Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Guanylate cyclase activator 2B

Gene

GUCA2B

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-SSC-8935690 Digestion

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate cyclase activator 2B
Cleaved into the following chain:
Uroguanylin
Short name:
UGN
Gene namesi
Name:GUCA2B
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
PropeptideiPRO_000001315228 – 97Add BLAST70
PeptideiPRO_000001315398 – 113UroguanylinAdd BLAST16

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi68 ↔ 81By similarity
Disulfide bondi101 ↔ 109By similarity
Disulfide bondi104 ↔ 112By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO13009

Expressioni

Gene expression databases

GenevisibleiO13009 SS

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000004292

Structurei

3D structure databases

ProteinModelPortaliO13009
SMRiO13009
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the guanylin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3M7 Eukaryota
ENOG410Z6NA LUCA
GeneTreeiENSGT00730000111420
HOGENOMiHOG000231183
HOVERGENiHBG051861
InParanoidiO13009
OrthoDBiEOG091G13KI

Family and domain databases

Gene3Di3.90.1450.101 hit
InterProiView protein in InterPro
IPR000879 Guanylin
IPR036382 Guanylin_sf
PANTHERiPTHR11318 PTHR11318, 1 hit
PfamiView protein in Pfam
PF02058 Guanylin, 1 hit
PIRSFiPIRSF001849 Guanylin, 1 hit
PRINTSiPR00774 GUANYLIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005588 Guanylin, 1 hit
SUPFAMiSSF89890 SSF89890, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O13009-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRAAAGLL LCGVALVFLV LLQGTQSVYI QYQGFRVQLK SVKKLSDLEG
60 70 80 90 100
QWAPSPRLQA QSPQPSVCHH SALPPDLQPI CQSEEAASIF QALRTIAGDD
110
CELCVNVACT GCS
Length:113
Mass (Da):12,044
Last modified:July 1, 1997 - v1
Checksum:i8160573287BAB642
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z83746 mRNA Translation: CAB06042.1
RefSeqiNP_001153747.1, NM_001160275.1
UniGeneiSsc.540

Genome annotation databases

EnsembliENSSSCT00000004392; ENSSSCP00000004292; ENSSSCG00000003970
ENSSSCT00000052709; ENSSSCP00000051736; ENSSSCG00000003970
GeneIDi100301561
KEGGissc:100301561

Similar proteinsi

Entry informationi

Entry nameiGUC2B_PIG
AccessioniPrimary (citable) accession number: O13009
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 1, 1997
Last modified: February 28, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome