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Protein

WD repeat and HMG-box DNA-binding protein 1

Gene

wdhd1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi1013 – 1076HMG boxPROSITE-ProRule annotationAdd BLAST64

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat and HMG-box DNA-binding protein 1
Alternative name(s):
Acidic nucleoplasmic DNA-binding protein 1
Short name:
And-1
Gene namesi
Name:wdhd1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Subcellular locationi

  • Nucleusnucleoplasm 1 Publication
  • Cytoplasm 1 Publication

  • Note: Transiently cytoplasmic during mitosis.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000513401 – 1127WD repeat and HMG-box DNA-binding protein 1Add BLAST1127

Proteomic databases

PRIDEiO13046.

Expressioni

Tissue specificityi

Found in oocytes and in various other cells.

Interactioni

Subunit structurei

Homodimer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
pola1Q9DE462EBI-3510652,EBI-3645423
tipinQ0IHI45EBI-3510652,EBI-7570880

Protein-protein interaction databases

IntActiO13046. 4 interactors.
MINTiMINT-7386302.

Structurei

3D structure databases

ProteinModelPortaliO13046.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 50WD 1Add BLAST40
Repeati52 – 91WD 2Add BLAST40
Repeati92 – 131WD 3Add BLAST40
Repeati134 – 173WD 4Add BLAST40
Repeati184 – 223WD 5Add BLAST40
Repeati228 – 267WD 6Add BLAST40
Repeati271 – 310WD 7Add BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi821 – 859Asp/Glu-rich (acidic)Add BLAST39
Compositional biasi859 – 878Glu-rich (acidic)Add BLAST20

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOVERGENiHBG074190.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
2.130.10.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR022100. Mcl1_mid.
IPR013979. TIF_beta_prop-like.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08662. eIF2A. 1 hit.
PF00505. HMG_box. 1 hit.
PF12341. Mcl1_mid. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
SM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
SSF50978. SSF50978. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O13046-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAIKKNMRY GHPEGHTDVC FDDSGNFLVT CGSDGDIRIW ESLDDDDPKS
60 70 80 90 100
ISIGEKAYSF ALKNGKVVTA ASNNAIQLHT FPDGEPDGIL TRFTTNANHV
110 120 130 140 150
VFNTDGTRIA AGSGDFLVKV LQVEDSTQQK TLRGHSAPVL SVSFDPKDIY
160 170 180 190 200
LASASCDGSV RIWKISDQTC EAVLPLLEKC NDVFNAKSIC RLAWQPKSGK
210 220 230 240 250
FVAIPVGKAV HLYDRDSLKN ICTLSDDFIT QPVNIVAWSP CGQYLVAGSV
260 270 280 290 300
DGCIVAWNIA TKACLERIKH EKGYTICALA WHPHLPQIAY TDNEGNLGLL
310 320 330 340 350
EDVCQGDVKQ PSAKVSSAET KDYDELFDGD DDEDFLNGDM IGHEGAVNDE
360 370 380 390 400
DDDDNFTALT GRPRNRGAIF DDDISSDVPS LKLVGNENPV VEDDQASSVQ
410 420 430 440 450
NFTSVASVKL SYNGPMPTPQ QKPFQSGSTP VHLMHRFMVW NSVGVIRCYN
460 470 480 490 500
DEQDNAIDVE FHDTSIHHAI HLTNSLNHTL ADVSQEAVLL ACETTEELAS
510 520 530 540 550
KLQCLHFSSW DTSKEWMVDM PKGENIQAIC LGQGWVACAT SALLIRIFSV
560 570 580 590 600
GGVQKELISL FGPVVCMASH GEQLIVVYHR GMGFDGDQCL GVQLLELGKK
610 620 630 640 650
KKQVLHGDPL PLSRKSYLSW LGFTAEGSPC YVDSEGIVRL LNRSLGDTWV
660 670 680 690 700
PICNTREHCK GKSDHYWVVG IHENPQQVRC IPCKGSRFPP TLPRPAVAVL
710 720 730 740 750
PFNLPYCQIT TEKGQMEEQY WRSQIFSNHS DYLSKHGYEC DENFKAEAQK
760 770 780 790 800
MQQELLMKMF ALSCKLEREF RCMELAEFMT QNVMNLAIKY ASRSKRLILA
810 820 830 840 850
QRLSEMALEK AAEQASAEQN EEEDEEEEDF RSRLTAGYSR TATEWGDSRA
860 870 880 890 900
KPVKQDQYEE NNEEEMEEEE KEQEEALESN TPTANPFNKS VKTPDVSESK
910 920 930 940 950
LGAILSSNQG RVNPFKVSAS QKSPAFASNS SRSTSILDNM GKFPRKPSAS
960 970 980 990 1000
GSPSTSKSDS VIIKPLAPKA KSKQGQATLF HSVQAKPIAK KTTEEKKAVP
1010 1020 1030 1040 1050
TPPKAAADIA ENKKPKTGFQ LWLDENRPSI LSENAGLDES EIIKEGMSRF
1060 1070 1080 1090 1100
RMLTSEERML WTEKAKGDYP GEDGADAKKR KRPEQENMAS NGCPQENTDS
1110 1120
GIAAAKKHKP LGQSANNKLS AFAFKKE
Length:1,127
Mass (Da):124,650
Last modified:July 1, 1997 - v1
Checksum:i4F4C4A3FC7422082
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98884 mRNA. Translation: CAA67387.1.
PIRiT30334.
UniGeneiXl.1131.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98884 mRNA. Translation: CAA67387.1.
PIRiT30334.
UniGeneiXl.1131.

3D structure databases

ProteinModelPortaliO13046.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO13046. 4 interactors.
MINTiMINT-7386302.

Proteomic databases

PRIDEiO13046.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG074190.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
2.130.10.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR022100. Mcl1_mid.
IPR013979. TIF_beta_prop-like.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08662. eIF2A. 1 hit.
PF00505. HMG_box. 1 hit.
PF12341. Mcl1_mid. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
SM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
SSF50978. SSF50978. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWDHD1_XENLA
AccessioniPrimary (citable) accession number: O13046
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2003
Last sequence update: July 1, 1997
Last modified: October 5, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.