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Protein
Submitted name:

AP-2 transcription factor

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: UniProtKB
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity Source: UniProtKB
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: UniProtKB
  4. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: UniProtKB
  5. transcription coactivator activity Source: UniProtKB

GO - Biological processi

  1. bone morphogenesis Source: UniProtKB
  2. cellular response to iron ion Source: UniProtKB
  3. embryonic cranial skeleton morphogenesis Source: UniProtKB
  4. embryonic forelimb morphogenesis Source: UniProtKB
  5. eyelid development in camera-type eye Source: UniProtKB
  6. inner ear morphogenesis Source: UniProtKB
  7. kidney development Source: UniProtKB
  8. negative regulation of apoptotic process Source: UniProtKB
  9. negative regulation of myoblast proliferation Source: UniProtKB
  10. negative regulation of reactive oxygen species metabolic process Source: UniProtKB
  11. negative regulation of transcription by competitive promoter binding Source: UniProtKB
  12. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  13. oculomotor nerve formation Source: UniProtKB
  14. optic cup structural organization Source: UniProtKB
  15. optic vesicle morphogenesis Source: UniProtKB
  16. palate development Source: UniProtKB
  17. positive regulation of bone mineralization Source: UniProtKB
  18. positive regulation of tooth mineralization Source: UniProtKB
  19. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  20. sensory perception of sound Source: UniProtKB
  21. transcription from RNA polymerase II promoter Source: GOC
  22. trigeminal nerve development Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
AP-2 transcription factorImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiO13111.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000020815.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG300693.
HOGENOMiHOG000231737.
HOVERGENiHBG002455.
KOiK09176.
PhylomeDBiO13111.

Family and domain databases

InterProiIPR004979. TF_AP2.
IPR008121. TF_AP2_alpha_N.
IPR013854. TF_AP2_C.
[Graphical view]
PANTHERiPTHR10812. PTHR10812. 1 hit.
PfamiPF03299. TF_AP-2. 1 hit.
[Graphical view]
PRINTSiPR01749. AP2ATNSCPFCT.
PR01748. AP2TNSCPFCT.

Sequencei

Sequence statusi: Complete.

O13111-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLWKLTDNIK YEECEERHDS ASNGTARLPQ LGAVGQSPYS SAPPLSHTPN
60 70 80 90 100
ADFQPPYFPP PYQPIYPQSQ DPYSHVNDPY SLNSLHTQPQ PQHPAWPGQR
110 120 130 140 150
QSQEPSLLHA HRGLPHQLGG LDPRRDYRRH DDLLHGPHGL GAGLADLPLH
160 170 180 190 200
SIPHAIEDVP HVDDPGINIP DQTVIKKGPV SLSKSNNNAV SSIPINKDAL
210 220 230 240 250
FGGVVNPNEV FCSVPGRLSL LSSTSKYKVT VAEVQRRLSP PECLNASLLG
260 270 280 290 300
GVLRRAKSKN GGRSLREKLD KIGLNLPAGR RKAANVTLLT SLVEGEAVHL
310 320 330 340 350
ARDFGYVCET EFPAKAVAEF LNRQHSDPNE QVTRKNMLLA TKQICKEFTD
360 370 380 390 400
LLAQDRSPLG NSRPNPILEP GIQSCLTHFN LISHGFGSPA VCAAVTALQN
410 420 430
YLTEALKAMD KMYLSNNPNS HTDNSTKSSD KEEKHRK
Length:437
Mass (Da):47,985
Last modified:November 1, 1998 - v2
Checksum:i38B23FDDDD6B1937
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72992 mRNA. Translation: AAB65081.1.
RefSeqiNP_990425.1. NM_205094.1.
UniGeneiGga.2351.

Genome annotation databases

GeneIDi395982.
KEGGigga:395982.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72992 mRNA. Translation: AAB65081.1.
RefSeqiNP_990425.1. NM_205094.1.
UniGeneiGga.2351.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000020815.

Proteomic databases

PaxDbiO13111.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395982.
KEGGigga:395982.

Organism-specific databases

CTDi7020.

Phylogenomic databases

eggNOGiNOG300693.
HOGENOMiHOG000231737.
HOVERGENiHBG002455.
KOiK09176.
PhylomeDBiO13111.

Miscellaneous databases

NextBioi20816046.
PROiO13111.

Family and domain databases

InterProiIPR004979. TF_AP2.
IPR008121. TF_AP2_alpha_N.
IPR013854. TF_AP2_C.
[Graphical view]
PANTHERiPTHR10812. PTHR10812. 1 hit.
PfamiPF03299. TF_AP-2. 1 hit.
[Graphical view]
PRINTSiPR01749. AP2ATNSCPFCT.
PR01748. AP2TNSCPFCT.
ProtoNetiSearch...

Publicationsi

  1. "Chicken transcription factor AP-2: cloning, expression and its role in outgrowth of facial prominences and limb buds."
    Shen H., Ashique A., Narvey M., Zerucha T., Savino E., Williams T., Richman J.M.
    Dev. Biol. 188:248-266(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: White leghornImported.

Entry informationi

Entry nameiO13111_CHICK
AccessioniPrimary (citable) accession number: O13111
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: November 1, 1998
Last modified: February 4, 2015
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.