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Protein

Hemoglobin subunit alpha-D

Gene

HBAD

Organism
Columba livia (Rock dove)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi57 – 571Iron (heme distal ligand)
Metal bindingi86 – 861Iron (heme proximal ligand)

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit alpha-D
Alternative name(s):
Alpha-D-globin
Hemoglobin alpha-D chain
Gene namesi
Name:HBAD
OrganismiColumba livia (Rock dove)
Taxonomic identifieri8932 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeColumbiformesColumbidaeColumba

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 140140Hemoglobin subunit alpha-DPRO_0000052825Add
BLAST

Proteomic databases

PRIDEiO12985.

Expressioni

Tissue specificityi

Red blood cells.

Developmental stagei

In birds, the alpha-D chain occurs in a minor hemoglobin component, called hemoglobin d, which is expressed in late embryonic and adult life.

Interactioni

Subunit structurei

Heterotetramer of two alpha-D chains and two beta chains.

Structurei

3D structure databases

ProteinModelPortaliO12985.
SMRiO12985. Positions 1-140.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009709.
KOiK13826.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O12985-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTDSDKKLV LQVWEKVIRH PDCGAEALER LFTTYPQTKT YFPHFDLHHG
60 70 80 90 100
SDQVRNHGKK VLAALGNAVK SLGNLSQALS DLSDLHAYNL RVDPVNFKLL
110 120 130 140
AQCFHVVLAT HLGNDYTPEA HAAFDKFLSA VCTVLAEKYR
Length:140
Mass (Da):15,717
Last modified:July 1, 1997 - v1
Checksum:i2FAC884799A152F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001981 Genomic DNA. Translation: BAA19668.1.
PIRiJC5515.
RefSeqiXP_005508517.1. XM_005508460.1.

Genome annotation databases

GeneIDi102090670.
KEGGiclv:102090670.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001981 Genomic DNA. Translation: BAA19668.1.
PIRiJC5515.
RefSeqiXP_005508517.1. XM_005508460.1.

3D structure databases

ProteinModelPortaliO12985.
SMRiO12985. Positions 1-140.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiO12985.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi102090670.
KEGGiclv:102090670.

Organism-specific databases

CTDi100301693.

Phylogenomic databases

HOVERGENiHBG009709.
KOiK13826.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation and sequencing of two alpha-globin genes alpha(A) and alpha(D) in pigeon and evidence for embryo-specific expression of the alpha(D)-globin gene."
    Ikehara T., Eguchi Y., Kayo S., Takei H.
    Biochem. Biophys. Res. Commun. 234:450-453(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiHBAD_COLLI
AccessioniPrimary (citable) accession number: O12985
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: July 1, 1997
Last modified: October 14, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.