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O13016 (PTN1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein phosphatase non-receptor type 1

EC=3.1.3.48
Alternative name(s):
CPTP1
Protein-tyrosine phosphatase 1B
Short name=PTP-1B
Gene names
Name:PTPN1
Synonyms:PTP1B
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length434 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side By similarity.

Post-translational modification

Phosphorylated on serine and threonine residues near the N-terminus by casein kinase II (CK2).

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.

Contains 1 tyrosine-protein phosphatase domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CDH2P1028810EBI-6938259,EBI-985728

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 434434Tyrosine-protein phosphatase non-receptor type 1
PRO_0000094751

Regions

Domain3 – 277275Tyrosine-protein phosphatase
Region215 – 2217Substrate binding By similarity

Sites

Active site2151Phosphocysteine intermediate By similarity
Binding site1811Substrate By similarity
Binding site2621Substrate By similarity

Amino acid modifications

Modified residue501Phosphoserine By similarity

Experimental info

Sequence conflict141A → R in AAA91186. Ref.3
Sequence conflict62 – 632GD → RC in AAA91186. Ref.3

Sequences

Sequence LengthMass (Da)Tools
O13016 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 0FF340B2333CC311

FASTA43450,334
        10         20         30         40         50         60 
MEIEKEFHRL DQAASWAAIY QDIRHEASDF PCKVAKHPRN KNRNRYRDVS PFDHSRIKLN 

        70         80         90        100        110        120 
QGDNDYINAS LIKMEEAQRS YILTQGPLPN TCGHFWEMVW EQKSRGVVML NRVMEKGSIK 

       130        140        150        160        170        180 
CAQYWPRKEE KEMFFEDTNL KLTLISEDIK SYYTVRQLEL ENLTTQETRE ILHFHYTTWP 

       190        200        210        220        230        240 
DFGVPESPAS FLNFLFKVRE SGSLNPEYGP VVVHCSAGIG RSGTFCLVDT CLLLMDKRKD 

       250        260        270        280        290        300 
PSSVDVKQVL LEMRKYRMGL IQTADQLRFS YLAVIEGAKF IMGDASVQEQ WKELSNEDLD 

       310        320        330        340        350        360 
PPPEHTPPPP RPPKRTSEMH NGRMHEHAEF FPKHQVVEEE IRCSVSTAEE TVSDGRVFSS 

       370        380        390        400        410        420 
VPLITDSTSQ DTEIRRRTVG ENLHVTAHKE ESKSESVEED DENMMTTWKP FLVNICMFTF 

       430 
LTAGAYLCYR VCFH 

« Hide

References

[1]"Regulated binding of PTP1B-like phosphatase to N-cadherin: control of cadherin-mediated adhesion by dephosphorylation of beta-catenin."
Balsamo J., Leung T., Ernst H., Zanin M.K., Hoffman S., Lilien J.
J. Cell Biol. 134:801-813(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Retina.
[2]"Multiple phosphorylation of chicken protein tyrosine phosphatase 1 and human protein tyrosine phosphatase 1B by casein kinase II and p60c-src in vitro."
Jung E.J., Kang Y.-S., Kim C.W.
Biochem. Biophys. Res. Commun. 246:238-242(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Cloning and characterization of a chicken protein tyrosine phosphatase, CPTP1."
Kim C.W., Jung E.J., Kang Y.-S.
Exp. Mol. Med. 28:207-213(1996)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 14-369.
Tissue: Intestine.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U86410 mRNA. Translation: AAB53270.1.
U46662 mRNA. Translation: AAA91186.1.
PIRJW0049.
RefSeqNP_990206.1. NM_204875.1.
UniGeneGga.4404.

3D structure databases

ProteinModelPortalO13016.
SMRO13016. Positions 1-299.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid675966. 3 interactions.
IntActO13016. 7 interactions.

Proteomic databases

PaxDbO13016.
PRIDEO13016.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000013001; ENSGALP00000012986; ENSGALG00000008010.
GeneID395688.
KEGGgga:395688.

Organism-specific databases

CTD5770.

Phylogenomic databases

eggNOGCOG5599.
GeneTreeENSGT00750000117312.
HOGENOMHOG000273908.
HOVERGENHBG008321.
InParanoidO13016.
KOK05696.
OMAMCMATVL.
OrthoDBEOG7RV9G4.
PhylomeDBO13016.
TreeFamTF315897.

Family and domain databases

Gene3D3.90.190.10. 1 hit.
InterProIPR029021. Prot-tyrosine_phosphatase-like.
IPR012265. Ptpn1/Ptpn2.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFPIRSF000926. Tyr-Ptase_nr1. 1 hit.
PRINTSPR00700. PRTYPHPHTASE.
SMARTSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMSSF52799. SSF52799. 1 hit.
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20815760.
PROO13016.

Entry information

Entry namePTN1_CHICK
AccessionPrimary (citable) accession number: O13016
Secondary accession number(s): Q90704
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 1, 1997
Last modified: June 11, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families