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Protein

Hemoglobin subunit alpha-D

Gene

HBAD

Organism
Columba livia (Rock dove)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi57Iron (heme distal ligand)1
Metal bindingi86Iron (heme proximal ligand)1

GO - Molecular functioni

Keywordsi

Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit alpha-D
Alternative name(s):
Alpha-D-globin
Hemoglobin alpha-D chain
Gene namesi
Name:HBAD
OrganismiColumba livia (Rock dove)
Taxonomic identifieri8932 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeColumbiformesColumbidaeColumba

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000528251 – 140Hemoglobin subunit alpha-DAdd BLAST140

Proteomic databases

PRIDEiO12985

Expressioni

Tissue specificityi

Red blood cells.

Developmental stagei

In birds, the alpha-D chain occurs in a minor hemoglobin component, called hemoglobin d, which is expressed in late embryonic and adult life.

Interactioni

Subunit structurei

Heterotetramer of two alpha-D chains and two beta chains.

Structurei

3D structure databases

ProteinModelPortaliO12985
SMRiO12985
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009709
KOiK13826

Family and domain databases

CDDicd08927 Hb-alpha_like, 1 hit
Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR002338 Haemoglobin_a-typ
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00612 ALPHAHAEM
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit

Sequencei

Sequence statusi: Complete.

O12985-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTDSDKKLV LQVWEKVIRH PDCGAEALER LFTTYPQTKT YFPHFDLHHG
60 70 80 90 100
SDQVRNHGKK VLAALGNAVK SLGNLSQALS DLSDLHAYNL RVDPVNFKLL
110 120 130 140
AQCFHVVLAT HLGNDYTPEA HAAFDKFLSA VCTVLAEKYR
Length:140
Mass (Da):15,717
Last modified:July 1, 1997 - v1
Checksum:i2FAC884799A152F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001981 Genomic DNA Translation: BAA19668.1
PIRiJC5515
RefSeqiXP_005508517.1, XM_005508460.1

Genome annotation databases

GeneIDi102090670
KEGGiclv:102090670

Similar proteinsi

Entry informationi

Entry nameiHBAD_COLLI
AccessioniPrimary (citable) accession number: O12985
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: July 1, 1997
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health