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Protein

Presenilin-1

Gene

psen1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (By similarity). May play a role in negative regulation of apoptotic cascades during oogenesis and embryogenesis, and in developmentally matured tissues such as brain tissue.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei223By similarity1
Active sitei351By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Keywords - Biological processi

Notch signaling pathway

Protein family/group databases

MEROPSiA22.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Presenilin-1 (EC:3.4.23.-)
Short name:
PS-1
Alternative name(s):
Presenilin alpha
Short name:
PS-alpha
Gene namesi
Name:psen1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-481920. psen1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 47CytoplasmicSequence analysisAdd BLAST47
Transmembranei48 – 68HelicalSequence analysisAdd BLAST21
Topological domaini69 – 98LumenalSequence analysisAdd BLAST30
Transmembranei99 – 119HelicalSequence analysisAdd BLAST21
Topological domaini120 – 126CytoplasmicSequence analysis7
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21
Topological domaini148 – 160LumenalSequence analysisAdd BLAST13
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Topological domaini182 – 183CytoplasmicSequence analysis2
Transmembranei184 – 204HelicalSequence analysisAdd BLAST21
Topological domaini205 – 209LumenalSequence analysis5
Transmembranei210 – 230HelicalSequence analysisAdd BLAST21
Topological domaini231 – 346CytoplasmicSequence analysisAdd BLAST116
Transmembranei347 – 367HelicalSequence analysisAdd BLAST21
Topological domaini368 – 373LumenalSequence analysis6
Transmembranei374 – 394HelicalSequence analysisAdd BLAST21
Topological domaini395 – 398CytoplasmicSequence analysis4
Intramembranei399 – 419HelicalSequence analysisAdd BLAST21
Topological domaini420 – 433CytoplasmicSequence analysisAdd BLAST14

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000738981 – 433Presenilin-1Add BLAST433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi371N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Highest expression in ovaries and to a lesser extent in testis, intestine, kidney, brain, eye and lung. Weak expression in liver and heart. Present in trace amounts in skeletal muscle.

Developmental stagei

Abundant in early stages of oogenesis. The expression is rapidly reduced between meiotic maturation and fertilization stages.

Interactioni

Subunit structurei

Homodimer. Probable component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PS-alpha or PS-beta), nicastrin (NCSTN), APH1 and PEN2 (Probable).Curated

Structurei

3D structure databases

ProteinModelPortaliO12976.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi399 – 401PAL3

Domaini

The PAL motif is required for normal active site conformation.By similarity

Sequence similaritiesi

Belongs to the peptidase A22A family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG011375.
KOiK04505.

Family and domain databases

InterProiIPR002031. Pept_A22A_PS1.
IPR001108. Peptidase_A22A.
IPR006639. Preselin/SPP.
[Graphical view]
PANTHERiPTHR10202. PTHR10202. 1 hit.
PTHR10202:SF18. PTHR10202:SF18. 1 hit.
PfamiPF01080. Presenilin. 1 hit.
[Graphical view]
PRINTSiPR01072. PRESENILIN.
SMARTiSM00730. PSN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O12976-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDTSERRSN ENSESQSNGQ TQSSSQQVLE QDEEEDEELT LKYGAKHVIM
60 70 80 90 100
LFVPVTLCMV VVVATIKSVS FYTRFDGQLI YTPFTEDTES VGQRALNSIL
110 120 130 140 150
NATIMISVII VMTILLVVLY KYRCYKVIHG WLIISSLLLL FFFSYIYLGE
160 170 180 190 200
VFKTYNVAVD YITLALLIWN FGVVGMICIH WKGPLLLQQA YLIMISALMA
210 220 230 240 250
LVFIKYLPEW TTWLILAVIS VYDLVAVLSP KGPLRMLVET AQERNETLFP
260 270 280 290 300
ALIYSSTMIW LVNMADGDPG LKQSASTKTY NTQAPTAHPR SDSAASDDNG
310 320 330 340 350
GFDTTWEDHR NAQIGPINST PESRVAVQAL PSNSPPSEDP EERGVKLGLG
360 370 380 390 400
DFIFYSVLVG KASATASGDW NTTLACFVAI LIGLCLTLLL LAIFKKALPA
410 420 430
LPISITFGLV FYFATDYLVQ PFMDQLAFHQ FYI
Length:433
Mass (Da):48,301
Last modified:July 1, 1997 - v1
Checksum:i71CCEE3F6BB9C0AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84427 mRNA. Translation: BAA19570.1.
BC077762 mRNA. Translation: AAH77762.1.
PIRiJC5390.
RefSeqiNP_001084023.1. NM_001090554.2.
UniGeneiXl.55408.

Genome annotation databases

GeneIDi399258.
KEGGixla:399258.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84427 mRNA. Translation: BAA19570.1.
BC077762 mRNA. Translation: AAH77762.1.
PIRiJC5390.
RefSeqiNP_001084023.1. NM_001090554.2.
UniGeneiXl.55408.

3D structure databases

ProteinModelPortaliO12976.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiA22.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi399258.
KEGGixla:399258.

Organism-specific databases

CTDi5663.
XenbaseiXB-GENE-481920. psen1.

Phylogenomic databases

HOVERGENiHBG011375.
KOiK04505.

Family and domain databases

InterProiIPR002031. Pept_A22A_PS1.
IPR001108. Peptidase_A22A.
IPR006639. Preselin/SPP.
[Graphical view]
PANTHERiPTHR10202. PTHR10202. 1 hit.
PTHR10202:SF18. PTHR10202:SF18. 1 hit.
PfamiPF01080. Presenilin. 1 hit.
[Graphical view]
PRINTSiPR01072. PRESENILIN.
SMARTiSM00730. PSN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPSN1_XENLA
AccessioniPrimary (citable) accession number: O12976
Secondary accession number(s): Q6DD65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 1, 1997
Last modified: November 30, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.