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Protein

Heat shock protein beta-1

Gene

hspb1

Organism
Poeciliopsis lucida (Desert topminnow)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Plays a role in stress resistance and actin organization.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein beta-1
Short name:
HspB1
Alternative name(s):
Heat shock 27 kDa protein
Short name:
HSP 27
Gene namesi
Name:hspb1
OrganismiPoeciliopsis lucida (Desert topminnow)
Taxonomic identifieri56613 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeCyprinodontiformesPoeciliidaePoeciliinaePoeciliopsis

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001259321 – 201Heat shock protein beta-1Add BLAST201

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15Phosphoserine; by PKA and PKCBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiO13224

Interactioni

Subunit structurei

Homooligomer. Homodimer; becomes monomeric upon activation. Heterooligomer.By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliO13224
SMRiO13224
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 193sHSPPROSITE-ProRule annotationAdd BLAST111

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG054766

Family and domain databases

CDDicd06475 ACD_HspB1_like, 1 hit
Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR002068 A-crystallin/Hsp20_dom
IPR037876 ACD_HspB1
IPR001436 Alpha-crystallin/HSP
IPR031107 HSP20
IPR008978 HSP20-like_chaperone
PANTHERiPTHR11527 PTHR11527, 1 hit
PfamiView protein in Pfam
PF00011 HSP20, 1 hit
PRINTSiPR00299 ACRYSTALLIN
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS01031 SHSP, 1 hit

Sequencei

Sequence statusi: Complete.

O13224-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAERRIPFTL QRTPSWDVPD LHQTSRIFDQ AFGLPPVFED FSGFPTTHWP
60 70 80 90 100
GYMRPSLMTP DIMIPQSPMM YHPGHMMAHQ ARALSRQMSS GMSEIKQTQD
110 120 130 140 150
NWKISLDVPH FSPEELVVKT KDGVLEISGK HEERKDEHGF VSRSFTRKYT
160 170 180 190 200
LPPTANIEKV TSSLSPEGVL TVEAPINKPA LEYSETTIPV NVESSGAVAK

K
Length:201
Mass (Da):22,649
Last modified:July 1, 1997 - v1
Checksum:i732AF8E1B56700F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85501 mRNA Translation: AAB46593.1

Similar proteinsi

Entry informationi

Entry nameiHSPB1_POELU
AccessioniPrimary (citable) accession number: O13224
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 1, 1997
Last modified: May 23, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health