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Protein

Hematopoietically-expressed homeobox protein hhex

Gene

hhex

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. Regulates the differentiation of both endothelial and blood cells (By similarity). Probably plays a role in the proliferation of vascular endothelial cells during blood vessel development. Establishes anterior identity at two levels; acts early to enhance canonical wnt-signaling by repressing expression of tle4, and acts later to inhibit nodal-signaling by directly targeting nodal/nr1 and nodal2/nr2. May play a role in liver development. Induces heart development.By similarity6 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi137 – 196HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: UniProtKB
  • embryonic hemopoiesis Source: UniProtKB
  • heart development Source: UniProtKB
  • liver development Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription by RNA polymerase II Source: UniProtKB
  • positive regulation of Wnt signaling pathway Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
  • vasculogenesis Source: UniProtKB
  • Wnt signaling pathway Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processTranscription, Transcription regulation, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Hematopoietically-expressed homeobox protein hhex
Short name:
Homeobox protein hex
Short name:
XHex
Alternative name(s):
Hhex-A protein
Gene namesi
Name:hhexBy similarity
Synonyms:hex1 Publication, hhex-a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-865680 hhex

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003262201 – 272Hematopoietically-expressed homeobox protein hhexAdd BLAST272

Expressioni

Tissue specificityi

First expressed in the dorsal endomesoderm of the gastrula stage embryo. The dorsal endomesoderm contributes to forming the embryonic liver, and expression continues in the liver throughout development. Also expressed in precursors of the developing thyroid gland, and beginning at the tailbud stage, expressed in the ventral region of the head. Also transiently expressed in the endothelial layer of developing vascular tissues of the embryo, beginning at the tailbud stages.4 Publications

Developmental stagei

Expressed zygotically. During gastrulation, expression levels rise rapidly to peak at about stage 10.5. Following gastrulation, levels decrease slightly and then increase again during early tailbud stages, with expression continuing throughout embryonic development.1 Publication

Inductioni

By maternal wnt-beta-catenin signaling and tgf-beta signaling.2 Publications

Structurei

3D structure databases

ProteinModelPortaliO13023
SMRiO13023
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG055460
KOiK08024

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

O13023-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQYQHPSSSA LGLSVPLFAP TPLQHPTPFY IDDILGRNSA SNGTPALPTP
60 70 80 90 100
TLPSPNSSFT SLVATYRTPI YEPTPIHPAF THPGAALAAS YGASTYASPL
110 120 130 140 150
YPFSRPVSDY THALIRHDSL GKPLLWSPFI QRPLHKRKGG QVRFSNDQTI
160 170 180 190 200
ELEKKFETQK YLSPPERKRL AKMLQLSERQ VKTWFQNRRA KWRRLKQENP
210 220 230 240 250
QGNKKDETES LENICEESQE RCLSAEQKSR ESSLDDPTSS PTSQGNLDSE
260 270
VSDDSDQEVD IEGDKGYYNC AH
Length:272
Mass (Da):30,576
Last modified:July 1, 1997 - v1
Checksum:i15FC2FDBBCAFFF6E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94837 mRNA Translation: AAB82335.1
BC059320 mRNA Translation: AAH59320.1
RefSeqiNP_001079059.1, NM_001085590.1
UniGeneiXl.225

Genome annotation databases

GeneIDi373590
KEGGixla:373590

Similar proteinsi

Entry informationi

Entry nameiHHEX_XENLA
AccessioniPrimary (citable) accession number: O13023
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 1, 1997
Last modified: March 28, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health