Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

17-beta-hydroxysteroid dehydrogenase

Gene

HSD17B1

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei71NADPUniRule annotation1
Binding sitei148SubstrateUniRule annotation1
Active sitei161Proton acceptorUniRule annotation1
Binding sitei165NADPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi17 – 45NADPUniRule annotationAdd BLAST29

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-GGA-193144. Estrogen biosynthesis.

Names & Taxonomyi

Protein namesi
Submitted name:
17-beta-hydroxysteroid dehydrogenaseImported
Gene namesi
Name:HSD17B1Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 27

Subcellular locationi

GO - Cellular componenti

Expressioni

Gene expression databases

BgeeiENSGALG00000027429.

Structurei

3D structure databases

ProteinModelPortaliO12968.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the short-chain dehydrogenases/reductases (SDR) family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00870000136396.
HOVERGENiHBG014077.
KOiK00044.
OMAiMRTIFIT.
OrthoDBiEOG091G0E9O.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiView protein in InterPro
IPR011348. 17beta_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PIRSFiPIRSF000095. 17beta-HSD. 1 hit.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.

Sequencei

Sequence statusi: Complete.

O12968-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGTAVPVEK TTVLITGCSS GIGLGLAVRL AADAARRFKV FATMRDLAKG
60 70 80 90 100
EQLLERLGGR CPDTLELLQL DVTDPRSLAA AVRCMRGRHP DVLVCNAGVG
110 120 130 140 150
LMAPLEMCSE QAMRAVFEVN VFGTARTIQA FLPAMKRHRA GRILVSSSVG
160 170 180 190 200
GLQGLPFNAV YCASKFALEG LCESLAIVLR PFNIHMTLVE CGPVHTAFMD
210 220 230 240 250
NAWRADPDGR ELRALDAETQ QLYRRYLQHC TQLFLDAAQE VDEVLQVFLE
260 270 280 290 300
AIAAPRPPLR CITARLPAPL ARLRPGGPDG ADYVRAMHDF VFGPGEAAEE

QP
Length:302
Mass (Da):32,810
Last modified:July 1, 1997 - v1
Checksum:iE4BCBD4E05AD2868
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000464 Genomic DNA. No translation available.
AB002410 mRNA. Translation: BAA19567.1.
RefSeqiNP_990168.1. NM_204837.1.
UniGeneiGga.384.

Genome annotation databases

EnsembliENSGALT00000042660; ENSGALP00000041465; ENSGALG00000027429.
GeneIDi395641.
KEGGigga:395641.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000464 Genomic DNA. No translation available.
AB002410 mRNA. Translation: BAA19567.1.
RefSeqiNP_990168.1. NM_204837.1.
UniGeneiGga.384.

3D structure databases

ProteinModelPortaliO12968.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000042660; ENSGALP00000041465; ENSGALG00000027429.
GeneIDi395641.
KEGGigga:395641.

Organism-specific databases

CTDi3292.

Phylogenomic databases

GeneTreeiENSGT00870000136396.
HOVERGENiHBG014077.
KOiK00044.
OMAiMRTIFIT.
OrthoDBiEOG091G0E9O.

Enzyme and pathway databases

ReactomeiR-GGA-193144. Estrogen biosynthesis.

Gene expression databases

BgeeiENSGALG00000027429.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiView protein in InterPro
IPR011348. 17beta_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PIRSFiPIRSF000095. 17beta-HSD. 1 hit.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiO12968_CHICK
AccessioniPrimary (citable) accession number: O12968
Secondary accession number(s): R4GHC4
Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 1, 1997
Last modified: March 15, 2017
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.