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Protein

Virion infectivity factor

Gene

vif

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interactionSAAS annotation, Ubl conjugation pathwaySAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Virion infectivity factorUniRule annotation
Gene namesi
Name:vifImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

  • Host cell membrane SAAS annotation; Peripheral membrane protein SAAS annotation; Cytoplasmic side SAAS annotation
  • Host cytoplasm SAAS annotation
  • Virion SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cell membraneSAAS annotation, Host cytoplasmSAAS annotation, Host membrane, Membrane, VirionSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the primate lentivirus group Vif protein family.SAAS annotation

Family and domain databases

InterProiIPR000475. Viral_infect.
[Graphical view]
PfamiPF00559. Vif. 1 hit.
[Graphical view]
PRINTSiPR00349. VIRIONINFFCT.

Sequencei

Sequence statusi: Complete.

O11968-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENRWQVMIV WQVDRMRIRT WHSLVKHHIY ISRKAKGWVY RHHYESTNPR
60 70 80 90 100
VSSEVHIPIK DTRLVITTYW GLHTGEKDWH LGQGVSIEWR ERRYRTQVDP
110 120 130 140 150
DLADQLIHLY YFDCFSESAI RKAIVGHIVS PRCEYQAGHN KVGSLQYLAL
160 170 180 190
AALIPPKKIR PPLPSVRKLT EDRWNKPQKT KGHRGCHTMN GH
Length:192
Mass (Da):22,760
Last modified:July 1, 1997 - v1
Checksum:iBC2AAA239320788C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D70882 Genomic DNA. Translation: BAA20321.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D70882 Genomic DNA. Translation: BAA20321.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR000475. Viral_infect.
[Graphical view]
PfamiPF00559. Vif. 1 hit.
[Graphical view]
PRINTSiPR00349. VIRIONINFFCT.
ProtoNetiSearch...

Publicationsi

  1. "A high frequency of defective vif genes in peripheral blood mononuclear cells from HIV type 1-infected individuals."
    Tominaga K., Kato S., Negishi M., Takano T.
    AIDS Res. Hum. Retroviruses 12:1543-1549(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO11968_9HIV1
AccessioniPrimary (citable) accession number: O11968
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 1, 1997
Last modified: July 6, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.