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Protein

Tyrosine-protein kinase

Gene

lyn

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
Name:lynImported
Synonyms:LynImported, lyn-AImported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-1015131. lyn.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 99SH3InterPro annotationAdd BLAST61
Domaini105 – 202SH2InterPro annotationAdd BLAST98
Domaini223 – 477Protein kinaseInterPro annotationAdd BLAST255

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotationSAAS annotation
Contains 1 SH2 domain.UniRule annotation
Contains 1 SH3 domain.UniRule annotation
Contains 1 protein kinase domain.UniRule annotation

Keywords - Domaini

SH3 domainUniRule annotationSAAS annotation

Phylogenomic databases

HOVERGENiHBG008761.
KOiK05854.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O13064-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCIKSKTDN PRDAMGKNNP ASRTPSLLPG QKMIQDIEEQ GNIVIALYPY
60 70 80 90 100
QGIHEDDLSF KKGEKLKVLE EHGEWWKAKS LSTKKEGFIP SNYVARVNTL
110 120 130 140 150
ETEEWFFKDL TRKDAERQLL APGNNPGAFL IRESETSKGS YSLSIRDCDP
160 170 180 190 200
QTGDVIKHYK IRTLDNGGYY ISPRITFTSI NEMIQHYQKQ ADGLCRKLDK
210 220 230 240 250
PCFSPKPQKP WDKDAWEIPR ESIKMVRKLG AGQFGEVWMG FYNNSTKVAV
260 270 280 290 300
KTLKPGSMSV QAFMEEANLM KTLQHDKLVR LYAVVSKEEP IYIITEYMAK
310 320 330 340 350
GSLLDFLKSD EGGKVILPKS IDFSAQIAEG MAYIEKKNYI HRDLRAANVL
360 370 380 390 400
VSESLMCKIA DFGLARVIED NEYTAREGAK FPIKWTAPEA INFGSFTIKS
410 420 430 440 450
DVWSFGVLLY EIITFGKIPY PGMSNSDVMS ALQRGYRMPR MENCPEELYD
460 470 480
IMKQCWKEKA EERPTFDYLQ SVLDDFYTAT ETQYQQQP
Length:488
Mass (Da):55,795
Last modified:July 1, 1997 - v1
Checksum:iB7E70668B6EA92B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC170242 mRNA. Translation: AAI70242.1.
AB003358 mRNA. Translation: BAA20078.1.
RefSeqiNP_001079115.1. NM_001085646.1.
UniGeneiXl.876.

Genome annotation databases

GeneIDi373649.
KEGGixla:373649.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC170242 mRNA. Translation: AAI70242.1.
AB003358 mRNA. Translation: BAA20078.1.
RefSeqiNP_001079115.1. NM_001085646.1.
UniGeneiXl.876.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi373649.
KEGGixla:373649.

Organism-specific databases

CTDi4067.
XenbaseiXB-GENE-1015131. lyn.

Phylogenomic databases

HOVERGENiHBG008761.
KOiK05854.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO13064_XENLA
AccessioniPrimary (citable) accession number: O13064
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 1, 1997
Last modified: October 5, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.