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Protein

Presenilin-2

Gene

psen2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (By similarity). May play a role in negative regulation of apoptotic cascades during oogenesis and embryogenesis, and in developmentally matured tissues such as brain tissue.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei266By similarity1
Active sitei367By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Keywords - Biological processi

Notch signaling pathway

Protein family/group databases

MEROPSiA22.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Presenilin-2 (EC:3.4.23.-)
Short name:
PS-2
Alternative name(s):
Presenilin beta
Short name:
PS-beta
Gene namesi
Name:psen2
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6252626. psen2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 90CytoplasmicSequence analysisAdd BLAST90
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Topological domaini112 – 141LumenalSequence analysisAdd BLAST30
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Topological domaini163 – 169CytoplasmicSequence analysis7
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21
Topological domaini191 – 203LumenalSequence analysisAdd BLAST13
Transmembranei204 – 224HelicalSequence analysisAdd BLAST21
Topological domaini225 – 226CytoplasmicSequence analysis2
Transmembranei227 – 247HelicalSequence analysisAdd BLAST21
Topological domaini248 – 252LumenalSequence analysis5
Transmembranei253 – 273HelicalSequence analysisAdd BLAST21
Topological domaini274 – 362CytoplasmicSequence analysisAdd BLAST89
Transmembranei363 – 383HelicalSequence analysisAdd BLAST21
Topological domaini384 – 389LumenalSequence analysis6
Transmembranei390 – 410HelicalSequence analysisAdd BLAST21
Topological domaini411 – 414CytoplasmicSequence analysis4
Intramembranei415 – 435HelicalSequence analysisAdd BLAST21
Topological domaini436 – 449CytoplasmicSequence analysisAdd BLAST14

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000739001 – 449Presenilin-2Add BLAST449

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi387N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Highest expression in ovaries and to a lesser extent in kidney, brain, eye and lung. Weak expression in testis, intestine, liver and heart. Present in trace amounts in skeletal muscle.

Developmental stagei

Abundant in early stages of oogenesis after which it is nearly constant.

Interactioni

Subunit structurei

Homodimer. Probable component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PS-alpha or PS-beta), nicastrin (NCSTN), APH1 and PEN2 (Probable).Curated

Structurei

3D structure databases

ProteinModelPortaliO12977.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi415 – 417PAL3

Domaini

The PAL motif is required for normal active site conformation.By similarity

Sequence similaritiesi

Belongs to the peptidase A22A family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG011375.
KOiK04522.

Family and domain databases

InterProiIPR001493. Pept_A22A_PS2.
IPR001108. Peptidase_A22A.
IPR006639. Preselin/SPP.
[Graphical view]
PANTHERiPTHR10202. PTHR10202. 1 hit.
PTHR10202:SF20. PTHR10202:SF20. 1 hit.
PfamiPF01080. Presenilin. 1 hit.
[Graphical view]
PRINTSiPR01072. PRESENILIN.
SMARTiSM00730. PSN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O12977-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKLSDSEDE ECNERTSLIT SESPPLPSYQ DGVQASEGLE TSYHRERQPD
60 70 80 90 100
STQNNEDVPN GRTSGADAYN SETTVENEEE ELTLKYGARH VIMLFVPVTL
110 120 130 140 150
CMVVVVATIK SVSFYTEKDG QLIYTPFSED TTSVGERLLN SVLNTLIMIS
160 170 180 190 200
VILVMTIFLV LLYKYRCYKF IHGWLILSSL MLLFMFTYIY LSEVFKTYNI
210 220 230 240 250
AMDYPTLFMV IWNFGAVGMI CIHWKGPLQL QQAYLIMISA LMALVFIKYL
260 270 280 290 300
PEWSAWVILG AISVYDLLAV LCPKGPLRML VETAQERNEP IFPALIYSSA
310 320 330 340 350
MMWTVGMADS ATADGRMNQQ VQHIDRNTPE GANSTVEDAA ETRIQTQSNL
360 370 380 390 400
SSEDPDEERG VKLGLGDFIF YSVLVGKAAA TASGDWNTTL ACFVAILIGL
410 420 430 440
CLTLLLLAVF KKALPALPIS ITFGLIFYFS TDNIVRPFMD TLASHQMYI
Length:449
Mass (Da):50,274
Last modified:July 1, 1997 - v1
Checksum:i2C2C105F5C723F2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84428 mRNA. Translation: BAA19571.1.
BC072862 mRNA. Translation: AAH72862.1.
PIRiJC5391.
RefSeqiNP_001081211.1. NM_001087742.1.
UniGeneiXl.1258.

Genome annotation databases

GeneIDi397713.
KEGGixla:397713.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84428 mRNA. Translation: BAA19571.1.
BC072862 mRNA. Translation: AAH72862.1.
PIRiJC5391.
RefSeqiNP_001081211.1. NM_001087742.1.
UniGeneiXl.1258.

3D structure databases

ProteinModelPortaliO12977.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiA22.002.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397713.
KEGGixla:397713.

Organism-specific databases

CTDi5664.
XenbaseiXB-GENE-6252626. psen2.

Phylogenomic databases

HOVERGENiHBG011375.
KOiK04522.

Family and domain databases

InterProiIPR001493. Pept_A22A_PS2.
IPR001108. Peptidase_A22A.
IPR006639. Preselin/SPP.
[Graphical view]
PANTHERiPTHR10202. PTHR10202. 1 hit.
PTHR10202:SF20. PTHR10202:SF20. 1 hit.
PfamiPF01080. Presenilin. 1 hit.
[Graphical view]
PRINTSiPR01072. PRESENILIN.
SMARTiSM00730. PSN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPSN2_XENLA
AccessioniPrimary (citable) accession number: O12977
Secondary accession number(s): Q6GQ85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 1, 1997
Last modified: November 2, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.