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Protein

Nodal homolog 4-A

Gene

nodal4-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cooperation and regulatory loops of multiple nodals are essential for mesendoderm patterning in early embryos. Plays a role in mesoderm formation and may be required for neural development.5 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Nodal homolog 4-A
Alternative name(s):
Nodal-related protein 4-A
Xnr-4
Xnr4
Gene namesi
Name:nodal4-a
Synonyms:nr4Imported
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-864954. nodal.

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Propeptidei19 – 278260Sequence analysisPRO_0000334505Add
BLAST
Chaini279 – 402124Nodal homolog 4-ASequence analysisPRO_0000334506Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi37 – 371N-linked (GlcNAc...)Sequence analysis
Glycosylationi238 – 2381N-linked (GlcNAc...)Sequence analysis
Disulfide bondi302 ↔ 368By similarity
Disulfide bondi331 ↔ 399By similarity
Disulfide bondi335 ↔ 401By similarity
Glycosylationi340 – 3401N-linked (GlcNAc...)Sequence analysis
Disulfide bondi367 – 367InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

During blastula stages, expressed in the endoderm at a higher level dorsally than ventrally. Expressed in the deep cells of the Spemann organizer at the gastrula stage. Expressed in the notochord (a derivative of the organizer) and neural tube during the neural stages.2 Publications

Developmental stagei

Expressed zygotically. First expressed at the midblastula transition (MBT).2 Publications

Inductioni

By dorsal-mesoderm inducing signals including vegt and other nodal-related proteins. By sox17.5 Publications

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Structurei

3D structure databases

ProteinModelPortaliO13048.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Sequence analysis

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG096160.
KOiK04666.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O13048-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLYFYCLIL LFVPGGNSLG INSYLKHMSN KPQDHVNRTK TVDSKDLAAL
60 70 80 90 100
PLSSYMLNLY QSFHHSELNH GTEGAPSLPS NHRADIIRSL AAKSFDHGGS
110 120 130 140 150
RWTLVFDFSS LSQEEEHQLA EVRFDFRAFE GAISAEMEVM VDFLHQSSSC
160 170 180 190 200
QSISGWCQSY LYVGSLTGTL RSRSSDTWVT FEATDIIHKW FERNEKGKSR
210 220 230 240 250
YEDREKQLKK LPRAKSAERR YQQQNTEDQQ IVMMVYSNIS KKERLSGTAT
260 270 280 290 300
LLQDAAHSKY LVVMPGIQTI AHTRRHRRSH IFKEHVMGMK HVPPADSSRT
310 320 330 340 350
LCRRVDFFVD FKQIGWDSWI IHPMKYNAYR CEGECPSPVN ESVKPNNHAY
360 370 380 390 400
MQSLLNYYVK GKAPEVCCVP IRMSSLSMVY YDHDDIAFQN HEGMIVEECG

CQ
Length:402
Mass (Da):46,271
Last modified:July 1, 1997 - v1
Checksum:i928B46B550443288
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79162 mRNA. Translation: AAC60127.1.
RefSeqiNP_001081816.1. NM_001088347.1.
UniGeneiXl.378.

Genome annotation databases

GeneIDi398068.
KEGGixla:398068.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79162 mRNA. Translation: AAC60127.1.
RefSeqiNP_001081816.1. NM_001088347.1.
UniGeneiXl.378.

3D structure databases

ProteinModelPortaliO13048.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi398068.
KEGGixla:398068.

Organism-specific databases

CTDi4838.
XenbaseiXB-GENE-864954. nodal.

Phylogenomic databases

HOVERGENiHBG096160.
KOiK04666.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNOD4A_XENLA
AccessioniPrimary (citable) accession number: O13048
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 1, 1997
Last modified: May 11, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.