Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O12947 (ICMT_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein-S-isoprenylcysteine O-methyltransferase

EC=2.1.1.100
Alternative name(s):
Farnesyl cysteine carboxyl methyltransferase
Short name=FCMT
Isoprenylcysteine carboxylmethyltransferase
Prenylated protein carboxyl methyltransferase
Short name=PPMT
Prenylcysteine carboxyl methyltransferase
Short name=pcCMT
Gene names
Name:icmt
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length288 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.

Catalytic activity

S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester.

Cofactor

Divalent cations. Probably zinc By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 288288Protein-S-isoprenylcysteine O-methyltransferase
PRO_0000209897

Regions

Topological domain1 – 1212Cytoplasmic Potential
Transmembrane13 – 2917Helical; Potential
Topological domain30 – 4516Lumenal Potential
Transmembrane46 – 6318Helical; Potential
Topological domain64 – 7310Cytoplasmic Potential
Transmembrane74 – 9118Helical; Potential
Topological domain92 – 965Lumenal Potential
Transmembrane97 – 11620Helical; Potential
Topological domain117 – 13519Cytoplasmic Potential
Transmembrane136 – 15318Helical; Potential
Topological domain154 – 1585Lumenal Potential
Transmembrane159 – 17820Helical; Potential
Topological domain179 – 21638Cytoplasmic Potential
Transmembrane217 – 23216Helical; Potential
Topological domain2331Lumenal Potential
Transmembrane234 – 24815Helical; Potential
Topological domain249 – 28840Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
O12947 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 7F32D5A7BC1B522B

FASTA28832,432
        10         20         30         40         50         60 
MAGARLLQEG RVSIVSFTLG ASVISLPLLT SSFTEQTLLA AAPGRIALVF FIAALNGLLL 

        70         80         90        100        110        120 
LLYKAQLYQV AIRASFLGFA FGCGLLLSIT QSPWKPFGWY VCSLSFFHYS EYLVTAMNNP 

       130        140        150        160        170        180 
RSLSIDSFLL NHSLEYTLAA LSSWVEFTIE TTIYPDLKQI TWLSVIGLIM VLFGEVLRKC 

       190        200        210        220        230        240 
AMLTAGSNFN HIVQNEKSDS HTLVTSGVYS WFRHPSYVGW FYWSIGTQVL LCNPLCLVGY 

       250        260        270        280 
TLASWRFFSE RIEEEEFSLI HFFGENYLEY KKKVPTGLPF IKGVKMEP 

« Hide

References

[1]"Genes encoding farnesyl cysteine carboxyl methyltransferase in Schizosaccharomyces pombe and Xenopus laevis."
Imai Y., Davey J., Kawagishi-Kobayashi M., Yamamoto M.
Mol. Cell. Biol. 17:1543-1551(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Ovary.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D87750 mRNA. Translation: BAA19000.1.
RefSeqNP_001081219.1. NM_001087750.1.
UniGeneXl.16.

3D structure databases

ProteinModelPortalO12947.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID397717.
KEGGxla:397717.

Organism-specific databases

CTD23463.
XenbaseXB-GENE-6068654. icmt.

Phylogenomic databases

HOVERGENHBG019034.
KOK00587.

Family and domain databases

InterProIPR007269. ICMT_MeTrfase.
IPR025770. PPMT_MeTrfase.
[Graphical view]
PfamPF04140. ICMT. 1 hit.
[Graphical view]
PROSITEPS51564. SAM_ICMT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameICMT_XENLA
AccessionPrimary (citable) accession number: O12947
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: July 1, 1997
Last modified: February 19, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families