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Protein

Tyrosine-protein phosphatase non-receptor type 1

Gene

PTPN1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei181 – 1811SubstrateBy similarity
Active sitei215 – 2151Phosphocysteine intermediatePROSITE-ProRule annotation
Binding sitei262 – 2621SubstrateBy similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB

GO - Biological processi

  1. actin cytoskeleton reorganization Source: UniProtKB
  2. endoplasmic reticulum unfolded protein response Source: UniProtKB
  3. peptidyl-tyrosine dephosphorylation Source: UniProtKB
  4. regulation of endocytosis Source: UniProtKB
  5. regulation of signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiREACT_197455. Growth hormone receptor signaling.
REACT_197530. Regulation of IFNA signaling.
REACT_197538. Regulation of IFNG signaling.
REACT_257604. Integrin alphaIIb beta3 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 1 (EC:3.1.3.48)
Alternative name(s):
CPTP1
Protein-tyrosine phosphatase 1B
Short name:
PTP-1B
Gene namesi
Name:PTPN1
Synonyms:PTP1B
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 20

Subcellular locationi

GO - Cellular componenti

  1. early endosome Source: UniProtKB
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Tyrosine-protein phosphatase non-receptor type 1PRO_0000094751Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei50 – 501PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated on serine and threonine residues near the N-terminus by casein kinase II (CK2).

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO13016.
PRIDEiO13016.

Expressioni

Gene expression databases

ExpressionAtlasiO13016. baseline.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CDH2P1028810EBI-6938259,EBI-985728

Protein-protein interaction databases

BioGridi675966. 3 interactions.
IntActiO13016. 7 interactions.

Structurei

3D structure databases

ProteinModelPortaliO13016.
SMRiO13016. Positions 1-299.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 277275Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni215 – 2217Substrate bindingBy similarity

Sequence similaritiesi

Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00770000120452.
HOGENOMiHOG000273908.
HOVERGENiHBG008321.
InParanoidiO13016.
KOiK05696.
OrthoDBiEOG7RV9G4.
PhylomeDBiO13016.
TreeFamiTF315897.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR012265. Ptpn1/Ptpn2.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF000926. Tyr-Ptase_nr1. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O13016-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIEKEFHRL DQAASWAAIY QDIRHEASDF PCKVAKHPRN KNRNRYRDVS
60 70 80 90 100
PFDHSRIKLN QGDNDYINAS LIKMEEAQRS YILTQGPLPN TCGHFWEMVW
110 120 130 140 150
EQKSRGVVML NRVMEKGSIK CAQYWPRKEE KEMFFEDTNL KLTLISEDIK
160 170 180 190 200
SYYTVRQLEL ENLTTQETRE ILHFHYTTWP DFGVPESPAS FLNFLFKVRE
210 220 230 240 250
SGSLNPEYGP VVVHCSAGIG RSGTFCLVDT CLLLMDKRKD PSSVDVKQVL
260 270 280 290 300
LEMRKYRMGL IQTADQLRFS YLAVIEGAKF IMGDASVQEQ WKELSNEDLD
310 320 330 340 350
PPPEHTPPPP RPPKRTSEMH NGRMHEHAEF FPKHQVVEEE IRCSVSTAEE
360 370 380 390 400
TVSDGRVFSS VPLITDSTSQ DTEIRRRTVG ENLHVTAHKE ESKSESVEED
410 420 430
DENMMTTWKP FLVNICMFTF LTAGAYLCYR VCFH
Length:434
Mass (Da):50,334
Last modified:July 1, 1997 - v1
Checksum:i0FF340B2333CC311
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 141A → R in AAA91186 (Ref. 3) Curated
Sequence conflicti62 – 632GD → RC in AAA91186 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U86410 mRNA. Translation: AAB53270.1.
U46662 mRNA. Translation: AAA91186.1.
PIRiJW0049.
RefSeqiNP_990206.1. NM_204875.1.
UniGeneiGga.4404.

Genome annotation databases

EnsembliENSGALT00000013001; ENSGALP00000012986; ENSGALG00000008010.
GeneIDi395688.
KEGGigga:395688.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U86410 mRNA. Translation: AAB53270.1.
U46662 mRNA. Translation: AAA91186.1.
PIRiJW0049.
RefSeqiNP_990206.1. NM_204875.1.
UniGeneiGga.4404.

3D structure databases

ProteinModelPortaliO13016.
SMRiO13016. Positions 1-299.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi675966. 3 interactions.
IntActiO13016. 7 interactions.

Proteomic databases

PaxDbiO13016.
PRIDEiO13016.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000013001; ENSGALP00000012986; ENSGALG00000008010.
GeneIDi395688.
KEGGigga:395688.

Organism-specific databases

CTDi5770.

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00770000120452.
HOGENOMiHOG000273908.
HOVERGENiHBG008321.
InParanoidiO13016.
KOiK05696.
OrthoDBiEOG7RV9G4.
PhylomeDBiO13016.
TreeFamiTF315897.

Enzyme and pathway databases

ReactomeiREACT_197455. Growth hormone receptor signaling.
REACT_197530. Regulation of IFNA signaling.
REACT_197538. Regulation of IFNG signaling.
REACT_257604. Integrin alphaIIb beta3 signaling.

Miscellaneous databases

NextBioi20815760.
PROiO13016.

Gene expression databases

ExpressionAtlasiO13016. baseline.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR012265. Ptpn1/Ptpn2.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF000926. Tyr-Ptase_nr1. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Regulated binding of PTP1B-like phosphatase to N-cadherin: control of cadherin-mediated adhesion by dephosphorylation of beta-catenin."
    Balsamo J., Leung T., Ernst H., Zanin M.K., Hoffman S., Lilien J.
    J. Cell Biol. 134:801-813(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Retina.
  2. "Multiple phosphorylation of chicken protein tyrosine phosphatase 1 and human protein tyrosine phosphatase 1B by casein kinase II and p60c-src in vitro."
    Jung E.J., Kang Y.-S., Kim C.W.
    Biochem. Biophys. Res. Commun. 246:238-242(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cloning and characterization of a chicken protein tyrosine phosphatase, CPTP1."
    Kim C.W., Jung E.J., Kang Y.-S.
    Exp. Mol. Med. 28:207-213(1996)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 14-369.
    Tissue: Intestine.

Entry informationi

Entry nameiPTN1_CHICK
AccessioniPrimary (citable) accession number: O13016
Secondary accession number(s): Q90704
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 1, 1997
Last modified: February 4, 2015
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.