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Protein

Presenilin-1

Gene

psen1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (By similarity). May play a role in negative regulation of apoptotic cascades during oogenesis and embryogenesis, and in developmentally matured tissues such as brain tissue.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei223 – 2231By similarity
Active sitei351 – 3511By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Keywords - Biological processi

Notch signaling pathway

Protein family/group databases

MEROPSiA22.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Presenilin-1 (EC:3.4.23.-)
Short name:
PS-1
Alternative name(s):
Presenilin alpha
Short name:
PS-alpha
Gene namesi
Name:psen1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-481920. psen1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4747CytoplasmicSequence analysisAdd
BLAST
Transmembranei48 – 6821HelicalSequence analysisAdd
BLAST
Topological domaini69 – 9830LumenalSequence analysisAdd
BLAST
Transmembranei99 – 11921HelicalSequence analysisAdd
BLAST
Topological domaini120 – 1267CytoplasmicSequence analysis
Transmembranei127 – 14721HelicalSequence analysisAdd
BLAST
Topological domaini148 – 16013LumenalSequence analysisAdd
BLAST
Transmembranei161 – 18121HelicalSequence analysisAdd
BLAST
Topological domaini182 – 1832CytoplasmicSequence analysis
Transmembranei184 – 20421HelicalSequence analysisAdd
BLAST
Topological domaini205 – 2095LumenalSequence analysis
Transmembranei210 – 23021HelicalSequence analysisAdd
BLAST
Topological domaini231 – 346116CytoplasmicSequence analysisAdd
BLAST
Transmembranei347 – 36721HelicalSequence analysisAdd
BLAST
Topological domaini368 – 3736LumenalSequence analysis
Transmembranei374 – 39421HelicalSequence analysisAdd
BLAST
Topological domaini395 – 3984CytoplasmicSequence analysis
Intramembranei399 – 41921HelicalSequence analysisAdd
BLAST
Topological domaini420 – 43314CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Presenilin-1PRO_0000073898Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi371 – 3711N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

PTM databases

iPTMnetiO12976.

Expressioni

Tissue specificityi

Highest expression in ovaries and to a lesser extent in testis, intestine, kidney, brain, eye and lung. Weak expression in liver and heart. Present in trace amounts in skeletal muscle.

Developmental stagei

Abundant in early stages of oogenesis. The expression is rapidly reduced between meiotic maturation and fertilization stages.

Interactioni

Subunit structurei

Homodimer. Probable component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PS-alpha or PS-beta), nicastrin (NCSTN), APH1 and PEN2 (Probable).Curated

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi399 – 4013PAL

Domaini

The PAL motif is required for normal active site conformation.By similarity

Sequence similaritiesi

Belongs to the peptidase A22A family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG011375.
KOiK04505.

Family and domain databases

InterProiIPR002031. Pept_A22A_PS1.
IPR001108. Peptidase_A22A.
IPR006639. Preselin/SPP.
[Graphical view]
PANTHERiPTHR10202. PTHR10202. 1 hit.
PTHR10202:SF18. PTHR10202:SF18. 1 hit.
PfamiPF01080. Presenilin. 1 hit.
[Graphical view]
PRINTSiPR01072. PRESENILIN.
SMARTiSM00730. PSN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O12976-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDTSERRSN ENSESQSNGQ TQSSSQQVLE QDEEEDEELT LKYGAKHVIM
60 70 80 90 100
LFVPVTLCMV VVVATIKSVS FYTRFDGQLI YTPFTEDTES VGQRALNSIL
110 120 130 140 150
NATIMISVII VMTILLVVLY KYRCYKVIHG WLIISSLLLL FFFSYIYLGE
160 170 180 190 200
VFKTYNVAVD YITLALLIWN FGVVGMICIH WKGPLLLQQA YLIMISALMA
210 220 230 240 250
LVFIKYLPEW TTWLILAVIS VYDLVAVLSP KGPLRMLVET AQERNETLFP
260 270 280 290 300
ALIYSSTMIW LVNMADGDPG LKQSASTKTY NTQAPTAHPR SDSAASDDNG
310 320 330 340 350
GFDTTWEDHR NAQIGPINST PESRVAVQAL PSNSPPSEDP EERGVKLGLG
360 370 380 390 400
DFIFYSVLVG KASATASGDW NTTLACFVAI LIGLCLTLLL LAIFKKALPA
410 420 430
LPISITFGLV FYFATDYLVQ PFMDQLAFHQ FYI
Length:433
Mass (Da):48,301
Last modified:July 1, 1997 - v1
Checksum:i71CCEE3F6BB9C0AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84427 mRNA. Translation: BAA19570.1.
BC077762 mRNA. Translation: AAH77762.1.
PIRiJC5390.
RefSeqiNP_001084023.1. NM_001090554.1.
UniGeneiXl.55408.

Genome annotation databases

GeneIDi399258.
KEGGixla:399258.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84427 mRNA. Translation: BAA19570.1.
BC077762 mRNA. Translation: AAH77762.1.
PIRiJC5390.
RefSeqiNP_001084023.1. NM_001090554.1.
UniGeneiXl.55408.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiA22.001.

PTM databases

iPTMnetiO12976.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi399258.
KEGGixla:399258.

Organism-specific databases

CTDi5663.
XenbaseiXB-GENE-481920. psen1.

Phylogenomic databases

HOVERGENiHBG011375.
KOiK04505.

Family and domain databases

InterProiIPR002031. Pept_A22A_PS1.
IPR001108. Peptidase_A22A.
IPR006639. Preselin/SPP.
[Graphical view]
PANTHERiPTHR10202. PTHR10202. 1 hit.
PTHR10202:SF18. PTHR10202:SF18. 1 hit.
PfamiPF01080. Presenilin. 1 hit.
[Graphical view]
PRINTSiPR01072. PRESENILIN.
SMARTiSM00730. PSN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of Xenopus presenilin-alpha and -beta cDNAs and their differential expression in oogenesis and embryogenesis."
    Tsujimura A., Yasojima K., Hashimoto-Gotoh T.
    Biochem. Biophys. Res. Commun. 231:392-396(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiPSN1_XENLA
AccessioniPrimary (citable) accession number: O12976
Secondary accession number(s): Q6DD65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 1, 1997
Last modified: May 11, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.