O10364 (CATV_NPVOP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Viral cathepsin
Short name=V-cath
EC=3.4.22.50

Alternative name(s):
Cysteine proteinase
Short name=CP

Gene names

Name:	VCATH
ORF Names:	ORF125

Organism

Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) [Complete proteome]

Taxonomic identifier

262177 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Baculoviridae › Alphabaculovirus

Virus host

Orgyia pseudotsugata (Douglas fir tussock moth) [TaxID: 33414]

Protein attributes

Sequence length	324 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cysteine protease that plays an essential role in host liquefaction to facilitate horizontal transmission of the virus. May participate in the degradation of foreign protein expressed by the baculovirus system By similarity.
Catalytic activity	Endopeptidase of broad specificity, hydrolyzing substrates of both cathepsin L and cathepsin B.
Post-translational modification	Synthesized as an inactive proenzyme and activated by proteolytic removal of the inhibitory propeptide By similarity.
Sequence similarities	Belongs to the peptidase C1 family.

Ontologies

Keywords
Domain	Signal
Molecular function	Hydrolase Protease Thiol protease
PTM	Disulfide bond Glycoprotein Zymogen
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	cysteine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	Potential
	Propeptide	17 – 113	97	Activation peptide Potential		PRO_0000322214
	Chain	114 – 324	211	Viral cathepsin		PRO_0000050584
Sites
	Active site	137	1	By similarity
	Active site	270	1	By similarity
	Active site	290	1	By similarity
Amino acid modifications
	Glycosylation	159	1	N-linked (GlcNAc...); by host Potential
	Disulfide bond	134 ↔ 175		By similarity
	Disulfide bond	168 ↔ 208		By similarity
	Disulfide bond	263 ↔ 311		By similarity

Sequences

	Sequence		Length	Mass (Da)
	O10364 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: D36A709D6063C15C	FASTA	324	36,982
	10 20 30 40 50 60 MNKIMLCLLV CGVVHAATYD LLKAPNYFED FLHKFNKNYS SESEKLHRFK IFQHNLEEII 70 80 90 100 110 120 NKNQNDSTAQ YEINKFSDLS KEEAISKYTG LSLPHQTQNF CEVVILDRPP DRGPLEFDWR 130 140 150 160 170 180 QFNKVTSVKN QGVCGACWAF ATLGSLESQF AIKYNRLINL SEQQFIDCDR VNAGCDGGLL 190 200 210 220 230 240 HTAFESAMEM GGVQMESDYP YETANGQCRI NPNRFVVGVR SCRRYIVMFE EKLKDLLRAV 250 260 270 280 290 300 GPIPVAIDAS DIVNYRRGIM RQCANHGLNH AVLLVGYAVE NNIPYWILKN TWGTDWGEDG 310 320 YFRVQQNINA CGIRNELVSS AEIY

References

[1]	"The sequence of the Orgyia pseudotsugata multinucleocapsid nuclear polyhedrosis virus genome." Ahrens C.H., Russell R.R., Funk C.J., Evans J., Harwood S., Rohrmann G.F. Virology 229:381-399(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	U75930 Genomic DNA. Translation: AAC59124.1.
RefSeq	NP_046281.1. NC_001875.2.
3D structure databases
ProteinModelPortal	O10364.
ModBase	Search...
Protein family/group databases
MEROPS	C01.083.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	912077.
Phylogenomic databases
ProtClustDB	CLSP2509984.
Family and domain databases
InterPro	IPR025661. Pept_asp_AS. IPR000169. Pept_cys_AS. IPR025660. Pept_his_AS. IPR013128. Peptidase_C1A. IPR000668. Peptidase_C1A_C. IPR013201. Prot_inhib_I29. [Graphical view]
PANTHER	PTHR12411. PTHR12411. 1 hit.
Pfam	PF08246. Inhibitor_I29. 1 hit. PF00112. Peptidase_C1. 1 hit. [Graphical view]
PRINTS	PR00705. PAPAIN.
SMART	SM00848. Inhibitor_I29. 1 hit. SM00645. Pept_C1. 1 hit. [Graphical view]
PROSITE	PS00640. THIOL_PROTEASE_ASN. 1 hit. PS00139. THIOL_PROTEASE_CYS. 1 hit. PS00639. THIOL_PROTEASE_HIS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CATV_NPVOP

Accession

Primary (citable) accession number: O10364

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	July 1, 1997
Last modified:	April 3, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program