Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O12947

- ICMT_XENLA

UniProt

O12947 - ICMT_XENLA

Protein

Protein-S-isoprenylcysteine O-methyltransferase

Gene

icmt

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.

    Catalytic activityi

    S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester.PROSITE-ProRule annotation

    Cofactori

    Divalent cations. Probably zinc By similarity.By similarity

    GO - Molecular functioni

    1. protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein-S-isoprenylcysteine O-methyltransferase (EC:2.1.1.100)
    Alternative name(s):
    Farnesyl cysteine carboxyl methyltransferase
    Short name:
    FCMT
    Isoprenylcysteine carboxylmethyltransferase
    Prenylated protein carboxyl methyltransferase
    Short name:
    PPMT
    Prenylcysteine carboxyl methyltransferase
    Short name:
    pcCMT
    Gene namesi
    Name:icmt
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-6068654. icmt.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 288288Protein-S-isoprenylcysteine O-methyltransferasePRO_0000209897Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliO12947.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1212CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini30 – 4516LumenalSequence AnalysisAdd
    BLAST
    Topological domaini64 – 7310CytoplasmicSequence Analysis
    Topological domaini92 – 965LumenalSequence Analysis
    Topological domaini117 – 13519CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini154 – 1585LumenalSequence Analysis
    Topological domaini179 – 21638CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini233 – 2331LumenalSequence Analysis
    Topological domaini249 – 28840CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei13 – 2917HelicalSequence AnalysisAdd
    BLAST
    Transmembranei46 – 6318HelicalSequence AnalysisAdd
    BLAST
    Transmembranei74 – 9118HelicalSequence AnalysisAdd
    BLAST
    Transmembranei97 – 11620HelicalSequence AnalysisAdd
    BLAST
    Transmembranei136 – 15318HelicalSequence AnalysisAdd
    BLAST
    Transmembranei159 – 17820HelicalSequence AnalysisAdd
    BLAST
    Transmembranei217 – 23216HelicalSequence AnalysisAdd
    BLAST
    Transmembranei234 – 24815HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG019034.
    KOiK00587.

    Family and domain databases

    InterProiIPR007269. ICMT_MeTrfase.
    IPR025770. PPMT_MeTrfase.
    [Graphical view]
    PfamiPF04140. ICMT. 1 hit.
    [Graphical view]
    PROSITEiPS51564. SAM_ICMT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O12947-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGARLLQEG RVSIVSFTLG ASVISLPLLT SSFTEQTLLA AAPGRIALVF    50
    FIAALNGLLL LLYKAQLYQV AIRASFLGFA FGCGLLLSIT QSPWKPFGWY 100
    VCSLSFFHYS EYLVTAMNNP RSLSIDSFLL NHSLEYTLAA LSSWVEFTIE 150
    TTIYPDLKQI TWLSVIGLIM VLFGEVLRKC AMLTAGSNFN HIVQNEKSDS 200
    HTLVTSGVYS WFRHPSYVGW FYWSIGTQVL LCNPLCLVGY TLASWRFFSE 250
    RIEEEEFSLI HFFGENYLEY KKKVPTGLPF IKGVKMEP 288
    Length:288
    Mass (Da):32,432
    Last modified:July 1, 1997 - v1
    Checksum:i7F32D5A7BC1B522B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D87750 mRNA. Translation: BAA19000.1.
    RefSeqiNP_001081219.1. NM_001087750.1.
    UniGeneiXl.16.

    Genome annotation databases

    GeneIDi397717.
    KEGGixla:397717.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D87750 mRNA. Translation: BAA19000.1 .
    RefSeqi NP_001081219.1. NM_001087750.1.
    UniGenei Xl.16.

    3D structure databases

    ProteinModelPortali O12947.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 397717.
    KEGGi xla:397717.

    Organism-specific databases

    CTDi 23463.
    Xenbasei XB-GENE-6068654. icmt.

    Phylogenomic databases

    HOVERGENi HBG019034.
    KOi K00587.

    Family and domain databases

    InterProi IPR007269. ICMT_MeTrfase.
    IPR025770. PPMT_MeTrfase.
    [Graphical view ]
    Pfami PF04140. ICMT. 1 hit.
    [Graphical view ]
    PROSITEi PS51564. SAM_ICMT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genes encoding farnesyl cysteine carboxyl methyltransferase in Schizosaccharomyces pombe and Xenopus laevis."
      Imai Y., Davey J., Kawagishi-Kobayashi M., Yamamoto M.
      Mol. Cell. Biol. 17:1543-1551(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Ovary.

    Entry informationi

    Entry nameiICMT_XENLA
    AccessioniPrimary (citable) accession number: O12947
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3