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Protein

Cholesterol side-chain cleavage enzyme, mitochondrial

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.UniRule annotation

Catalytic activityi

Cholesterol + 6 reduced adrenodoxin + 3 O2 + 6 H+ = pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H2O.UniRule annotation

Cofactori

hemeUniRule annotation

Pathwayi: C21-steroid hormone metabolism

This protein is involved in the pathway C21-steroid hormone metabolism, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway C21-steroid hormone metabolism and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenaseUniRule annotation, Oxidoreductase
Biological processCholesterol metabolismUniRule annotation, Lipid metabolism, Steroid metabolism, SteroidogenesisUniRule annotation, Sterol metabolism
LigandHemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00229.

Names & Taxonomyi

Protein namesi
Recommended name:
Cholesterol side-chain cleavage enzyme, mitochondrialUniRule annotation (EC:1.14.15.6UniRule annotation)
Alternative name(s):
Cholesterol desmolaseUniRule annotation
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

  • Mitochondrion membrane UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

MembraneUniRule annotation, MitochondrionUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiO13254.
PRIDEiO13254.

Structurei

3D structure databases

ProteinModelPortaliO13254.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

eggNOGiKOG0159. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000013161.
HOVERGENiHBG051098.
KOiK00498.
PhylomeDBiO13254.

Family and domain databases

InterProiView protein in InterPro
IPR033283. CYP11A1.
IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
PANTHERiPTHR24279:SF93. PTHR24279:SF93. 1 hit.
PfamiView protein in Pfam
PF00067. p450. 1 hit.
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiView protein in PROSITE
PS00086. CYTOCHROME_P450. 1 hit.

Sequencei

Sequence statusi: Complete.

O13254-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSRAAPIAG SFQACRCAGG IPALAGVHYP LPSSSGARPF DQVPGEWRAG
60 70 80 90 100
WLNLYHFWKE GGFHNVHNIM ASKFQRFGPI YREKLGVYES VNIISPRDAA
110 120 130 140 150
TLFKSEGMLP ERFSVPPWVA YRDYRNKPYG VLLKTGEAWR SDRLTLNKEV
160 170 180 190 200
LSPQVVDSFV PLLDQVSQDF LRRARAQVQQ SGRERWTADF SHELFRFALE
210 220 230 240 250
SVCHVLYGER LGLLQDFVDP EAQQFIDAVT LMFHTTSPML YVPPALLRHL
260 270 280 290 300
NTKTWRDHVH AWDAIFTQAD KCIQNVYRDI RLQRKSTEEH TGILFSLLVQ
310 320 330 340 350
DKLPLDDIKA SVTEMMAGGV DTTSMTLQWA MLELARSPGI QERLRAEVLA
360 370 380 390 400
AKQEAQGDRV KMLKSIRLLK AAIKETLRLH PVAVTLQRYT TQEVILQDYR
410 420 430 440 450
IPPKTLVQVG LYAMGRDPEV FPKPEQFNPE RWLVMGSKHF KGLSFGFGPR
460 470 480 490 500
QCLGRRIAEL EMQLFLMHIL ENFKIETKRA VEVGTKFDLI LVPEKPIYLR

LRPLQPQE
Length:508
Mass (Da):58,195
Last modified:July 1, 1997 - v1
Checksum:i33608AC594F735D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49803 mRNA. Translation: BAA18920.1.
PIRiJC6200.
S11144.
RefSeqiNP_001001756.1. NM_001001756.1.
UniGeneiGga.591.

Genome annotation databases

GeneIDi414838.
KEGGigga:414838.

Similar proteinsi

Entry informationi

Entry nameiO13254_CHICK
AccessioniPrimary (citable) accession number: O13254
Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 1, 1997
Last modified: August 30, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)