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Protein

Homeobox protein Hox-B4a

Gene

hoxb4a

Organism
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi160 – 21960HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B4a
Alternative name(s):
FrHOXB-4
Gene namesi
Name:hoxb4a
Synonyms:hoxb4
OrganismiTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Taxonomic identifieri31033 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu
Proteomesi
  • UP000005226 Componenti: Unplaced

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Homeobox protein Hox-B4aPRO_0000200126Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi31033.ENSTRUP00000024389.

Structurei

3D structure databases

ProteinModelPortaliO13074.
SMRiO13074. Positions 134-220.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi139 – 1446Antp-type hexapeptide

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
InParanoidiO13074.
KOiK09304.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O13074-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMSSYLINS NYVDPKFPPC EEYSQSDYLP NHSPDYYSSQ RQEPAAFQPD
60 70 80 90 100
SLYHHHPHQQ QRAEPPYTQC QRAGQPASVV MSPRGHVLPP SGLQTTPVPE
110 120 130 140 150
QSHRCESVTP SPPPPPSCGQ TPHSQGASSP ASTRKDPVVY PWMKKVHVNI
160 170 180 190 200
VSSNYTGGEP KRSRTAYTRQ QVLELEKEFH YNRYLTRRRR VEIAHTLCLS
210 220 230 240 250
ERQIKIWFQN RRMKWKKDHK LPNTKVRSGS TNTNSQVLTG FPKPHWTPIA
260 270 280
GRDTCMIYAP SLAVPDCETE CRSGSHASDH PSLHFGPE
Length:288
Mass (Da):32,723
Last modified:December 12, 2006 - v2
Checksum:i9282E464046E8C9F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti59 – 591Q → HPQH (PubMed:7878040).Curated
Sequence conflicti59 – 591Q → HPQH (PubMed:9140399).Curated
Sequence conflicti241 – 27636FPKPH…RSGSH → SQNRTGPL (PubMed:7878040).CuratedAdd
BLAST
Sequence conflicti241 – 27636FPKPH…RSGSH → SQNRTGPL (PubMed:9140399).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U92575 Genomic DNA. Translation: AAC60205.1.
DQ481665 Genomic DNA. Translation: ABF22416.1.
RefSeqiXP_011601866.1. XM_011603564.1.

Genome annotation databases

GeneIDi101061711.
KEGGitru:101061711.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U92575 Genomic DNA. Translation: AAC60205.1.
DQ481665 Genomic DNA. Translation: ABF22416.1.
RefSeqiXP_011601866.1. XM_011603564.1.

3D structure databases

ProteinModelPortaliO13074.
SMRiO13074. Positions 134-220.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi31033.ENSTRUP00000024389.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101061711.
KEGGitru:101061711.

Organism-specific databases

CTDi3214.

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
InParanoidiO13074.
KOiK09304.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHXB4A_TAKRU
AccessioniPrimary (citable) accession number: O13074
Secondary accession number(s): Q1KKX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: December 12, 2006
Last modified: May 11, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.