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Protein

Occlusion-derived virus envelope protein E27

Gene

ORF141

Organism
Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Acts as a cyclin-like protein and plays a role in the modulation of host cell cycle. May promote G2/S arrest by interacting with host mus209/PCNA, cdc2 and cdk6. The cell cycle arrest is characterized by an intact nuclear envelope, concomitant with sustained activity of host cdc2. However, viral DNA replication still occurs in the arrested cells (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Modulation of host cell cycle by viral cyclin-like protein, Modulation of host cell cycle by virus

Names & Taxonomyi

Protein namesi
Recommended name:
Occlusion-derived virus envelope protein E27
Short name:
ODV-E27
Gene namesi
ORF Names:ORF141
OrganismiOrgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV)
Taxonomic identifieri262177 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageBaculoviridaeAlphabaculovirus
Virus hostiOrgyia pseudotsugata (Douglas-fir tussock moth) [TaxID: 33414]
Proteomesi
  • UP000009248 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001329221 – 297Occlusion-derived virus envelope protein E27Add BLAST297

Interactioni

Subunit structurei

Interacts with host mus209/PCNA, cdc2 and cdk6.By similarity

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi218 – 222Poly-Leu5

Sequence similaritiesi

Belongs to the baculoviridae E27 family.Curated

Phylogenomic databases

OrthoDBiVOG090000HD.

Family and domain databases

InterProiView protein in InterPro
IPR007978. Baculo_ODV-E27.
PfamiView protein in Pfam
PF05314. Baculo_ODV-E27. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD017661. Baculo_ODV-E27. 1 hit.

Sequencei

Sequence statusi: Complete.

O10372-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRVRCNKVR TVTEVKPNNA KIRKTYDLNE FDLKNLSSLE SFENTKVKLA
60 70 80 90 100
LSKYMAMINT LEMTQPLLEV FRNRADTRQI VAVVQATMGF VHNRFNPLVT
110 120 130 140 150
HFTNKMEFVT TETAETIIPG EPILFTENDG ALLCAIDRPS IVKMLSREFD
160 170 180 190 200
LSVAAEPQTS NREVLVAKTL VSNKRKRRSS NDEGYEFIKR PRTFSEYNQC
210 220 230 240 250
MDALSDFNVT EIETTQYLLL LLIVEHAYLH YYIFKNYGAL EYSKSLMDHS
260 270 280 290
LFVNKLRSST NAKMHNLLLS KFRFTVEESD KTSSGTTSKF TVYNFNK
Length:297
Mass (Da):34,330
Last modified:July 1, 1997 - v1
Checksum:iFB23F3C29988C032
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75930 Genomic DNA. Translation: AAC59140.1.
RefSeqiNP_046297.1. NC_001875.2.

Genome annotation databases

GeneIDi912081.
KEGGivg:912081.

Similar proteinsi

Entry informationi

Entry nameiOE27_NPVOP
AccessioniPrimary (citable) accession number: O10372
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: October 25, 2017
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families