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Protein
Submitted name:

Ryanodine receptor RyR1 isoform

Gene

RyR1

Organism
Makaira nigricans (Atlantic blue marlin)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Ryanodine receptor RyR1 isoformImported
Gene namesi
Name:RyR1Imported
OrganismiMakaira nigricans (Atlantic blue marlin)Imported
Taxonomic identifieri13604 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataCarangariaIstiophoriformesMakaira

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4365 – 438824HelicalSequence analysisAdd
BLAST
Transmembranei4596 – 461621HelicalSequence analysisAdd
BLAST
Transmembranei4686 – 470722HelicalSequence analysisAdd
BLAST
Transmembranei4824 – 484522HelicalSequence analysisAdd
BLAST
Transmembranei4883 – 490321HelicalSequence analysisAdd
BLAST
Transmembranei4962 – 498524HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Structurei

3D structure databases

ProteinModelPortaliO13054.
SMRiO13054. Positions 3649-3675.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini103 – 15856MIRInterPro annotationAdd
BLAST
Domaini165 – 21046MIRInterPro annotationAdd
BLAST
Domaini218 – 27356MIRInterPro annotationAdd
BLAST
Domaini279 – 32951MIRInterPro annotationAdd
BLAST
Domaini344 – 40158MIRInterPro annotationAdd
BLAST
Domaini604 – 803200B30.2/SPRYInterPro annotationAdd
BLAST
Domaini1019 – 1215197B30.2/SPRYInterPro annotationAdd
BLAST
Domaini1349 – 1562214B30.2/SPRYInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1899 – 192123Sequence analysisAdd
BLAST
Coiled coili3775 – 380228Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

