SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O13267

- WNT5A_PLEWA

UniProt

O13267 - WNT5A_PLEWA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Protein Wnt-5a
Gene
WNT5A
Organism
Pleurodeles waltl (Iberian ribbed newt)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters By similarity.

GO - Biological processi

  1. Wnt signaling pathway Source: UniProtKB-KW
  2. multicellular organismal development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-5a
Short name:
PWnt-5a
Gene namesi
Name:WNT5A
OrganismiPleurodeles waltl (Iberian ribbed newt)
Taxonomic identifieri8319 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaCaudataSalamandroideaSalamandridaePleurodelinaePleurodeles

Subcellular locationi

GO - Cellular componenti

  1. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 359339Protein Wnt-5a
PRO_0000041430Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi83 ↔ 94 By similarity
Glycosylationi93 – 931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi99 – 991N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi133 ↔ 141 By similarity
Disulfide bondi143 ↔ 161 By similarity
Disulfide bondi217 ↔ 231 By similarity
Disulfide bondi219 ↔ 226 By similarity
Lipidationi223 – 2231O-palmitoyl serine; by PORCN By similarity
Glycosylationi291 – 2911N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi304 ↔ 319 By similarity
Glycosylationi305 – 3051N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi334 ↔ 349 By similarity
Disulfide bondi336 ↔ 346 By similarity
Disulfide bondi341 ↔ 342 By similarity

Post-translational modificationi

Palmitoylation at Ser-223 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiO13267.

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG001595.

Family and domain databases

InterProiIPR005817. Wnt.
IPR026538. Wnt5a.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF33. PTHR12027:SF33. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O13267-1 [UniParc]FASTAAdd to Basket

« Hide

MASRYLTLAA ALLASFLQVD IEANSWWSLA MNPVQIPEAY IVGAQPLCSQ    50
LAGLSPGQKK LCQLYQDHMQ YIGEGAKTGI KECQYQFRHR RWNCSTVDNI 100
SVFGRVMQIG SRETAFTYSI SAAGVVNAVS RACRAGELST CGCSRARRPK 150
DLQRDWLWGG CGDNLDYGYR FAKEFVDARE REKIHQKGSY ESSRTLMNLH 200
NNEAGRRTVY NLADVACKCH GVSGSCSLKT CWLQLADFRK VGDFLKEKYD 250
SAASMKLNSR GKLVQVNSRF NPPTTNDLVY VDPSPDYCVR NESTGSMGTQ 300
GRLCNKTSEG MDGCELMCCG RGYDQFKTVQ TERCHCKFHW CCYVKCKKCT 350
EIVDQFVCK 359
Length:359
Mass (Da):40,346
Last modified:July 1, 1997 - v1
Checksum:i425CF9C6614137FB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U80582 Genomic DNA. Translation: AAB58495.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U80582 Genomic DNA. Translation: AAB58495.1 .

3D structure databases

ModBasei Search...

Proteomic databases

PRIDEi O13267.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG001595.

Family and domain databases

InterProi IPR005817. Wnt.
IPR026538. Wnt5a.
IPR018161. Wnt_CS.
[Graphical view ]
PANTHERi PTHR12027. PTHR12027. 1 hit.
PTHR12027:SF33. PTHR12027:SF33. 1 hit.
Pfami PF00110. wnt. 1 hit.
[Graphical view ]
PRINTSi PR01349. WNTPROTEIN.
SMARTi SM00097. WNT1. 1 hit.
[Graphical view ]
PROSITEi PS00246. WNT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Possible roles for Wnt genes in growth and axial patterning during regeneration of the tail in urodele amphibians."
    Caubit X., Nicolas S., Le Parco Y.
    Dev. Dyn. 210:1-10(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiWNT5A_PLEWA
AccessioniPrimary (citable) accession number: O13267
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: September 3, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi