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O12947

- ICMT_XENLA

UniProt

O12947 - ICMT_XENLA

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Protein

Protein-S-isoprenylcysteine O-methyltransferase

Gene
icmt
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.

Catalytic activityi

S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester.

Cofactori

Divalent cations. Probably zinc By similarity.

GO - Molecular functioni

  1. protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-S-isoprenylcysteine O-methyltransferase (EC:2.1.1.100)
Alternative name(s):
Farnesyl cysteine carboxyl methyltransferase
Short name:
FCMT
Isoprenylcysteine carboxylmethyltransferase
Prenylated protein carboxyl methyltransferase
Short name:
PPMT
Prenylcysteine carboxyl methyltransferase
Short name:
pcCMT
Gene namesi
Name:icmt
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6068654. icmt.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1212Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei13 – 2917Helical; Reviewed predictionAdd
BLAST
Topological domaini30 – 4516Lumenal Reviewed predictionAdd
BLAST
Transmembranei46 – 6318Helical; Reviewed predictionAdd
BLAST
Topological domaini64 – 7310Cytoplasmic Reviewed prediction
Transmembranei74 – 9118Helical; Reviewed predictionAdd
BLAST
Topological domaini92 – 965Lumenal Reviewed prediction
Transmembranei97 – 11620Helical; Reviewed predictionAdd
BLAST
Topological domaini117 – 13519Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei136 – 15318Helical; Reviewed predictionAdd
BLAST
Topological domaini154 – 1585Lumenal Reviewed prediction
Transmembranei159 – 17820Helical; Reviewed predictionAdd
BLAST
Topological domaini179 – 21638Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei217 – 23216Helical; Reviewed predictionAdd
BLAST
Topological domaini233 – 2331Lumenal Reviewed prediction
Transmembranei234 – 24815Helical; Reviewed predictionAdd
BLAST
Topological domaini249 – 28840Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Protein-S-isoprenylcysteine O-methyltransferasePRO_0000209897Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO12947.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG019034.
KOiK00587.

Family and domain databases

InterProiIPR007269. ICMT_MeTrfase.
IPR025770. PPMT_MeTrfase.
[Graphical view]
PfamiPF04140. ICMT. 1 hit.
[Graphical view]
PROSITEiPS51564. SAM_ICMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O12947-1 [UniParc]FASTAAdd to Basket

« Hide

MAGARLLQEG RVSIVSFTLG ASVISLPLLT SSFTEQTLLA AAPGRIALVF    50
FIAALNGLLL LLYKAQLYQV AIRASFLGFA FGCGLLLSIT QSPWKPFGWY 100
VCSLSFFHYS EYLVTAMNNP RSLSIDSFLL NHSLEYTLAA LSSWVEFTIE 150
TTIYPDLKQI TWLSVIGLIM VLFGEVLRKC AMLTAGSNFN HIVQNEKSDS 200
HTLVTSGVYS WFRHPSYVGW FYWSIGTQVL LCNPLCLVGY TLASWRFFSE 250
RIEEEEFSLI HFFGENYLEY KKKVPTGLPF IKGVKMEP 288
Length:288
Mass (Da):32,432
Last modified:July 1, 1997 - v1
Checksum:i7F32D5A7BC1B522B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D87750 mRNA. Translation: BAA19000.1.
RefSeqiNP_001081219.1. NM_001087750.1.
UniGeneiXl.16.

Genome annotation databases

GeneIDi397717.
KEGGixla:397717.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D87750 mRNA. Translation: BAA19000.1 .
RefSeqi NP_001081219.1. NM_001087750.1.
UniGenei Xl.16.

3D structure databases

ProteinModelPortali O12947.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 397717.
KEGGi xla:397717.

Organism-specific databases

CTDi 23463.
Xenbasei XB-GENE-6068654. icmt.

Phylogenomic databases

HOVERGENi HBG019034.
KOi K00587.

Family and domain databases

InterProi IPR007269. ICMT_MeTrfase.
IPR025770. PPMT_MeTrfase.
[Graphical view ]
Pfami PF04140. ICMT. 1 hit.
[Graphical view ]
PROSITEi PS51564. SAM_ICMT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genes encoding farnesyl cysteine carboxyl methyltransferase in Schizosaccharomyces pombe and Xenopus laevis."
    Imai Y., Davey J., Kawagishi-Kobayashi M., Yamamoto M.
    Mol. Cell. Biol. 17:1543-1551(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiICMT_XENLA
AccessioniPrimary (citable) accession number: O12947
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: July 1, 1997
Last modified: February 19, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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