HOVERGENiHBG006699.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.25.10.30. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom.
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR014821. Ins145_P3_rcpt.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR000699. RIH_dom.
IPR013333. Ryan_recept.
IPR003032. Ryanodine_rcpt.
IPR015925. Ryanodine_recept-rel.
IPR009460. Ryanrecept_TM4-6.
IPR003877. SPRY_dom.
[Graphical view]
PANTHERiPTHR13715. PTHR13715. 6 hits.
PfamiPF13833. EF-hand_8. 1 hit.
PF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF06459. RR_TM4-6. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
PF02026. RyR. 4 hits.
PF00622. SPRY. 3 hits.
[Graphical view]
PRINTSiPR00795. RYANODINER.
SMARTiSM00472. MIR. 4 hits.
SM00449. SPRY. 3 hits.
[Graphical view]
SUPFAMiSSF100909. SSF100909. 2 hits.
SSF47473. SSF47473. 1 hit.
SSF49899. SSF49899. 3 hits.
SSF82109. SSF82109. 2 hits.
PROSITEiPS50188. B302_SPRY. 3 hits.
PS50919. MIR. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O13054-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGADGEEE IQFLRTDDHV VLQCTASILK EQIKLCLSCE GFGNRLCFLE
60 70 80 90 100
TTSNAQNVPP DLAICCFILE QSLSVRALQE MLSNTSVDEA VDLDKWSSQG
110 120 130 140 150
GGHRTLLYGH AILLKHTHSS MYLSCLTTSR SLTDKLAFDV GLQEDSTGEA
160 170 180 190 200
CWWTIHPASK QRSEGEKVRV GDDLILVSVS SERYLHLSYA SGDLMVDASF
210 220 230 240 250
MQTLWTMTPV MSGCELAEGF LIGGYVLRLF HGHMDECLAI PGADQGDDQR
260 270 280 290 300
RVAHYEGGAV CSHARSLWRL EPLRIAWSGG HIKWGQSFRR HEITTGRYLC
310 320 330 340 350
LEEEKGLLLV DPEKAVSKMS AFCFRISKEK IEVTQKRDVE GMGTPEIKYG
360 370 380 390 400
ESMCFVQHAS SGLWLTYAAV DAKSARLGPL KRKAILHKEG HMDDALTVAR
410 420 430 440 450
SQTEEAQAAR MIYSTTGLFN QFIKGLDTLS GKNKSANPPS LPMDTVVLSL
460 470 480 490 500
QDLIFYFRPP GHELEHEDKQ FKLRSLKNRQ NLFQEEGMIT LVLDCVDRLN
510 520 530 540 550
VYNTAAHFSE YAGEEAAESW KEIVNLLYEL LASLIRGNRA NCALFCDNLD
560 570 580 590 600
WLVSKLDRLE ASSGILEVLY CVLIESPEVL NIIQENHIKS IISLLDKHGR
610 620 630 640 650
NHKVLDVLCS LCVCNGVAVR SNQNLITENL LPGRDLLLQT NIINYVTSMR
660 670 680 690 700
PNIFLGTCEG STQYKKWYFE VMVDQVEPFV TAQPYHLRVG WALTEGYSPY
710 720 730 740 750
PGGGEGWGGN GVGDDLYSYG FDGLHLWSGR VPRHVATPSQ HILAAEDVVS
760 770 780 790 800
CCLDLSVPSI SFRINGHPVQ GMFENFNLDG LFFPVVSFSA GVKLRFLLGG
810 820 830 840 850
RHGDFKFLPP PGYAPCYEAV LPRDRLRIEP IKEYKHDFDG IRNLLGPTQS
860 870 880 890 900
LSHTAFTPCP VDTIQIVLPP HLERIREKLA ENSHELWAVT RIEQGWTYGP
910 920 930 940 950
FRDDNKKLHP CLVDFQSLPE PEKNYNLAMS GETLKTLLAL GCHVGMGDEK
960 970 980 990 1000
AEENLKRTKL PKTYMQSSGY KPAPLDLNHV KLTPNQNTLV ERLAENGHNV
1010 1020 1030 1040 1050
WARDRVRQGW TYSIVQDILN KRNPRLVPYN LLDEKTKKTN RDTVCAAVRT
1060 1070 1080 1090 1100
LIGYGYNIEP PDQESSGHGP GSARENKIRL FRAEKSYAIT QGKWYFEFEA
1110 1120 1130 1140 1150
VTVGEMRVGW ARPSVRADTE LVADELAYVF NGFKAQRWHV GNEPFGRQWQ
1160 1170 1180 1190 1200
SGDVGGCMIA HRGMNIMFTL NGDMLISDSV SEMVYRDIEI GEGFIPVCSL
1210 1220 1230 1240 1250
GLSQVGRINL GQNVSSLRYF TICGLQEGFE PFAINMKRDI TMWFSKSLPQ
1260 1270 1280 1290 1300
FITAPTDHPH MEVSRVDGTV ETAPCLKVTH KTFGSQNANT DLLFLRLSMP
1310 1320 1330 1340 1350
VEFHETFKVP AGTTLLTRVL TIPEDEVLEV DPDSDYEILK KSASRKEQEE
