SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O13016

- PTN1_CHICK

UniProt

O13016 - PTN1_CHICK

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Tyrosine-protein phosphatase non-receptor type 1
Gene
PTPN1, PTP1B
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET By similarity.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei181 – 1811Substrate By similarity
Active sitei215 – 2151Phosphocysteine intermediate By similarity
Binding sitei262 – 2621Substrate By similarity

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. protein tyrosine phosphatase activity Source: UniProtKB

GO - Biological processi

  1. actin cytoskeleton reorganization Source: UniProtKB
  2. endoplasmic reticulum unfolded protein response Source: UniProtKB
  3. peptidyl-tyrosine dephosphorylation Source: UniProtKB
  4. regulation of endocytosis Source: UniProtKB
  5. regulation of signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiREACT_197455. Growth hormone receptor signaling.
REACT_197530. Regulation of IFNA signaling.
REACT_197538. Regulation of IFNG signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 1 (EC:3.1.3.48)
Alternative name(s):
CPTP1
Protein-tyrosine phosphatase 1B
Short name:
PTP-1B
Gene namesi
Name:PTPN1
Synonyms:PTP1B
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 20

Subcellular locationi

GO - Cellular componenti

  1. early endosome Source: UniProtKB
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Tyrosine-protein phosphatase non-receptor type 1
PRO_0000094751Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei50 – 501Phosphoserine By similarity

Post-translational modificationi

Phosphorylated on serine and threonine residues near the N-terminus by casein kinase II (CK2).

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO13016.
PRIDEiO13016.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CDH2P1028810EBI-6938259,EBI-985728

Protein-protein interaction databases

BioGridi675966. 3 interactions.
IntActiO13016. 7 interactions.

Structurei

3D structure databases

ProteinModelPortaliO13016.
SMRiO13016. Positions 1-299.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 277275Tyrosine-protein phosphatase
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni215 – 2217Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00750000117312.
HOGENOMiHOG000273908.
HOVERGENiHBG008321.
InParanoidiO13016.
KOiK05696.
OMAiMCMATVL.
OrthoDBiEOG7RV9G4.
PhylomeDBiO13016.
TreeFamiTF315897.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR012265. Ptpn1/Ptpn2.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF000926. Tyr-Ptase_nr1. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O13016-1 [UniParc]FASTAAdd to Basket

« Hide

MEIEKEFHRL DQAASWAAIY QDIRHEASDF PCKVAKHPRN KNRNRYRDVS    50
PFDHSRIKLN QGDNDYINAS LIKMEEAQRS YILTQGPLPN TCGHFWEMVW 100
EQKSRGVVML NRVMEKGSIK CAQYWPRKEE KEMFFEDTNL KLTLISEDIK 150
SYYTVRQLEL ENLTTQETRE ILHFHYTTWP DFGVPESPAS FLNFLFKVRE 200
SGSLNPEYGP VVVHCSAGIG RSGTFCLVDT CLLLMDKRKD PSSVDVKQVL 250
LEMRKYRMGL IQTADQLRFS YLAVIEGAKF IMGDASVQEQ WKELSNEDLD 300
PPPEHTPPPP RPPKRTSEMH NGRMHEHAEF FPKHQVVEEE IRCSVSTAEE 350
TVSDGRVFSS VPLITDSTSQ DTEIRRRTVG ENLHVTAHKE ESKSESVEED 400
DENMMTTWKP FLVNICMFTF LTAGAYLCYR VCFH 434
Length:434
Mass (Da):50,334
Last modified:July 1, 1997 - v1
Checksum:i0FF340B2333CC311
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 141A → R in AAA91186. 1 Publication
Sequence conflicti62 – 632GD → RC in AAA91186. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U86410 mRNA. Translation: AAB53270.1.
U46662 mRNA. Translation: AAA91186.1.
PIRiJW0049.
RefSeqiNP_990206.1. NM_204875.1.
UniGeneiGga.4404.

Genome annotation databases

EnsembliENSGALT00000013001; ENSGALP00000012986; ENSGALG00000008010.
GeneIDi395688.
KEGGigga:395688.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U86410 mRNA. Translation: AAB53270.1 .
U46662 mRNA. Translation: AAA91186.1 .
PIRi JW0049.
RefSeqi NP_990206.1. NM_204875.1.
UniGenei Gga.4404.

3D structure databases

ProteinModelPortali O13016.
SMRi O13016. Positions 1-299.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 675966. 3 interactions.
IntActi O13016. 7 interactions.

Proteomic databases

PaxDbi O13016.
PRIDEi O13016.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000013001 ; ENSGALP00000012986 ; ENSGALG00000008010 .
GeneIDi 395688.
KEGGi gga:395688.

Organism-specific databases

CTDi 5770.

Phylogenomic databases

eggNOGi COG5599.
GeneTreei ENSGT00750000117312.
HOGENOMi HOG000273908.
HOVERGENi HBG008321.
InParanoidi O13016.
KOi K05696.
OMAi MCMATVL.
OrthoDBi EOG7RV9G4.
PhylomeDBi O13016.
TreeFami TF315897.

Enzyme and pathway databases

Reactomei REACT_197455. Growth hormone receptor signaling.
REACT_197530. Regulation of IFNA signaling.
REACT_197538. Regulation of IFNG signaling.

Miscellaneous databases

NextBioi 20815760.
PROi O13016.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR029021. Prot-tyrosine_phosphatase-like.
IPR012265. Ptpn1/Ptpn2.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000926. Tyr-Ptase_nr1. 1 hit.
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Regulated binding of PTP1B-like phosphatase to N-cadherin: control of cadherin-mediated adhesion by dephosphorylation of beta-catenin."
    Balsamo J., Leung T., Ernst H., Zanin M.K., Hoffman S., Lilien J.
    J. Cell Biol. 134:801-813(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Retina.
  2. "Multiple phosphorylation of chicken protein tyrosine phosphatase 1 and human protein tyrosine phosphatase 1B by casein kinase II and p60c-src in vitro."
    Jung E.J., Kang Y.-S., Kim C.W.
    Biochem. Biophys. Res. Commun. 246:238-242(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cloning and characterization of a chicken protein tyrosine phosphatase, CPTP1."
    Kim C.W., Jung E.J., Kang Y.-S.
    Exp. Mol. Med. 28:207-213(1996)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 14-369.
    Tissue: Intestine.

Entry informationi

Entry nameiPTN1_CHICK
AccessioniPrimary (citable) accession number: O13016
Secondary accession number(s): Q90704
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 1, 1997
Last modified: September 3, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi