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Protein

Hematopoietically-expressed homeobox protein hhex

Gene

hhex

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. Regulates the differentiation of both endothelial and blood cells (By similarity). Probably plays a role in the proliferation of vascular endothelial cells during blood vessel development. Establishes anterior identity at two levels; acts early to enhance canonical wnt-signaling by repressing expression of tle4, and acts later to inhibit nodal-signaling by directly targeting nodal/nr1 and nodal2/nr2. May play a role in liver development. Induces heart development.By similarity6 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi137 – 19660HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: UniProtKB
  • embryonic hemopoiesis Source: UniProtKB
  • heart development Source: UniProtKB
  • liver development Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • positive regulation of Wnt signaling pathway Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
  • vasculogenesis Source: UniProtKB
  • Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation, Wnt signaling pathway

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hematopoietically-expressed homeobox protein hhex
Short name:
Homeobox protein hex
Short name:
XHex
Alternative name(s):
Hhex-A protein
Gene namesi
Name:hhexBy similarity
Synonyms:hex1 Publication, hhex-a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-865680. hhex.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 272272Hematopoietically-expressed homeobox protein hhexPRO_0000326220Add
BLAST

Expressioni

Tissue specificityi

First expressed in the dorsal endomesoderm of the gastrula stage embryo. The dorsal endomesoderm contributes to forming the embryonic liver, and expression continues in the liver throughout development. Also expressed in precursors of the developing thyroid gland, and beginning at the tailbud stage, expressed in the ventral region of the head. Also transiently expressed in the endothelial layer of developing vascular tissues of the embryo, beginning at the tailbud stages.4 Publications

Developmental stagei

Expressed zygotically. During gastrulation, expression levels rise rapidly to peak at about stage 10.5. Following gastrulation, levels decrease slightly and then increase again during early tailbud stages, with expression continuing throughout embryonic development.1 Publication

Inductioni

By maternal wnt-beta-catenin signaling and tgf-beta signaling.2 Publications

Structurei

3D structure databases

ProteinModelPortaliO13023.
SMRiO13023. Positions 141-194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG055460.
KOiK08024.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O13023-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQYQHPSSSA LGLSVPLFAP TPLQHPTPFY IDDILGRNSA SNGTPALPTP
60 70 80 90 100
TLPSPNSSFT SLVATYRTPI YEPTPIHPAF THPGAALAAS YGASTYASPL
110 120 130 140 150
YPFSRPVSDY THALIRHDSL GKPLLWSPFI QRPLHKRKGG QVRFSNDQTI
160 170 180 190 200
ELEKKFETQK YLSPPERKRL AKMLQLSERQ VKTWFQNRRA KWRRLKQENP
210 220 230 240 250
QGNKKDETES LENICEESQE RCLSAEQKSR ESSLDDPTSS PTSQGNLDSE
260 270
VSDDSDQEVD IEGDKGYYNC AH
Length:272
Mass (Da):30,576
Last modified:July 1, 1997 - v1
Checksum:i15FC2FDBBCAFFF6E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94837 mRNA. Translation: AAB82335.1.
BC059320 mRNA. Translation: AAH59320.1.
RefSeqiNP_001079059.1. NM_001085590.1.
UniGeneiXl.225.

Genome annotation databases

GeneIDi373590.
KEGGixla:373590.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94837 mRNA. Translation: AAB82335.1.
BC059320 mRNA. Translation: AAH59320.1.
RefSeqiNP_001079059.1. NM_001085590.1.
UniGeneiXl.225.

3D structure databases

ProteinModelPortaliO13023.
SMRiO13023. Positions 141-194.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi373590.
KEGGixla:373590.

Organism-specific databases

CTDi3087.
XenbaseiXB-GENE-865680. hhex.

Phylogenomic databases

HOVERGENiHBG055460.
KOiK08024.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHHEX_XENLA
AccessioniPrimary (citable) accession number: O13023
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 1, 1997
Last modified: October 14, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.