Tyrosine-protein phosphatase non-receptor type 1

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O13016 (PTN1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 99. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Tyrosine-protein phosphatase non-receptor type 1
EC=3.1.3.48

Alternative name(s):
CPTP1
Protein-tyrosine phosphatase 1B
Short name=PTP-1B

Gene names

Name:	PTPN1
Synonyms:	PTP1B

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	434 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion By similarity.
Catalytic activity	Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate.
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side By similarity.
Post-translational modification	Phosphorylated on serine and threonine residues near the N-terminus by casein kinase II (CK2).
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily. Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Molecular function	Hydrolase Protein phosphatase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	actin cytoskeleton reorganization Inferred from sequence or structural similarity. Source: UniProtKB endoplasmic reticulum unfolded protein response Inferred from sequence or structural similarity. Source: UniProtKB insulin receptor signaling pathway Inferred from electronic annotation. Source: Compara regulation of endocytosis Inferred from sequence or structural similarity. Source: UniProtKB regulation of signal transduction Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	early endosome Inferred from sequence or structural similarity. Source: UniProtKB endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: Compara
Molecular_function	protein tyrosine phosphatase activity Inferred from sequence or structural similarity. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 434

434

Tyrosine-protein phosphatase non-receptor type 1

PRO_0000094751

Regions

Domain

3 – 277

275

Tyrosine-protein phosphatase

Region

215 – 221

Substrate binding By similarity

Sites

Active site

215

Phosphocysteine intermediate By similarity

Binding site

181

Substrate By similarity

Binding site

262

Substrate By similarity

Amino acid modifications

Modified residue

Phosphoserine By similarity

Experimental info

Sequence conflict

A → R in AAA91186. Ref.3

Sequence conflict

62 – 63

GD → RC in AAA91186. Ref.3

Sequences

Sequence

Length

Mass (Da)

Tools

O13016 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 0FF340B2333CC311
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FASTA

434

50,334

        10         20         30         40         50         60 
MEIEKEFHRL DQAASWAAIY QDIRHEASDF PCKVAKHPRN KNRNRYRDVS PFDHSRIKLN 

        70         80         90        100        110        120 
QGDNDYINAS LIKMEEAQRS YILTQGPLPN TCGHFWEMVW EQKSRGVVML NRVMEKGSIK 

       130        140        150        160        170        180 
CAQYWPRKEE KEMFFEDTNL KLTLISEDIK SYYTVRQLEL ENLTTQETRE ILHFHYTTWP 

       190        200        210        220        230        240 
DFGVPESPAS FLNFLFKVRE SGSLNPEYGP VVVHCSAGIG RSGTFCLVDT CLLLMDKRKD 

       250        260        270        280        290        300 
PSSVDVKQVL LEMRKYRMGL IQTADQLRFS YLAVIEGAKF IMGDASVQEQ WKELSNEDLD 

       310        320        330        340        350        360 
PPPEHTPPPP RPPKRTSEMH NGRMHEHAEF FPKHQVVEEE IRCSVSTAEE TVSDGRVFSS 

       370        380        390        400        410        420 
VPLITDSTSQ DTEIRRRTVG ENLHVTAHKE ESKSESVEED DENMMTTWKP FLVNICMFTF 

       430 
LTAGAYLCYR VCFH

« Hide

References

[1]	"Regulated binding of PTP1B-like phosphatase to N-cadherin: control of cadherin-mediated adhesion by dephosphorylation of beta-catenin." Balsamo J., Leung T., Ernst H., Zanin M.K., Hoffman S., Lilien J. J. Cell Biol. 134:801-813(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Retina.
[2]	"Multiple phosphorylation of chicken protein tyrosine phosphatase 1 and human protein tyrosine phosphatase 1B by casein kinase II and p60c-src in vitro." Jung E.J., Kang Y.-S., Kim C.W. Biochem. Biophys. Res. Commun. 246:238-242(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Cloning and characterization of a chicken protein tyrosine phosphatase, CPTP1." Kim C.W., Jung E.J., Kang Y.-S. Exp. Mol. Med. 28:207-213(1996) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 14-369. Tissue: Intestine.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U86410 mRNA. Translation: AAB53270.1. U46662 mRNA. Translation: AAA91186.1.
IPI	IPI00581788.
PIR	JW0049.
RefSeq	NP_990206.1. NM_204875.1.
UniGene	Gga.4404.
3D structure databases
ProteinModelPortal	O13016.
SMR	O13016. Positions 1-299.
ModBase	Search...
Proteomic databases
PaxDb	O13016.
PRIDE	O13016.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSGALT00000013001; ENSGALP00000012986; ENSGALG00000008010.
GeneID	395688.
KEGG	gga:395688.
Organism-specific databases
CTD	5770.
Phylogenomic databases
eggNOG	COG5599.
GeneTree	ENSGT00700000104092.
HOGENOM	HOG000273908.
HOVERGEN	HBG008321.
InParanoid	O13016.
KO	K05696.
OMA	DGPIKEE.
OrthoDB	EOG418BND.
Gene expression databases
ArrayExpress	O13016.
Family and domain databases
InterPro	IPR012265. Ptpn1/Ptpn2. IPR000387. Tyr/Dual-sp_Pase. IPR016130. Tyr_Pase_AS. IPR000242. Tyr_Pase_rcpt/non-rcpt. [Graphical view]
PANTHER	PTHR19134:SF57. PTHR19134:SF57. 1 hit.
Pfam	PF00102. Y_phosphatase. 1 hit. [Graphical view]
PIRSF	PIRSF000926. Tyr-Ptase_nr1. 1 hit.
PRINTS	PR00700. PRTYPHPHTASE.
SMART	SM00194. PTPc. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50055. TYR_PHOSPHATASE_PTP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20815760.

Entry information

Entry name

PTN1_CHICK

Accession

Primary (citable) accession number: O13016
Secondary accession number(s): Q90704

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	July 1, 1997
Last modified:	May 29, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents