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O10364

- CATV_NPVOP

UniProt

O10364 - CATV_NPVOP

Protein

Viral cathepsin

Gene

VCATH

Organism
Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Cysteine protease that plays an essential role in host liquefaction to facilitate horizontal transmission of the virus. May participate in the degradation of foreign protein expressed by the baculovirus system By similarity.By similarity

    Catalytic activityi

    Endopeptidase of broad specificity, hydrolyzing substrates of both cathepsin L and cathepsin B.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei137 – 1371By similarity
    Active sitei270 – 2701By similarity
    Active sitei290 – 2901By similarity

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Protein family/group databases

    MEROPSiC01.083.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Viral cathepsin (EC:3.4.22.50)
    Short name:
    V-cath
    Alternative name(s):
    Cysteine proteinase
    Short name:
    CP
    Gene namesi
    Name:VCATH
    ORF Names:ORF125
    OrganismiOrgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV)
    Taxonomic identifieri262177 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageBaculoviridaeAlphabaculovirus
    Virus hostiOrgyia pseudotsugata (Douglas-fir tussock moth) [TaxID: 33414]
    ProteomesiUP000009248: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Propeptidei17 – 11397Activation peptideSequence AnalysisPRO_0000322214Add
    BLAST
    Chaini114 – 324211Viral cathepsinPRO_0000050584Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi134 ↔ 175By similarity
    Glycosylationi159 – 1591N-linked (GlcNAc...); by hostSequence Analysis
    Disulfide bondi168 ↔ 208By similarity
    Disulfide bondi263 ↔ 311By similarity

    Post-translational modificationi

    Synthesized as an inactive proenzyme and activated by proteolytic removal of the inhibitory propeptide.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Structurei

    3D structure databases

    ProteinModelPortaliO10364.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Family and domain databases

    InterProiIPR025661. Pept_asp_AS.
    IPR000169. Pept_cys_AS.
    IPR025660. Pept_his_AS.
    IPR013128. Peptidase_C1A.
    IPR000668. Peptidase_C1A_C.
    IPR013201. Prot_inhib_I29.
    [Graphical view]
    PANTHERiPTHR12411. PTHR12411. 1 hit.
    PfamiPF08246. Inhibitor_I29. 1 hit.
    PF00112. Peptidase_C1. 1 hit.
    [Graphical view]
    PRINTSiPR00705. PAPAIN.
    SMARTiSM00848. Inhibitor_I29. 1 hit.
    SM00645. Pept_C1. 1 hit.
    [Graphical view]
    PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
    PS00139. THIOL_PROTEASE_CYS. 1 hit.
    PS00639. THIOL_PROTEASE_HIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O10364-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNKIMLCLLV CGVVHAATYD LLKAPNYFED FLHKFNKNYS SESEKLHRFK    50
    IFQHNLEEII NKNQNDSTAQ YEINKFSDLS KEEAISKYTG LSLPHQTQNF 100
    CEVVILDRPP DRGPLEFDWR QFNKVTSVKN QGVCGACWAF ATLGSLESQF 150
    AIKYNRLINL SEQQFIDCDR VNAGCDGGLL HTAFESAMEM GGVQMESDYP 200
    YETANGQCRI NPNRFVVGVR SCRRYIVMFE EKLKDLLRAV GPIPVAIDAS 250
    DIVNYRRGIM RQCANHGLNH AVLLVGYAVE NNIPYWILKN TWGTDWGEDG 300
    YFRVQQNINA CGIRNELVSS AEIY 324
    Length:324
    Mass (Da):36,982
    Last modified:July 1, 1997 - v1
    Checksum:iD36A709D6063C15C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U75930 Genomic DNA. Translation: AAC59124.1.
    RefSeqiNP_046281.1. NC_001875.2.

    Genome annotation databases

    GeneIDi912077.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U75930 Genomic DNA. Translation: AAC59124.1 .
    RefSeqi NP_046281.1. NC_001875.2.

    3D structure databases

    ProteinModelPortali O10364.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi C01.083.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 912077.

    Family and domain databases

    InterProi IPR025661. Pept_asp_AS.
    IPR000169. Pept_cys_AS.
    IPR025660. Pept_his_AS.
    IPR013128. Peptidase_C1A.
    IPR000668. Peptidase_C1A_C.
    IPR013201. Prot_inhib_I29.
    [Graphical view ]
    PANTHERi PTHR12411. PTHR12411. 1 hit.
    Pfami PF08246. Inhibitor_I29. 1 hit.
    PF00112. Peptidase_C1. 1 hit.
    [Graphical view ]
    PRINTSi PR00705. PAPAIN.
    SMARTi SM00848. Inhibitor_I29. 1 hit.
    SM00645. Pept_C1. 1 hit.
    [Graphical view ]
    PROSITEi PS00640. THIOL_PROTEASE_ASN. 1 hit.
    PS00139. THIOL_PROTEASE_CYS. 1 hit.
    PS00639. THIOL_PROTEASE_HIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of the Orgyia pseudotsugata multinucleocapsid nuclear polyhedrosis virus genome."
      Ahrens C.H., Russell R.R., Funk C.J., Evans J., Harwood S., Rohrmann G.F.
      Virology 229:381-399(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiCATV_NPVOP
    AccessioniPrimary (citable) accession number: O10364
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3