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O13269

- MT1_CYPCA

UniProt

O13269 - MT1_CYPCA

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Protein

Metallothionein-1

Gene

mt1

Organism
Cyprinus carpio (Common carp)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi4 – 41Divalent metal cation; cluster B
Metal bindingi6 – 61Divalent metal cation; cluster B
Metal bindingi12 – 121Divalent metal cation; cluster B
Metal bindingi14 – 141Divalent metal cation; cluster B
Metal bindingi18 – 181Divalent metal cation; cluster B
Metal bindingi20 – 201Divalent metal cation; cluster B
Metal bindingi23 – 231Divalent metal cation; cluster B
Metal bindingi25 – 251Divalent metal cation; cluster B
Metal bindingi28 – 281Divalent metal cation; cluster B
Metal bindingi32 – 321Divalent metal cation; cluster A
Metal bindingi33 – 331Divalent metal cation; cluster A
Metal bindingi35 – 351Divalent metal cation; cluster A
Metal bindingi36 – 361Divalent metal cation; cluster A
Metal bindingi40 – 401Divalent metal cation; cluster A
Metal bindingi43 – 431Divalent metal cation; cluster A
Metal bindingi47 – 471Divalent metal cation; cluster A
Metal bindingi49 – 491Divalent metal cation; cluster A
Metal bindingi54 – 541Divalent metal cation; cluster A
Metal bindingi58 – 581Divalent metal cation; cluster A
Metal bindingi59 – 591Divalent metal cation; cluster A

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-1
Short name:
MT-1
Alternative name(s):
Metallothionein-I
Short name:
MT-I
Gene namesi
Name:mt1
Synonyms:mt
OrganismiCyprinus carpio (Common carp)
Taxonomic identifieri7962 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeCyprinus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6060Metallothionein-1PRO_0000197279Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO13269.
SMRiO13269. Positions 2-29, 31-60.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2828BetaAdd
BLAST
Regioni29 – 6032AlphaAdd
BLAST

Domaini

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG096097.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O13269-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDPCDCAKTG TCNCGATCKC TNCQCKTCKK SCCPCCPSGC SKCASGCVCK
60
GNSCGSSCCQ
Length:60
Mass (Da):5,999
Last modified:July 1, 1997 - v1
Checksum:i54389FF53F1BB701
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF002161 mRNA. Translation: AAB61577.1.
AF002162 mRNA. Translation: AAB61578.1.
AF001983 Genomic DNA. Translation: AAB70467.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF002161 mRNA. Translation: AAB61577.1 .
AF002162 mRNA. Translation: AAB61578.1 .
AF001983 Genomic DNA. Translation: AAB70467.1 .

3D structure databases

ProteinModelPortali O13269.
SMRi O13269. Positions 2-29, 31-60.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG096097.

Family and domain databases

Gene3Di 4.10.10.10. 1 hit.
InterProi IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view ]
PANTHERi PTHR23299. PTHR23299. 1 hit.
Pfami PF00131. Metallothio. 1 hit.
[Graphical view ]
PRINTSi PR00860. MTVERTEBRATE.
SUPFAMi SSF57868. SSF57868. 1 hit.
PROSITEi PS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Common carp metallothionein gene."
    Shiu K.M., Chan P.C., Wong W.Y.F., Chan K.M.
    Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiMT1_CYPCA
AccessioniPrimary (citable) accession number: O13269
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 1, 1997
Last modified: October 1, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3