O13154 (PACN2_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein kinase C and casein kinase substrate in neurons protein 2

Alternative name(s):
Focal adhesion protein of 52 kDa
Short name=FAP52

Gene names

Name:

PACSIN2

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	448 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Forms part of the multimolecular complex constituting focal adhesion sites. Colocalizes with the focal adhesion proteins vinculin, talin and paxillin.
Subcellular location	Cell junction › focal adhesion. Cell membrane; Peripheral membrane protein. Note: Localization in focal adhesions.
Tissue specificity	Expressed in all tissues tested, including, gizzard, liver, cardiac muscle, skeletal muscle and skin.
Post-translational modification	Phosphorylated.
Sequence similarities	Belongs to the PACSIN family. Contains 1 FCH domain. Contains 1 SH3 domain.

Ontologies

Keywords
Biological process	Endocytosis
Cellular component	Cell junction Cell membrane Membrane
Domain	Coiled coil SH3 domain
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	endocytosis Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of endocytosis Inferred from sequence or structural similarity. Source: AgBase
Cellular_component	cytosol Inferred from sequence or structural similarity. Source: AgBase focal adhesion Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cytoskeletal protein binding Inferred from sequence or structural similarity. Source: AgBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 448	448	Protein kinase C and casein kinase substrate in neurons protein 2		PRO_0000161798
Regions
	Domain	11 – 75	65	FCH
	Domain	388 – 448	61	SH3
	Coiled coil	185 – 239	55	Potential
	Coiled coil	257 – 279	23	Potential

Sequences

	Sequence		Length	Mass (Da)
	O13154 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: 344218153F8698EF	FASTA	448	51,971
	10 20 30 40 50 60 MSGSYDDSVG VEVSSDSFWE VGNYKRTVKR IDDGHRLCND LMNCIHERAR IEKVYAQQLT 70 80 90 100 110 120 EWAKRWKQLV EKGPQYGTVE RAWCAFMSEA EKVSELHLEV KGSLMNEDFE KIKNWQKEAF 130 140 150 160 170 180 HKQMMGGFKE TKEAEDGFRK AQKPWAKKLK EVEAAKKAYH AACKEEKLAI SRETNSKADP 190 200 210 220 230 240 ALNPEQLKKL QDKVERSKQD VLKTKAKYEK SLKELDNATP QYMENMEQVF EQCQQFEEKR 250 260 270 280 290 300 LRFFREVLLE VQKHLDLSNV ASYKNIYREL EQNIKTADAV EDLRWFRANQ GPGMSMNWPQ 310 320 330 340 350 360 FEDDEWSADL NRTLSRREKK KASDGVTLTG INQTGDQVSQ PNKHSSVSSY EKNQSYPTDW 370 380 390 400 410 420 SDEESNNPFS STDAKGDTNP FDEDTSPVME VRVRALYDYE GQEQDELSFK AGDELTKMEN 430 440 EDEQGWCKGR LDNGQVGLYP ANYVEPIQ

References

[1]	"FAP52, a novel, SH3 domain-containing focal adhesion protein." Merilaeinen J., Lehto V.-P., Wasenius V.-M. J. Biol. Chem. 272:23278-23284(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z50798 mRNA. Translation: CAA90678.1.
IPI	IPI00582295.
RefSeq	NP_001152983.1. NM_001159511.1. NP_990420.1. NM_205089.1.
UniGene	Gga.3831.
3D structure databases
ProteinModelPortal	O13154.
ModBase	Search...
Protein-protein interaction databases
STRING	9031.ENSGALP00000022861.
Proteomic databases
PaxDb	O13154.
PRIDE	O13154.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	395975.
KEGG	gga:395975.
Organism-specific databases
CTD	11252.
Phylogenomic databases
eggNOG	NOG283356.
HOGENOM	HOG000007245.
HOVERGEN	HBG053486.
OrthoDB	EOG4K3KW7.
Family and domain databases
InterPro	IPR001060. FCH_dom. IPR001452. SH3_domain. [Graphical view]
Pfam	PF00611. FCH. 1 hit. PF00018. SH3_1. 1 hit. [Graphical view]
PRINTS	PR00452. SH3DOMAIN.
SMART	SM00055. FCH. 1 hit. SM00326. SH3. 1 hit. [Graphical view]
SUPFAM	SSF50044. SH3. 1 hit.
PROSITE	PS50133. FCH. 1 hit. PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20816040.

Entry information

Entry name

PACN2_CHICK

Accession

Primary (citable) accession number: O13154

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 13, 2002
Last sequence update:	July 1, 1997
Last modified:	May 1, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program