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Protein

Guanylate cyclase activator 2B

Gene

GUCA2B

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate cyclase activator 2B
Cleaved into the following chain:
Uroguanylin
Short name:
UGN
Gene namesi
Name:GUCA2B
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Propeptidei28 – 9770PRO_0000013152Add
BLAST
Peptidei98 – 11316UroguanylinPRO_0000013153Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi68 ↔ 81By similarity
Disulfide bondi101 ↔ 109By similarity
Disulfide bondi104 ↔ 112By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO13009.

Expressioni

Gene expression databases

BgeeiENSSSCG00000003970.
GenevisibleiO13009. SS.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000004292.

Structurei

3D structure databases

ProteinModelPortaliO13009.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the guanylin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3M7. Eukaryota.
ENOG410Z6NA. LUCA.
HOGENOMiHOG000231183.
HOVERGENiHBG051861.
InParanoidiO13009.
OrthoDBiEOG091G13KI.

Family and domain databases

Gene3Di3.90.1450.10. 1 hit.
InterProiIPR000879. Guanylin.
[Graphical view]
PANTHERiPTHR11318. PTHR11318. 1 hit.
PfamiPF02058. Guanylin. 1 hit.
[Graphical view]
PIRSFiPIRSF001849. Guanylin. 1 hit.
PRINTSiPR00774. GUANYLIN.
ProDomiPD005588. Guanylin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF89890. SSF89890. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O13009-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRAAAGLL LCGVALVFLV LLQGTQSVYI QYQGFRVQLK SVKKLSDLEG
60 70 80 90 100
QWAPSPRLQA QSPQPSVCHH SALPPDLQPI CQSEEAASIF QALRTIAGDD
110
CELCVNVACT GCS
Length:113
Mass (Da):12,044
Last modified:July 1, 1997 - v1
Checksum:i8160573287BAB642
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z83746 mRNA. Translation: CAB06042.1.
RefSeqiNP_001153747.1. NM_001160275.1.
UniGeneiSsc.540.

Genome annotation databases

GeneIDi100301561.
KEGGissc:100301561.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z83746 mRNA. Translation: CAB06042.1.
RefSeqiNP_001153747.1. NM_001160275.1.
UniGeneiSsc.540.

3D structure databases

ProteinModelPortaliO13009.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000004292.

Proteomic databases

PaxDbiO13009.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100301561.
KEGGissc:100301561.

Organism-specific databases

CTDi2981.

Phylogenomic databases

eggNOGiENOG410J3M7. Eukaryota.
ENOG410Z6NA. LUCA.
HOGENOMiHOG000231183.
HOVERGENiHBG051861.
InParanoidiO13009.
OrthoDBiEOG091G13KI.

Gene expression databases

BgeeiENSSSCG00000003970.
GenevisibleiO13009. SS.

Family and domain databases

Gene3Di3.90.1450.10. 1 hit.
InterProiIPR000879. Guanylin.
[Graphical view]
PANTHERiPTHR11318. PTHR11318. 1 hit.
PfamiPF02058. Guanylin. 1 hit.
[Graphical view]
PIRSFiPIRSF001849. Guanylin. 1 hit.
PRINTSiPR00774. GUANYLIN.
ProDomiPD005588. Guanylin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF89890. SSF89890. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGUC2B_PIG
AccessioniPrimary (citable) accession number: O13009
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 1, 1997
Last modified: September 7, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.