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O13060 (VSPA_TRIGA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Snake venom serine protease 2A homolog
Short name=SVSP 2A
Gene names
Name:TLG2A
OrganismTrimeresurus gramineus (Bamboo pit viper) (Indian green tree viper)
Taxonomic identifier8767 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Scleroglossa › Serpentes › Colubroidea › Viperidae › Crotalinae › Trimeresurus

Protein attributes

Sequence length260 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Sequence similarities

Belongs to the peptidase S1 family. Snake venom subfamily.

Contains 1 peptidase S1 domain.

Caution

Arg-67 is present instead of the conserved His which is expected to be an active site residue.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionToxin
   PTMDisulfide bond
Glycoprotein
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 By similarity
Propeptide19 – 246 By similarity
PRO_0000028393
Chain25 – 260236Snake venom serine protease 2A homolog
PRO_0000028394

Regions

Domain25 – 251227Peptidase S1

Amino acid modifications

Glycosylation831N-linked (GlcNAc...) Potential
Glycosylation1231N-linked (GlcNAc...) Potential
Glycosylation1241N-linked (GlcNAc...) Potential
Disulfide bond31 ↔ 165 By similarity
Disulfide bond52 ↔ 68 By similarity
Disulfide bond100 ↔ 258 By similarity
Disulfide bond144 ↔ 212 By similarity
Disulfide bond176 ↔ 191 By similarity
Disulfide bond202 ↔ 227 By similarity

Sequences

Sequence LengthMass (Da)Tools
O13060 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 67C639F93E4F7100

FASTA26028,695
        10         20         30         40         50         60 
MVLIRVLANL LILQLSYAQK SSELIIGGDE CNINEHRFLV ALYTFRSRRF HCGGTLINQE 

        70         80         90        100        110        120 
WVLSAARCDR KNIRIKLGMH STNVTNEDVQ TRVPKEKFFC LSSKTYTKWN KDIMLIRLKR 

       130        140        150        160        170        180 
PVNNSTHIAP VSLPSNPPSL GSVCRVMGWG TISATKETHP DVPHCANINI LDYSVCRAAY 

       190        200        210        220        230        240 
ARLPATSRTL CAGILEGGKD TCHGDSGGPL ICNGQVQGIV SWGGHPCGQP RKPGLYTKVF 

       250        260 
DHLDWIKSII AGNKDATCPP

« Hide

References

[1]"Accelerated evolution of crotalinae snake venom gland serine proteases."
Deshimaru M., Ogawa T., Nakashima K., Nobuhisa I., Chijiwa T., Shimohigashi Y., Fukumaki Y., Niwa M., Yamashina I., Hattori S., Ohno M.
FEBS Lett. 397:83-88(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Venom gland.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D67082 mRNA. Translation: BAA19980.1.

3D structure databases

ProteinModelPortalO13060.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG013304.

Family and domain databases

InterProIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. Pept_Ser_Cys. 1 hit.
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. False negative.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameVSPA_TRIGA
AccessionPrimary (citable) accession number: O13060
Entry history
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: July 1, 1997
Last modified: April 3, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

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