Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O12947

- ICMT_XENLA

UniProt

O12947 - ICMT_XENLA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Protein-S-isoprenylcysteine O-methyltransferase

Gene

icmt

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.

Catalytic activityi

S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester.PROSITE-ProRule annotation

Cofactori

Divalent cations. Probably zinc (By similarity).By similarity

GO - Molecular functioni

  1. protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-S-isoprenylcysteine O-methyltransferase (EC:2.1.1.100)
Alternative name(s):
Farnesyl cysteine carboxyl methyltransferase
Short name:
FCMT
Isoprenylcysteine carboxylmethyltransferase
Prenylated protein carboxyl methyltransferase
Short name:
PPMT
Prenylcysteine carboxyl methyltransferase
Short name:
pcCMT
Gene namesi
Name:icmt
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6068654. icmt.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Protein-S-isoprenylcysteine O-methyltransferasePRO_0000209897Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO12947.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1212CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini30 – 4516LumenalSequence AnalysisAdd
BLAST
Topological domaini64 – 7310CytoplasmicSequence Analysis
Topological domaini92 – 965LumenalSequence Analysis
Topological domaini117 – 13519CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini154 – 1585LumenalSequence Analysis
Topological domaini179 – 21638CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini233 – 2331LumenalSequence Analysis
Topological domaini249 – 28840CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 2917HelicalSequence AnalysisAdd
BLAST
Transmembranei46 – 6318HelicalSequence AnalysisAdd
BLAST
Transmembranei74 – 9118HelicalSequence AnalysisAdd
BLAST
Transmembranei97 – 11620HelicalSequence AnalysisAdd
BLAST
Transmembranei136 – 15318HelicalSequence AnalysisAdd
BLAST
Transmembranei159 – 17820HelicalSequence AnalysisAdd
BLAST
Transmembranei217 – 23216HelicalSequence AnalysisAdd
BLAST
Transmembranei234 – 24815HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG019034.
KOiK00587.

Family and domain databases

InterProiIPR007269. ICMT_MeTrfase.
IPR025770. PPMT_MeTrfase.
[Graphical view]
PfamiPF04140. ICMT. 1 hit.
[Graphical view]
PROSITEiPS51564. SAM_ICMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O12947-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGARLLQEG RVSIVSFTLG ASVISLPLLT SSFTEQTLLA AAPGRIALVF
60 70 80 90 100
FIAALNGLLL LLYKAQLYQV AIRASFLGFA FGCGLLLSIT QSPWKPFGWY
110 120 130 140 150
VCSLSFFHYS EYLVTAMNNP RSLSIDSFLL NHSLEYTLAA LSSWVEFTIE
160 170 180 190 200
TTIYPDLKQI TWLSVIGLIM VLFGEVLRKC AMLTAGSNFN HIVQNEKSDS
210 220 230 240 250
HTLVTSGVYS WFRHPSYVGW FYWSIGTQVL LCNPLCLVGY TLASWRFFSE
260 270 280
RIEEEEFSLI HFFGENYLEY KKKVPTGLPF IKGVKMEP
Length:288
Mass (Da):32,432
Last modified:July 1, 1997 - v1
Checksum:i7F32D5A7BC1B522B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D87750 mRNA. Translation: BAA19000.1.
RefSeqiNP_001081219.1. NM_001087750.1.
UniGeneiXl.16.

Genome annotation databases

GeneIDi397717.
KEGGixla:397717.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D87750 mRNA. Translation: BAA19000.1 .
RefSeqi NP_001081219.1. NM_001087750.1.
UniGenei Xl.16.

3D structure databases

ProteinModelPortali O12947.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 397717.
KEGGi xla:397717.

Organism-specific databases

CTDi 23463.
Xenbasei XB-GENE-6068654. icmt.

Phylogenomic databases

HOVERGENi HBG019034.
KOi K00587.

Family and domain databases

InterProi IPR007269. ICMT_MeTrfase.
IPR025770. PPMT_MeTrfase.
[Graphical view ]
Pfami PF04140. ICMT. 1 hit.
[Graphical view ]
PROSITEi PS51564. SAM_ICMT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genes encoding farnesyl cysteine carboxyl methyltransferase in Schizosaccharomyces pombe and Xenopus laevis."
    Imai Y., Davey J., Kawagishi-Kobayashi M., Yamamoto M.
    Mol. Cell. Biol. 17:1543-1551(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiICMT_XENLA
AccessioniPrimary (citable) accession number: O12947
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: July 1, 1997
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3