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O13269

- MT1_CYPCA

UniProt

O13269 - MT1_CYPCA

Protein

Metallothionein-1

Gene

mt1

Organism
Cyprinus carpio (Common carp)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Metallothioneins have a high content of cysteine residues that bind various heavy metals.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi4 – 41Divalent metal cation; cluster B
    Metal bindingi6 – 61Divalent metal cation; cluster B
    Metal bindingi12 – 121Divalent metal cation; cluster B
    Metal bindingi14 – 141Divalent metal cation; cluster B
    Metal bindingi18 – 181Divalent metal cation; cluster B
    Metal bindingi20 – 201Divalent metal cation; cluster B
    Metal bindingi23 – 231Divalent metal cation; cluster B
    Metal bindingi25 – 251Divalent metal cation; cluster B
    Metal bindingi28 – 281Divalent metal cation; cluster B
    Metal bindingi32 – 321Divalent metal cation; cluster A
    Metal bindingi33 – 331Divalent metal cation; cluster A
    Metal bindingi35 – 351Divalent metal cation; cluster A
    Metal bindingi36 – 361Divalent metal cation; cluster A
    Metal bindingi40 – 401Divalent metal cation; cluster A
    Metal bindingi43 – 431Divalent metal cation; cluster A
    Metal bindingi47 – 471Divalent metal cation; cluster A
    Metal bindingi49 – 491Divalent metal cation; cluster A
    Metal bindingi54 – 541Divalent metal cation; cluster A
    Metal bindingi58 – 581Divalent metal cation; cluster A
    Metal bindingi59 – 591Divalent metal cation; cluster A

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    Keywords - Ligandi

    Metal-binding, Metal-thiolate cluster

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metallothionein-1
    Short name:
    MT-1
    Alternative name(s):
    Metallothionein-I
    Short name:
    MT-I
    Gene namesi
    Name:mt1
    Synonyms:mt
    OrganismiCyprinus carpio (Common carp)
    Taxonomic identifieri7962 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeCyprinus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6060Metallothionein-1PRO_0000197279Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliO13269.
    SMRiO13269. Positions 2-29, 31-60.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 2828BetaAdd
    BLAST
    Regioni29 – 6032AlphaAdd
    BLAST

    Domaini

    Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

    Sequence similaritiesi

    Phylogenomic databases

    HOVERGENiHBG096097.

    Family and domain databases

    Gene3Di4.10.10.10. 1 hit.
    InterProiIPR017854. Metalthion_dom.
    IPR023587. Metalthion_dom_vert.
    IPR003019. Metalthion_sfam_euk.
    IPR000006. Metalthion_vert.
    IPR018064. Metalthion_vert_metal_BS.
    [Graphical view]
    PANTHERiPTHR23299. PTHR23299. 1 hit.
    PfamiPF00131. Metallothio. 1 hit.
    [Graphical view]
    PRINTSiPR00860. MTVERTEBRATE.
    SUPFAMiSSF57868. SSF57868. 1 hit.
    PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O13269-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPCDCAKTG TCNCGATCKC TNCQCKTCKK SCCPCCPSGC SKCASGCVCK   50
    GNSCGSSCCQ 60
    Length:60
    Mass (Da):5,999
    Last modified:July 1, 1997 - v1
    Checksum:i54389FF53F1BB701
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF002161 mRNA. Translation: AAB61577.1.
    AF002162 mRNA. Translation: AAB61578.1.
    AF001983 Genomic DNA. Translation: AAB70467.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF002161 mRNA. Translation: AAB61577.1 .
    AF002162 mRNA. Translation: AAB61578.1 .
    AF001983 Genomic DNA. Translation: AAB70467.1 .

    3D structure databases

    ProteinModelPortali O13269.
    SMRi O13269. Positions 2-29, 31-60.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG096097.

    Family and domain databases

    Gene3Di 4.10.10.10. 1 hit.
    InterProi IPR017854. Metalthion_dom.
    IPR023587. Metalthion_dom_vert.
    IPR003019. Metalthion_sfam_euk.
    IPR000006. Metalthion_vert.
    IPR018064. Metalthion_vert_metal_BS.
    [Graphical view ]
    PANTHERi PTHR23299. PTHR23299. 1 hit.
    Pfami PF00131. Metallothio. 1 hit.
    [Graphical view ]
    PRINTSi PR00860. MTVERTEBRATE.
    SUPFAMi SSF57868. SSF57868. 1 hit.
    PROSITEi PS00203. METALLOTHIONEIN_VRT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Common carp metallothionein gene."
      Shiu K.M., Chan P.C., Wong W.Y.F., Chan K.M.
      Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiMT1_CYPCA
    AccessioniPrimary (citable) accession number: O13269
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. Metallothioneins
      Classification of metallothioneins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3