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Protein

Adenosine receptor A2b

Gene

ADORA2B

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-GGA-417973. Adenosine P1 receptors.
R-GGA-418555. G alpha (s) signalling events.
R-GGA-5683826. Surfactant metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine receptor A2b
Alternative name(s):
Adenosine receptor 2b
Gene namesi
Name:ADORA2B
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 19

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66ExtracellularBy similarity
Transmembranei7 – 3125Helical; Name=1By similarityAdd
BLAST
Topological domaini32 – 4110CytoplasmicBy similarity
Transmembranei42 – 6524Helical; Name=2By similarityAdd
BLAST
Topological domaini66 – 7611ExtracellularBy similarityAdd
BLAST
Transmembranei77 – 9923Helical; Name=3By similarityAdd
BLAST
Topological domaini100 – 11920CytoplasmicBy similarityAdd
BLAST
Transmembranei120 – 14223Helical; Name=4By similarityAdd
BLAST
Topological domaini143 – 17836ExtracellularBy similarityAdd
BLAST
Transmembranei179 – 20325Helical; Name=5By similarityAdd
BLAST
Topological domaini204 – 23532CytoplasmicBy similarityAdd
BLAST
Transmembranei236 – 25924Helical; Name=6By similarityAdd
BLAST
Topological domaini260 – 2678ExtracellularBy similarity
Transmembranei268 – 29124Helical; Name=7By similarityAdd
BLAST
Topological domaini292 – 34049CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340Adenosine receptor A2bPRO_0000069006Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi76 ↔ 171PROSITE-ProRule annotation
Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence analysis
Glycosylationi154 – 1541N-linked (GlcNAc...)Sequence analysis
Lipidationi310 – 3101S-palmitoyl cysteineSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiO13076.

Expressioni

Gene expression databases

ExpressionAtlasiO13076. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000027991.

Structurei

3D structure databases

ProteinModelPortaliO13076.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni173 – 18210Agonist bindingBy similarity
Regioni247 – 2548Agonist bindingBy similarity
Regioni266 – 27611Agonist bindingBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00550000074524.
HOGENOMiHOG000015770.
HOVERGENiHBG106962.
InParanoidiO13076.
KOiK04267.
OMAiCTDFYGC.
PhylomeDBiO13076.

Family and domain databases

InterProiIPR001435. Adeno_A2B_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00554. ADENOSINA2BR.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O13076-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTMKTTYIV LELIIAVLSI AGNVLVCWAV AINSTLKNAT NYFLVSLAVA
60 70 80 90 100
DIAVGLLAIP FAITISIGFQ VDFHSCLFFA CFVLVLTQSS IFSLLAVAID
110 120 130 140 150
RYLAIKIPLR YNSLVTGKRA RGLIAVLWLL SFVIGLTPLM GWNKAMSGCP
160 170 180 190 200
NSTNETGADH GAGHHGCFIS CLFENVVTMS YMVYFNFFGC VLLPLIIMLG
210 220 230 240 250
IYIKIFMVAC KQLHQIELMG NSRTTLQKEV HAAKSLAIIV GLFAFCWLPL
260 270 280 290 300
HILNCITHFH EEFSKSKPEW VMYVAIILSH ANSVINPIIY AYRIRDFRYT
310 320 330 340
FHKIISKILC KTDDFPKCTT DNNQHLTVTN VNAPAASVTI
Length:340
Mass (Da):37,772
Last modified:July 1, 1997 - v1
Checksum:i2DAC18E6DC6A950F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12601 mRNA. Translation: CAA73173.1.
AY169692 Genomic DNA. Translation: AAN87848.1.
RefSeqiNP_990418.1. NM_205087.1.
UniGeneiGga.43285.

Genome annotation databases

EnsembliENSGALT00000028044; ENSGALP00000027991; ENSGALG00000014182.
GeneIDi395971.
KEGGigga:395971.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12601 mRNA. Translation: CAA73173.1.
AY169692 Genomic DNA. Translation: AAN87848.1.
RefSeqiNP_990418.1. NM_205087.1.
UniGeneiGga.43285.

3D structure databases

ProteinModelPortaliO13076.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000027991.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiO13076.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000028044; ENSGALP00000027991; ENSGALG00000014182.
GeneIDi395971.
KEGGigga:395971.

Organism-specific databases

CTDi136.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00550000074524.
HOGENOMiHOG000015770.
HOVERGENiHBG106962.
InParanoidiO13076.
KOiK04267.
OMAiCTDFYGC.
PhylomeDBiO13076.

Enzyme and pathway databases

ReactomeiR-GGA-417973. Adenosine P1 receptors.
R-GGA-418555. G alpha (s) signalling events.
R-GGA-5683826. Surfactant metabolism.

Miscellaneous databases

NextBioi20816036.
PROiO13076.

Gene expression databases

ExpressionAtlasiO13076. baseline and differential.

Family and domain databases

InterProiIPR001435. Adeno_A2B_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00554. ADENOSINA2BR.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The chicken adenosine receptor 2B gene is regulated by v-myb."
    Worpenberg S., Burk O., Klempnauer K.H.
    Oncogene 15:213-221(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: SPAFAS.
  2. "Analysis of DNase I-hypersensitive sites in the chromatin of the chicken adenosine receptor 2B gene reveals multiple cell-type-specific cis-regulatory elements."
    Braas D., Kattmann D., Miethe J., Klempnauer K.H.
    Gene 303:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiAA2BR_CHICK
AccessioniPrimary (citable) accession number: O13076
Secondary accession number(s): Q540H7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: May 11, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.