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O13134

- S4A4_AMBTI

UniProt

O13134 - S4A4_AMBTI

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Protein

Electrogenic sodium bicarbonate cotransporter 1

Gene

SLC4A4

Organism
Ambystoma tigrinum (Eastern tiger salamander)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Electrogenic sodium/bicarbonate cotransporter with a Na+:HCO3- stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH.1 Publication

GO - Molecular functioni

  1. inorganic anion exchanger activity Source: InterPro
  2. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. sodium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Electrogenic sodium bicarbonate cotransporter 1
Short name:
Sodium bicarbonate cotransporter
Alternative name(s):
Na(+)/HCO3(-) cotransporter
Solute carrier family 4 member 4
Gene namesi
Name:SLC4A4
Synonyms:NBC, NBCE1
OrganismiAmbystoma tigrinum (Eastern tiger salamander)
Taxonomic identifieri8305 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaCaudataSalamandroideaAmbystomatidaeAmbystoma

Subcellular locationi

Basolateral cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 426426CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei427 – 44721HelicalSequence AnalysisAdd
BLAST
Topological domaini448 – 4547ExtracellularSequence Analysis
Transmembranei455 – 47521HelicalSequence AnalysisAdd
BLAST
Topological domaini476 – 51136CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei512 – 53221HelicalSequence AnalysisAdd
BLAST
Topological domaini533 – 644112ExtracellularSequence AnalysisAdd
BLAST
Transmembranei645 – 66521HelicalSequence AnalysisAdd
BLAST
Topological domaini666 – 68116CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei682 – 70221HelicalSequence AnalysisAdd
BLAST
Topological domaini703 – 73230ExtracellularSequence AnalysisAdd
BLAST
Transmembranei733 – 75321HelicalSequence AnalysisAdd
BLAST
Topological domaini754 – 77825CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei779 – 79921HelicalSequence AnalysisAdd
BLAST
Topological domaini800 – 83738ExtracellularSequence AnalysisAdd
BLAST
Transmembranei838 – 85821HelicalSequence AnalysisAdd
BLAST
Transmembranei859 – 87921HelicalSequence AnalysisAdd
BLAST
Topological domaini880 – 91940ExtracellularSequence AnalysisAdd
BLAST
Transmembranei920 – 94021HelicalSequence AnalysisAdd
BLAST
Topological domaini941 – 103595CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10351035Electrogenic sodium bicarbonate cotransporter 1PRO_0000079232Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi591 – 5911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi596 – 5961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi609 – 6091N-linked (GlcNAc...)Sequence Analysis
Glycosylationi617 – 6171N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Expressed in kidney and to a lower extent in bladder, brain, intestine, large intestine and eye.1 Publication

Structurei

3D structure databases

ProteinModelPortaliO13134.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi965 – 98016Lys-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004326.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR003024. Na/HCO3_transpt.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR01231. HCO3TRNSPORT.
PR01232. NAHCO3TRSPRT.
SUPFAMiSSF55804. SSF55804. 1 hit.
TIGRFAMsiTIGR00834. ae. 1 hit.

Sequencei

Sequence statusi: Complete.

