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O13134

- S4A4_AMBTI

UniProt

O13134 - S4A4_AMBTI

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Protein

Electrogenic sodium bicarbonate cotransporter 1

Gene
SLC4A4, NBC, NBCE1
Organism
Ambystoma tigrinum (Eastern tiger salamander)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Electrogenic sodium/bicarbonate cotransporter with a Na+:HCO3- stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH.1 Publication

GO - Molecular functioni

  1. inorganic anion exchanger activity Source: InterPro
  2. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. sodium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Electrogenic sodium bicarbonate cotransporter 1
Short name:
Sodium bicarbonate cotransporter
Alternative name(s):
Na(+)/HCO3(-) cotransporter
Solute carrier family 4 member 4
Gene namesi
Name:SLC4A4
Synonyms:NBC, NBCE1
OrganismiAmbystoma tigrinum (Eastern tiger salamander)
Taxonomic identifieri8305 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaCaudataSalamandroideaAmbystomatidaeAmbystoma

Subcellular locationi

Basolateral cell membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 426426Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei427 – 44721Helical; Reviewed predictionAdd
BLAST
Topological domaini448 – 4547Extracellular Reviewed prediction
Transmembranei455 – 47521Helical; Reviewed predictionAdd
BLAST
Topological domaini476 – 51136Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei512 – 53221Helical; Reviewed predictionAdd
BLAST
Topological domaini533 – 644112Extracellular Reviewed predictionAdd
BLAST
Transmembranei645 – 66521Helical; Reviewed predictionAdd
BLAST
Topological domaini666 – 68116Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei682 – 70221Helical; Reviewed predictionAdd
BLAST
Topological domaini703 – 73230Extracellular Reviewed predictionAdd
BLAST
Transmembranei733 – 75321Helical; Reviewed predictionAdd
BLAST
Topological domaini754 – 77825Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei779 – 79921Helical; Reviewed predictionAdd
BLAST
Topological domaini800 – 83738Extracellular Reviewed predictionAdd
BLAST
Transmembranei838 – 85821Helical; Reviewed predictionAdd
BLAST
Transmembranei859 – 87921Helical; Reviewed predictionAdd
BLAST
Topological domaini880 – 91940Extracellular Reviewed predictionAdd
BLAST
Transmembranei920 – 94021Helical; Reviewed predictionAdd
BLAST
Topological domaini941 – 103595Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10351035Electrogenic sodium bicarbonate cotransporter 1PRO_0000079232Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi591 – 5911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi596 – 5961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi609 – 6091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi617 – 6171N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Expressed in kidney and to a lower extent in bladder, brain, intestine, large intestine and eye.1 Publication

Structurei

3D structure databases

ProteinModelPortaliO13134.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi965 – 98016Lys-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004326.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR003024. Na/HCO3_transpt.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR01231. HCO3TRNSPORT.
PR01232. NAHCO3TRSPRT.
SUPFAMiSSF55804. SSF55804. 1 hit.
TIGRFAMsiTIGR00834. ae. 1 hit.

Sequencei

Sequence statusi: Complete.

O13134-1 [UniParc]FASTAAdd to Basket

« Hide

MSSEKECLEN MLNGYAESGR VLSRTSLVIN QAVNRSIFTS TVSPAAERIR     50
FILGEEDDSP APPQLFTELD ELLAVDGQEM EWKETARWIK FEEKVEQGGE 100
RWSKPHVATL SLHSLFELRT CIEKGTILLD LEATSLPQIV EIVINNQIEL 150
GLLKADMKEN VTRTLLRKHR HQTKKSNLRS LADIGKTVSS ASRLFSTPDN 200
GSPTMTHRNL TSTSLNDVSD KPDKEQLKNK FMKKLPRDAE ASNVLVGEVD 250
FLESPFIAFV RLQQAVMLGS LTEVPVPTRF LFILLGPKGK AKSYHEIGRS 300
IATLMSDEVF HDIAYKAKNR EDLIAGIDEF LDEVIVLPLG EWDPTIRIEP 350
PKSLPSSDKR KNMYSGGDNL QMNGDAPHDD GGGGHGDSEE LQRTGRFCGG 400
LIKDIQRKAP FFASDFYDAL SIQSLSAILF IYLGTVTNAI TFGGLLGDAT 450
ENMQGVLESF LGTAVSGAVF CLFGGQPLTI LSSTGPVLVF ERLLFNFSKD 500
NDFDYLEFRL WIGLWSAFQC LILVATDASF LVKYFTRFTE EGFSSLISFI 550
FIYDAFKKMI KLADYYPINS HFKVDYITQY SCACFPPEPA NSSWFNMTTA 600
ATTTQFLTNA STDMAYNGTI DWSLLSKKEC LKYGGLLVGS NCKYVPDITL 650
MSFILFLGTY TCSMALKKFK TSRYFPTTAR KLISDFAIIL SILIFCGLDA 700
LLGVDTPKLI VPSEFKPTSP NRGWFVPPFG GNPWWVYLAA AIPALLVTIL 750
IFMDQQITGV IVNRKEHKLK KGAGYHLDLF WVAILMVVCS FMALPWYVAA 800
TVISIAHIDS LKMETETSAP GEQPKFLGVR EQRVTGTVVF LLTGLSVFMA 850
PILKFIPMPV LYGVFLYMGV ASLNGVQFMD RLKLLLMPPK YQPDFIYLRH 900
VPLRRVHLFT FLQVVCLAML WILKSTVAAI IFPVMILALV AVRKAMDYFF 950
SQHDLSFLDD VIPEKDKKKK EDEKKKKKKK GSIDSDVEDS DCPYPEKVPS 1000
IKIPMDIMEK EPFLIDSKPS DRENSPTFLE RHTSC 1035
Length:1,035
Mass (Da):116,108
Last modified:July 1, 1997 - v1
Checksum:i3CF50B31275A81AF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF001958 mRNA. Translation: AAB61339.1.
PIRiT31336.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF001958 mRNA. Translation: AAB61339.1 .
PIRi T31336.

3D structure databases

ProteinModelPortali O13134.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG004326.

Family and domain databases

Gene3Di 3.40.1100.10. 1 hit.
InterProi IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR003024. Na/HCO3_transpt.
IPR016152. PTrfase/Anion_transptr.
[Graphical view ]
PANTHERi PTHR11453. PTHR11453. 1 hit.
Pfami PF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view ]
PRINTSi PR01231. HCO3TRNSPORT.
PR01232. NAHCO3TRSPRT.
SUPFAMi SSF55804. SSF55804. 1 hit.
TIGRFAMsi TIGR00834. ae. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Expression cloning and characterization of a renal electrogenic Na+/HCO3- cotransporter."
    Romero M.F., Hediger M.A., Boulpaep E.L., Boron W.F.
    Nature 387:409-413(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Kidney.
  2. "Immunoelectron microscopic localization of the electrogenic Na/HCO(3) cotransporter in rat and ambystoma kidney."
    Maunsbach A.B., Vorum H., Kwon T.-H., Nielsen S., Simonsen B., Choi I., Schmitt B.M., Boron W.F., Aalkjaer C.
    J. Am. Soc. Nephrol. 11:2179-2189(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiS4A4_AMBTI
AccessioniPrimary (citable) accession number: O13134
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 1, 1997
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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