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O13134

- S4A4_AMBTI

UniProt

O13134 - S4A4_AMBTI

Protein

Electrogenic sodium bicarbonate cotransporter 1

Gene

SLC4A4

Organism
Ambystoma tigrinum (Eastern tiger salamander)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Electrogenic sodium/bicarbonate cotransporter with a Na+:HCO3- stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH.1 Publication

    GO - Molecular functioni

    1. inorganic anion exchanger activity Source: InterPro
    2. symporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. sodium ion transport Source: UniProtKB-KW

    Keywords - Biological processi

    Ion transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Electrogenic sodium bicarbonate cotransporter 1
    Short name:
    Sodium bicarbonate cotransporter
    Alternative name(s):
    Na(+)/HCO3(-) cotransporter
    Solute carrier family 4 member 4
    Gene namesi
    Name:SLC4A4
    Synonyms:NBC, NBCE1
    OrganismiAmbystoma tigrinum (Eastern tiger salamander)
    Taxonomic identifieri8305 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaCaudataSalamandroideaAmbystomatidaeAmbystoma

    Subcellular locationi

    Basolateral cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. basolateral plasma membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10351035Electrogenic sodium bicarbonate cotransporter 1PRO_0000079232Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi591 – 5911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi596 – 5961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi609 – 6091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi617 – 6171N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Expressioni

    Tissue specificityi

    Expressed in kidney and to a lower extent in bladder, brain, intestine, large intestine and eye.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliO13134.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 426426CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini448 – 4547ExtracellularSequence Analysis
    Topological domaini476 – 51136CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini533 – 644112ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini666 – 68116CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini703 – 73230ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini754 – 77825CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini800 – 83738ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini880 – 91940ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini941 – 103595CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei427 – 44721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei455 – 47521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei512 – 53221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei645 – 66521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei682 – 70221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei733 – 75321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei779 – 79921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei838 – 85821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei859 – 87921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei920 – 94021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi965 – 98016Lys-richAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG004326.

    Family and domain databases

    Gene3Di3.40.1100.10. 1 hit.
    InterProiIPR013769. Band3_cytoplasmic_dom.
    IPR011531. HCO3_transpt_C.
    IPR003020. HCO3_transpt_euk.
    IPR003024. Na/HCO3_transpt.
    IPR016152. PTrfase/Anion_transptr.
    [Graphical view]
    PANTHERiPTHR11453. PTHR11453. 1 hit.
    PfamiPF07565. Band_3_cyto. 1 hit.
    PF00955. HCO3_cotransp. 1 hit.
    [Graphical view]
    PRINTSiPR01231. HCO3TRNSPORT.
    PR01232. NAHCO3TRSPRT.
    SUPFAMiSSF55804. SSF55804. 1 hit.
    TIGRFAMsiTIGR00834. ae. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O13134-1 [UniParc]FASTAAdd to Basket

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    MSSEKECLEN MLNGYAESGR VLSRTSLVIN QAVNRSIFTS TVSPAAERIR     50
    FILGEEDDSP APPQLFTELD ELLAVDGQEM EWKETARWIK FEEKVEQGGE 100
    RWSKPHVATL SLHSLFELRT CIEKGTILLD LEATSLPQIV EIVINNQIEL 150
    GLLKADMKEN VTRTLLRKHR HQTKKSNLRS LADIGKTVSS ASRLFSTPDN 200
    GSPTMTHRNL TSTSLNDVSD KPDKEQLKNK FMKKLPRDAE ASNVLVGEVD 250
    FLESPFIAFV RLQQAVMLGS LTEVPVPTRF LFILLGPKGK AKSYHEIGRS 300
    IATLMSDEVF HDIAYKAKNR EDLIAGIDEF LDEVIVLPLG EWDPTIRIEP 350
    PKSLPSSDKR KNMYSGGDNL QMNGDAPHDD GGGGHGDSEE LQRTGRFCGG 400
    LIKDIQRKAP FFASDFYDAL SIQSLSAILF IYLGTVTNAI TFGGLLGDAT 450
    ENMQGVLESF LGTAVSGAVF CLFGGQPLTI LSSTGPVLVF ERLLFNFSKD 500
    NDFDYLEFRL WIGLWSAFQC LILVATDASF LVKYFTRFTE EGFSSLISFI 550
    FIYDAFKKMI KLADYYPINS HFKVDYITQY SCACFPPEPA NSSWFNMTTA 600
    ATTTQFLTNA STDMAYNGTI DWSLLSKKEC LKYGGLLVGS NCKYVPDITL 650
    MSFILFLGTY TCSMALKKFK TSRYFPTTAR KLISDFAIIL SILIFCGLDA 700
    LLGVDTPKLI VPSEFKPTSP NRGWFVPPFG GNPWWVYLAA AIPALLVTIL 750
    IFMDQQITGV IVNRKEHKLK KGAGYHLDLF WVAILMVVCS FMALPWYVAA 800
    TVISIAHIDS LKMETETSAP GEQPKFLGVR EQRVTGTVVF LLTGLSVFMA 850
    PILKFIPMPV LYGVFLYMGV ASLNGVQFMD RLKLLLMPPK YQPDFIYLRH 900
    VPLRRVHLFT FLQVVCLAML WILKSTVAAI IFPVMILALV AVRKAMDYFF 950
    SQHDLSFLDD VIPEKDKKKK EDEKKKKKKK GSIDSDVEDS DCPYPEKVPS 1000
    IKIPMDIMEK EPFLIDSKPS DRENSPTFLE RHTSC 1035
    Length:1,035
    Mass (Da):116,108
    Last modified:July 1, 1997 - v1
    Checksum:i3CF50B31275A81AF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF001958 mRNA. Translation: AAB61339.1.
    PIRiT31336.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF001958 mRNA. Translation: AAB61339.1 .
    PIRi T31336.

    3D structure databases

    ProteinModelPortali O13134.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG004326.

    Family and domain databases

    Gene3Di 3.40.1100.10. 1 hit.
    InterProi IPR013769. Band3_cytoplasmic_dom.
    IPR011531. HCO3_transpt_C.
    IPR003020. HCO3_transpt_euk.
    IPR003024. Na/HCO3_transpt.
    IPR016152. PTrfase/Anion_transptr.
    [Graphical view ]
    PANTHERi PTHR11453. PTHR11453. 1 hit.
    Pfami PF07565. Band_3_cyto. 1 hit.
    PF00955. HCO3_cotransp. 1 hit.
    [Graphical view ]
    PRINTSi PR01231. HCO3TRNSPORT.
    PR01232. NAHCO3TRSPRT.
    SUPFAMi SSF55804. SSF55804. 1 hit.
    TIGRFAMsi TIGR00834. ae. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Expression cloning and characterization of a renal electrogenic Na+/HCO3- cotransporter."
      Romero M.F., Hediger M.A., Boulpaep E.L., Boron W.F.
      Nature 387:409-413(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Tissue: Kidney.
    2. "Immunoelectron microscopic localization of the electrogenic Na/HCO(3) cotransporter in rat and ambystoma kidney."
      Maunsbach A.B., Vorum H., Kwon T.-H., Nielsen S., Simonsen B., Choi I., Schmitt B.M., Boron W.F., Aalkjaer C.
      J. Am. Soc. Nephrol. 11:2179-2189(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiS4A4_AMBTI
    AccessioniPrimary (citable) accession number: O13134
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3