O13134-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSEKECLEN MLNGYAESGR VLSRTSLVIN QAVNRSIFTS TVSPAAERIR
60 70 80 90 100
FILGEEDDSP APPQLFTELD ELLAVDGQEM EWKETARWIK FEEKVEQGGE
110 120 130 140 150
RWSKPHVATL SLHSLFELRT CIEKGTILLD LEATSLPQIV EIVINNQIEL
160 170 180 190 200
GLLKADMKEN VTRTLLRKHR HQTKKSNLRS LADIGKTVSS ASRLFSTPDN
210 220 230 240 250
GSPTMTHRNL TSTSLNDVSD KPDKEQLKNK FMKKLPRDAE ASNVLVGEVD
260 270 280 290 300
FLESPFIAFV RLQQAVMLGS LTEVPVPTRF LFILLGPKGK AKSYHEIGRS
310 320 330 340 350
IATLMSDEVF HDIAYKAKNR EDLIAGIDEF LDEVIVLPLG EWDPTIRIEP
360 370 380 390 400
PKSLPSSDKR KNMYSGGDNL QMNGDAPHDD GGGGHGDSEE LQRTGRFCGG
410 420 430 440 450
LIKDIQRKAP FFASDFYDAL SIQSLSAILF IYLGTVTNAI TFGGLLGDAT
460 470 480 490 500
ENMQGVLESF LGTAVSGAVF CLFGGQPLTI LSSTGPVLVF ERLLFNFSKD
510 520 530 540 550
NDFDYLEFRL WIGLWSAFQC LILVATDASF LVKYFTRFTE EGFSSLISFI
560 570 580 590 600
FIYDAFKKMI KLADYYPINS HFKVDYITQY SCACFPPEPA NSSWFNMTTA
610 620 630 640 650
ATTTQFLTNA STDMAYNGTI DWSLLSKKEC LKYGGLLVGS NCKYVPDITL
660 670 680 690 700
MSFILFLGTY TCSMALKKFK TSRYFPTTAR KLISDFAIIL SILIFCGLDA
710 720 730 740 750
LLGVDTPKLI VPSEFKPTSP NRGWFVPPFG GNPWWVYLAA AIPALLVTIL
760 770 780 790 800
IFMDQQITGV IVNRKEHKLK KGAGYHLDLF WVAILMVVCS FMALPWYVAA
810 820 830 840 850
TVISIAHIDS LKMETETSAP GEQPKFLGVR EQRVTGTVVF LLTGLSVFMA
860 870 880 890 900
PILKFIPMPV LYGVFLYMGV ASLNGVQFMD RLKLLLMPPK YQPDFIYLRH
910 920 930 940 950
VPLRRVHLFT FLQVVCLAML WILKSTVAAI IFPVMILALV AVRKAMDYFF
960 970 980 990 1000
SQHDLSFLDD VIPEKDKKKK EDEKKKKKKK GSIDSDVEDS DCPYPEKVPS
1010 1020 1030
IKIPMDIMEK EPFLIDSKPS DRENSPTFLE RHTSC
Length:1,035
Mass (Da):116,108
Last modified:July 1, 1997 - v1
Checksum:i3CF50B31275A81AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001958 mRNA. Translation: AAB61339.1.
PIRiT31336.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001958 mRNA. Translation: AAB61339.1 .
PIRi T31336.

3D structure databases

ProteinModelPortali O13134.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG004326.

Family and domain databases

Gene3Di 3.40.1100.10. 1 hit.
InterProi IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR003024. Na/HCO3_transpt.
IPR016152. PTrfase/Anion_transptr.
[Graphical view ]
PANTHERi PTHR11453. PTHR11453. 1 hit.
Pfami PF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view ]
PRINTSi PR01231. HCO3TRNSPORT.
PR01232. NAHCO3TRSPRT.
SUPFAMi SSF55804. SSF55804. 1 hit.
TIGRFAMsi TIGR00834. ae. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Expression cloning and characterization of a renal electrogenic Na+/HCO3- cotransporter."
    Romero M.F., Hediger M.A., Boulpaep E.L., Boron W.F.
    Nature 387:409-413(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Kidney.
  2. "Immunoelectron microscopic localization of the electrogenic Na/HCO(3) cotransporter in rat and ambystoma kidney."
    Maunsbach A.B., Vorum H., Kwon T.-H., Nielsen S., Simonsen B., Choi I., Schmitt B.M., Boron W.F., Aalkjaer C.
    J. Am. Soc. Nephrol. 11:2179-2189(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiS4A4_AMBTI
AccessioniPrimary (citable) accession number: O13134
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 1, 1997
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3