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O11459

- VP24_EBOG4

UniProt

O11459 - VP24_EBOG4

Protein

Membrane-associated protein VP24

Gene

VP24

Organism
Zaire ebolavirus (strain Gabon-94) (ZEBOV) (Zaire Ebola virus)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. Blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1, by interacting with the STAT1-binding region of host importin alpha-1/KPNA1 protein, thereby inhibiting the latter. Without the activity of this protein, activated STAT1 would not enter the nucleus and be unable to activate IFN-induced genes. Plays a role in assembly of viral nucleocapsid and virion budding. May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding.

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    GO - Biological processi

    1. evasion or tolerance by virus of host immune response Source: UniProtKB-KW

    Keywords - Biological processi

    Host-virus interaction, Interferon antiviral system evasion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Membrane-associated protein VP24
    Gene namesi
    Name:VP24
    OrganismiZaire ebolavirus (strain Gabon-94) (ZEBOV) (Zaire Ebola virus)
    Taxonomic identifieri128947 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesFiloviridaeEbolavirus
    Virus hostiEpomops franqueti (Franquet's epauleted fruit bat) [TaxID: 77231]
    Homo sapiens (Human) [TaxID: 9606]
    Myonycteris torquata (Little collared fruit bat) [TaxID: 77243]

    Subcellular locationi

    Virion membrane By similarity; Peripheral membrane protein By similarity. Host cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Host endomembrane system By similarity; Peripheral membrane protein By similarity
    Note: In virion, localizes on the intravirional side of the membrane. In the host cell, it is found associated with virus-induced membrane proliferation foci and to the plasma membrane where budding takes place By similarity.By similarity

    GO - Cellular componenti

    1. host cell endomembrane system Source: UniProtKB-SubCell
    2. host cell plasma membrane Source: UniProtKB-SubCell
    3. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cell membrane, Host membrane, Membrane, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 251251Membrane-associated protein VP24PRO_0000222155Add
    BLAST

    Interactioni

    Subunit structurei

    Binds to host importin alpha-1/KPNA1.By similarity

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR009433. Filo_VP24.
    [Graphical view]
    PfamiPF06389. Filo_VP24. 1 hit.
    [Graphical view]
    PIRSFiPIRSF011355. VP24. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O11459-1 [UniParc]FASTAAdd to Basket

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    MAKATGRYNL ISPKKDLEKG VVLSDLCNFL VSQTIQGWKV YWAGIEFDVT    50
    HKGMALLHRL KTNDFAPAWS MTRNLFPHLF QNPNSTIESP LWALRVILAA 100
    GIQDQLIDQS LIEPLAGALG LISDWLLTTN TNHFNMRTQR VKEQLSLKML 150
    SLIRSNILKF INKLDALHVV NYNGLLSSIE IGTQNHTIII TRTNMGFLVE 200
    LQEPDKSAMN RKKPGPAKFS LLHESTLKAF TQGSSTRMQS LILEFNSSLA 250
    I 251
    Length:251
    Mass (Da):28,216
    Last modified:July 1, 1997 - v1
    Checksum:iCD114B6AF2CC5A59
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U77385 Genomic RNA. Translation: AAC57991.1.
    AY058897 mRNA. Translation: AAL25817.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U77385 Genomic RNA. Translation: AAC57991.1 .
    AY058897 mRNA. Translation: AAL25817.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR009433. Filo_VP24.
    [Graphical view ]
    Pfami PF06389. Filo_VP24. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF011355. VP24. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Sequence analysis of the GP, NP, VP40 and VP24 genes of Ebola virus isolated from deceased, surviving and asymptomatically infected individuals during the 1996 outbreak in Gabon: comparative studies and phylogenetic characterization."
      Leroy E.M., Baize S., Mavoungou E., Apetrei C.
      J. Gen. Virol. 83:67-73(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Isolate Bouee-96.

    Entry informationi

    Entry nameiVP24_EBOG4
    AccessioniPrimary (citable) accession number: O11459
    Secondary accession number(s): Q6YNP9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3