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Protein

Tyrosine-protein kinase

Gene

lyn

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
Name:lynImported
Synonyms:LynImported, lyn-AImported
ORF Names:XELAEV_18032028mgImported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus
Proteomesi
  • UP000186698 Componenti: Chromosome 6l

Organism-specific databases

XenbaseiXB-GENE-1015131 lyn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 99SH3InterPro annotationAdd BLAST61
Domaini105 – 202SH2InterPro annotationAdd BLAST98
Domaini223 – 477Protein kinaseInterPro annotationAdd BLAST255

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotationSAAS annotation

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

HOVERGENiHBG008761
KOiK05854

Family and domain databases

CDDicd10364 SH2_Src_Lyn, 1 hit
cd12004 SH3_Lyn, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR035852 Lyn_SH2
IPR035748 Lyn_SH3
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PF00017 SH2, 1 hit
PF00018 SH3_1, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00452 SH3DOMAIN
PR00109 TYRKINASE
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00326 SH3, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF55550 SSF55550, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS50001 SH2, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

O13064-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCIKSKTDN PRDAMGKNNP ASRTPSLLPG QKMIQDIEEQ GNIVIALYPY
60 70 80 90 100
QGIHEDDLSF KKGEKLKVLE EHGEWWKAKS LSTKKEGFIP SNYVARVNTL
110 120 130 140 150
ETEEWFFKDL TRKDAERQLL APGNNPGAFL IRESETSKGS YSLSIRDCDP
160 170 180 190 200
QTGDVIKHYK IRTLDNGGYY ISPRITFTSI NEMIQHYQKQ ADGLCRKLDK
210 220 230 240 250
PCFSPKPQKP WDKDAWEIPR ESIKMVRKLG AGQFGEVWMG FYNNSTKVAV
260 270 280 290 300
KTLKPGSMSV QAFMEEANLM KTLQHDKLVR LYAVVSKEEP IYIITEYMAK
310 320 330 340 350
GSLLDFLKSD EGGKVILPKS IDFSAQIAEG MAYIEKKNYI HRDLRAANVL
360 370 380 390 400
VSESLMCKIA DFGLARVIED NEYTAREGAK FPIKWTAPEA INFGSFTIKS
410 420 430 440 450
DVWSFGVLLY EIITFGKIPY PGMSNSDVMS ALQRGYRMPR MENCPEELYD
460 470 480
IMKQCWKEKA EERPTFDYLQ SVLDDFYTAT ETQYQQQP
Length:488
Mass (Da):55,795
Last modified:July 1, 1997 - v1
Checksum:iB7E70668B6EA92B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC170242 mRNA Translation: AAI70242.1
AB003358 mRNA Translation: BAA20078.1
CM004476 Genomic DNA Translation: OCT76824.1
RefSeqiNP_001079115.1, NM_001085646.1
XP_018121678.1, XM_018266189.1
XP_018121679.1, XM_018266190.1
UniGeneiXl.876

Genome annotation databases

GeneIDi373649
KEGGixla:373649

Similar proteinsi

Entry informationi

Entry nameiO13064_XENLA
AccessioniPrimary (citable) accession number: O13064
Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 1, 1997
Last modified: May 23, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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