O13001 (ATNG_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sodium/potassium-transporting ATPase subunit gamma
Short name=Na(+)/K(+) ATPase subunit gamma

Alternative name(s):
FXYD domain-containing ion transport regulator 2
Sodium pump gamma chain

Gene names

Name:

fxyd2

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	61 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.
Subunit structure	Composed of three subunits: alpha (catalytic), beta and gamma.
Subcellular location	Membrane; Single-pass type III membrane protein Potential.
Sequence similarities	Belongs to the FXYD family.

Ontologies

Keywords
Biological process	Ion transport Potassium transport Sodium transport Sodium/potassium transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Potassium Sodium
Gene Ontology (GO)
Biological process	potassium ion transport Inferred from electronic annotation. Source: UniProtKB-KW sodium ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ion channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 61	61	Sodium/potassium-transporting ATPase subunit gamma		PRO_0000148189
Regions
	Transmembrane	24 – 44	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	O13001 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: E34DD85B20A6A19E	FASTA	61	6,999
	10 20 30 40 50 60 MADAQDDMSQ MQDKFTYDYE TIRKGGLIFA AIAFVVGMLI IFSGRFRCGR KKQLRALNDD M

References

[1]	"The gamma subunit is a specific component of the Na,K-ATPase and modulates its transport function." Beguin P., Wang X., Firsov D., Puoti A., Claeys D., Horisberger J.-D., Geering K. EMBO J. 16:4250-4260(1997) [PubMed: 9250668] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y11587 mRNA. Translation: CAA72326.1.
RefSeq	NP_001081551.1. NM_001088082.2.
UniGene	Xl.1251.
3D structure databases
ProteinModelPortal	O13001.
SMR	O13001. Positions 19-47.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	397916.
KEGG	xla:397916.
Organism-specific databases
CTD	486.
Xenbase	XB-GENE-864939. fxyd2.
Phylogenomic databases
HOVERGEN	HBG100880.
Family and domain databases
InterPro	IPR000272. Ion-transport_regulator_FXYD. [Graphical view]
KO	K01538.
Pfam	PF02038. ATP1G1_PLM_MAT8. 1 hit. [Graphical view]
ProDom	PD005989. PD005989. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS01310. FXYD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATNG_XENLA

Accession

Primary (citable) accession number: O13001

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 1, 1997
Last modified:	November 16, 2011
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program