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O13060

- VSPA_TRIGA

UniProt

O13060 - VSPA_TRIGA

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Protein
Snake venom serine protease 2A homolog
Gene
TLG2A
Organism
Trimeresurus gramineus (Bamboo pit viper) (Indian green tree viper)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Serine protease homolog, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Snake venom serine protease 2A homolog
Short name:
SVSP 2A
Gene namesi
Name:TLG2A
OrganismiTrimeresurus gramineus (Bamboo pit viper) (Indian green tree viper)
Taxonomic identifieri8767 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeCrotalinaeTrimeresurus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 By similarity
Add
BLAST
Propeptidei19 – 246 By similarity
PRO_0000028393
Chaini25 – 260236Snake venom serine protease 2A homolog
PRO_0000028394Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 165 By similarity
Disulfide bondi52 ↔ 68 By similarity
Glycosylationi83 – 831N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi100 ↔ 258 By similarity
Glycosylationi123 – 1231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi124 – 1241N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi144 ↔ 212 By similarity
Disulfide bondi176 ↔ 191 By similarity
Disulfide bondi202 ↔ 227 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Monomer By similarity.

Structurei

3D structure databases

ProteinModelPortaliO13060.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 251227Peptidase S1
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG013304.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O13060-1 [UniParc]FASTAAdd to Basket

« Hide

MVLIRVLANL LILQLSYAQK SSELIIGGDE CNINEHRFLV ALYTFRSRRF    50
HCGGTLINQE WVLSAARCDR KNIRIKLGMH STNVTNEDVQ TRVPKEKFFC 100
LSSKTYTKWN KDIMLIRLKR PVNNSTHIAP VSLPSNPPSL GSVCRVMGWG 150
TISATKETHP DVPHCANINI LDYSVCRAAY ARLPATSRTL CAGILEGGKD 200
TCHGDSGGPL ICNGQVQGIV SWGGHPCGQP RKPGLYTKVF DHLDWIKSII 250
AGNKDATCPP 260
Length:260
Mass (Da):28,695
Last modified:July 1, 1997 - v1
Checksum:i67C639F93E4F7100
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D67082 mRNA. Translation: BAA19980.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D67082 mRNA. Translation: BAA19980.1 .

3D structure databases

ProteinModelPortali O13060.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG013304.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Venom gland.

Entry informationi

Entry nameiVSPA_TRIGA
AccessioniPrimary (citable) accession number: O13060
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: July 1, 1997
Last modified: June 11, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Caution

Arg-67 is present instead of the conserved His which is expected to be an active site residue.

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi