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O10363 (CHIT_NPVOP) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable endochitinase

EC=3.2.1.14
Gene names
ORF Names:ORF124
OrganismOrgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) [Complete proteome]
Taxonomic identifier262177 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageBaculoviridaeAlphabaculovirus
Virus hostOrgyia pseudotsugata (Douglas-fir tussock moth) [TaxID: 33414]

Protein attributes

Sequence length550 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Random hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.

Subcellular location

Host endoplasmic reticulum lumen Potential.

Sequence similarities

Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Chitin degradation
Polysaccharide degradation
   Cellular componentHost endoplasmic reticulum
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processchitin catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

polysaccharide catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componenthost cell endoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionchitinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Chain17 – 550534Probable endochitinase
PRO_0000011951

Regions

Motif547 – 5504Prevents secretion from ER Potential

Sites

Active site3041Proton donor By similarity

Amino acid modifications

Glycosylation1461N-linked (GlcNAc...); by host Potential
Glycosylation1721N-linked (GlcNAc...); by host Potential
Glycosylation3441N-linked (GlcNAc...); by host Potential

Sequences

Sequence LengthMass (Da)Tools
O10363 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 77947F5CF00E07BD

FASTA55060,734
        10         20         30         40         50         60 
MLHYLATILW LAVAHASPGT PVIDWADRNY ALVSVNSEAT AYENLVERKA GVSVPVSWNV 

        70         80         90        100        110        120 
WNGGVGDMAY VLFNENQVWK GAAAAKRATI DVSKSGQFNM RVKLCDDDGF SVSEPVTVRV 

       130        140        150        160        170        180 
ADTDGGHLSP LEYAWGENNK PGRPHNKTVA AYFVEWGVYG RGFPVDKVPL PNLSHLLYGF 

       190        200        210        220        230        240 
IPICGGDGLN DALKTIPGSF EALQRSCKGR ADFKVAIHDP WAAIQKPQKG VSAWNEPYKG 

       250        260        270        280        290        300 
NFGQLMAAKL ANPHLKILPS IGGWTLSDPF YFMHDADKRR VFVESVKEFL QVWKFFDGVD 

       310        320        330        340        350        360 
IDWEFPGGKG ANPALGNGER DADTYLVLLK ELRAMLDELQ LQTNKTYELT SAISSGYDKI 

       370        380        390        400        410        420 
AVVKYDAAQR FLDKIFLMSY DFKGAWSNTD LGYQTTLYAP SWNANELYTT DHAVKLLTGQ 

       430        440        450        460        470        480 
GVAAHKLIVG VAMYGRGWTG VSGYAGDKYF SGTADGPVPG TWENGVVDYR QINNELSKYI 

       490        500        510        520        530        540 
YRFDAAAKAA YVFNKERGDL ISFDSVDSVL AKNVYVQQNG LGGLFAWEID ADNGDLLNAM 

       550 
NERVRVKDEL 

« Hide

References

[1]"The sequence of the Orgyia pseudotsugata multinucleocapsid nuclear polyhedrosis virus genome."
Ahrens C.H., Russell R.R., Funk C.J., Evans J., Harwood S., Rohrmann G.F.
Virology 229:381-399(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U75930 Genomic DNA. Translation: AAC59123.1.
RefSeqNP_046280.1. NC_001875.2.

3D structure databases

ProteinModelPortalO10363.
SMRO10363. Positions 16-541.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH18. Glycoside Hydrolase Family 18.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID912030.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
3.10.50.10. 1 hit.
3.20.20.80. 2 hits.
InterProIPR011583. Chitinase_II.
IPR029070. Chitinase_insertion.
IPR013540. ChitinaseA_N.
IPR001223. Glyco_hydro18cat.
IPR001579. Glyco_hydro_18_chit_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR022409. PKD/Chitinase_dom.
[Graphical view]
PfamPF08329. ChitinaseA_N. 1 hit.
PF00704. Glyco_hydro_18. 1 hit.
[Graphical view]
SMARTSM00636. Glyco_18. 1 hit.
SM00089. PKD. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 2 hits.
SSF54556. SSF54556. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEPS01095. CHITINASE_18. 1 hit.
PS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCHIT_NPVOP
AccessionPrimary (citable) accession number: O10363
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: June 11, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries