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O13060

- VSPA_TRIGA

UniProt

O13060 - VSPA_TRIGA

Protein

Snake venom serine protease 2A homolog

Gene

TLG2A

Organism
Trimeresurus gramineus (Bamboo pit viper) (Indian green tree viper)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Serine protease homolog, Toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Snake venom serine protease 2A homolog
    Short name:
    SVSP 2A
    Gene namesi
    Name:TLG2A
    OrganismiTrimeresurus gramineus (Bamboo pit viper) (Indian green tree viper)
    Taxonomic identifieri8767 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeCrotalinaeTrimeresurus

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818By similarityAdd
    BLAST
    Propeptidei19 – 246By similarityPRO_0000028393
    Chaini25 – 260236Snake venom serine protease 2A homologPRO_0000028394Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi31 ↔ 165PROSITE-ProRule annotation
    Disulfide bondi52 ↔ 68PROSITE-ProRule annotation
    Glycosylationi83 – 831N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi100 ↔ 258PROSITE-ProRule annotation
    Glycosylationi123 – 1231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi124 – 1241N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi144 ↔ 212PROSITE-ProRule annotation
    Disulfide bondi176 ↔ 191PROSITE-ProRule annotation
    Disulfide bondi202 ↔ 227PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliO13060.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 251227Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family. Snake venom subfamily.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG013304.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O13060-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVLIRVLANL LILQLSYAQK SSELIIGGDE CNINEHRFLV ALYTFRSRRF    50
    HCGGTLINQE WVLSAARCDR KNIRIKLGMH STNVTNEDVQ TRVPKEKFFC 100
    LSSKTYTKWN KDIMLIRLKR PVNNSTHIAP VSLPSNPPSL GSVCRVMGWG 150
    TISATKETHP DVPHCANINI LDYSVCRAAY ARLPATSRTL CAGILEGGKD 200
    TCHGDSGGPL ICNGQVQGIV SWGGHPCGQP RKPGLYTKVF DHLDWIKSII 250
    AGNKDATCPP 260
    Length:260
    Mass (Da):28,695
    Last modified:July 1, 1997 - v1
    Checksum:i67C639F93E4F7100
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D67082 mRNA. Translation: BAA19980.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D67082 mRNA. Translation: BAA19980.1 .

    3D structure databases

    ProteinModelPortali O13060.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG013304.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Venom gland.

    Entry informationi

    Entry nameiVSPA_TRIGA
    AccessioniPrimary (citable) accession number: O13060
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 4, 2001
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Caution

    Arg-67 is present instead of the conserved His which is expected to be an active site residue.Curated

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3