Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O10364 (CATV_NPVOP) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Viral cathepsin

Short name=V-cath
EC=3.4.22.50
Alternative name(s):
Cysteine proteinase
Short name=CP
Gene names
Name:VCATH
ORF Names:ORF125
OrganismOrgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) [Complete proteome]
Taxonomic identifier262177 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageBaculoviridaeAlphabaculovirus
Virus hostOrgyia pseudotsugata (Douglas-fir tussock moth) [TaxID: 33414]

Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cysteine protease that plays an essential role in host liquefaction to facilitate horizontal transmission of the virus. May participate in the degradation of foreign protein expressed by the baculovirus system By similarity.

Catalytic activity

Endopeptidase of broad specificity, hydrolyzing substrates of both cathepsin L and cathepsin B.

Post-translational modification

Synthesized as an inactive proenzyme and activated by proteolytic removal of the inhibitory propeptide By similarity.

Sequence similarities

Belongs to the peptidase C1 family.

Ontologies

Keywords
   DomainSignal
   Molecular functionHydrolase
Protease
Thiol protease
   PTMDisulfide bond
Glycoprotein
Zymogen
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functioncysteine-type peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Propeptide17 – 11397Activation peptide Potential
PRO_0000322214
Chain114 – 324211Viral cathepsin
PRO_0000050584

Sites

Active site1371 By similarity
Active site2701 By similarity
Active site2901 By similarity

Amino acid modifications

Glycosylation1591N-linked (GlcNAc...); by host Potential
Disulfide bond134 ↔ 175 By similarity
Disulfide bond168 ↔ 208 By similarity
Disulfide bond263 ↔ 311 By similarity

Sequences

Sequence LengthMass (Da)Tools
O10364 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: D36A709D6063C15C

FASTA32436,982
        10         20         30         40         50         60 
MNKIMLCLLV CGVVHAATYD LLKAPNYFED FLHKFNKNYS SESEKLHRFK IFQHNLEEII 

        70         80         90        100        110        120 
NKNQNDSTAQ YEINKFSDLS KEEAISKYTG LSLPHQTQNF CEVVILDRPP DRGPLEFDWR 

       130        140        150        160        170        180 
QFNKVTSVKN QGVCGACWAF ATLGSLESQF AIKYNRLINL SEQQFIDCDR VNAGCDGGLL 

       190        200        210        220        230        240 
HTAFESAMEM GGVQMESDYP YETANGQCRI NPNRFVVGVR SCRRYIVMFE EKLKDLLRAV 

       250        260        270        280        290        300 
GPIPVAIDAS DIVNYRRGIM RQCANHGLNH AVLLVGYAVE NNIPYWILKN TWGTDWGEDG 

       310        320 
YFRVQQNINA CGIRNELVSS AEIY 

« Hide

References

[1]"The sequence of the Orgyia pseudotsugata multinucleocapsid nuclear polyhedrosis virus genome."
Ahrens C.H., Russell R.R., Funk C.J., Evans J., Harwood S., Rohrmann G.F.
Virology 229:381-399(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U75930 Genomic DNA. Translation: AAC59124.1.
RefSeqNP_046281.1. NC_001875.2.

3D structure databases

ProteinModelPortalO10364.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSC01.083.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID912077.

Family and domain databases

InterProIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERPTHR12411. PTHR12411. 1 hit.
PfamPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSPR00705. PAPAIN.
SMARTSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCATV_NPVOP
AccessionPrimary (citable) accession number: O10364
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: May 14, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries