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O13267

- WNT5A_PLEWA

UniProt

O13267 - WNT5A_PLEWA

Protein

Protein Wnt-5a

Gene

WNT5A

Organism
Pleurodeles waltl (Iberian ribbed newt)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters By similarity.By similarity

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Wnt-5a
    Short name:
    PWnt-5a
    Gene namesi
    Name:WNT5A
    OrganismiPleurodeles waltl (Iberian ribbed newt)
    Taxonomic identifieri8319 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaCaudataSalamandroideaSalamandridaePleurodelinaePleurodeles

    Subcellular locationi

    GO - Cellular componenti

    1. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 359339Protein Wnt-5aPRO_0000041430Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi83 ↔ 94By similarity
    Glycosylationi93 – 931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi133 ↔ 141By similarity
    Disulfide bondi143 ↔ 161By similarity
    Disulfide bondi217 ↔ 231By similarity
    Disulfide bondi219 ↔ 226By similarity
    Lipidationi223 – 2231O-palmitoyl serine; by PORCNBy similarity
    Glycosylationi291 – 2911N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi304 ↔ 319By similarity
    Glycosylationi305 – 3051N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi334 ↔ 349By similarity
    Disulfide bondi336 ↔ 346By similarity
    Disulfide bondi341 ↔ 342By similarity

    Post-translational modificationi

    Palmitoylation at Ser-223 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PRIDEiO13267.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Wnt family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG001595.

    Family and domain databases

    InterProiIPR005817. Wnt.
    IPR026538. Wnt5a.
    IPR018161. Wnt_CS.
    [Graphical view]
    PANTHERiPTHR12027. PTHR12027. 1 hit.
    PTHR12027:SF33. PTHR12027:SF33. 1 hit.
    PfamiPF00110. wnt. 1 hit.
    [Graphical view]
    PRINTSiPR01349. WNTPROTEIN.
    SMARTiSM00097. WNT1. 1 hit.
    [Graphical view]
    PROSITEiPS00246. WNT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O13267-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASRYLTLAA ALLASFLQVD IEANSWWSLA MNPVQIPEAY IVGAQPLCSQ    50
    LAGLSPGQKK LCQLYQDHMQ YIGEGAKTGI KECQYQFRHR RWNCSTVDNI 100
    SVFGRVMQIG SRETAFTYSI SAAGVVNAVS RACRAGELST CGCSRARRPK 150
    DLQRDWLWGG CGDNLDYGYR FAKEFVDARE REKIHQKGSY ESSRTLMNLH 200
    NNEAGRRTVY NLADVACKCH GVSGSCSLKT CWLQLADFRK VGDFLKEKYD 250
    SAASMKLNSR GKLVQVNSRF NPPTTNDLVY VDPSPDYCVR NESTGSMGTQ 300
    GRLCNKTSEG MDGCELMCCG RGYDQFKTVQ TERCHCKFHW CCYVKCKKCT 350
    EIVDQFVCK 359
    Length:359
    Mass (Da):40,346
    Last modified:July 1, 1997 - v1
    Checksum:i425CF9C6614137FB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U80582 Genomic DNA. Translation: AAB58495.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U80582 Genomic DNA. Translation: AAB58495.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi O13267.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG001595.

    Family and domain databases

    InterProi IPR005817. Wnt.
    IPR026538. Wnt5a.
    IPR018161. Wnt_CS.
    [Graphical view ]
    PANTHERi PTHR12027. PTHR12027. 1 hit.
    PTHR12027:SF33. PTHR12027:SF33. 1 hit.
    Pfami PF00110. wnt. 1 hit.
    [Graphical view ]
    PRINTSi PR01349. WNTPROTEIN.
    SMARTi SM00097. WNT1. 1 hit.
    [Graphical view ]
    PROSITEi PS00246. WNT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Possible roles for Wnt genes in growth and axial patterning during regeneration of the tail in urodele amphibians."
      Caubit X., Nicolas S., Le Parco Y.
      Dev. Dyn. 210:1-10(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiWNT5A_PLEWA
    AccessioniPrimary (citable) accession number: O13267
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3