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O13267 (WNT5A_PLEWA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein Wnt-5a

Short name=PWnt-5a
Gene names
Name:WNT5A
OrganismPleurodeles waltl (Iberian ribbed newt)
Taxonomic identifier8319 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaCaudataSalamandroideaSalamandridaePleurodelinaePleurodeles

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters By similarity.

Subcellular location

Secretedextracellular spaceextracellular matrix.

Post-translational modification

Palmitoylation at Ser-223 is required for efficient binding to frizzled receptors. It is also required for subsequent palmitoylation at Cys-83. Palmitoylation is necessary for proper trafficking to cell surface By similarity.

Sequence similarities

Belongs to the Wnt family.

Ontologies

Keywords
   Biological processWnt signaling pathway
   Cellular componentExtracellular matrix
Secreted
   DomainSignal
   Molecular functionDevelopmental protein
   PTMGlycoprotein
Lipoprotein
Palmitate
Gene Ontology (GO)
   Biological_processWnt signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

multicellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentproteinaceous extracellular matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 359339Protein Wnt-5a
PRO_0000041430

Amino acid modifications

Lipidation831S-palmitoyl cysteine By similarity
Lipidation2231O-palmitoyl serine; by PORCN By similarity
Glycosylation931N-linked (GlcNAc...) Potential
Glycosylation991N-linked (GlcNAc...) Potential
Glycosylation2911N-linked (GlcNAc...) Potential
Glycosylation3051N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O13267 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 425CF9C6614137FB

FASTA35940,346
        10         20         30         40         50         60 
MASRYLTLAA ALLASFLQVD IEANSWWSLA MNPVQIPEAY IVGAQPLCSQ LAGLSPGQKK 

        70         80         90        100        110        120 
LCQLYQDHMQ YIGEGAKTGI KECQYQFRHR RWNCSTVDNI SVFGRVMQIG SRETAFTYSI 

       130        140        150        160        170        180 
SAAGVVNAVS RACRAGELST CGCSRARRPK DLQRDWLWGG CGDNLDYGYR FAKEFVDARE 

       190        200        210        220        230        240 
REKIHQKGSY ESSRTLMNLH NNEAGRRTVY NLADVACKCH GVSGSCSLKT CWLQLADFRK 

       250        260        270        280        290        300 
VGDFLKEKYD SAASMKLNSR GKLVQVNSRF NPPTTNDLVY VDPSPDYCVR NESTGSMGTQ 

       310        320        330        340        350 
GRLCNKTSEG MDGCELMCCG RGYDQFKTVQ TERCHCKFHW CCYVKCKKCT EIVDQFVCK 

« Hide

References

[1]"Possible roles for Wnt genes in growth and axial patterning during regeneration of the tail in urodele amphibians."
Caubit X., Nicolas S., Le Parco Y.
Dev. Dyn. 210:1-10(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U80582 Genomic DNA. Translation: AAB58495.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEO13267.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG001595.

Family and domain databases

InterProIPR005817. Wnt.
IPR026538. Wnt5a.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF33. PTHR12027:SF33. 1 hit.
PfamPF00110. wnt. 1 hit.
[Graphical view]
PRINTSPR01349. WNTPROTEIN.
SMARTSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameWNT5A_PLEWA
AccessionPrimary (citable) accession number: O13267
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: February 19, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families