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O13016

- PTN1_CHICK

UniProt

O13016 - PTN1_CHICK

Protein

Tyrosine-protein phosphatase non-receptor type 1

Gene

PTPN1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET By similarity.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei181 – 1811SubstrateBy similarity
    Active sitei215 – 2151Phosphocysteine intermediatePROSITE-ProRule annotation
    Binding sitei262 – 2621SubstrateBy similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. protein tyrosine phosphatase activity Source: UniProtKB

    GO - Biological processi

    1. actin cytoskeleton reorganization Source: UniProtKB
    2. endoplasmic reticulum unfolded protein response Source: UniProtKB
    3. peptidyl-tyrosine dephosphorylation Source: UniProtKB
    4. regulation of endocytosis Source: UniProtKB
    5. regulation of signal transduction Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Enzyme and pathway databases

    ReactomeiREACT_197455. Growth hormone receptor signaling.
    REACT_197530. Regulation of IFNA signaling.
    REACT_197538. Regulation of IFNG signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 1 (EC:3.1.3.48)
    Alternative name(s):
    CPTP1
    Protein-tyrosine phosphatase 1B
    Short name:
    PTP-1B
    Gene namesi
    Name:PTPN1
    Synonyms:PTP1B
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 20

    Subcellular locationi

    GO - Cellular componenti

    1. early endosome Source: UniProtKB
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 434434Tyrosine-protein phosphatase non-receptor type 1PRO_0000094751Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei50 – 501PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylated on serine and threonine residues near the N-terminus by casein kinase II (CK2).

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiO13016.
    PRIDEiO13016.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CDH2P1028810EBI-6938259,EBI-985728

    Protein-protein interaction databases

    BioGridi675966. 3 interactions.
    IntActiO13016. 7 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliO13016.
    SMRiO13016. Positions 1-299.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 277275Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni215 – 2217Substrate bindingBy similarity

    Sequence similaritiesi

    Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5599.
    GeneTreeiENSGT00750000117312.
    HOGENOMiHOG000273908.
    HOVERGENiHBG008321.
    InParanoidiO13016.
    KOiK05696.
    OMAiMCMATVL.
    OrthoDBiEOG7RV9G4.
    PhylomeDBiO13016.
    TreeFamiTF315897.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR029021. Prot-tyrosine_phosphatase-like.
    IPR012265. Ptpn1/Ptpn2.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00102. Y_phosphatase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000926. Tyr-Ptase_nr1. 1 hit.
    PRINTSiPR00700. PRTYPHPHTASE.
    SMARTiSM00194. PTPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O13016-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEIEKEFHRL DQAASWAAIY QDIRHEASDF PCKVAKHPRN KNRNRYRDVS    50
    PFDHSRIKLN QGDNDYINAS LIKMEEAQRS YILTQGPLPN TCGHFWEMVW 100
    EQKSRGVVML NRVMEKGSIK CAQYWPRKEE KEMFFEDTNL KLTLISEDIK 150
    SYYTVRQLEL ENLTTQETRE ILHFHYTTWP DFGVPESPAS FLNFLFKVRE 200
    SGSLNPEYGP VVVHCSAGIG RSGTFCLVDT CLLLMDKRKD PSSVDVKQVL 250
    LEMRKYRMGL IQTADQLRFS YLAVIEGAKF IMGDASVQEQ WKELSNEDLD 300
    PPPEHTPPPP RPPKRTSEMH NGRMHEHAEF FPKHQVVEEE IRCSVSTAEE 350
    TVSDGRVFSS VPLITDSTSQ DTEIRRRTVG ENLHVTAHKE ESKSESVEED 400
    DENMMTTWKP FLVNICMFTF LTAGAYLCYR VCFH 434
    Length:434
    Mass (Da):50,334
    Last modified:July 1, 1997 - v1
    Checksum:i0FF340B2333CC311
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti14 – 141A → R in AAA91186. 1 PublicationCurated
    Sequence conflicti62 – 632GD → RC in AAA91186. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U86410 mRNA. Translation: AAB53270.1.
    U46662 mRNA. Translation: AAA91186.1.
    PIRiJW0049.
    RefSeqiNP_990206.1. NM_204875.1.
    UniGeneiGga.4404.

    Genome annotation databases

    EnsembliENSGALT00000013001; ENSGALP00000012986; ENSGALG00000008010.
    GeneIDi395688.
    KEGGigga:395688.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U86410 mRNA. Translation: AAB53270.1 .
    U46662 mRNA. Translation: AAA91186.1 .
    PIRi JW0049.
    RefSeqi NP_990206.1. NM_204875.1.
    UniGenei Gga.4404.

    3D structure databases

    ProteinModelPortali O13016.
    SMRi O13016. Positions 1-299.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 675966. 3 interactions.
    IntActi O13016. 7 interactions.

    Proteomic databases

    PaxDbi O13016.
    PRIDEi O13016.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000013001 ; ENSGALP00000012986 ; ENSGALG00000008010 .
    GeneIDi 395688.
    KEGGi gga:395688.

    Organism-specific databases

    CTDi 5770.

    Phylogenomic databases

    eggNOGi COG5599.
    GeneTreei ENSGT00750000117312.
    HOGENOMi HOG000273908.
    HOVERGENi HBG008321.
    InParanoidi O13016.
    KOi K05696.
    OMAi MCMATVL.
    OrthoDBi EOG7RV9G4.
    PhylomeDBi O13016.
    TreeFami TF315897.

    Enzyme and pathway databases

    Reactomei REACT_197455. Growth hormone receptor signaling.
    REACT_197530. Regulation of IFNA signaling.
    REACT_197538. Regulation of IFNG signaling.

    Miscellaneous databases

    NextBioi 20815760.
    PROi O13016.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR029021. Prot-tyrosine_phosphatase-like.
    IPR012265. Ptpn1/Ptpn2.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00102. Y_phosphatase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000926. Tyr-Ptase_nr1. 1 hit.
    PRINTSi PR00700. PRTYPHPHTASE.
    SMARTi SM00194. PTPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Regulated binding of PTP1B-like phosphatase to N-cadherin: control of cadherin-mediated adhesion by dephosphorylation of beta-catenin."
      Balsamo J., Leung T., Ernst H., Zanin M.K., Hoffman S., Lilien J.
      J. Cell Biol. 134:801-813(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Retina.
    2. "Multiple phosphorylation of chicken protein tyrosine phosphatase 1 and human protein tyrosine phosphatase 1B by casein kinase II and p60c-src in vitro."
      Jung E.J., Kang Y.-S., Kim C.W.
      Biochem. Biophys. Res. Commun. 246:238-242(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Cloning and characterization of a chicken protein tyrosine phosphatase, CPTP1."
      Kim C.W., Jung E.J., Kang Y.-S.
      Exp. Mol. Med. 28:207-213(1996)
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 14-369.
      Tissue: Intestine.

    Entry informationi

    Entry nameiPTN1_CHICK
    AccessioniPrimary (citable) accession number: O13016
    Secondary accession number(s): Q90704
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3