPrimary (citable) accession number: O13270
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: March 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health