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Protein

Hemoglobin subunit alpha-D

Gene

HBAD

Organism
Columba livia (Rock dove)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi57Iron (heme distal ligand)1
Metal bindingi86Iron (heme proximal ligand)1

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit alpha-D
Alternative name(s):
Alpha-D-globin
Hemoglobin alpha-D chain
Gene namesi
Name:HBAD
OrganismiColumba livia (Rock dove)
Taxonomic identifieri8932 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeColumbiformesColumbidaeColumba

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000528251 – 140Hemoglobin subunit alpha-DAdd BLAST140

Proteomic databases

PRIDEiO12985.

Expressioni

Tissue specificityi

Red blood cells.

Developmental stagei

In birds, the alpha-D chain occurs in a minor hemoglobin component, called hemoglobin d, which is expressed in late embryonic and adult life.

Interactioni

Subunit structurei

Heterotetramer of two alpha-D chains and two beta chains.

Structurei

3D structure databases

ProteinModelPortaliO12985.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009709.
KOiK13826.

Family and domain databases

CDDicd08927. Hb-alpha_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a-typ.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O12985-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTDSDKKLV LQVWEKVIRH PDCGAEALER LFTTYPQTKT YFPHFDLHHG
60 70 80 90 100
SDQVRNHGKK VLAALGNAVK SLGNLSQALS DLSDLHAYNL RVDPVNFKLL
110 120 130 140
AQCFHVVLAT HLGNDYTPEA HAAFDKFLSA VCTVLAEKYR
Length:140
Mass (Da):15,717
Last modified:July 1, 1997 - v1
Checksum:i2FAC884799A152F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001981 Genomic DNA. Translation: BAA19668.1.
PIRiJC5515.
RefSeqiXP_005508517.1. XM_005508460.1.

Genome annotation databases

GeneIDi102090670.
KEGGiclv:102090670.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001981 Genomic DNA. Translation: BAA19668.1.
PIRiJC5515.
RefSeqiXP_005508517.1. XM_005508460.1.

3D structure databases

ProteinModelPortaliO12985.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiO12985.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi102090670.
KEGGiclv:102090670.

Organism-specific databases

CTDi100301693.

Phylogenomic databases

HOVERGENiHBG009709.
KOiK13826.

Family and domain databases

CDDicd08927. Hb-alpha_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a-typ.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHBAD_COLLI
AccessioniPrimary (citable) accession number: O12985
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: July 1, 1997
Last modified: October 5, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.