1360 1370 1380 1390 1400
EKKEPSVPKD IPATKNGENE KDPQQRKQEE RFLFKAKKPA LITPPPVVPT
1410 1420 1430 1440 1450
MPRLVEDVVP DDRDDVDIIL NTTTYYYSVR VFAGQEPSGV WVGWITPDYH
1460 1470 1480 1490 1500
QYDPHFDISK VRNVTVTVGD DKGNIHDSIK RSNCYMVWGG EFSSSQQTRV
1510 1520 1530 1540 1550
SQEDFVIGCL IDLDTGLMTF TANGKEINTF YQVAPNTKLF PAVFVLPSSQ
1560 1570 1580 1590 1600
NMIQFELGKL KNIMPISAAM FRSERKNPVP QCPPRLDVQM LTPVIWSRMP
1610 1620 1630 1640 1650
NHFLTPDTGR ITERLGWVVE CQEPLTMMAL HIPEENRCID ILELSERMDL
1660 1670 1680 1690 1700
LKFHYHTLKL YGSVCALGNN RVAHALCSHV DESQLFYAIE NTYLPGPMRS
1710 1720 1730 1740 1750
GFYDLLISMH LESAKRNRLG TNKEFIVPMT DETRTITLYS DRSHALPGVG
1760 1770 1780 1790 1800
LTTCLRPKLH FSSTGFVGTD PDIYTLSPVI PLQVLKTKAL NMLTEAVQDG
1810 1820 1830 1840 1850
GQAMRDPVGG SVEFHFVPIL KLISTLLIMG VFDDEDVTHI LKMIEPTVFS
1860 1870 1880 1890 1900
GKKAEEPAEE NTKLKEEKEQ KGPPKVGPVK EEQQEAVEDE EEEYEDDGLG
1910 1920 1930 1940 1950
EEEEEEEEME EEEELEEMES IIPDEDTGNK TEPPHGEKGA EETEKEIKPV
1960 1970 1980 1990 2000
ETTGEAKEEH LEQGLFQMKL PESVKLQMCT LLQYFCDCEL RHRVEAITAF
2010 2020 2030 2040 2050
SDEFVSQIQS NQRQRYNELM LAFTMSAAET ARKTREFRSP PQEQVNMLMN
2060 2070 2080 2090 2100
LKNCSEDEEC PIPDEVRESL LAFHNALLAH SGVHIVEEEQ GEEVDNSVRG
2110 2120 2130 2140 2150
RLLRLLEKVK KFREKKVEVE PEPQEDKKPS TLQELISHTM IHWAQESFIQ
2160 2170 2180 2190 2200
NPELVRMMLS LLHRQYDGLG ELMRALPKAH TINAVSIQDT MDLLECLGQI
2210 2220 2230 2240 2250
RSLLIVLMGP EEERLMIQSI GNIMSNKVFY QNPNLMRALG MHETVMEVMV
2260 2270 2280 2290 2300
NVLGGGDSKE IRFPRVVTNC CRFLCYFCRI SRQNQRSMFD HLSYLLQNSG
2310 2320 2330 2340 2350
IGLGMRGSTP LDVAAASCID NNELALALQE QDLEMVVKYL AGCGLQSCPM
2360 2370 2380 2390 2400
LLSKGYPDIG WNPCGGEKYL DFLRFAVFVN GESVEENANV VVRLLIRRPE
2410 2420 2430 2440 2450
CFGPALRGEG GNGLLAAIEE AIKISEDPAR DGPSVKKDRR FPMFGGEEQH
2460 2470 2480 2490 2500
EENRVHLGNA IMSFYSALID LLGRCAPEMH LIQAGKGEAL RIRAILRSLV
2510 2520 2530 2540 2550
PIEDLVGVIS LPVQIPSFGK DNSIIEPKMS ASFVPDHKAP MVLFLDRVYG
2560 2570 2580 2590 2600
IDNQDFLLHV LEVGFLPDMR AAASLDTVAF STTEMALALN RYLCSAVLPL
2610 2620 2630 2640 2650
ITKCAPLFAG SDHRAIMIDS MLHTIYRLSR GRAFTKAQRD IIEECLMALC
2660 2670 2680 2690 2700
KHLRPSMLQH LLRRLVFDVP ILNEYAQMPL KLLTNHYERC WKYYCLPNGW
2710 2720 2730 2740 2750
ANFGVASEEE LYLTRKLFWG IFESLAHKKF DAEIFKISMP CICAIAGAIP
2760 2770 2780 2790 2800
PDYVDASYSS KTEKKASVDA EGNFDPKPVE TTNTIIPERL DPFINRFAEY
2810 2820 2830 2840 2850
THDKWAFEKI QNNWSYGEVL DENAKTHPML RPYKTFSEKD KEIYRWPIKE
2860 2870 2880 2890 2900
SIKAMLAWEW NIEKAREEEE SEKKKATSRK ISQTAQATYD PSHGYSPQPI
2910 2920 2930 2940 2950
DISHVALSRD LQSMAEQLAE NYHNTWGRKK KLELQAKGGG THPLLVPYDT
2960 2970 2980 2990 3000
LTAKEKARDR EKAYELLKFL QLNGYAVTRG LKDMESDISS IEKRFAYGFL
3010 3020 3030 3040 3050
QKLLKWMEIA QEFIAHLEAV VSSGRVEKSP HEQEIKFFAK ILMPLINQYF
3060 3070 3080 3090 3100
KNHCLYFLST PAKVLGSGGH SSNKEKEMIA SIFCKMSALV RHRVSLFGTD
3110 3120 3130 3140 3150
APAIVNCLHI LARSLDARTV MKSGPEIVKA GLRSFFESAA DDIEKMVENL
3160 3170 3180 3190 3200
KLGKVSKGNQ QVKGVSQNIN YTTIALLPVL TSLFDHIAQH QFGDDVILDD
3210 3220 3230 3240 3250
LQMSCYRIMC SIYSLGTVKN PHVERQRPAL GECLAHLAAA MPVAYLEPLL
3260 3270 3280 3290 3300
NEFNAFSVYT TKTPRERAIL GLPNEVQELC PDIPELDALL KEIGDLAESG
