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O11459

- VP24_EBOG4

UniProt

O11459 - VP24_EBOG4

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Protein
Membrane-associated protein VP24
Gene
VP24
Organism
Zaire ebolavirus (strain Gabon-94) (ZEBOV) (Zaire Ebola virus)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. Blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1, by interacting with the STAT1-binding region of host importin alpha-1/KPNA1 protein, thereby inhibiting the latter. Without the activity of this protein, activated STAT1 would not enter the nucleus and be unable to activate IFN-induced genes. Plays a role in assembly of viral nucleocapsid and virion budding. May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding.

GO - Molecular functioni

  1. structural molecule activity Source: InterPro

GO - Biological processi

  1. evasion or tolerance by virus of host immune response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Interferon antiviral system evasion

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-associated protein VP24
Gene namesi
Name:VP24
OrganismiZaire ebolavirus (strain Gabon-94) (ZEBOV) (Zaire Ebola virus)
Taxonomic identifieri128947 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesFiloviridaeEbolavirus
Virus hostiEpomops franqueti (Franquet's epauleted fruit bat) [TaxID: 77231]
Homo sapiens (Human) [TaxID: 9606]
Myonycteris torquata (Little collared fruit bat) [TaxID: 77243]

Subcellular locationi

Virion membrane; Peripheral membrane protein By similarity. Host cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Host endomembrane system; Peripheral membrane protein By similarity
Note: In virion, localizes on the intravirional side of the membrane. In the host cell, it is found associated with virus-induced membrane proliferation foci and to the plasma membrane where budding takes place By similarity.

GO - Cellular componenti

  1. host cell endomembrane system Source: UniProtKB-SubCell
  2. host cell plasma membrane Source: UniProtKB-SubCell
  3. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 251251Membrane-associated protein VP24
PRO_0000222155Add
BLAST

Interactioni

Subunit structurei

Binds to host importin alpha-1/KPNA1 By similarity.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR009433. Filo_VP24.
[Graphical view]
PfamiPF06389. Filo_VP24. 1 hit.
[Graphical view]
PIRSFiPIRSF011355. VP24. 1 hit.

Sequencei

Sequence statusi: Complete.

O11459-1 [UniParc]FASTAAdd to Basket

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MAKATGRYNL ISPKKDLEKG VVLSDLCNFL VSQTIQGWKV YWAGIEFDVT    50
HKGMALLHRL KTNDFAPAWS MTRNLFPHLF QNPNSTIESP LWALRVILAA 100
GIQDQLIDQS LIEPLAGALG LISDWLLTTN TNHFNMRTQR VKEQLSLKML 150
SLIRSNILKF INKLDALHVV NYNGLLSSIE IGTQNHTIII TRTNMGFLVE 200
LQEPDKSAMN RKKPGPAKFS LLHESTLKAF TQGSSTRMQS LILEFNSSLA 250
I 251
Length:251
Mass (Da):28,216
Last modified:July 1, 1997 - v1
Checksum:iCD114B6AF2CC5A59
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U77385 Genomic RNA. Translation: AAC57991.1.
AY058897 mRNA. Translation: AAL25817.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U77385 Genomic RNA. Translation: AAC57991.1 .
AY058897 mRNA. Translation: AAL25817.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR009433. Filo_VP24.
[Graphical view ]
Pfami PF06389. Filo_VP24. 1 hit.
[Graphical view ]
PIRSFi PIRSF011355. VP24. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Sequence analysis of the GP, NP, VP40 and VP24 genes of Ebola virus isolated from deceased, surviving and asymptomatically infected individuals during the 1996 outbreak in Gabon: comparative studies and phylogenetic characterization."
    Leroy E.M., Baize S., Mavoungou E., Apetrei C.
    J. Gen. Virol. 83:67-73(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Isolate Bouee-96.

Entry informationi

Entry nameiVP24_EBOG4
AccessioniPrimary (citable) accession number: O11459
Secondary accession number(s): Q6YNP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 1, 1997
Last modified: April 3, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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