ID   O13021_XENLA            Unreviewed;       189 AA.
AC   O13021;
DT   01-JUL-1997, integrated into UniProtKB/TrEMBL.
DT   01-JUL-1997, sequence version 1.
DT   27-MAR-2024, entry version 121.
DE   RecName: Full=small monomeric GTPase {ECO:0000256|ARBA:ARBA00011984};
DE            EC=3.6.5.2 {ECO:0000256|ARBA:ARBA00011984};
GN   Name=K-ras {ECO:0000313|EMBL:CAA73253.1};
GN   Synonyms=LOC100505423 {ECO:0000313|RefSeq:XP_041440772.1};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355 {ECO:0000313|EMBL:CAA73253.1};
RN   [1] {ECO:0000313|EMBL:CAA73253.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Kidney {ECO:0000313|EMBL:CAA73253.1};
RX   PubMed=9178633; DOI=10.1007/s004240050403;
RA   Spindler B., Mastroberardino L., Custer M., Verrey F.;
RT   "Characterization of early aldosterone-induced RNAs identified in A6 kidney
RT   epithelia.";
RL   Pflugers Arch. 434:323-331(1997).
RN   [2] {ECO:0000313|RefSeq:XP_041440772.1}
RP   IDENTIFICATION.
RC   STRAIN=J_2021 {ECO:0000313|RefSeq:XP_041440772.1};
RC   TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_041440772.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00023421};
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004342};
CC       Lipid-anchor {ECO:0000256|ARBA:ARBA00004342}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004342}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004423}; Lipid-anchor
CC       {ECO:0000256|ARBA:ARBA00004423}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004423}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Ras family.
CC       {ECO:0000256|ARBA:ARBA00008344}.
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DR   EMBL; Y12715; CAA73253.1; -; mRNA.
DR   RefSeq; NP_001084379.1; NM_001090910.1.
DR   RefSeq; XP_041440772.1; XM_041584838.1.
DR   AGR; Xenbase:XB-GENE-494552; -.
DR   AGR; Xenbase:XB-GENE-6252869; -.
DR   OrthoDB; 8685at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 399470; Expressed in gastrula and 19 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd04138; H_N_K_Ras_like; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   InterPro; IPR020849; Small_GTPase_Ras-type.
DR   NCBIfam; TIGR00231; small_GTP; 1.
DR   PANTHER; PTHR24070:SF388; GTPASE KRAS; 1.
DR   PANTHER; PTHR24070; RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY; 1.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00449; RASTRNSFRMNG.
DR   SMART; SM00175; RAB; 1.
DR   SMART; SM00173; RAS; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51419; RAB; 1.
DR   PROSITE; PS51421; RAS; 1.
DR   PROSITE; PS51420; RHO; 1.
PE   2: Evidence at transcript level;
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Prenylation {ECO:0000256|ARBA:ARBA00023289};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186698}.
SQ   SEQUENCE   189 AA;  21733 MW;  4442EC2DB0A535F9 CRC64;
     MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET CLLDILDTAG
     QEEYSAMRDQ YMRTGEGFLC VFAINNIKSF EDIHHYREQI KRVKDSEDVP MVLVGNKCDL
     PSRTVDTKQA QDLARSYGIP FIETSAKTRQ RVEDAFYTLV REIRQFRLKK MSKEEKTPGC
     VKFKKCRVM
//