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Protein

Estrogen receptor beta

Gene

esr2

Organism
Anguilla japonica (Japanese eel)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi171 – 23666Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri171 – 19121NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri207 – 23125NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Lipid-binding, Metal-binding, Steroid-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Estrogen receptor beta
Short name:
ER-beta
Alternative name(s):
Nuclear receptor subfamily 3 group A member 2
Gene namesi
Name:esr2
Synonyms:nr3a2
OrganismiAnguilla japonica (Japanese eel)
Taxonomic identifieri7937 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiAnguilliformesAnguillidaeAnguilla

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 573573Estrogen receptor betaPRO_0000053651Add
BLAST

Expressioni

Tissue specificityi

Liver.

Inductioni

By 17-beta-estradiol.

Interactioni

Subunit structurei

Binds DNA as a homodimer. Can form a heterodimer with ER-alpha.

Structurei

3D structure databases

ProteinModelPortaliO13012.
SMRiO13012. Positions 170-238, 290-529.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni15 – 170156ModulatingAdd
BLAST
Regioni237 – 573337Steroid-bindingAdd
BLAST

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri171 – 19121NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri207 – 23125NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

HOVERGENiHBG108344.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR028355. ER-beta/gamma.
IPR021064. Estrogen_rcpt_beta_N.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF12497. ERbeta_N. 1 hit.
PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PIRSFiPIRSF500102. ER-b. 1 hit.
PIRSF002527. ER-like_NR. 1 hit.
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O13012-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGSPGNELP LLQLQEVDSS KVGESGGSSG LLPTMYNGAL PALSMESHAV
60 70 80 90 100
CIPSPYTDSS HDYAALTFYS PPILSHGGPA VPESPAARQS LSPSLFWPAH
110 120 130 140 150
GHHGHVSPLA LHFQQPLVYR EPAHSPWAEP KPLEHGQAQT SKLAGKRMAE
160 170 180 190 200
SEEGTSSVGG CFAGKGDMHF CAVCHDYASG YHYGVWSCEG CKAFFKRSIQ
210 220 230 240 250
GHNGYICPAT NQCTIDKNRR KSCQACRLRK CYEVGMMKCG VRRERCTYRG
260 270 280 290 300
ARHRRMPHIR ELAGTGGGAR TQRRGEGVVP QTQEAQSSAL TPEQLINRII
310 320 330 340 350
EAEPPEIYLM KELKKPFTED SMMMSLTNLA DKELVLMISW AKKIPGFVEL
360 370 380 390 400
DLSDQVHLLE CCWLEVLMLG LMWRSVDHPG KLIFSPDLKL NRDEGSCVEG
410 420 430 440 450
ILEIFDMVLA ATSRFRELKL QREEYVCLKA IILLNPNLCT TSSENREELE
460 470 480 490 500
SRNKLLHMLD SVTDALVWTI AKKGLTFQQQ SARLAHLLML LAHIRHLSNK
510 520 530 540 550
GMEHLSNMKR KNVVPLYDLL LEMLDANTMH SSRMSASYSS QPSPWSQAAQ
560 570
SQPGPPPSCS GECPCPPKES STI
Length:573
Mass (Da):63,421
Last modified:July 1, 1997 - v1
Checksum:i9C64C1D8D39ED4CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB003356 mRNA. Translation: BAA19851.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB003356 mRNA. Translation: BAA19851.1.

3D structure databases

ProteinModelPortaliO13012.
SMRiO13012. Positions 170-238, 290-529.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG108344.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR028355. ER-beta/gamma.
IPR021064. Estrogen_rcpt_beta_N.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF12497. ERbeta_N. 1 hit.
PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PIRSFiPIRSF500102. ER-b. 1 hit.
PIRSF002527. ER-like_NR. 1 hit.
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiESR2_ANGJA
AccessioniPrimary (citable) accession number: O13012
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: July 1, 1997
Last modified: October 14, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.