3310 3320 3330 3340 3350
ARYTEMPHVI EITLPMLCNY LPRWWERGPE NSPEMDGQLC TEVTSEHLNQ
3360 3370 3380 3390 3400
LLGSIMKIVV NNLGIDEASW MKRLAVFSQP IVSRAKPEML KSHFIPTMEK
3410 3420 3430 3440 3450
VKKRTSKVVA EEDHLRMEGK SEGDEEDGTI RDEFAVLCRD LYALYPLLIR
3460 3470 3480 3490 3500
YVDNNRARWL TCPDPDAEEL FRMVGEVFIF WSKSHNFMRE EQNFVVMNEI
3510 3520 3530 3540 3550
NNMSFLTADS KSKMSKGGDS EGGGSDTERT KKKRRGDRYS VQTSLIVAAL
3560 3570 3580 3590 3600
KKMLPIGLNM CSPADQELIN LAKIRYSLRD TDEEVREFLQ NNLHLQGKVD
3610 3620 3630 3640 3650
NPSMRWQMAL YKEMAGKAED ADAPVKVVKR VQEVSAVLYH LEVTEHPFKS
3660 3670 3680 3690 3700
KKMVWHKLLS KQRRRAVVAC FRMTPLYNIP RHRASNMFLE GYKRNWLHTE
3710 3720 3730 3740 3750
GYAFEDRMID DLSKAMEQEE GDEEEEQETK PDPLHQLILH FSRTALTEKS
3760 3770 3780 3790 3800
KLDTDHLYMA YADIMAKSCH IGEEEEGGEE MVENAEDEMS FEEKEMEKQR
3810 3820 3830 3840 3850
LLYQQSRLHN RGAAEMVLQM ISACKGDTGP MVSTTLKLGI SILNGGNSEV
3860 3870 3880 3890 3900
QRKMLEYLKD KRDVGFFLSV QALMQTCCVL DLNAFERQNK AEGLGMVSEE
3910 3920 3930 3940 3950
GTNEKVMSDD EFTCDLFRFL QLLCEGHNND FQNYLRTQTG STTTINIIIC
3960 3970 3980 3990 4000
TVDYLLRLQE SISDFYWYYS GKDVIDEPGK KNFSKAMTVA KQIFNSLTEY
4010 4020 4030 4040 4050
IQGPCTGNQQ SLAHSRLWDA IVGFLHVFGH MMMKLAQGKD SSQIGLLKEL
4060 4070 4080 4090 4100
LDLQKDMVVM LLSLLEGNVV NGTIARQMVD MLVESSSNVE MILKFFDMFL
4110 4120 4130 4140 4150
KLKDIVASDA FSDYVTDPRG LISKKDFQKA MDSQKQYSPS EIQFLLSCSE
4160 4170 4180 4190 4200
ADENDMINYE EFANRFQEPA KDIGFNIAVL LTNLSEHVPH DTRLQNFLEQ
4210 4220 4230 4240 4250
AESVLNYFRP FLGRIEIMGA SRKIERIYFE ISEVNRRQWE MPQVRESKRQ
4260 4270 4280 4290 4300
FIFDVVNEGG ESEKMEMFVN FCEDTIFEMN IASQISEQEE EEKGEEDDEI
4310 4320 4330 4340 4350
DEGGGEIGPG GGANGGGDED SNGEEGQPES SSAFADFINS MLSFFSIFTF
4360 4370 4380 4390 4400
RNLRRQYRRV RKMTFKEIAV ALTTFFWTIL MSILHFIYNV CKGFFMIIWQ
4410 4420 4430 4440 4450
TLFGGGLVEG AKNITVTEIL ASMPDPTQDD VHGDGPGEPR TGEEQDTGGV
4460 4470 4480 4490 4500
TDTGETGSGE EEEEDTQEKE GGRIPGIDAP GGLGDMGVEA PVEPPTPEGT
4510 4520 4530 4540 4550
PITKRKMQPE ETDASQKPPE PVPVEEPPQE PEKADVETGE KAEKESQSKE
4560 4570 4580 4590 4600
KEEPEEPKKS ATKKEKKLKK EGGFQIWTEL ETQRNKFMNY LSRNFYNLRF
4610 4620 4630 4640 4650
LALFLAFALN FILLFYRVSD TPPEGEEMEG SGLFEGSGMF EGSGLFEDLG
4660 4670 4680 4690 4700
EEAEGSGMDE GGDEDEEDMP VFYYLEERHC YMQPTLAFLA ILHTVISFIC
4710 4720 4730 4740 4750
IIGYNCLKIP LVIFKREKEL ARKLEFDGLY ITEQPEDDDI KGQWDRLVLN
4760 4770 4780 4790 4800
TPSFPNNCWD KFVKRKVLDK YGDIYGRERI AELLGVDLAS LDVSQQHEKK
4810 4820 4830 4840 4850
QEEPDNSVFA WVTSIDIKYQ IWKFGVVFTD GTFLYLCWYL IMSLLGHYNN
4860 4870 4880 4890 4900
FFFACHLLDI AMGVKTLRTI LSSVTHNGKQ LMMTVGLLAV VVYLYTVVAF
4910 4920 4930 4940 4950
NFFRKFYNKS EDEDEPDMKC DDMMTCYLFH MYVGVRAGGG IGDEIEDPAG
4960 4970 4980 4990 5000
DEYELYRVVF DITFFFFVIV ILLAIIQGLI IDAFGELRDQ QEQVKEDMET
5010 5020 5030 5040 5050
KCFICGIGSD YFDTTPHGFE THTLDEHNLA NYMFFLMYLI NKDETEHTGQ
5060 5070 5080
ESYVWKMYQE RCWDFFPAGD CFRKQYEDQL S
Length:5,081
Mass (Da):576,233
Last modified:July 1, 1997 - v1
Checksum:i5A3D7E253CFBC09B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U97329 mRNA. Translation: AAB58117.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U97329 mRNA. Translation: AAB58117.1.

3D structure databases

ProteinModelPortaliO13054.
SMRiO13054. Positions 3649-3675.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG006699.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.25.10.30. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom.
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR014821. Ins145_P3_rcpt.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR000699. RIH_dom.
IPR013333. Ryan_recept.
IPR003032. Ryanodine_rcpt.
IPR015925. Ryanodine_recept-rel.
IPR009460. Ryanrecept_TM4-6.
IPR003877. SPRY_dom.
[Graphical view]
PANTHERiPTHR13715. PTHR13715. 6 hits.
PfamiPF13833. EF-hand_8. 1 hit.
PF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF06459. RR_TM4-6. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
PF02026. RyR. 4 hits.
PF00622. SPRY. 3 hits.
[Graphical view]
PRINTSiPR00795. RYANODINER.
SMARTiSM00472. MIR. 4 hits.
SM00449. SPRY. 3 hits.
[Graphical view]
SUPFAMiSSF100909. SSF100909. 2 hits.
SSF47473. SSF47473. 1 hit.
SSF49899. SSF49899. 3 hits.
SSF82109. SSF82109. 2 hits.
PROSITEiPS50188. B302_SPRY. 3 hits.
PS50919. MIR. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO13054_MAKNI
AccessioniPrimary (citable) accession number: O13054
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 1, 1997
Last modified: September 7, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.