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Protein

Viral cathepsin

Gene

VCATH

Organism
Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cysteine protease that plays an essential role in host liquefaction to facilitate horizontal transmission of the virus. May participate in the degradation of foreign protein expressed by the baculovirus system (By similarity).By similarity

Catalytic activityi

Endopeptidase of broad specificity, hydrolyzing substrates of both cathepsin L and cathepsin B.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei137By similarity1
Active sitei270By similarity1
Active sitei290By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Protein family/group databases

MEROPSiC01.083.

Names & Taxonomyi

Protein namesi
Recommended name:
Viral cathepsin (EC:3.4.22.50)
Short name:
V-cath
Alternative name(s):
Cysteine proteinase
Short name:
CP
Gene namesi
Name:VCATH
ORF Names:ORF125
OrganismiOrgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV)
Taxonomic identifieri262177 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageBaculoviridaeAlphabaculovirus
Virus hostiOrgyia pseudotsugata (Douglas-fir tussock moth) [TaxID: 33414]
Proteomesi
  • UP000009248 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
PropeptideiPRO_000032221417 – 113Activation peptideSequence analysisAdd BLAST97
ChainiPRO_0000050584114 – 324Viral cathepsinAdd BLAST211

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi134 ↔ 175By similarity
Glycosylationi159N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Disulfide bondi168 ↔ 208By similarity
Disulfide bondi263 ↔ 311By similarity

Post-translational modificationi

Synthesized as an inactive proenzyme and activated by proteolytic removal of the inhibitory propeptide.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Structurei

3D structure databases

ProteinModelPortaliO10364.
SMRiO10364.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

OrthoDBiVOG090000OO.

Family and domain databases

InterProiView protein in InterPro
IPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiView protein in Pfam
PF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
PRINTSiPR00705. PAPAIN.
SMARTiView protein in SMART
SM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
PROSITEiView protein in PROSITE
PS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O10364-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKIMLCLLV CGVVHAATYD LLKAPNYFED FLHKFNKNYS SESEKLHRFK
60 70 80 90 100
IFQHNLEEII NKNQNDSTAQ YEINKFSDLS KEEAISKYTG LSLPHQTQNF
110 120 130 140 150
CEVVILDRPP DRGPLEFDWR QFNKVTSVKN QGVCGACWAF ATLGSLESQF
160 170 180 190 200
AIKYNRLINL SEQQFIDCDR VNAGCDGGLL HTAFESAMEM GGVQMESDYP
210 220 230 240 250
YETANGQCRI NPNRFVVGVR SCRRYIVMFE EKLKDLLRAV GPIPVAIDAS
260 270 280 290 300
DIVNYRRGIM RQCANHGLNH AVLLVGYAVE NNIPYWILKN TWGTDWGEDG
310 320
YFRVQQNINA CGIRNELVSS AEIY
Length:324
Mass (Da):36,982
Last modified:July 1, 1997 - v1
Checksum:iD36A709D6063C15C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75930 Genomic DNA. Translation: AAC59124.1.
RefSeqiNP_046281.1. NC_001875.2.

Genome annotation databases

GeneIDi912077.
KEGGivg:912077.

Similar proteinsi

Entry informationi

Entry nameiCATV_NPVOP
AccessioniPrimary (citable) accession number: O10364
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: October 25, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families